Indications:

By the intramuscular or intravenous route:

Allergic states: Bronchial Asthma including status asthmaticus, drug hyper sensitivity reactions, urticarial transfusion reactions, serum sickness, laryngeal oedema, anaphylaxis, contact dermatitis, acute dermatitis, seasonal or perennial allergic rhinitis.

Shock: Injection Dexona is recommended for the adjunctive treatment of shock where high doses of corticosteroids are needed; severe shock or hemorrhagic, traumatic, surgical or septic origin. Treatment with injection Dexona Phosphate is an adjunct to and not a substitute for specific supportive measures that the patient may require e.g. restoration of circulating blood volume, correction of fluid and electrolyte balance, oxygen, surgical measures and antibiotics.

Cerebral oedema: Cerebral oedema associated with primary or metastatic brain tumours, cerebrovascular accidents (acute strokes) involving the cerebral cortex. Also in the pre-operative preparation of patients with increased intracranial pressure secondary to brain tumours and for palliation of patients with inoperable or recurrent brain neoplasm.

Miscellaneous: Primary and secondary adrenocortical insufficiency, military tuberculosis chemotherapy, rheumatoid arthritis, connective tissue disorders, nephrotic syndrome, lymphatic leukemia and other steroid responsive conditions:

By intra-articular or soft-tissue injection: An adjunctive therapy for short-term administration (to support patients during an acute episode or exacerbation) in:

- Synovitis or osteoarthritis

- Rheumatoid arthritis

- Acute and sub-acute bursitis

- Acute gouty arthritis

- Acute nonspecific tenosynovitis

- Post-traumatic osteoarthritis

CONTRAINDICATIONS:

Systemic fungal infections.

ADMINISTARTION AND DOSAGE: By slow intravenous (4 to 5 minutes) or intramuscular injection or by prolonged intravenous infusion, the dosage and the rate of the injection depending essentially on the nature of the case being treated. The duration of the treatment is generally short (1 to 3 days) and is followed by oral therapy. Any infectious syndrome calls for the simultaneous administration of an antibiotic. Generally 1 to 5 ml. (4 mg. to 20 mg.) can be given 3 to 4 times in 24 hours. After initial improvement single dose of 05.ml. to 1 ml. (2 mg. to 4 mg.) is to be repeated if required. The dose of intra-articular and soft tissue or local injection varies from 1/10 ml to 2 ml at intervals varying from 2 to 3 days to 1 to 2 weeks.

PRECAUTIONS:

Drug induced secondary adrenocortical insufficiency may result from too rapid withdrawal of corticosteroids and may be minimized by gradual reduction of dosage. Corticosteroids may mask some signs of infections and new infections may appear during their use. Corticosteroids may activate latent amebiasis.

Therefore, it is recommended that latent or activate amebiasis be ruled out before initiating corticosteroid therapy in any patient who has spent time in the tropics or any patient with unexplained diarrhoea. Prolonged use of corticosteroids may produce posterior subcapsular cataracts and glaucoma with possible damage to the optic nerves and may enhance the establishment of secondary ocular infections due to fungi or viruses.

USAGE IN PREGANANCY:

Since adequate human reproduction studies have not been done with corticosteroids, the use of these drugs in pregnancy, nursing mother or woman of child bearing potential requires that the possible benefits for the drug be weighed against the potential hazards to the mother and embryo or foetus.

ADVERSE RECATIONS:

Fluid and Sodium retention, hypertension, muscle weakness, osteoporosis, peptic ulcer with possible subsequent perforation and hemorrhage, pancreatitis, impaired wound healing, convulsion, increased intracranial pressure with papilloedema (Pseudotumour cerebri) usually after treatment, vertigo, headache glaucoma, development of cushingoid state, menstrual irregularity manifestations of latent diabetes mellitus, negative nitrogen balance due to protein catabolism, hypersensitivity.

Treatments of over-dosage: Anaphylactic and Hypersensitivity reactions may be treated with adrenaline, positive-pressure artificial respiration and aminophylline. The patients should be kept warm and quiet.

PRESENTAION:

In vial of 2 ml.

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