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218. Mitchell B, MacPhail T, Vivian D, Verrills P, Barnard A.
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219. Rosenberg JM, Quint TJ, de Rosayro AM. Computerized
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221. Fortin JD, Washington WJ, Falco FJ. ree pathways between
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227. King W, Ahmed SU, Baisden J, et al. Diagnosis and treatment
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230. Siivola SM, Levoska S, Tervonen O, et al. MRI changes of
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231. Anderberg L, Annertz M, Brandt L, Saveland H. Selective
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of nerve-root involvement in sixty-eight patients. J Bone Joint
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237. Schutz H, Lougheed WM, Wortzman G, Awerbuck BG.
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238. Tajima T, Furukawa K, Kuramochi E. Selective lumbosacral
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241. Herron LD. Selective nerve root block in patient selection
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242. Porter DG, Valentine AR, Bradford R. A retrospective
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244. Haueisen DC, Smith BS, Myers SR, Pryce ML. e diagnostic
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246. Kumar K, Taylor RS, Jacques L, et al. Spinal cord
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sheath inltration. Acta Orthop Scand Suppl. 1993;251:61-63.
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17
CHAPTER
Provocative discography is a diagnostic test sometimes used
to evaluate the disc as a potential source of persistent back and
neck pain syndromes. In its simplest form, provocative discography is an injection into the nucleus of an intervertebral disc;
the test result is determined by the pain response to this
injection. If the injection reproduces the patient’s usual pain,
some authors have proposed that the “cause” of the axial pain
syndrome can be ascribed to that disc—that is, primary disco-
genic pain.
In 1948, Lindblom1 originally reported discography as a
method to identify herniated discs in the lumbar spine by
injecting contrast medium into the disc and following the
outline of contrast medium into the spinal canal. It was noted
as only a secondary consideration of the test that reproduction
of the patient’s usual sciatica sometimes occurred during the
disc injection. It was observed later that back pain was sometimes reproduced during the injection as opposed to sciatica.
Eventually, some clinicians began using the test to evaluate
discs as the source of axial pain in patients without radicular
symptoms.
Since the early use of discography, it has been unclear
whether reproduction of pain with injection indicated that
the injected disc is the true primary source of clinical back
pain, or whether the injection had simulated the usual pain in
an articial manner. Over time, attempts have been made to
determine the specicity of the test and to rene the technique
to reduce the risk of false-positive or false-negative results.
Currently, this test remains highly controversial. Even the
staunchest proponents of the procedure state that “discography is a test that is easily abused.”2 Assessment of provocative
discography as a basic diagnostic test has found fundamental
problems with test reliability (i.e., does the test give the
same result on repeated testing?) and validity (i.e., does the
test prove what it purports to prove?). Also, it has not been
shown that using the test improves the outcomes in patients
receiving the test compared with patients not receiving the
test. More recently, the long-term safety of disc puncture and
injection has also been questioned. is chapter discusses the
rationale, technique, utility, and clinical eects of provocative
discography when used in patients with primary axial pain
syndromes.
Discography
Eugene Carragee
Michael Stau
Clinical Context
Back and neck pain are very common, and in most cases
determining the “cause” of a specic episode of back or neck
pain is unimportant because these symptoms frequently
resolve in a short time or do not seriously interfere with function.1 Provocative discography may be described as representing a tertiary diagnostic evaluation, which should be considered
only in a select group of patients.
A primary diagnostic evaluation usually involves screening
for serious underlying disease (“red ags”) by history and
physical examination aimed at detecting systemic disease,
spinal deformity, and neurologic loss. In most patients, these
examinations are negative, and nonspecic treatment alone is
recommended. In a patient who does not recover good function in 6 to 12 weeks, a secondary diagnostic survey may be
indicated. is follow-up evaluation should identify serious
psychosocial barriers to recovery (“yellow ags”) and deni-
tively rule out serious conditions that may result in neurologic
injury; structural failure; or progression of a visceral disease,
systemic infection, or malignant process. Diagnostic tests for
serious structural disease, including blood tests and imaging
studies, have become so sensitive that these serious conditions
are usually identied in the early stages.
Establishing a more specic pathoanatomic diagnosis than
“nonspecic back pain syndrome” or “persistent back pain
illness” becomes important only if specic therapy directed to
common age-related structural changes is considered because
of continued serious symptoms and functional loss. At this
point, if the primary and secondary evaluations have revealed
neither serious structural pathology nor signicant confounding psychosocial or neurophysiologic factors, a tertiary diagnostic evaluation may be undertaken. is evaluation may
occasionally uncover a clear degenerative cause of symptoms,
such as unstable spondylolisthesis or progressive degenerative
deformity, such as degenerative scoliosis.
e most common structural degenerative changes (e.g.,
loss of disc height, loss of nuclear signal, minor facet arthrosis,
anular ssures) may be very dicult to reconcile with the
severity of apparent symptoms and pain behavior, however,
II
301
302 DIAGNOSIS
because many people with minimal or no spinal symptoms
have similar mild degenerative ndings. e question is why
do individuals with such benign ndings sometimes report
severe and persistent pain and impairment? e rationale of
provocative discography in the tertiary evaluation is to separate anatomic spinal changes causing serious primary pain
illnesses from similarly appearing common degenerative
changes that do not cause serious illness. As this chapter
shows, it is unclear that this goal is routinely achievable with
provocative discography.
Discography Technique
Discography is performed using local anesthetic and mild
sedation. e objective is percutaneous injection of a nonirritating radiopaque dye, under uoroscopic guidance, into
one or more intervertebral discs. e technique involves
using a long, ne-gauge needle to penetrate the nucleus from
a posterolateral approach in the thoracolumbar spine and
anterolaterally in the cervical spine. In the lumbar spine, the
needle passes posterior to the exiting nerve root and anterolateral to the traversing root. Sometimes a bend of the needle or
introducer is required to place the needle accurately, especially
at L5–S1.
e passage of the needle in skilled hands should be quick
and atraumatic. When the position is veried in two planes
using uoroscopy, the dye is slowly injected into the nucleus
of several lumbar discs with the patient blinded to the timing
and site of injection. e spread of the dye in the disc is noted
on the images, and the patient’s response to the injection is
documented. e patient is queried at each injection or at
random intervals as to whether or not the procedure is painful
and is asked to rate the pain against a standardized scale (e.g.,
0–5, 0–10, none to unbearable). If the injection is painful, the
patient is asked to describe the discomfort provoked qualitatively. e injection is usually rated as exactly the same as,
similar to (concordant), or dissimilar to the patient’s usual
back or neck pain.
Criteria for Positive Test
In an eort to improve the specicity of discography in diag-
nosing so-called discogenic pain, some investigators have used
additional criteria beyond pain reproduction on injection. e
criteria for establishing a positive discogram are controversial.
e primary criteria for a “positive” disc injection are pain of
“signicant” intensity on disc injections (usually dened as
≥6 out of 10 pain scale) and a reported similarity of that pain
to the patient’s usual, clinical discomfort (concordant pain).
Walsh and colleagues proposed these basic criteria in their
experimental work in 1990.3 In this study, “signicant pain”
was dened as 3 out of 5 (or 6 out of 10) on an arbitrary pain
thermometer. “Bad pain” was dened as 3 out of 5 pain, and
“moderate pain” was described as 2 out of 5 pain. e authors
did not stringently dene concordance of pain reproduction.
Some investigators have proposed additional and sometimes
idiosyncratic criteria for positive injections (Table 17.1).
Pain Generator Concept and
Provocative Discography
e diagnosis made by a “positive provocative discogram”
should indicate that the disc identied is the primary or only
cause of the patient’s back pain illness, or the pain generator.
e idea of a pain generator, however, has proven to be problematic. In a patient with persistent symptoms and a secondary
workup with only degenerative ndings, the task of identifying
a specic isolated pain generator can be formidable. Most
patients have multiple ndings of disc changes and facet
arthrosis, oen at multiple levels. To determine which degen-
erative nding is associated with a patient’s severe axial back
pain can be dicult. Many people have occasional back or
neck ache with common activities or episodic axial pain
without impairment. e question is not whether any previous
or possible future back or neck pain may be coming from a
certain spinal structure because it may be assumed that most
people with degenerative change of the axial skeleton may
have occasional discomfort from several sites alone or at the
same time.
e pertinent question is whether or not a suspected local
anatomic structure (e.g., disc, facet, sacroiliac joint) is causing
serious, disabling axial pain illness or is only a minor contributor to a generalized pain-sensitivity syndrome (e.g.,
bromyalgia), a central pain-processing syndrome, an overuse
syndrome related to posture or activity, or other conditions. It
is hoped that some diagnostic test can identify whether or not
a specic local spinal pathoanatomic structure adequately
explains the severity of clinical symptoms. As a matter of
practical denition, for a pathoanatomic diagnosis to be clinically relevant requires that the identied pain generator not
only be capable of causing some discomfort under any circumstances (e.g., puncture and injection of a disc) but also
that this structure is a primary independent cause of the
patient’s apparent severe illness.
When only degenerative changes are found, it is controversial that a discrete local pain generator can be identied as the
cause of serious back pain illness. Some clinicians believe that
serious axial pain and disability can be so multifactorial
(mechanical, psychological, social, and neurophysiologic
contributors) that it is unreasonable to expect specic diagnostic studies to conrm an anatomic “diagnosis” for axial
pain illness in every patient.
suspected, it is unclear how this can be reliably conrmed as
the cause of the patient’s perceived pain, impairment, and
disability in the face of complex social, emotional, and neurophysiologic confounders.
Other clinicians believe that identifying a pain generator is
central to spine evaluations because it meets patients’ expectations and leads to an optimal treatment that focuses on an
anatomic structure. In this model, social issues such as disability, litigation, psychological distress, and pain intolerance
are believed to be secondary issues to the structural pathol-
1,7–13
ogy.
history and physical examination may be helpful in suggesting
serious underlying pathology, such as infection and tumor,
ese clinicians generally believe that although the
4–6
Even if a pain generator is