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Table 2.1 Dermatological classication of psychocutaneous diseases. (Modied, from Ref. [1])
1. Self-inicted cutaneous disorders whose nature is denied or hidden A.Factitious disorders without external incentives (psychiatric disorders with cutaneous
symptoms) Dermatitis artefacta Dermatological pathomimicry (in part) Gardner-Diamond syndrome Münchausen syndrome Münchausen syndrome by proxy Dermatitis simulata Dermatitis passivata (“Diogenes syndrome”) B.Factitious disorders with external incentives (malingering) Malingering in adolescents Malingering in soldiers Occupational dermatitis artefacta Dermatitis artefacta with patch test artefacts Witchcraft syndrome Secrétan syndrome (in part) Dermatological pathomimicry (in part) Religious stigmata as malingering artefacts
2. Cutaneous disorders with a non-denied and non-hidden behavior (impulsive/compulsive disorders)
Psychogenic pruritus Lichen simplex Prurigo nodularis Acne excoriée Trichotillomania Trichoteiromania Trichotemnomania Onychophagia Onychotillomania Onychotemnomania Cheilitis factitia Morsicatio buccarum Pseudo-knuckle pads Rhinotillexomania
3. Cutaneous diseases precipitated or perpetuated by emotional factors (psychosomatic or psychophysiological disorders)
Acne Hemangiomas and vascular malformations Vitiligo Albinism Chronic eczema
G. Angelini et al.
(continued)
2 Psychocutaneous Diseases
Table 2.1 (continued)
Atopic dermatitis Psoriasis Seborrheic dermatitis Vesicular eczema of palms and soles Alopecia areata Hyperhidrosis Urticaria and angioedema Aphthosis Flushing reactions and rosacea
4. Psychiatric disorders without signicant dermatological disease A.Delusional syndromes Parasitosis Smell Impregnations and contamination Folie à deux Morgellons syndrome B.Disorders of body awareness Body dysmorphic disorders Psychogenic pruritus Phobias: Venereophobia Parasitophobia Steroid phobia Compulsive behaviors: Hand washing Pain disorders: Glossodynia Vulvodynia Scrotodynia Anodynia Drug-dependence syndromes: Alcohol-related syndrome Substance abuse Psychosis and skin cancer Cutaneous disorders due to psychopharmacological medicaments
5. Group and mass population reactions Sick building syndrome Epidemic hysteria
19
Ideally, these patients should be assessed in a psychodermatology clinic, by an interdisciplinary team including dermatologists, psychologists, and psychiatrists [8]. The treatment aims must be not only to reduce or resolve the cutaneous symp­toms, eliminate sleep disturbances, boost self-esteem, and cure anxiety and
20
Table 2.2 Interrelation between psychocutaneous disorders and underlying personality disorders
Psychocutaneous disorders Personality disorders
Factitious disorders with a non-denied and non-hidden behavior Obsessive-compulsive
Factitious disorders with a denied and hidden behavior without external incentives
Body awareness disorders Narcissistic personality
behavior Borderline personality disorder Narcissistic personality disorder
Borderline personality disorder
disorder
G. Angelini et al.
depression, but also to improve the patient’s relational life. The various treatments, both pharmacological and non pharmacological therapy, can be used alone or in combination, depending on the assessment of the individual patient and his or her individual needs.
The management of patients with personality disorders is quite challenging. However, a joint liaison between psychiatry and dermatology has proven very help­ful to patients. In a study by Raikhy and Coll., 36.32% of dermatological patients presented depression, while in 18.61% of patients an anxiety disorder was diag­nosed [50]. These gures underline the importance of the liaison among different specialists. There are ten specic personality disorders; in dermatological clinical practice, however, the most common are borderline, narcissistic, and obsessive­compulsive personality disorders [36]. Self-inicted cutaneous disorders of a non­denied and non-hidden nature, such as trichotillomania, onychotillomania, face picking (acne excoriée), and rhinotillexomania, are commonly associated with compulsive-obsessive behavior although they can also be linked to borderline per­sonality and narcissistic personality disorders [36]. Patients with factitious disor­ders of a denied or hidden nature and not prompted by external incentives (dermatitis artefacta), who tend rstly to resort to a visit to the dermatologist, come into the borderline personality disorder category [51–53]. Subjects who need admiration and seek grandiosity, who are often among those who request cosmetic procedures, belong to the narcissistic personality disorder category (Table2.2) [54–59].
Based on the above considerations, and in view of the considerable percentage of dermopatients with psychiatric disturbances, it is essential that the dermatologist be familiar with the most common personality disorders, as well as working in close collaboration with psychiatrists and psychologists in order to ensure the optimal management of these patients [36, 60].

References

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2 Psychocutaneous Diseases
2. Rieder E, Tausk FA.Psychocutaneous skin diseases. In: Goldsmith LS, Katz SJ, Gilchrest BA, etal., editors. Fitzpratick’s dermatology in general medicine. 8th ed. NewYork: McGraw-Hill;
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4. Bewley A, Lepping P, Taylor RE. Psychodermatology in clinical practice. Switzerland A6: Springer Nature; 2021.
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7. Jafferany M, Franҫa K. Psychodermatology: basics concepts. Acta Derm Venereol. 2016;96:35–7.
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9. Jafferany M, Ferreira BR, Patel A. The essentials of psychodermatology. Cham: Springer International Publishing; 2020. p.29–34.
10. Kuhn H, Mennella C, Magid M, etal. Psychocutaneous disease: clinical perspectives. J Am Acad Dermatol. 2017;76:779–91.
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14. Korabel H, Dudek D, Jaworek A, etal. Psychodermatology: psychological and psychiatrical aspects of dermatology. Przegl Lek. 2008;65:244–8.
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17. Dhabhar FS.Psychological stress and immunoprotection versus immunopathology in the skin. Clin Dermatol. 2013;31:18–30.
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19. Lonne-Rahm SB, Rickberg H, El-Nour H, etal. Neuroimmune mechanisms in patients with atopic dermatitis during chronic stress. J Eur Acad Dermatol Venereol. 2008;22:11–8.
20. American Academy of Dermatology. Managing stress can help people improve their skin con­ditions. Available from http://www.aad.org/storics- and- news/news- releases/managing- stress-
can- help- people- improve- their- skin- conditions. Accessed 2 Oct 2012.
21. Slominski A, Mihm MC. Potential mechanism of skin response to stress. Int J Dermatol. 1996;35:849–51.
22. Dave ND, Xiang L, Rehm KE, etal. Stress and allergic diseases. Immunol Allergy Clin North Am. 2011;31:55–68.
23. Jafferany M, Salimi S, Mkhoyan R, etal. Psychological aspects of aesthetic and cosmetic surgery: clinical and therapeutic implications. Dermatol Ther. 2020;33:e13727.
24. Ha B, Uvais NA, Jafferany M, etal. Palliative psychodermatology care during COVID-19 pandemic. Dermatol Ther. 2020;3:e13732.
25. Jafferany M, Patel A.Understanding psychocutaneous disease: psychosocial and psychoneu­roimmunologic perspectives. Int J Dermatol. 2019;59:8–15.
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26. Engel GL.From biomedical to biopsychosocial. 1. Being scientic in the human domain. Psychother Psychosom. 1997;66:57–62.
27. White P.Biopsychosocial medicine. Oxford: Oxford University Press; 2005.
28. Koo JYM, Lee CS.General approach to evaluating psychodermatological disorders. In: Koo JYM, Lee CS, editors. Psychocutaneous medicine. New York: Marcel Dekker, Inc.; 2003. p.1–29.
29. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. DSM-V. 5th ed. Arlington: American Psychiatric Association; 2013.
30. International classication of diseases. Tenth revision (ICD-10); 2010. Available from: http://
www.whp.int/classication/icd.Geneva. Cited 2022, Ang 28.
31. Koblenzer CS. Psychosomatic concepts in dermatology. A dermatologist-psychoanalyst’s viewpoint. Arch Dermatol. 1983;119:501–12.
32. Gupta MA, Gupta AK. Self-induced dermatoses: a great imitator. Clin Dermatol. 2019;37:268–77.
33. Medansky RS, Handler RM.Dermatopsychosomatics: classication, physiology, and thera­peutic approaches. J Am Acad Dermatol. 1981;5:125–38.
34. Musalek M, Hable B, Mossabacher U. Diagnostics in psychodermatology. Dermatol Psychosom. 2011;2:110–5.
35. Gieler U, Consoli SG, Tomás-Aragones L, etal. Self-inicted lesions in dermatology: termi­nology and classication—a position paper from the European Society for Dermatology and Psychiatry (ESDaP). Acta Derm Venereol. 2013;93:4–12.
36. Jafferany M, Afrin A, Mkhoyan R, etal. Therapeutic implications of personality disorders in dermatology. Dermatol Ther. 2020;33:e13910.
37. Patel A, Jafferany M. Multidisciplinary and holistic models of care for patients with der­matologic disease and psychosocial comorbidity: a systematic review. JAMA Dermatol. 2020;156:686–94.
38. Gould WM, Gragg TM. A dermatology-psychiatry liaison clinic. J Am Acad Dermatol. 1983;9:73–7.
39. Woodruff PW, Higgins EM, du Vivier AW, et al. Psychiatric illness in patients referred to a dermatology-psychiatry clinic. Gen Hosp Psychiatry. 1997;19:29–35.
40. Fritzsche K, Ott J, Zschocke I, etal. Psychosomatic liaison service in dermatology. Need for psychotherapeutic interventions and their realization. Dermatology. 2001;203:27–31.
41. Misery L, Chastaing M. Joint consultation by psychiatrist and a dermatologist. Dermatol Psychosom. 2003;4:160–4.
42. Deshponde SS, More Y, Gokhale NR. Identication and management of psychiatric comor­bidities in dermatological disorders. Malay J Psychiatry. 2015;24:1–6.
43. Altaf K, Mohandas P, Marshall C, et al. Managing patients with delusional infestations in an integrated psychodermatology clinic is much more cost-effective than a general dermatology or primary care setting. Br J Dermatol. 2017;177:544–5.
44. Goulding JMR, Harper N, Kennedy L, etal. Cost-effectiveness in psychodermatology: a case series. Acta Derm Venereol. 2017;97:663–4.
45. Seale L, Gaulding JV, Porto D, etal. Implementation of a psychodermatology clinic at a major health system in Detroit. Int J Womens Dermatol. 2018;4:227–9.
46. Franger K, Mahmud M. Doctor-patient relationship in geriatric psychodermatology. In: Jafferany M, Franҫa K, editors. Geriatric psychodermatology: psychocutaneous disorders in the elderly. NewYork: Nova Science Publishers; 2015. p.9–13.
47. Kuhn H, Mennella C, Magid M, etal. Psychocutaneous disease: Pharmacotherapy and psycho­therapy. J Am Acad Dermatol. 2017;76:795–808.
48. Reichenberg JS, Kroumpouzos G, Magid M.Approach to a psychodermatology patient. G Ital Dermatol Venereol. 2018;153:494–6.
49. Shah RB.Psychological assessment and interventions for people with skin disease. In: Bewley A, Taylor RE, Reichenberg JS, et al., editors. Practical psychodermatology. Oxford, UK: Wiley-Blackwell; 2014. p.40–9.
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50. Raikhy S, Gautam S, Kanodia S. Pattern and prevalence of psychiatric disorders among patients attending dermatology OPD.Asian J Psychiatr. 2017;29:85–8.
51. Briere J, Gil E.Self-mutilation in clinical and general population samples: prevalence, cor­relates, and functions. Am J Orthopsychiatry. 1998;68:609–20.
52. Chatterjee SS, Mitra S.Dermatitis artefacta mimicking borderline personality disorder: some­times, skin could be misleading. Clin Psychopharmacol Neurosci. 2016;14:311–3.
53. Harth W, Mayer K, Linse R. The borderline syndrome in psychosomatic dermatology. Overview and case report. J Eur Acad Dermatol Venereol. 2004;18:503–7.
54. Loron AM, Ghaffari A, Poursafargholi N. Personality disorders among individuals seeking cosmetic botulinum toxin type A (BoNTA) injection, a cross-sectional study. Eurasian J Med. 2018;50:164–7.
55. Koblenzer CS. Body dysmorphic disorder in the dermatology patient. Clin Dermatol. 2017;35:298–301.
56. Phillips KA, Dufresne RG Jr, Wilkel CS, etal. Rate of body dysmorphic disorder in dermatol­ogy patients. J Am Acad Dermatol. 2000;42:436–41.
57. Bowe WP, Leyden JJ, Crerand CE, etal. Body dysmorphic disorder symptoms among patients with acne vulgaris. J Am Acad Dermatol. 2007;57:222–30.
58. Bjornsson AS, Didie ER, Grant JE, etal. Age at onset and clinical correlates in body dysmor­phic disorder. Compr Psychiatry. 2013;54:893–903.
59. Afeck A, Stewart M.Body dysmorphic disorder in dermatology: beware of diagnostic over­labelling. Clin Exp Dermatol. 2016;41:214–5.
60. Azambuja RD.The need of dermatologists, psychiatrists and psychologists joint care in psy­chodermatology. An Bras Dermatol. 2017;92:63–71.
23
Chapter 3
Self-Inicted Skin Disorders: Diagnosis andManagement
GianniAngelini, AuroraDe Marco, andDomenicoBonamonte
Self-inicted skin disorders (SISD) belong to the vast group of self-inicted disor­ders (SID) that can be observed in all branches of specialist medicine.
SID, or factitious (from the Latin factitious: articial, not natural, artful, self­induced) [1] diseases, are dened as a “falsication of physical or psychological signs or symptoms, or induction of injury or disease, associated with identied deception” [2]. Factitious disorders are, therefore, psychiatric disorders in which patients intentionally fabricate psychological or physical symptoms in order to acquire the role of patient affected by a disease [3–5].

3.1 General Clinical Remarks

In accordance with the DSM-5 and the eleventh revision of the International Classication of Diseases, most patients with SID are not, in fact, actuated by motives of external gain [2, 6]. On the contrary, in cases of malingering the self­inicted disorder is motivated by clear external rewards or incentives, in order to avoid various duties (e.g. military service) or a prison sentence, or else to gain some advantage, usually of an occupational nature [6–13].
The motivations of patients with SID are often complex and not always entirely intelligible. In general, such subjects are driven by a more or less conscious need for
G. Angelini Dermatology, University of Bari “Aldo Moro”, Bari, Italy e-mail: gianniang@alice.it
A. De Marco · D. Bonamonte ( Department of Precision and Regenerative Medicine and Ionian Area, University of Bari “Aldo Moro”, Bari, Italy e-mail: a.demarco24@studenti.uniba.it; domenico.bonamonte@uniba.it
Switzerland AG 2024 G. Angelini et al. (eds.), Psychocutaneous Diseases,
https://doi.org/10.1007/978-3-031-70296-9_3
*)
25© The Author(s), under exclusive license to Springer Nature
26
G. Angelini et al.
affection and care, and so for this purpose they often have recourse to medical treat­ments and surgical procedures [14]. In this sense, an emblematic case is that of a patient who underwent 42 surgical procedures in the course of 850 admissions to 650 different hospitals [15]. Inevitably, such behaviour exposes them to a consider­able risk of iatrogenic harm [16] and even, in rare cases, of a possible fatality [17–19]. And of course, the impact of such behaviour on health care costs is quite heavy [3, 20, 21]. Another problem is that patients with SID can have a heavy psy­chological impact on the hospital staff, that may feel they are being deceived in some way [22], or else that the patient is manipulating their emotions and making them feel guilty [23]. Sometimes, the patient with SID can also feel some satisfac­tion when observing the doctor’s evident difculties in making a diagnosis and pre­scribing treatment [24].
Although they have been known for centuries, the rst extensive study of SID was made by Asher in the context of the Münchausen syndrome, named after the eighteenth century European aristocrat Hieronymus Karl Friedrich, Baron von Münchausen (1720–1797) [25]. Since then, the term Münchausen syndrome, that refers to a particular picture of severe, chronic SID, is often used interchangeably with factitious. Other names for SID in the literature, often mocking or derisive, are “hospital hopper syndrome”, “hospital hobo syndrome”, “thick chart syndrome”, and “black hole syndrome” [3].
The precise prevalence of SID is not known but ranges from 0.02% to 3% in the general clinical population [26–31]. A recent study of factitious disorders, con­ducted in Germany and Norway in somatic hospitals from 2008 to 2016, reported a comparable incidence, of 3.71% and 3.18% per 100,000 patients, respectively [32].
Subjects with SID have been reported all over the world, but in particular in the United States and Europe [3]. Various studies show a prevalence in the female gen­der, with percentages ranging from 65.4%, 66.2% [3], to 73.5% [5]. Subjects with SID tend to come to medical attention already as young adults. The mean age ranges from 32 [3], 33.5 [33], to 38.4 [5] years, excluding young subjects and minors under the age of 18years. The mean age is generally lower in females.
A number of studies show a preponderance of patients employed in the health care sector; this suggests that health care work may be a risk factor when associated with stressful life events [33–35]. Such health care work includes nursing, but also medical assistants, pharmacists, administrators, and nutritionists [4].
From the literature, a preponderance of comorbidities with personality disorders, in particular borderline personality disorders and depression, also emerges [3–5, 33,
36, 37]. Overall, these epidemiological data describe the SID phenotype: young
women with health care experience and psychopathology [4, 38, 39].
In an analysis of a wide sample of patients, Yates and Feldman found that 58.7% of subjects with factitious disorders prefer to induce the illness or injury rather than simulating it (19.1%) or falsely referring (22.2%) a medical problem [3]. Therefore, these patients are at high risk of self-injury, and this risk must be taken into account in the patient management plan: family members, partners, and friends must be informed and involved in the management, so as to control the patient’s access to various harmful tools and substances (drugs, poisons) that can be employed for
3 Self-Inicted Skin Disorders: Diagnosis andManagement
27
self-injury. However, these patients sometimes use methods of self-injury that are difcult to control, such as abuse of insulin to induce hypoglycaemia, or self­venesection to provoke anaemia [3]. Once again, therefore, early detection of SID is very important to limit self-harm and promote improved outcomes. In this regard, special guidelines are needed to show how a self-inicted injury can be diagnosed by the clinician and how such injuries can be detected early on, in the relative medi­cal specialty eld [3].
Patients with SID can induce diseases in various ways, depending on their level of imagination, medical knowledge, and on the nature of the problem they wish to produce [40]. The same patient can actually use various different methods at once to create different diseases, for example, an ulcerative dermatological lesion using metal tools or caustic substances as well as haematuria by adding blood to urine samples. In all cases, however, a certain diagnosis of a simulated disease is difcult to make and must always follow a complete series of clinical examinations and laboratory tests.
All medical specialists may nd themselves in the position of needing to manage patients with an SID.In literature, the data on the predominance of cases in one specialty rather than another are conicting. This variability may be due to a differ­ent interest in diagnosing SID in the various medical branches. Alternatively, it may be explained by the difculties related to making a diagnosis of SID in the various specialist sectors. A simulated disease can be diagnosed more easily in dermatol­ogy, owing to the particular morphological features of self-inicted lesions, or in endocrinology because a factitious hypoglycaemia can be revealed by laboratory tests of insulin abuse [7, 10–12, 41–47]. Clearly, the greater frequency of one type of simulation than another also depends on the fact that it is easier for the patient to induce skin damage or an endocrinological problem than to act on other organs or systems.
Whatever the true distribution of SID cases in the various specialist elds, bear­ing in mind the ample volume of literature on this subject it is important that all specialists be aware of this problem, and especially dermatologists, neuropsychia­trists, and endocrinologists.
In any case, it is clear from the literature that dermatology is the specialty with the highest number of cases of SID [5, 48], or at least one of the specialties with the highest incidence [3]. The lower dermatological incidence reported in some studies could depend on the patients sample enrolled: it should be remembered that patients presenting with SID in dermatology are more often under ambulatorial manage­ment. Thus, such patients would not be included in studies of only hospital patients [5]. The medical branches with the lowest incidence of SID seem to be obstetrics and gynaecology [3], as well as oncology [3, 49–51]: it is difcult to achieve simu­lation in the former elds, and not easy to convince the physician of the existence of a cancer unless specic imaging tests show some signs.
It is also likely that the incidence of SID is underestimated in the general popula­tion. Clinicians are led to believe the clinical history referred by the patient and, in any case, have little familiarity with SID.And even in cases of suspected SID, it remains difcult to make a denitive diagnosis of simulation, also in view of the
28
G. Angelini et al.
medico-legal problems that such a diagnosis can provoke, when needing to differ­entiate between true simulating (malingering) and psychosomatic disease [52]. It can also be difcult to differentiate SID from a simple exaggeration or amplication of the symptoms [5]. A certain reluctance to make a diagnosis of an SID has also been reported, even in cases with strong evidence of simulation [39]. It must be remembered, however, that failure to diagnose an SID can lead to the prescription of unnecessary tests that may also be potentially harmful [5].
Other important characteristics among patients with SID are the denial of self­harm, refusal to accept a diagnosis of self-inicted pathology, and refusal in most cases to undergo psychiatric consultation or treatment. This anomalous behaviour is inevitably accompanied by failure of all treatments and a high disease recurrence.
In conclusion, SID are one of the most challenging problems in clinical medicine and warrant further in-depth study. It is important that general practitioners and the various specialists be fully aware of this major medical problem.
3.2 Self-Inicted Disorders inDermatology
SISD are due to excessive manipulation of the skin and appendages, hair, and nails. This anomalous behaviour is typically repetitive, and it is this reiteration that gener­ally leads to chronic damage. Manipulation of the skin can cause a de novo disease, or else complicate the course of a primary dermatological condition, as in the cases of pre-existing acne, psoriasis, and other itchy skin conditions [53–55].
In cases of trichotillomania and skin picking, as well as being repetitive, the nature of the behaviour is “automatic”, in the sense that the patient is often unaware of doing it. These disorders are described as “stereotypic”: the motor behaviour interferes with the patient’s normal activity and nally results in self-inicted injury, that is often severe enough to require medical treatment [53].
Another important aspect of the problem is the observation of several SISD together: in more than 38% of adults, skin picking is associated with trichotilloma­nia, and in more than 20% of cases, hair pulling, or skin picking are associated with compulsive nail biting [56–58].
Self-induced dermatoses are inicted using multiple different means, for differ­ent purposes [59–71]. They are among the most frequent self-inicted disorders in medicine, in particular because the use of an exogenous mechanism to induce an artefact is not only easier than an endogenous mechanism, but also allows the dis­ease to become “manifest” to all; this is the true reason motivating the whole arte­factual procedure. The adoption of an exogenous mechanism, moreover, allows the patient to choose the cutaneous site very carefully, to avoid affecting the whole organism (as may occur in the case of a self-inicted systemic disease), and to stop the harmful action when he/she wishes [7, 10, 43–45, 72–75].
In the great majority of cases, the simulation of a cutaneous disorder is dictated by psychiatric problems: in such an event, the subject desires to attract the attention of those around him, in particular the general practitioner, or else is reacting to a