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271

ovErviEw oF tHE EvalUation oF lowEr Urinary tract dysFUnction

It is our practice to fill the bladder initially in the supine position and the volume at first sensation of filling is noted. When the subject first experiences discomfort, the radiographic table is tipped toward the standing position and subsequent bladder filling discontinued when at the maximum tolerated capacity.During bladder filling the patient is asked to consciously suppress bladder contraction and may be asked to cough or heel bounce. The patient is then turned to the oblique position relative to the X-ray machine and asked to void into the flowmeter provided.

In units where a tipping table is not available, the study can be carried out in the sitting or standing position initially; but it is important to subsequently stand the patient upright at the end of the study to assess where there is postural detrusor instability and to determine whether there is stress incontinence; in the absence of radiological screening this is assessed with the patient standing with legs slightly apart and squatting.

Throughout the study continuous rectal pressure, total bladder pressure and electronically subtracted detrusor pressure (total bladder pressure minus rectal pressure) measurements are sampled at a predetermined rate (usually 1 Hz) and the results displayed on the video display unit / stored to disc / polygraph chart recorder; depending on the equipment in use. Figure 20.4a and b shows a typical workstation and schematic.

Videodynamics provides an excellent method of evaluating the urethral outlet in female patients with urinary incontinence, males with complex voiding problems and are essential to the optimum management of neurological patients. Standing quietly and partially obliqued,the bladder neck position may be abnormally low, below the level of the upper third of the symphysis pubis, signifying loss of pelvic floor support in female patients with hypermobile urethras/ anatomical stress incontinence. Coughing or valsalva maneuvers cause these vesicourethral units to descend and leak. With termination of the increased intra-abdominal pressure the bladder neck quickly “springs back” to its original position terminating leakage. The semi-lateral/ oblique position enables to distinguish between the bladder neck from a dependent cystocele and it also helps to evaluate the size and functional significance of the cystocele.

Breaking or funneling of the bladder neck probably represents a normal finding,is common

in continent females, but should be distinguished from a rectangular-shaped incompetent bladder neck common in patients with intrinsic sphincter deficiency (ISD). Typically patients with pure ISD as the cause of their incontinence demonstrate severe leakage with minimal intra-abdom- inalpressureincreasesandminimalurethrovesical hypermobility. The urethra does not spring back but appears to hold open and continue leaking even after the stress event. Patients often have both bladder neck hypermobility and ISD and experience is necessary in order to interpret their relative functional significance.

Cystourethrography via the adjacent X-ray screening apparatus allows the synchronous display of pressure and flow, and also radiographic data relating to bladder morphology e.g. diverticula, vesicoureteric reflux and the appearances of the bladder outlet and urethra, to be displayed alongside the numerical data on a video display unit.

Cystometric Findings

As filling continues the patient is asked to confirm the following bladder sensations which are recorded on the computer:

First desire to void

Strong desire to void

Desire at which the patient cannot delay micturition (Maximum cystometric capacity)

Urgency – sudden compelling desire to void

Bladder pain – should not occur during filling

The computer calculates the pressures and plots them on a temporal graph. The above sensations are recorded at specific times and give an indication of how full the bladder was when these sensations occurred. Figure 20.5 shows a typical readout from the study, showing both storage and voiding phases with regular quality controls (coughing). The detrusor pressure is the result of the intravesical pressure minus the intra-abdominal pressure.

The four graphs in the order produced are:

Intra-abdominal pressure (Pabd)

Intra-vesical pressure (Pves)

Detrusor pressure (Pdet)

Urinary flow rate (Q)

272

Practical Urology: EssEntial PrinciPlEs and PracticE

Figure 20.4. (a) a typical workstation

a

comprising: (a) transducers to be

 

 

 

 

 

 

 

 

placed at height of patients symphysis

 

 

 

 

 

 

 

 

pubis, (B) Pump for bladder filling,

 

 

 

 

C

 

 

 

 

 

 

 

 

 

 

 

(c) display, (d) uroflowmeter. (b) the

 

 

 

 

 

 

 

 

bladder is filled at a predetermined

 

 

 

 

 

 

 

 

A

rate with a radio-opaque contrast

 

 

 

 

 

 

 

 

medium, with the simultaneous

 

 

 

 

 

 

 

 

measurement of intra-vesical pressure

 

 

 

 

 

 

 

 

and intra-abdominal pressure.the

 

 

 

 

 

 

 

 

 

 

 

 

 

 

B

subtracted detrusor pressure is

 

 

 

 

 

 

 

 

calculated automatically and flow is

 

 

 

 

 

 

 

 

recorded with the flow meter.this

 

 

 

 

 

 

 

 

information with accompanying

 

 

 

 

 

 

 

 

radiographic pictures and a sound

 

 

 

 

 

 

 

 

track can be recorded allowing

 

 

 

 

 

 

 

 

subsequent review and analysis.22

 

 

 

 

 

 

 

 

 

D

 

b

X-ray

 

 

 

 

screening unit

 

 

 

Peristaltic

 

 

pump

 

Bladder

 

 

Rectum

 

 

Tilting table

Pressure

 

 

 

X-ray

transducers

 

 

 

Pabd

 

 

Pves

Control

 

 

computer

 

Pdet

Flow

 

meter

 

 

 

Monitor display

 

Practical Points: Since a number of variations in technique are currently available, the following points deserve specific consideration.

i.Type of catheter

a.Fluid-filled catheter – specify number of catheters, single or multiple lumens, type of catheter, size of catheter.

b.Catheter tip transducer – specifications vary between manufacturers; these catheters

tend to be expensive and rather too fragile for routine use.

ii.Measuring equipment.

A number of commercial urodynamic systems are currently available. These vary greatly in terms of sampling rate, associated computer software backup,and price.A major problem with existing computer programs is the ease with which such programs will

273

ovErviEw oF tHE EvalUation oF lowEr Urinary tract dysFUnction

Figure 20.5. a typical graphical display of the pressure flow data, showing both storage and voiding phases with regular coughing acting as a quality control (small blips in Pdet).the graph shows good contraction of the detrusor during the voiding phase and no contractions during the storage phase. not included are the sensations as described by the patient, which will be plotted along the x-axis at the time they occurred, allowing us to calculate volumes at which sensory perceptions occur.22

Pabd

(cm H2O)

Pves

(cm H2O)

Pdet

(cm H2O)

Flow rate (Q) (ml/s)

Filing phase

Voiding phase

record artifacts which can then bias the results of the subsequent automatic data analysis. The investigator is strongly advised not to rely upon the computer generated data sheets but to use an appropriate standardized reading sheet which allows interpretation of the urodynamic findings by the investigator.

iii.Test medium (liquid or gas)

This is obviously not applicable to catheter tip transducers. The advantage of equipment using gas as a medium is that it can be more compact and is therefore more easily portable. A major drawback with gas cystometry is its susceptibility to artifact being introduced by changes in the temperature of the gaseous medium; a far less important consideration when fluid is used.

iv.Position of patient (e.g. supine, sitting, or standing).

v.Type of filling

This may be by diuresis or catheter. Filling by catheter may be continuous or incremental; the precise filling rate should be stated (vide infra).When the incremental method is used the volume increment should be stated.

vi.Continuous or intermittent pressure measurement

Continuous pressure measurement is of greatest usefulness in clinical practice; in patients for example with a suprapubic catheter and no urethral access, staged measurement of pressures can be carried out through the suprapubic catheter.

 

 

 

 

274

 

 

 

 

 

 

 

 

 

Practical Urology: EssEntial PrinciPlEs and PracticE

vii. Who carries out the study and how? – data

Our experience would support the use of

quality

 

 

graduated coughs as a means of assessing leakage,

It is essential that urodynamic studies are

ideally coupled with cystourethrography or vid-

carried out or supervised by experienced

eocystometry. Basically, both tests suffer limita-

investigators:-

 

 

tions.Since women leak with stress efforts in their

a. Always take a clinical history of the patient

everyday life and not with Valsalva, the Valsalva

leak point pressure serves at best as a surrogate

before carrying out the study and counsel

marker of sphincter competency. For the urethral

the patient before they attend on the day

pressure profile, the methodology imposed by the

and at the start of the study as to the nature

test (passive measurement, supine position)

of the test.

 

 

negates the real life effect of the stress component

 

 

over a presumably deficient sphincter.

b. Make sure the urodynamic equipment is

 

regularly serviced and calibrate the trans-

Comment:

ducers on a regular basis.

 

c. Make sure that the lines are zeroed at the

i. Before starting to fill the bladder, the residual

start of the

study, check subtraction is

urine may be measured.However,the removal

perfect before starting the study with a

of a large volume of residual urine may alter

detrusor pressure between 0 and 5 cm

detrusor function especially in neuropathic

H2O, and every minute during the study

disorders. Certain cystometric parameters

ask the patient to cough and verify that

may be significantly altered by the speed of

the rectal and vesical pressure lines track

bladder filling.

together in

their response. If in doubt

ii. During cystometry it is taken for granted that

about artifact, repeat the study.

 

 

the patient is awake, unanasthetized, and nei-

d. Choose the

correct filling rate for

the

ther sedated nor taking drugs that affect

study, e.g. normal filling at 50 mL/min and

bladder function. Any variations from this

slower filling at a rate of 10–20 mL/min for

ideal must be taken into account when inter-

neuropaths and patients with a reduced

preting results.

functional capacity.

 

 

iii. In a small group of women who present with

e. Leak point pressure:

 

 

incontinence, urinary leakage cannot be

 

 

 

 

The abdominal pressure or vesical pres-

demonstrated either clinically or radiograph-

ically. Conventional testing can be repeated

sure at which leakage occurs is a major

problem because there is no standard

or continuous ambulatory urodynamic mon-

technique with regard to:

 

itoring considered if available.

Catheter caliber

 

Measurements During the Storage Phase:

Presence of prolapse

 

 

 

Bladder volume at which the leakage is

Detrusor activity – during the storage phase

 

measured

 

 

the detrusor muscle should be inactive.Any

Valsalva versus cough

 

activity should be correlated with episodes

Straining

(contraction/relaxation

of

of urgency and/or incontinence. The vol-

 

pelvic floor)

 

ume at which this occurred should be noted.

Absolute measurement or relative mea-

Provocation maneuvers may be employed

to stimulate detrusor overactivity.

 

surement compared to baseline

 

 

 

Bladder compliance – describes the intrin-

No defined threshold values for treat-

sic ability of the bladder to change in vol-

 

ment decision

 

 

 

ume without significantly altering detrusor

The literature abounds with contradictory reports

pressure.

as to whether there is any correlation between

Bladder capacity – is the volume at the end

urethral pressure and leak point pressure.17,18

of the storage phase. It may be reduced