Добавил:
Sekretar
kiopkiopkiop18@yandex.ru
t.me/Prokururor I Вовсе не секретарь, но почту проверяю
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5958_Библиотеки_им_академика_М_И_Перельмана
.pdf
Indian gooseberry (Emblica officinalis), commonly referred to as Amla be-
longing to the Phyllanthaceae family is one of the important herbs in most of
the traditional systems of medicine including the ayurvedic practices.
Phytochemical evaluations have either quantified or identified the constitu-
ents like ellagic acid, chebulinic acid, apigenin, gallic acid, quercetin, che-
bulagic acid, isostrictiniin, corilagin, methyl gallate, luteolin, etc.
151
Emblicanin A, emblicanin B, phyllaemblicin B, punigluconin, and ped-
unculagin are the tannins which are also present in the fruit extract of
E. officinalis.
152
Supplementation of raw amla powder or the concentrated
extract has a positive impact on controlling type 2 diabetes mellitus which
was proved clinically in subjects with diabetes mellitus.
153–155
Dried fruit
choorna of amla called amlaki given at a dose of 5 g for 45 days was evaluated
to check the possibility of controlling the hyperacidity or Amalpitta. The
study showed that above 40% of the study subjects showed improvement in
the symptoms associated with hyperacidity.
156
Six grams of Jawarish amla, a
Unani product of amla, was evaluated for its role in pulmonary tuberculosis.
Significant improvements in the clinical indications were observed.
157
The
capsules of amla extract were evaluated for their potential to be used in cold
pressor induced cardiovascular changes. Amla extract showed a significant
decrease in the cold pressor stress test induced changes on aortic wave re-
flections and a significant decrease was reported in the indices of arterial
stiffness.
158
Addyzoa, a herbo-mineral agent that contains Withania somnifera
and Emblica officinalis as its principal constituent was evaluated for its role in
idiopathic oligoasthenoteratospermia in a randomized study. The study
showed significant improvement in the total and progressive motility of the
semen in men with idiopathic oligoasthenoteratospermia after 3 months of
therapy.
159
An oral supplement containing amla (100 mg), vitamin E (10 mg),
and carotenoids (4.7 mg) for a duration of six months showed an increase in
the effectiveness of other vitiligo treatments.
160
Clinical studies have also
focused on the role of amla in various sorts of dental disorders.
161,162
14.4 Future Prospective
The clinical efficacy of the ayurvedic formulations if properly evaluated in a
suitable study design can provide more insights into the efficacy of the
herbs. Another area which needs to be focused on is the study design as
ayurvedic drug administration varies from person to person and not a par-
ticular group of subjects. Standardization of the bioactive in the formulation
and the extract can prevent a too high dosage for human consumption.
14.5 Conclusion
The Ayurvedic system of medicine if appropriately evaluated using suitable
clinical studies can open a door to curing many diseases with natural
extracts. Most modern nutraceutical industries can utilize the principles
of this traditional system of medicine to create new formulations.
382 Chapter 14
https://t.me/med1917
An appropriate standardization method is also needed in fingerprinting the
formulations and herbs used in ayurvedic principles.
References
1. K. Ramakrishnappa, Impact of cultivation and gathering of medicinal
plants on biodiversity: Case studies from India, in Food and Agriculture
Organization of the United Nations (FAO), Biodiversity and the Eco-
system Approach in Agriculture, Forestry and Fisheries, Satellite event
on the occasion of the Ninth Regular Session of the Commission on
Genetic Resources for Food and Agriculture, Rome, Italy, FAO, Rome,
October 12–13, 2002.
2. S. Sen, R. Chakraborty and B. De, J. Herb. Med., 2011, 1, 67.
3. A. Altemimi, N. Lakhssassi, A. Baharlouei, D. G. Watson and
D. A. Lightfoot, Plants, 2017, 6, 42.
4. S. Kannaiyan, Diversity, sustainable use and conservation of medicinal
plants, Inaugural address to the International Seminar on Medicinal
Plants and Herbal Products, Tirupati, India, March 7–9, 2008.
5. M. Borins, Can. Fam. Physician, 1987, 33, 1061.
6. R. K. Singla, V. Yadav and S. Jayalakshmi, Webmedcentral, 2012,
3(4), WMC003299.
7. J. M. Kendall, Emerg. Med., 2003, 20, 164.
8. P. R. Manohar, Anc. Sci. Life, 2013, 33,1.
9. P. V. Sharma, Charaka samhita of agnivesha, vimana sthana, ro-
gabhishagjiteeyam vimanam, Chaukhambha Orientalia, 2nd edn, 1981,
ch. 8, ver. 94.
10. B. Patwardhan, J. Ayurveda. Integr. Med., 2011, 2,1.
11. P. A. Gautama, J. Ayurveda. Integr. Med., 2021, 12, 556.
12. V. Fønnebø, S. Grimsgaard, H. Walach, C. Ritenbaugh, A. J. Norheim,
H. MacPherson, G. Lewith, L. Launsø, M. Koithan, T. Falkenberg,
H. Boon and M. Aickin, BMC. Med. Res. Methodol., 2007, 7,2.
13. B. Patwardhan, D. Warude, P. Pushpangadan and N. Bhatt, Evidence-
Based Complementary Altern. Med., 2005, 2, 465.
14. A. Chopra, P. Lavin, B. Patwardhan and D. Chitre, J. Rheumatol., 2000,
27, 1365.
15. R. Gupta, S. Singhal, A. Goyle and V. N. Sharma, J. Assoc. Physicians.
India., 2000, 49, 231.
16. P. U. Kumar, P. Adhikari, P. Pereira and P. Bhat, J. Assoc. Physicians.
India., 1999, 47, 685.
17. T. Balganesh, T. K. Kundu, T. K. Chakraborty and S. Roy, ACS. Med.
Chem. Lett., 2014, 5, 724.
18. J. Srinagesh, P. Krishnappa and S. N. Somanna, Indian. J. Dent. Res.,
2012, 23, 696.
19. A. Deshpande, S. Tandon and N. Deshpande, Ayu, 2014, 35, 160.
20. S. H. Kamali, A. R. Khalaj, S. Hasani-Ranjbar, M. M. Esfehani,
M. Kamalinejad, O. Soheil and S. A. Kamali, Daru, 2012,
20, 33.
Ayurvedic Formulation and Their Clinical Uses 383
https://t.me/med1917
21. S. S. Rajan and S. Antony, Ancient. Sci. Life, 2008, 27, 45.
22. A. Saxena, S. K. Gupta, J. Saxena and S. Niranjan, int. Ayurvedic Med. J.,
2020, 7, 2382.
23. D. N. Shukla, H. M. Chandola and B. Ravishankar, J. Res. Ayurveda
Siddha, 2008, 29,1.
24. P. Aniket, D. Pallavi, A. Aziz, K. Avinash and S. Vikas, J. Ayurveda Integr.
Med. Sci., 2017, 2, 11.
25. A. Ghosh, D. Laloo and N. K. Singh, Int. J. Pharm. Pharm. Sci., 2013,
5, 801.
26. K. S. Sailesh, R. Archana, S. Mishra and J. K. Symphoria Mukkadan,
Int. J. Res. Ayurveda Pharm, 2014, 5, 435.
27. J. L. N. Sastry, A. Gupta, N. B. Brindavanam, S. Kanjilal, S. Kumar,
M. Setia, S. Vedula and R. Srivastava, Ind. J. Appl. Res., 2014, 4, 205.
28. A. Gupta, S. Kumar, S. Dole, S. Deshpande, V. Deshpande, S. Singh and
V. Sasibhushan, Ancient Sci. Life, 2017, 36, 141.
29. J. S. Yadav, S. Thakur and P. Chadha, Int. J. Hum. Genet., 2003, 3, 33.
30. S. Kumar, A. Gupta, R. Ghungralekar and V. S. Deshpande, Altern.
Integr. Med., 2017, 6 , 230.
31. S. K. Dalai, L. Dwivedi, G. Dadheech, S. Mishra and P. Sharma, Anc. Sci.
Life, 2005, 24, 183.
32. D. Veena, S. Bharatbhushan, G. Gayatrhin and G. Umesh, Int. J. Res.
Rev., 2021, 8, 2349.
33. K. Abascal and E. Yarnell, Altern. Complementary Ther., 2011, 17, 21.
34. C. Calabrese, W. L. Gregory, M. Leo, D. Kraemer, K. Bone and B. Oken,
J. Altern. Complementary Med., 2008, 14, 707.
35. A. Morgan and J. Stevens, J. Altern. Complementary Med., 2010, 16, 735.
36. N. L. Impeanchob, S. Jaipan, S. Rattanakaruna, W. Phrompittayarat and
K. Ingkaninan, J. Ethnopharmacol., 2008, 120, 112.
37. N. Uabundit, J. Wattanathorn, S. Mucimapura and K. Ingkaninan,
J. Ethnophar macol., 2010, 127, 26.
38. C. Calabrese, W. L. Gregory, M. Leo, D. Kraemer, K. Bone and B. Oken,
J. Altern. Complementary Med., 2008, 14, 707.
39. J. Morgan and J. Stevens, J. Altern. Complementary Med.
, 2010, 16, 735.
40. S. Raghav, H. Singh, P. K. Dalai, J. S. Srivastava and O. P. Asthana,
Indian J. Psychiatry, 2006, 48, 238.
41. S. Roodenrys, D. Booth, S. Bulzomi, A. Phipps, C. Micallef and
J. Smoker, Neuropsychopharmacol., 2006, 27, 279.
42. C. Stough, L. A. Downey, J. Lloyd, B. Silber, S. Redman, C. W. Hutchison,
K. Wesnes and P. J. Nathan, Phytother. Res., 2008, 22, 1629.
43. C. Stough, J. Lloyd, L. A. Downey, C. W. Hutchison, T. Rodgers and
P. J. Nathan, Psychopharmacol., 2001, 156, 481.
44. T. Peth-Nui, J. Wattanathorn, S. Muchimapura, T. Tong-Un,
N. Piyavhatkul, P. Rangseekajee, K. Ingkaninan and S. Vittaya-areekul,
Evidence-Based Complementary Altern. Med., 2012, 2012, 606424.
45. V. Sathyanarayanan, T. Thomas, S. J. L. Eino
¨
ther, R. Dobriyal,
M. K. Joshi and S. Krishnamachari, Psychopharmacol., 2013, 227, 299.
384 Chapter 14
https://t.me/med1917
46. T. Mitra-Ganguli, S. Kalita, S. Bhushan, C. Stough, J. Kean, N. Wang,
V. Sethi and A. Khadilkar, Front. Pharmacol., 2017, 8, 678.
47. K. S. Chaudhari, N. R. Tiwari, R. R. Tiwari and R. S. Sharma,
Ann. Neurosci., 2017, 24, 111.
48. P. J. Nathan, J. Clarke, J. Lloyd, C. W. Hutchison, L. Downey and
C. Stough, Hum. Psychopharmacol. Clin. Exp., 2001, 16, 345.
49. S. Raghav, H. Singh, P. K. Dalal, J. S. Srivastawa and O. P. Asthana,
Indian J. Psychiatry, 2006, 48, 238.
50. V. M. Gogte, Ayurvedic pharma cology and therapeutic uses of medicinal
plants, SPARC, Mumbai, 2000.
51. Atreya, Ayurvedic healing for women, Samuel Weis er Inc, York, 1999.
52. H. S. Puri, ‘Rasayana’ – Ayurvedic herbs for longevity and rejuvenation,
Taylor and Francis, Londo n, 2003.
53. R. K. Sharma and B. Dash, Charaka samhita-text with English translation
and critical exposition based on Chakrapani Datta’s Ayurveda dipika ,
Chowkhamba Varanasi, India, 2003.
54. W. K. B. D. S. Fernando and K. C. Perera, Eur. J. Biomed. Pharm. Sci.,
2019, 3, 26.
55. K. Sharma and M. Bhatnagar, Int. J. Pharm. Bio.l Arch., 2011, 2, 855.
56. S. A. Dayani Siriwardene, L. Karunathilaka, N. D. Kodituwakku and
Y. Karunarathne, Ayu, 2010, 31, 24.
57. A. Amalraj, K. Varma, J. Jacob, C. Divya, A. B. Kunnumakkara, S. J. Stohs
and S. Gopi, J. Med. Food, 2017, 20, 1022.
58. B. Lal, A. Kapoor, O. Asthana, P. Agrawal, R. Prasad, P. Kumar and
R. Srimal, Phytother. Res., 1999, 13, 318.
59. P. Usharani, A. Mateen, M. Naidu, Y. Raju and N. Chandra, Drugs R D,
2008, 9, 243.
60. S. Dcodhar, R. Sethi and R. Srimal, Indian J. Med. Res., 1980, 71, 632.
61. R. Kulkarni, P. Patki, V. Jog, S. Gandage and B. Patwardhan, J. Ethno-
pharmacol., 1991, 33, 91.
62. G. Belcaro, M. R. Cesarone, M. Dugall, L. Pellegrini, A. Ledda,
M. G. Grossi, S. Togni and G. Appendino, Altern. Med. Rev., 2010,
15, 337.
63. N. Kertia, A. Asdie and W. Rochmah, Acta Med Indones., 2012,
44, 105.
64. V. Kuptniratsaikul, S. Thanakhumtorn, P. Chinswangwatanakul,
L. Wattanamongkonsil and V. Thamlikitkul, J. Altern. Complementary
Med., 2009, 15
, 891.
65. R. Satoskar, S. Shah and S. Shenoy, Int. J. Clin. Pharmacol. Ther., 1986,
24, 651.
66. K. Madhu, K. Chanda and M. Saji, Inflammopharmacology, 2013,
21, 129.
67. M. Heng, M. Song, J. Harker and M. Heng, Br. J. Dermatol. Suppl., 2000,
143, 937.
68. S. K. Kurd, N. Smith, A. VanVoorhees, A. B. Troxel, V. Badmaev,
J. T. Seykora and J. M. Gelfand, J. Am. Acad. Dermatol., 2008, 58, 625.
Ayurvedic Formulation and Their Clinical Uses 385
https://t.me/med1917
69. Y. Panahi, A. Sahebkar, M. Amiri, S. M. Davoudi, F. Beiraghdar,
S. L. Hoseininejad and M. Kolivand, Br. J. Nutr., 2012, 108, 1272.
70. J. M. Ringm an, S. A. Frautschy, E. Teng, A. N. Begum, J. Bardens,
M. Beigi, K. H. Gylys, V. Badmaev, D. D. Heath and L. G. Apostolova,
Alzheimer’s Res. Ther., 2012, 4, 43.
71. S. R. Rainey-Smith, B. M. Brown, H. R. Sohrabi, T. Shah, K. G. Goozee,
V. B. Gupta and R. N. Martins, Br. J. Nutr., 2016, 115, 2106.
72. N. Hishikawa, Y. Takahashi, Y. Amakusa, Y. Tanno, Y. Tuji, H. Niwa,
N. Murakami and U. Krishna, Ayu, 2012, 33, 499.
73. K. H. Cox, A. Pipingas and A. B. Scholey, J. Psychopharmacol., 2015,
29, 642.
74. L. Baum, C. W. K. Lam, S. K.-K. Cheung, T. Kwok, V. Lui, J. Tsoh,
L. Lam, V. Leung, E. Hui and C. Ng, J. Clin. Psychopharmacol, 2008,
28, 110.
75. J. M. Ringm an, S. A. Frautschy, E. Teng, A. N. Begum, J. Bardens,
M. Beigi, K. H. Gylys, V. Badmaev, D. D. Heath and L. G. Apostolova,
Alzheimer’s. Res. Ther. , 2012, 4, 43.
76. N. Hishikawa, Y. Takahashi, Y. Amakusa, Y. Tanno, Y. Tuji, H. Niwa,
N. Murakami and U. Krishna, Ayu, 2012, 33, 499.
77. K. H. Cox, A. Pipingas and A. B. Scholey, J. Psychopharmacol., 2015,
29, 642.
78. K. Soni and R. Kuttan, Indian J. Physiol. Pharmacol., 1992, 36, 273.
79. A. Ramırez-Bosca
´
, A. Soler, M. A. Carrion, J. Dıaz-Alperi, A. Bernd,
C. Quintanilla, E. Q. Almagro and J. Miquel, Mech. Ageing. Dev., 2000,
119, 41.
80. I. Alwi, T. Santoso, S. Suyono, B. Sutrisna, F. D. Suyatna, S. B. Kresno
and S. Ernie, Acta Med. Indones., 2008, 40, 201.
81. R. A. DiSilvestro, E. Joseph, S. Zhao and J. Bomser, Nutr. J., 2012,
11, 79.
82. S. Durgaprasad, C. G. Pai and J. F. Alvres, Indian J. Med. Res., 2005,
122, 315.
83. A. Rasyid and A. Lelo, Aliment. Pharmacol. Ther, 1999, 13, 245.
84. Y. S. Yang, Y. F. Su, H. W. Yang, Y. H. Lee, J. I. Chou and K. C. Ueng,
Phytother. Res., 2014, 28, 1770.
85. M. R. Adhvaryu, N. M. Reddy and B. C. Vakharia, World J. Gastroenterol.,
2008, 14, 4753.
86. S. W. Kim, K. C. Ha, E. K. Choi, S. Y. Jung, M. G. Kim, D. Y. Kwon,
H. J. Yang, M. J. Kim, H. J. Kang and H. I. Back, BMC Complementary
Altern. Med., 2013, 13
, 58.
87. S. Rahmani, S. Asgary, G. Askari, M. Keshvari, M. Hatamipour, A. Feizi
and A. Sahebkar, Phytother. Res., 2016, 30, 1540.
88. R. Bundy, A. F. Walker, R. W. Middleton and J. Booth, J. Altern. Com-
plementary Med., 2004, 10, 1015.
89. S. Durgaprasad, C. G. Pai and J. F. Alvres, Indian J. Med. Res., 2005,
122, 315.
90. A. Rasyid and A. Lelo, Aliment. Pharmacol. Ther, 1999, 13, 245.
386 Chapter 14
https://t.me/med1917
91. A. Rasyid, A. R. A. Rahman, K. Jaalam and A. Lelo, Asia. Pac. J. Clin.
Nutr., 2002, 11, 314.
92. C. Niederau and E. Go
¨
pfert, Med. Klin., 1999, 94, 425.
93. D. Shoskes, C. Lapierre, M. Cruz-Corerra, N. Muruve, R. Rosario,
B. Fromkin, M. Braun and J. Copley, Transplantation, 2005, 80, 1556.
94. P. Khajehdehi, M. Pakfetrat, K. Javidnia, F. Azad, L. Malekmakan,
M. H. Nasab and G. Dehghanzadeh, Scand. J. Urol. Nep., 2011,
45, 365.
95. T. Cai, S. Mazzoli, A. Bechi, P. Addonisio, N. Mondaini, R. C. Pagliai
and R. Bartoletti, Int. J. Antimicrob. Agents, 2009, 33, 549.
96. M. Srinivasan, Indian J. Med. Sci., 1972, 26, 269.
97. J. Wickenberg and S. L. Ingemansson, Nutr. J., 2010, 9, 43.
98. L. X. Na, Y. Li, H. Z. Pan, X. L. Zhou, D. J. Sun, M. Meng, X. X. Li and
C. H. Sun, Mol. Nutr. Food Res., 2013, 57, 1569.
99. N. M. K. Selvi, M. Sridhar, R. Swaminathan and R. Sripradha, Indian. J.
Clin. Biochem., 2015, 30, 180.
100. J. Heshmati, A. Moini, M. Sepidarkish, M. Morvaridzadeh, M. Salehi,
A. Palmowski, M. F. Mojtahedi and F. Shidfar, J. Phymed., 2020,
80, 153395.
101. H. R. Rahimi, A. H. Mohammadpour, M. Dastani, M. R. Jaafari,
K. Abnous, M. G. Mobarhan and R. K. Oskuee, Avicenna J Phytomed.,
2016, 6, 567.
102. J. Biswas, D. Sinha, S. Mukherjee, S. Roy, M. Siddiqi and M. Roy, Hum.
Exp. Toxicol., 2010, 29, 513.
103. R. Kuttan, P. Sudheeran and C. Josph, Tumori, 1987, 73, 29.
104. K. Hastak, N. Lubri, S. Jakhi, C. More, A. John, S. Ghaisas and S. Bhide,
Cancer. Lett., 1997, 116, 265.
105. C. Hsieh, Anticancer. Res., 2001, 21, 2895.
106. N. Chainani-Wu, S. Silverman Jr, A. Reingold, A. Bostrom,
C. Mc Culloch, F. Lozada-Nur and J. Weintraub, Phytomedicine, 2007,
14, 437.
107. M. H. Mirjalili, E. Moyano, M. Bonfill, R. M. Cusido and J. Palazon,
Molecules, 2009, 14, 2373.
108. J. Salve, S. Pate, K. Debnath and D. Langade, Cureus, 2009,
11, 6466.
109. D. Choudhary, S. Bhattacharyya and S. Bose, J. Diet. Suppl., 2017,
14, 599.
110. R. Nasimi Doost Azgomi, H. Nazemiyeh, H. Sadeghi Bazargani,
S. M. B. Fazljou, F. Nejatbakhsh, A. Moini Jazani, Y. Ahmadi AsrBadr
and A. Zomorrodi, Andrologia, 2018, 50, 13041.
111. S. Dongre, D. Langade and S. Bhattacharyya, Biomed. Res. Int., 2015,
2015, 284154.
112. V. R. Ambiye, D. Langade, S. Dongre, P. Aptikar, M. Kulkarni and
A. Dongre, Evidence-Based Complementary Altern. Med., 2013,
2013, 571420.
113. A. Gupta, A. A. Mahdi, K. K. Shukla, M. K. Ahmad, N. Bansal,
P. Sankhwar and S. N. Sankhwar, J. Ethnopharmacol., 2013, 26, 208.
Ayurvedic Formulation and Their Clinical Uses 387
https://t.me/med1917
114. P. Mamidi and A. B. Thakar, Ayu, 2011, 32, 322.
115. A. A. Mahdi, K. K. Shukla, M. K. Ahmad, S. Rajender, S. N. Shankhwar,
V. Singh and D. Dalela, Evidence-Based Complementary Altern. Med.,
2009, 29, 576962.
116. P. Sengupta, A. Agarwal, M. Pogrebetskaya, S. Roychoudhury,
D. Durairajanayagam and R. Henkel, Reprod. Biomed. Online, 2018,
36,311.
117. T. N. Zeigenfuses, A. W. Kedia, J. E. Sandrock, B. J. Raub, C. M. Kerksick
and H. L. Lopez, Nutrients, 2018, 10, 1807.
118. B. Choudhary, A. Shetty and D. G. Langade, Ayu, 2015, 36, 63.
119. S. Wankhede, D. Langade, K. Joshi, S. R. Sinha and S. Bhattacharyya,
J. Int. Soc. Sports Nutr., 2015, 12, 43.
120. S. Shenoy, U. Chaskar, J. S. Sandhu and M. M. Paadhi, J. Ayurveda.
Integr. Med., 2012, 3, 209.
121. J. S. Sandhu, B. Shah, S. Shenoy, S. Chauhan, G. S. Lavekar and
M. M. Padhi, Int. J. Ayurveda Res., 2010, 1, 144.
122. U. Pingali, R. Pilli and N. Fatima, Pharmacogn. Res., 2014, 6, 12.
123. D. Choudhary, S. Bhattacharyya and S. Bose, J. Diet. Suppl., 2017,
14, 599.
124. K. N. Chengappa, C. R. Bowie, P. J. Schlicht, D. Fleet, J. S. Brar and
R. Jindal, J. Clin. Psychiatry, 2013, 74, 1076.
125. G. S. Ramakanth, C. Uday Kumar, P. V. Kishan and P. Usharani,
J. Ayurveda Integr. Med., 2016, 7, 151.
126. B. M. Biswal, S. A. Sulaiman, H. C. Ismail, H. Zakaria and K. I. Musa,
Integr. Cancer Ther., 2013, 12, 312.
127. A. L. Lopresti, S. J. Smith, H. Malvi and R. Kodgule, Medicine, 2019,
98, e17186.
128. A. P. Agnihotri, S. D. Sontakke, V. R. Thawani, A. Saoji and
V. S. Goswami, Indian. J. Pharmacol., 2013, 45, 417.
129. S. Nayak, S. Nayak, B. K. Panda and S. Das, Ayushdhara, 2015,
2, 413.
130. S. P. Jahanbakhsh, A. A. Manteghi, S. A. Emami, S. Mahyari,
B. Gholampour, A. H. Mohammadpour and A. Sahebkar, Comple-
mentary Ther. Med., 2016, 27, 25.
131. D. Langade, S. Kanchi, J. Salve, K. Debnath and D. Ambegaokar, Cureus,
2019, 11, e5797.
132. S. B. Kelgane, J. Salve, P. Sampara and K. Debnath, Cureus, 2020,
12, e7083.
133. B. M. Myers, J. L. Smith and D. Y. Graham, Am. J. Gastroenterol, 1987,
82, 21.
134. H. H. Ahmed, A. A. Abd-Rabou, A. Z. Hassan and S. E. Kotob, Asian. Pac.
J. Cancer Prev., 2015, 16, 7179.
135. P. K. Gupta, S. M. Samarakoon, H. M. Chandola and B. Ravishankar,
Ayu, 2011, 32, 478.
136. J. R. Streffer, M. Bitzer, M. Schabet, J. Dichgans and M. Weller,
Neurology, 2001, 56, 1219.
388 Chapter 14
https://t.me/med1917
137. F. Sharifzadeh, M. Kashanian, J. Koohpayehzadeh, F. Rezaian,
N. Sheikhansari and N. Eshraghi, J. Matern. Fetal. Neonatal. Med., 2018,
31, 2509.
138. L. B. Martins, A. M. D. S. Rodrigues, D. F. Rodrigues, L. C. Dos Santos,
A. L. Teixeira and A. V. M. Ferreira, Cephalalgia, 2019, 39, 68.
139. H. Mozaffari-Khosravi, Z. Nad eri, A. Dehghan, A. Nadjarzadeh and
H. Fallah Huseini, J. Nutr. Gerontol. Geriatr, 2016, 35, 209.
140. N. Aryaeian, F. Shahram, M. Mahmoudi, H. Tavakoli, B. Yousefi,
T. Arablou and S. Jafari Karegar, Gene, 2019, 698, 179.
141. M. Makhdoomi Arzati, N. Mohammadzadeh Honarvar,
A. Saedisomeolia, S. Anvari, M. Effatpanah, R. Makhdoomi Arzati,
M. S. Yekaninejad, R. Hashemi and M. Djalali, Int. J. Endocrinol. Metab.,
2017, 15, e57927.
142. F. Kashefi, M. Khajehei, M. Alavinia, E. Golmakani and J. Asili, Phyt-
other. Res., 2015, 29, 114.
143. F. Kashefi, M. Khajehei, M. Tabatabaeichehr, M. Alavinia and J. Asili,
Pain Manag. Nurs., 2014, 15, 826.
144. C. D. Black, M. P. Herring, D. J. Hurley and P. J. O’Connor, J. Pain, 2010,
11, 894.
145. M. A. van Tilburg, O. S. Palsson, Y. Ringel and W. E. Whitehead,
Complementary Ther. Med., 2014, 22, 17.
146. K. Nadkarni and A. Nadkarni, Indian Materia Medica with Ayurvedic,
Unani-Tibbi, Siddha, Allopathic, Homeopathic, Naturopathic & Home
Remedies, Popular Prakashan Private Ltd, Bombay, India, 1982, vol. 2.
147. J. Giri, B. Suganthi and G. Meera, Indian. J. Nutr. Diet, 1987, 24, 193.
148. M. Ahmad, A. A. Faraazi and M. N. Aami, Bull. Chem. Soc. Ethiop., 2013,
27, 469.
149. S. Sarvaiya, Studies on hypertension with special reference to hypo-
tensive effect of Ocimum sanctum, PhD thesis, Sardar Patel University,
Anand, India, 1986.
150. M. Venu Prasad, Antifatigue and Neuroprotective Properties of Selected
Species of Ocimum L., University of Mysore, Mysore, India, 2014.
151. K. A. Habib-ur-Rehman, M. A. Yasin, N. Choudhary and M. I. Atta-ur-
Rahman, Nat. Prod. Res., 2007, 21, 775.
152. L. D. Kapoor, Handbook of Ayurvedic Medicinal Plants: Herbal Reference
Library, CRC Press, 2000, ISBN 9780849329296.
153. P. Usharani, N. Fatima and N. Muralidhar, Diabetes. Metab. Syndr. Obes,
2013, 6, 275.
154. K. Walia, R. Boolchandani, S. Dhand and B. Antony, Int. J. Basic. Appl.
Med. Sci., 2015, 5, 251.
155. M. S. Akhtar, A. Ramzan, A. Ali and M. Ahmad, Int. J. Food Sci. Nutr.,
2011, 62, 609.
156. Y. K. Pandit, P. K. Garg, K. Agarwal, S. Balakrishna and P. S. Mehta, Int.
Res. J. Pharm., 2015, 6, 199.
157. A. M. K. Sherwani, M. Zulkifle and R. M. Saleha, J. Islam. Med. Assoc.
North. Am, 2012, 44,1.
Ayurvedic Formulation and Their Clinical Uses 389
https://t.me/med1917
158. N. Fatima, U. Pingali and R. Pilli, Pharmacogn. Res, 2014, 6, 29.
159. R. Kumar, V. Saxena, M. B. Shamsi, S. Venkatesh and R. Dada, Indian
J. Urol., 2011, 27, 357.
160. R. Colucci, F. Dragoni, R. Conti, L. Pisaneschi, L. Lazzeri and S. Moretti,
Dermatol. Ther., 2015, 28, 17.
161. S. Grover, S. Tewari, R. K. Sharma, G. Singh, A. Yadav and S. C. Naula,
Phytother. Res., 2016, 30, 956.
162. A. Velmurugan, M. M. Madhubala, S. Bhavani, K. S. Satheesh Kumar,
S. S. Sathyanarayana and N. Gurucharan, J. Conserv. Dent., 2013,
16, 546.
390 Chapter 14
https://t.me/med1917
CHAPTER 15
Ayurvedic and Traditional
Systems of Medicine in Clinical
Trials: An Overview
SHINTU JUDE,* KARTHIK VARMA A. C.,
SASIKUMAR KUTTAPPAN AND AUGUSTINE AMALRAJ
R&D Centre, Aurea Biolabs (P) Ltd, Kolenchery, Cochin-682 311, Kerala,
India
*Emails: shintujude2@gmail.com; shintu.jude@plantlipids.com
15.1 Introduction
Since the very beginning mankind has faced many issues regarding health
and well-being. As such, there have been attempts to find solutions from
every possible means, including plants, animals, and other available natural
substances. The resulting healthcare systems (including the knowledge,
approaches, medicines, exercises, etc.), which have been effectively applied
to diagnose, treat, or prevent illness and to maintain well-being are con-
sidered as traditional medical systems. They were developed in different
parts of the world in ancient times, mostly related to cultural systems. Some
of the major traditional medical systems are Ayurveda, Yunani, and Siddha
from India, Koryo medicine from Korea, Traditional Chinese Medicine from
China, Kampo medicine from Japan, traditional medicine of Sri Lanka,
traditional Arabic and Islamic medicine in Arab countries and Traditional
Medicine from Africa (especially from Egypt). All of these indigenous sys-
tems included the natural and locally available materials for the treatment
protocols, and as such there are variations according to the regions.
Chemistry, Biological Activities and Therapeutic Applications of Medicinal Plants in Ayurveda
Edited by Augustine Amalraj, Sasikumar Kuttappan and Karthik Varma A. C.
r The Royal Society of Chemistry 2023
Published by the Royal Society of Chemistry, www.rsc.org
391
https://t.me/med1917
Соседние файлы в папке Библиотека им академика М.И. Перельмана