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1.Thachev A.V., Rukavishnikov A.V., Chibirjaev A.M., Volodarsky L.B. Conversion of terpenic compounds to #-ketonitriles // Synthetic Communication. 1990. V. 20. C14. P. 2123–2132.
17
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R |
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NH |
RCOCI |
N |
O |
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N |
Et3N |
N |
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O |
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O |
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R |
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CH(CH3)2 |
CH2CH(CH3)2 |
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C(CH3)3 |
CH=CHCH3 |
(1) |
(2) |
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(3) |
(4) |
CH2CI |
CH2Br |
|
CHCICH3 |
CHBrCH3 |
(5) |
(6) |
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(7) |
(8) |
CH2OHCICH3 |
CCI3 |
|
H3C |
H3CO |
(9) |
(10) |
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(11) |
(12) |
18
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CI |
H |
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CI |
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(13) |
(14) |
(15) |
(16) |
!"#$%&'( '")*&+)+&, - -&*) ./'#/ & 0)#"1" 23&'4/##&%)'2"1" -)- 5)'4-/, 6"3"7" 3/'4-"3&.8) - "31/+&%)'2&6 3/'4-"3&4)#,6 & +) 3/'4-"- 3&.8) - -"*). !3& 94". -86"* :3"*$24"- 3)/2;&& '"'4/- "4 60–78%.
<43")+&) '&+4)=&3"-/++86 '")*&+)+&> :"*4-)3?*)+" */++8.& @A-, !BC-':)243"'2":&&, / 4/2?) */++8.& 9#).)+4+"1" /+/#&=/. D @A- ':)243/6 1–16 &.)E4', 6/3/24)3+8) *#, !-:&3&*"+"-"1" ;&2#/ :"#"'8 :"1#"5)+&, :3& 1645–1660, 1530–1550 '.-1, / 13$::/ /.&*+"1" 2/30"+&- #/ :3& 1680–1695 '.-1. D !BC ':)243/6 1–16 "*+"=+/%+" &*)+4&F&;&3"- -/+8 '&1+/#8 :3"4"+"- !-:&3&*"+"-"1" ;&2#/ ;&4&=&+/ :3& 6,15–6,30 & 7,16 ..*., / 4/2?) &.)E4', '&1+/#8 - '#/0". :"#), 2"4"38) '""4-)4'4-$- E4 :3"4"+/. 0)+="#(+86 ,*)3 :3& 7,1–7,3 ..*. - 2&'#"4+"> %/'4& ."#)- 2$#8. G/#&%&) *3$1&6 '&1+/#"- ":3)*)#,)4', 6/3/24)3". =/.)'4&4)#,. H/3/24)3+8) &=.)+)+&, $1#/ -3/5)+&, [!] 20D '&+4)=&3"-/++86 :3"&=- -"*+86 ;&4&=&+/, 4/2?) '#$?/4 :"*4-)3?*)+&). !"#$%-2"+F&1$3/;&& '43$24$38. N-/;(+8) :3"&=-"*+8) ;&4&=&+/ 1-16 +) "0#/*/E4 /24&-- +"'4(E :3"4&- /+4&-HIV CEM-SS :3& 2"+;)+43/;&& 5,00"10–5 [5] & :3"- ,-#,E4 '#/0$E /24&-+"'4( :3"4&- 74/../ Mycobacterium tuberculosis
H37Rv :3& 2"+;)+43/;&,6 12,5 µg/ml in vitro [6].
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1.</*82"- I.<., I'#/+"- H.I., A$7.$3/*"- J.A. I#2/#"&*8 6&+"#&-
=&*&+"1" 3,*/. B., 1975. <. 54–64.
2.H/2&."-/ K.D., C$=#,2"-/ L.I. & *3. <&+4)= & '4)3)"6&.&, +"-86 N- =/.)5)++86 :3"&=-"*+86 ;&4&=&+/ // H&.&, :3&3"*+86 '")*&+)+&>.
2001. M4. <. 301–305.
3.C/6&."- I.I., D&+"13/*"-/ D.@., K/7.$6/.)*"-/ I.A. <&+4)= +"-86 :3"&=-"*+86 ;&4&=&+/ ' F3/1.)+4/.& 0)+="23/$+-9F&3"- // H&.&, :3&3"*+86 '")*&+)+&>. 2002. M4. <. 288–289.
4.B/72"-'2&> B.N. O)2/3'4-)++8) '3)*'4-/. B., 1998. K. 1. <. 127.
5.Weislow O.W, Kiser R, Fine D. ed al. New soluble-formazan assay for HIV-1 cytopathic effects; application to high-flux screening of Synthetic and natural products for AIDS-antiviral activity // J. Nate. Cancer Inst. 1989. V. 81. P. 577–586.
6.<ollins L., Franzblau S.G. Microplate Alamar Blue Assay versus BACTEC 460 System for High-throughput Screening of Compounds against Mycobacterium tuberculosis and Mycobacterium avium // Antimicrob. Agents Chemother. 1997. V. 41. P. 1004–1009.
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