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DDDD Types of Echocardiography
Measurement Specifications (Informative)
DDDD.1 Overview
Real-world quantities of clinical interest are exchanged in DICOM Structured Reports. These real-world quantities are identified using concept codes of three different types:
•Standard measurements that are defined by professional organizations such as the American Society of Echocardiography (ASE), and codified by vocabulary standards such as the Logical Observation Identifiers Names and Codes (LOINC) or Systematized Nomenclature of Medicine - Clinical Terms (SNOMED-CT) standards.
•Non-Standard measurements that are defined by a medical equipment vendor or clinical institution and codified using a private or standard Coding Scheme.
•Adhocmeasurementsarethosemeasurementsthataregenerallyacquiredonetimetoquantifysomeatypicalanatomyorpathology that may be observed during an exam. These measurements are not codified, but rather are described by the image itself and a label assigned at the time the measurement is taken.
ThisAnnexdiscussestherequirementsforidentifyingmeasurementsinsuchamannerthattheyareaccuratelyacquiredandcorrectly interpreted by medical practitioners.
DDDD.2 Specification of Standard Measurements
Clinicalorganizationspublishrecommendationsforstandardizedmeasurementsthatcompriseanecessaryandsufficientquantification ofparticularanatomyandphysiologyusefulinobtainingaclinicaldiagnosis.Foreachmeasurementrecommendation,themeasurement definition is specific enough so that any trained medical practitioner would know exactly how to acquire the measurement and how to interpret the measurement. Thus, there would be a 1:1 correspondence between the intended measurement recommendation and the practitioner's understanding of the intended measurement and the technique used to measure it (anatomy and physiology, image view, cardiac/respiratory phase, and position/orientation of measurement calipers). This is illustrated in Figure DDDD.2-1.
ASE
Recommendation
sonographer
follows recommendation defined by to measure
Real-World
Quantity of
Clinical
Interest
Figure DDDD.2-1. Matching Intended Quantity with Measurement Definition
The goal is for each recommended measurement to be fully specified such that every medical practitioner making the measurement onagivenpatientatagiventimeachievesthesameresult.However,iftherecommendationweretobeunclearorambiguous,different qualified medical practitioners would achieve different results measuring the same quantity on the same patient, as illustrated in Fig- ure DDDD.2-2.
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ASE
Recommendation
sonographer 1 measures |
defined |
by |
sonographer 2 measures |
Measured |
Intended |
Measured |
Real-World |
Real-World |
Real-World |
Quantity |
Quantity |
Quantity |
Figure DDDD.2-2. Result of Unclear or Ambiguous Measurement Definition
There are a number of characteristics that should be included in a measurement recommendation in order to ensure that all practi- tioners making that measurement achieve the same results in making the measurement. Some characteristics are:
•Anatomy being measured, specified to appropriate level of detail
•Reference points (e.g., "OFD is measurement in the same plane as BPD from the outer table of the proximal skull with the cranial bones perpendicular to the US beam to the inner table of the distal skull")
•Type of measurement (distance, area, volume, velocity, time, VTI, etc.)
•Sampling method (average of several samples, peak value of several samples, etc.)
•Image view in which the measurement is made
•Cardiac and/or respiratory phase
The measurement definition should specify these characteristics in order that the definition is clear and unambiguous. Since the characteristics are published by the professional society as part of the Standard measurement definition document are incorporated in the codes that are added to LOINC, a pre-coordinated measurement code is sufficient to specify the measurement in a structured report.
Because of the detail in the definition of each standard measurement, it is sufficient to represent such measurements with a pre-co- ordinated measurement code and a minimum of circumstantial modifiers. This approach is being followed by TID 5301, for example.
DDDD.3 Specification of Non-standard Measurements
Non-Standard Measurements are defined by a particular vendor or clinical institution, and are not necessarily understood by users of other vendors' equipment or practitioners in other clinical institutions. A system producing such measurements cannot expect a consumingapplicationtoimplicitlyunderstandthemeasurementanditscharacteristics.Further,suchmeasurementsmaynotbefully understood by the medical practitioners who are acquiring the measurements, so there is some risk that the measurement acquired may not match the real-world quantity intended by the measurement definition, as illustrated by Figure DDDD.3-1.
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Non-standard
Measurement
Definition
sonographer measures |
defined |
by |
Measured |
Intended |
Real-World |
Real-World |
Quantity |
Quantity |
Figure DDDD.3-1. Inadequate Definition of Non-Standard Measurement
It is important for all non-standard measurement definitions to include all the characteristics of the measurement as would have been specified for Standard (baseline) measurement definitions, such as:
•Anatomy being measured, specified to appropriate level of detail
•Reference points (e.g., "OFD is measurement in the same plane as BPD from the outer table of the proximal skull with the cranial bones perpendicular to the US beam to the inner table of the distal skull")
•Type of measurement (distance, area, volume, velocity, time, VTI, etc.)
•Sampling method (average of several samples, peak value of several samples, etc.)
•Image view in which the measurement is made
•Cardiac and/or respiratory phase
Fully specifying the characteristics of such measurements is important for several reasons:
1.Ensuring medical practitioners correctly measure the intended real-world quantity
2.Aidingreceivingapplicationsincorrectlyinterpretingthenon-standardmeasurementandmappingthenon-standardmeasurement to the most appropriate internally-supported measurement.
3.Aid in determining whether non-standard measurements from different sources are in fact equivalent measurements and could thus be described by a common measurement definition.
Each of these reasons is elaborated upon in the sections to follow. This is the justification for representing such non-standard meas- urements using both post-coordinated concepts and a pre-coordinated concept code for the measurement, such as is done in TID 5302 “Post-coordinated Echo Measurement”.
DDDD.3.1 Acquiring the Intended Real-World Quantity
A medical practitioner can be expected to correctly acquire the real-world quantity intended by the non-standard measurement definition only if it is completely specified. This includes explicitly specifying all the essential clinical characteristics as are described for Standard measurements. While the resultant measurement value can be described by a pre-coordinated concept code, the char- acteristics of the intended real-world quantity must be defined and known.
DDDD.3.2 Interpreting the Non-Standard Measurement
Thecharacteristicsofthereal-worldmeasurementmeasuredbytheacquisitionsystemanduserareconveyedinthemandatorypost- coordinated descriptors recorded alongside the measurement value.
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The presence of such post-coordinated descriptors aids the consumer application in
1.Mapping the non-standard measurement to a corresponding internally-supported measurement. The full details provided by in- cluding the post-coordinated descriptors greatly simplifies the task of determining measurement equivalence.
2.Organizing the display of the non-standard measurement values in a report. It is clinically useful to structure written reports in a hierarchical manner by displaying all measurements that pertain to the same anatomical structure or physiological condition to- gether.
3.Interpreting similar anatomical measurements differently depending on such characteristics as acquisition image mode (e.g., 2D vs. M-mode image). Since the clinical interpretation may depend on this information, it should be explicitly included along with the measurement concept code/code meaning.
4.Analyzing accumulated report data (trending, data mining, and big data analytics)
Note
Some of these benefits are reduced if the context groups specified for each post-coordinated descriptor are extended with custom codes. A user should take great care when considering the extension of the standard context groups to minimize the proliferation of modifier codes.
The first time that a consumer application encounters a new post-coordinated measurement, it will need to evaluate it based on the values of the post-coordinated descriptors. To help the consumer application with subsequent encounters with the same type of measurement, the acquisition system can consistently populate the Concept Name of the measurement with a code that corresponds to the collection of post-coordinated descriptor values; effectively a non-standard, but stable, pre-coordinated measurement code. (See TID 5302 “Post-coordinated Echo Measurement”, Row 1)
The presence of the pre-coordinated code in addition to the post-coordinated descriptors allows subsequent receipt of the same measurementtoutilizethemappingthatwasperformedasdescribedaboveandtreatthemeasurementasaneffectivelypre-coordinated measurement.
If the acquisition system is aware of other pre-coordinated codes (e.g., those used by other vendor carts) that are also equivalent to the collection of post-coordinated descriptor values for a given measurement, those pre-coordinated codes may be listed as (121050, DCM, "Equivalent Meaning of Concept Name"). These "known mappings" provided by the acquisition system can also be useful for consumer applications trying to recognize or map measurements.
DDDD.3.3 Determining Equivalence of Measurements from Different Sources
Itiscustomaryforindividualvendorstoprovidetoolstoacquiremeasurementsthataren'tcurrentlydefinedinaStandardmeasurement template. In the normal evolution of the Standard, standard measurement sets are periodically updated to reflect the state of medical practice. Often, individual vendors and/or clinical users are first to implement the acquisition of new measurements.
Some measurements may be defined and used within a particular clinical institution. For maximum interoperability, if there exists a Standard or vendor-defined measurement concept code for that measurement, the Standard or vendor-defined concept code should be used instead of creating a custom measurement code unique to that institution.
Determiningwhethertwoormoredifferentmeasurementdefinitionspertaintothesamereal-worldquantityisanon-trivialtask.Itrequires clinical experts to carefully examine alternative measurement definitions to determine if two or more definitions are equivalent. This task is greatly simplified if the distinct characteristics of the non-standard measurement are explicitly stated and conveyed. If two measurements differ in one or more critical characteristics then it can be concluded that the two measurement definitions describe differentreal-worldquantities.Onlythosemeasurementsthatshareallthecriticalclinicalcharacteristicsneedtobecarefullyexamined by clinical experts to see if they are equivalent.
It may be determined that two measurements that share all specified clinical characteristics are actually distinct real-world quantities. If this occurs, it may be an indication that not all relevant clinical characteristics have been isolated and codified. In this case, the convention for defining the measurement should be extended to include the unspecified clinical characteristic.
DDDD.4 Specification of Adhoc (One-Time) Measurements
Inthecaseofameasurementthatisonlybeingperformedonce,thereislittlevalueinincurringtheoverheadtospecifyallmeasurement characteristics and assign a code to the measurement as it will never be used again. Rather, the descriptive text associated with the
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measurement may provide sufficient clinical context. Association of the measurement with the source image (and/or particular points in the source image) can often provide additional relevant context so it is recommended to provide image coordinate references in the Structured Report (See TID 5303).
Ifauserfindsthatthesamequantityisbeingmeasuredrepeatedlyasanadhocmeasurement,anon-standardmeasurementdefinition should be created for the measurement as described in Section DDDD.3.
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EEEE Encoding Diffusion Model Parameters for Parametric Maps and ROI Measurements (Informative)
ThisAnnexcontainsexamplesofhowtoencodediffusionmodelsandacquisitionparameterswithintheQuantityDefinitionSequence of Parametric Maps and in ROIs in Measurement Report SR Documents.
The approach suggested is to describe that an ADC value is being measured by using ADC (generic) as the concept name of the numeric measurement, and to add post-coordinated concept modifiers to describe:
•themodel(e.g.,mono-exponential,bi-exponentialorothermulti-compartmentmodels)(drawnfromCID7273“MRDiffusionModels”)
•the method of fitting the data points to that model (e.g., for mono-exponential models, log of ratio of two samples, linear least- squares for log-intensities of all b-values) (drawn from CID 7274 “MR Diffusion Model Fitting Methods”)
•relevantnumericparameters,suchastheb-valuesusedduringacquisitionofthesourceimages(drawnfromCID7275“MRDiffusion Model Specific Methods”)
The model and method of fitting are encoded separately since even though the method of fitting is sometimes dependent on the model, the model may be known but not the method of fitting, or there may be no code for the method of fitting.
Note
1.The generic concept of ADC, (113041, DCM, "Apparent Diffusion Coefficient"), is used, rather than the specific concept of ADCm, (113290, DCM, "Mono-exponential Apparent Diffusion Coefficient"), since the model is expressed in a post- coordinated manner. Most clinical users will not be concerned with which model was used, and so the ability to display and query for a single generic concept is preferred. However, model-specific pre-coordinated concepts for ADC are provided, as are concepts for other model parameters when a single ADC concept is inappropriate, e.g., for the fast and slow components of a bi-dimensional model.
2.The generic concept of (370129005, SCT, "Measurement Method") is used to describe the model, rather than being used to described the fitting method, since the model is the more important aspect of the measurement to distinguish. This pattern is consistent with historical precedent (e.g., in Section RRR.3 the model (Extended Tofts) for DCE-MR measurements is described using the Measurement Method and the fitting method is not described).
Also illustrated is how the (121050, DCM, "Equivalent Meaning of Concept Name") can be used to communicate a single human readable textual description for the entire concept.
EEEE.1 Encoding Diffusion Model Parameters for Parametric Maps
This example shows how to use the Table C.7.6.16-12b “Real World Value Mapping Item Macro Attributes” in PS3.3 to describe pixel values of an ADC parametric map obtained from a pair of B0 and B1000 images fitting the log ratio ot two samples to a mono-expo- nential function (single compartment model). It elaborates on the simple example provided in Section C.7.6.16.2.11.1.2 “Real World ValuesMappingSequenceAttributes”byaddingcodedconceptsthatdescribethemodel,themethodoffittingandlistingtheb-values used.
•Real World Value Mapping Sequence (0040,9096)
•...
•Real World Value Intercept (0040,9224) = "0"
•Real World Value Slope (0040,9225) = "1E-06"
•LUT Explanation (0028,3003) = "ADC mm2/s mono-exponential log ratio B0 and B1000"
•LUT Label (0040,9210) = "ADC mm2/s"
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•Measurement Units Code Sequence (0040,08EA) = (mm2/s, UCUM, "mm2/s")
•Quantity Definition Sequence (0040,9220):
•CODE (246205007, SCT, "Quantity") = (113041, DCM, "Apparent Diffusion Coefficient")
•CODE (370129005, SCT, "Measurement Method") = (113250, DCM, "Mono-exponential ADC model")
•CODE (113241, DCM, "Model fitting method") = (113260, DCM, "Log of ratio of two samples")
•NUMERIC (113240, DCM, "Source image diffusion b-value") = 0 (s/mm2, UCUM, "s/mm2")
•NUMERIC (113240, DCM, "Source image diffusion b-value") = 1000 (s/mm2, UCUM, "s/mm2")
•TEXT (121050, DCM, "Equivalent Meaning of Concept Name") = "ADC mono-exponential log ratio B0 and B1000"
In this usage, the text of the (121050, DCM, "Equivalent Meaning of Concept Name") is redundant with the value of LUT Explanation (0028,3003); either or both could be omitted.
The parameter describing a b-value of 0 is expected to be sent, and one should not assume that a b-value of 0 is used if it is absent, since some methods may use a low b-value (e.g., 50), which is not 0.
There is no consensus in the MR community or scientific literature as to the appropriate units to use to report diffusion coefficient values to the user, nor amongst the MR vendors as to how to encode them. In this example, the units are specified as "s/mm2". If the diffusion coefficient pixel values were encoded as integers with such a unit, they could then be encoded with a Rescale Slope of 1E- 06, given the typical range of values encountered. Alternatively, the pixel values could be encoded as floating point pixel data values with identity rescaling. Or, if the units were specified "um2/s" (or "10-6.mm2/s", which is the same thing), then integer pixels could be used with a Rescale Slope of 1. Application software can of course rescale the values for display and convert the units as appropriate to the user's preference, as long as they are unambiguously encoded.
EEEE.2 Encoding Diffusion Model Parameters for ROIs in Measurement Report SR Documents
This example shows how to describe the mean ADC value of a region of interest on a volume of ADC values obtained from a pair of B0 and B1000 images fitting the log ratio ot two samples to a mono-exponential function (single compartment model). In this case the template used is TID 1419 “ROI Measurements”.
•NUM (113041, DCM, "Apparent Diffusion Coefficient") = 0.75E-3 (mm2/s, UCUM, "mm2/s")
•HAS CONCEPT MOD CODE (370129005, SCT, "Measurement Method") = (113250, DCM, "Mono-exponential ADC model")
•HAS CONCEPT MOD CODE (113241, DCM, "Model fitting method") = (113260, DCM, "Log of ratio of two samples")
•HAS CONCEPT MOD CODE (121401, DCM, "Derivation") = (373098007, SCT, "Mean")
•INFERRED FROM NUM (113240, DCM, "Source image diffusion b-value") = 0 (s/mm2, UCUM, "s/mm2")
•INFERRED FROM NUM (113240, DCM, "Source image diffusion b-value") = 1000 (s/mm2, UCUM, "s/mm2")
•HAS CONCEPT MOD TEXT (121050, DCM, "Equivalent Meaning of Concept Name") = "Mean ADC mono-exponential log ratio B0 and B1000"
EEEE.3 Relationship of Derived Diffusion Model Parametric Maps to Diffusion Weighted Source Images
ThisexampleillustrateshowtodescribethemannerinwhichanADCParametricMapimagewasderivedfromB0andB1000images.
Theintentistoprovidelinkstotheimages,nottoreplicatealltheinformationthatcanbeprovidedintheQuantityDefinitionSequence.
ThisparticularexampleillustratesthereferencefromanADCParametricMaptoapairofEnhancedMRimages,oneforeachb-value (or a pair of subsets of frames of a single Enhanced MR image), but the same principle is applicable when single frame IODs are used as source or derived image.
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•Derivation Image Sequence (0008,9124)
•Derivation Description (0008,2111) = "Calculation of mono-exponential ADC from log of ratio of B0 and B1000 images"
•Derivation Code Sequence (0008,9215)
•(113041, DCM, "Apparent Diffusion Coefficient")
•(113250, DCM, "Mono-exponential ADC from log of ratio of two samples")
•Source Image Sequence (0008,2112)
•Item 1:
•Referenced SOP Class UID (0008,1150) of B0 image
•Referenced SOP Instance UID (0008,1155) of B0 image
•Referenced Frame Number (0008,1160) of B0 frames in image
•Purpose of Reference Code Sequence
•(121322, DCM, "Source image for image processing operation")
•Item 2:
•Referenced SOP Class UID (0008,1150) of B1000 image
•Referenced SOP Instance UID (0008,1155) of B1000 image
•Referenced Frame Number (0008,1160) of B1000 frames in image
•Purpose of Reference Code Sequence
•(121322, DCM, "Source image for image processing operation")
In this approach:
•since multiple items are permitted in the Derivation Code Sequence (0008,9215), both the general concept (calculation of ADC) and the specific method have been listed; alternatively, just one or the other could be provided
•a textual description has also be provided, which in this case provides more information than the structured content (i.e., about the b-values used)
•a generic purpose of reference code has been used, since only a single code is permitted and there is no mechanism (other then creating pre-coordinated codes for every possible b-value) to convey which image (set) was acquired with which b-value; the more specificalternativeofacodedconceptfor"sourceimageforADCcalculation"wouldaddnovalueovertheconceptalreadydescribed in Derivation Code Sequence
•the SOP Instance UID in the first and second items may be the same, but a different range of frames referenced, e.g., if all of the source frames (all of the b-values) are in the same instance, as is required by the IHE Diffusion (DIFF) profile (http://wiki.ihe.net/ index.php/MR_Diffusion_Imaging); if all of the frames in a single source image are used, then only a single item is necessary and the Referenced Frame Number can be omitted.
•all of the images have been listed in a single item of Derivation Image Sequence (0008,9124); alternatively, multiple items of Deriv- ationImageSequence(0008,9124)couldbesent.oneforeachofthedifferentb-valuesused;thiswouldallowDerivationDescription (0008,2111) to communicate which set contained which b-value, but there is no structured way to communicate such numeric parameters (other then creating pre-coordinated codes for every possible b-value)
EEEE.4 Image and Frame of Derived Diffusion Model Parametric Maps
This example illustrates how to encode the Image and Frame Type values of an ADC Parametric Map image.
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Parametric maps are of the enhanced multi-frame family, so they use the standard roles of Image Flavor for Value 3 and Derived Pixel Contrast for Value 4.
ThespecificrequirementaredefinedinSectionC.8.32.2“ParametricMapImageModule”inPS3.3andSectionC.8.32.3.1“Parametric
Map Frame Type Macro” in PS3.3.
Since this is a derived diffusion image that contains ADC value, suitable values are:
•Image Type (0008,0008) = "DERIVED\PRIMARY\DIFFUSION\ADC"
This usage is consistent with the requirements for Image and Frame Type in the IHE Diffusion (DIFF) profile (http://wiki.ihe.net/ index.php/MR_Diffusion_Imaging).
EEEE.5 Informative References
This section lists useful references related to the taxonomy of ADC calculation methods.
EEEE.5.1 ADC Method Descriptions
[Burdette 1998] J Comput Assist Tomogr. Burdette JH, Elster AD, and Ricci PE. 1998. 22. 5. 792–4. “Calculation of apparent diffusion coefficients (ADCs) in brain using two-point and six-point methods”. http://journals.lww.com/jcat/pages/articleviewer.aspx? year=1998&issue=09000&article=00023&type=abstract .
[Barbieri2016]MagneticResonanceinMedicine.BarbieriS,DonatiOF,FroehlichJM,andThoenyHC.2016.75.5.2175–84.“Impact of the calculation algorithm on biexponential fitting of diffusion-weighted MRI in upper abdominal organs”. http://dx.doi.org/ 10.1002/mrm.25765 .
[Bennett 2003] Magnetic Resonance in Medicine. Bennett KM, Schmainda KM, Bennett RT, Rowe DB, Lu H, and Hyde JS. 2003. 50. 727–734. “Characterization of continuously distributed cortical water diffusion rates with a stretched-exponential model”. http://dx.doi.org/10.1002/mrm.10581 .
[Gatidis 2016] Journal of Magnetic Resonance Imaging. Gatidis S, Schmidt H, Martirosian P, Nikolaou K, and Schwenzer NF. 2016. 43. 4. 824–32. “Apparent diffusion coefficient-dependent voxelwise computed diffusion-weighted imaging: An approach for improving SNR and reducing T2 shine-through effects”. http://dx.doi.org/10.1002/jmri.25044 .
[Graessner 2011] MAGNETOM Flash. Graessner J. 2011. 84-87. “Frequently Asked Questions: Diffusion-Weighted Imaging (DWI)”. Siemens Healthcare. http://clinical-mri.com/wp-content/uploads/software_hardware_updates/Graessner.pdf .
[Merisaari 2016] Magnetic Resonance in Medicine. Merisaari H, Movahedi P, Perez IM, Toivonen J, Pesola M, Taimen P, Boström PJ, Pahikkala T, Kiviniemi A, Aronen HJ, and Jambor I. 2016. “Fitting methods for intravoxel incoherent motion imaging of prostatecanceronregionofinterestlevel:Repeatabilityandgleasonscoreprediction”. http://dx.doi.org/10.1002/mrm.26169
.
[Neil1993]MagneticResonanceinMedicine.NeilJJandBretthorstGL.1993.29.5.642–7.“Ontheuseofbayesianprobabilitytheory for analysis of exponential decay date: An example taken from intravoxel incoherent motion experiments”. http://dx.doi.org/ 10.1002/mrm.1910290510 .
[Oshio2014]MagnResonMedSci.OshioK,ShinmotoH,andMulkernRV.2014.13.191–195.“InterpretationofdiffusionMRimaging data using a gamma distribution model”. http://dx.doi.org/10.2463/mrms.2014-0016 .
[Toivonen 2015] Magnetic Resonance in Medicine. Toivonen J, Merisaari H, Pesola M, Taimen P, Boström PJ, Pahikkala T, Aronen HJ, and Jambor I. 2015. 74. 4. 1116–24. “Mathematical models for diffusion-weighted imaging of prostate cancer using b values up to 2000 s/mm2: Correlation with Gleason score and repeatability of region of interest analysis”. http://dx.doi.org/ 10.1002/mrm.25482 .
[Yablonskiy 2003] Magnetic Resonance in Medicine. Yablonskiy DA, Bretthorst GL, and Ackerman JJH. 2003. 50. 4. 664–9. “Statist- ical model for diffusion attenuated MR signal”. http://dx.doi.org/10.1002/mrm.10578 .
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