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Case Studies_ Stahl's Essential - Stephen M. Stahl.docx
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Pretest self-assessment question (answer at the end of the case)

How much different can a generic drug be from its brand name counterpart, based upon individual regulatory tests of bioequivalence?

A. 0%

B. 5%

C. 15%

D. 25%

Patient evaluation on intake

Patient #1

  • – 60-year-old man with a chief complaint of “being angry and down”

Patient #2

  • – 15-year-old girl with a chief complaint of “everything sucks”

Patient #1 states that he was involved in a fracas at work, was pushed down the stairs, and was in a coma for a week

Patient #2 states that she has been having a difficult time at home and at school

Psychiatric history

Patient #1 had been without any psychiatric issues until his head injury. He states his symptoms developed after this

Patient #2 states that she has gradually become more emotionally labile, depressed, and anxious over the last one to two years

Patient #1 has not been able to go back to work at all due to his depression, amotivation, and anger management problems

Patient #2 has been absent from school due to her inability to get up and get ready for school

Patient #1 admits to full syndrome MDD

  • – He has passive suicidal thoughts that there is “not much to life” and he “wouldn’t mind if he didn’t wake up”

  • – Admits to poor focus, concentration, and amotivation as chief complaints

He states that little things make him angry quickly

  • – Experiences road rage and followed fellow drivers after incidents

    • He states that he was never like this prior to his accident

  • – Denies PTSD-related avoidance, flashbacks, or nightmares as he does not remember the accident due to his head injury and coma

  • – Is tense and hyperaroused most of the time

He has relatively few friends as most were colleagues at his previous job. He is at home more and not motivated to leave his home

Patient #2 admits to full MDD symptoms

  • – Has suicidal thoughts that occur more when stressed

  • – Admits to having an inability to focus, poor concentration, and lack of enjoyment as chief complaints

She states that “little things make her angry quickly”

  • – She is afraid that going to school puts her in situations where she may strike out and get into fights, even though this has never been her social pattern

  • – She has friends but feels disenfranchised from them

  • – She gets along with her grandmother but not her parents

Medication history

Patient #1

  • – Has had a few treatments so far while in the care of his PCP

  • – He failed to respond to a low-dose SSRI

    • Fluoxetine (Prozac) 20 mg/d

    • Sertraline (Zoloft) 100 mg/d

    • Paroxetine (Paxil) 20 mg/d

  • – SNRIs as well

    • Venlafaxine-XR (Effexor-XR) 75 mg/d

    • Duloxetine (Cymbalta) 60 mg/d

  • – Additionally, an NDRI

    • bupropion-SR (Wellbutrin-SR) 300 mg/d

  • – He stopped his medication several weeks ago due to lack of clinical improvement

Patient #2

  • – A few subtherapeutic treatments so far while in the care of her PCP

  • – Failed to respond

    • To a low-dose SSRI (fluoxetine [Prozac]) 10 mg/d due to agitation side effects

    • To an SNRI (venlafaxine-XR [Effexor-XR]) 75 mg/d due to agitation side effects

    • Each of these treatments lasted less than one week

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