Экзаменационная аннотация на лекарственный препарат для перевода без словаря по дисциплине «Английский язык»

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DUSPATALIN

Trade name: Duspatalin®

DOSAGE FORM:

Prolonged-release capsules

COMPOSITION:

Active ingredient: Each retard capsule contains 200 mg of mebeverine hydrochloride.

Excipients: Magnesium stearate; metacryl acid copolymer; talc; hypromelloze; methylhydroxypropyl-cellulose, methacryl and ethacryl acid copolymer; glycerol triacetate; hard gelatin capsule: gelatin, titanium dioxide.

DESCRIPTION:

Hard white opaque gelatin capsules No. 1 with «245» imprinted on the shell of a capsule and with «S» and «V» on its cap. The contents of the capsules are white or almost white granules.

PHARMACOTHERAPEUTIC GROUP:

Spasmolytic.

PHARMACOLOGICAL ACTION:

This is a myotropic spasmolytic that directly affects the smooth muscles of the gastrointestinal tract (chiefly the large bowel). It eliminates spasm, without exerting any effect on normal intestinal motility. The drug has no anticholinergic activity.

PHARMACO-KINETICS :

When orally used, duspatalin undergoes presystemic hydrolysis and it is undetectable in the plasma. The drug is hepatiсаllу metabolized to veratric acid and mebeverine alcohol. It is mainly excreted by kidneys as metabolites, in small quantities by bile. Mebeverine capsules have the properties of prolonged release. Significant accumulation of the drug does not occur even after its multiple use.

INDICATIONS:

Gastrointestinal spasm (including that caused by an organic disease), intestinal colic, biliary colic, irritable colon syndrome.

Children aged above 12 years

Gastrointestinal functional disorders accompanied by abdominal pain.

CONTRAINDICATIONS:

Hypersensitivity to any components of the drug.

PREGNANCY AND LACTATION:

Animal experiments have revealed no teratogenic effect of the drug. However, it is necessary to compare maternal benefits with potential fetal risks when the drug is administered to pregnant women. When administered in therapeutic doses, mebeverine does not penetrate into breast milk so this drug may be used during lactation.

DOSAGE AND ADMINISTRATION

The drug should be swallowed whole by taking with water.

A capsule (200 mg) should be orally taken 20 minutes before a

meal twice a day (in the morning and in the evening).

ADVERSE REACTIONS

Dizziness has been rarely observed. In extremely rare cases, there may be following hypersensitivity reactions: urticaria, Ouincke's edema, facial edema, and exanthema.

OVERDOSAGE

Theoretically, there may be occasionally hyperexcitability of the central nervous system. The specific antidote of the drug is unknown. Gastric lavage and symptomatic treatment are recommended.

PRECAUTIONS

During therapy, caution should be exercised while driving motor-vehicle transport and being engaged in the potentially dangerous activities that require increased attention concentration and rapid psychomotor reactions.

DOSAGE FORM

200-mg prolonged-release capsules. 10 capsules in a blister made from aluminum foil and PVC film. 2 or 3 blisters are placed together with a package insert in a cardboard pack.

STORAGE

ListB.

Store in a dry place at a temperature of 5 to 30'C.

Keep out of the reach of children!

SHELF-LIFE

3 years.

Do not use the drug after the expiry date indicated on its pack.

DISPENSING TERMS

The drug to be prescribed.

motility - перистальтика ; colon – толстая кишка

maternal – материнский; lavage – промывание

№ 3