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CHAPTER 0 | MISCELLANEOUS
15. A 45- year- old man presented with abdominal bloating, watery
diarrhoea, and atulence. Aglucose- hydrogen breath test was arranged.
Which statement regarding glucose- hydrogen breath testing is correct?
A. Adouble peak in expired breath hydrogen should be considered normal
B. Arise in breath hydrogen by more than 20 ppm from baseline within 90 minutes would be
consistent with a positive test result
C. Glucose- hydrogen breath testing correlates well with jejunal aspirates
D. Lactulose is well absorbed across the small intestinal mucosa
E. The test is not aected by small bowel transit time

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MISCELLANEOUS
0
ANSWERS
1. B. Stop apixaban 48 hours before, continue aspirin
• Aspirin is safe to continue prior to routine endoscopic procedures
• Apixaban should be stopped 48 hours prior to high- risk procedures
• Cardiology advice should be sought for patients with high- risk conditions
AF and ischaemic heart disease with long- standing stents are low- risk conditions for stopping
anticoagulant and antiplatelet agents. Therefore, consulting a cardiologist is not required. Diagnostic
gastroscopy is a low- risk procedure. However, the colonoscopy should best be considered a highrisk procedure to allow for polypectomy, given the patient’s preference. Aspirin is safe to continue
prior to routine endoscopy.
High- riskconditions
• <12months after drug eluting coronary stent
• <1month after bare metal coronary stent
• AF + prosthetic heart valve
• Prosthetic mitral valve
• AF + mitral stenosis
• <3months after VTE
Low- riskconditions
• IHD with no recent stents
• Cerebral vascular disease
• Peripheral vascular disease
• Tissue heart valve
• Prosthetic aortic valve
• Non- valvular AF
• >3months after venous thromboembolism (VTE)
Direct oral anticoagulants (apixaban,dabigatran, edoxaban, rivaroxaban)
Low- risk procedures:omit on the morning of procedure
High- risk procedures:stop 48 hours before procedure (72 hours for dabigatran with CrCl 30– 50
ml/ min)
Warfarin
Low- risk procedures:continue therapy, check international normalized ratio (INR) does not exceed
therapeutic range
Best of Five MCQs for the European Specialty Examination in Gastroenterology and Hepatology. Thomas Marjot, Colleen G C McGregor,
Tim Ambrose, Aminda N De Silva, Jeremy Cobbold, and Simon Travis, Oxford University Press (2021). © Oxford University Press.
DOI: 10.1093/oso/9780198834373.003.0010

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High- risk procedures:assess risk of underlying condition
• If low- risk condition, stop ve days before procedure, check INR <1.5
• If high- risk condition, stop ve days before procedure and bridge with low molecular weight
heparin (LMWH)
P2Y12 receptor antagonists (clopidogrel, prasugrel, ticagrelor)
Low- risk procedures:continue
High risk procedures:
• If low- risk condition, stop ve days before procedure
• If high- risk condition, consult cardiologist
Veitch AM etal. Endoscopy in patients on antiplatelet or anticoagulant therapy, including direct oral
anticoagulants:British Society of Gastroenterology (BSG) and European Society of Gastrointestinal
Endoscopy (ESGE) guidelines. Gut. 206;65:374– 389. Doi:0.36/ gutjnl- 205- 30.
2. B. CT abdomen
Post- polypectomy syndrome:
• Presents similarly to colonic perforation and often requires a CT to dierentiate
• Occurs more commonly in larger polypectomies (>2cm)
• Is managed conservatively in the majority of cases
The most likely diagnosis in this case is post- polypectomy syndrome (or post- polypectomy
electrocoagulation syndrome). The electrical current arising from diathermy extends beyond the
mucosa and muscularis propria into the serosal surface of the colon. Thermal injury ensues, without
evidence of colonic perforation, and results in a localized inammatory reaction. The syndrome
occurs after large amounts of sustained thermal energy have been applied, so it is more commonly
seen after larger polypectomies (>2cm in diameter), or when normal mucosa is inadvertently caught
within the snare alongside the polyp. Anecdotal evidence suggests the injection of uid submucosally
prior to polypectomy may reduce the risk of developing post- polypectomy syndrome.
Post- polypectomy syndrome occurs in 0.5%– 1% of polypectomies, and in 7%– 8% after endoscopic
submucosal dissection. Patients can present acutely (within 12 hours) or delayed (up to 5days post
procedure). Clinical presentation includes fever, tachycardia, abdominal pain, and leucocytosis. The
main dierential is colonic perforation. As such, the denitive investigation to dierentiate is a CT scan,
which may show focal thickening of the colon and periluminal fat stranding. In contrast to perforation,
there will be no evidence of pneumoperitoneum. Therefore, an erect chest radiograph is unhelpful.
Management is conservative and includes nil by mouth, intravenous uids, and antibiotics until
symptoms and inammatory markers settle. If symptoms and signs are mild, some patients may
even be managed as outpatients. There is a very low risk of evolution to frank perforation, and the
prognosis is generally excellent.
In this case, repeating a colonoscopy would be inappropriate given the concern of perforation. Equally,
surgical intervention would only be indicated if a large perforation were conrmed radiologically.
Cha JM. Clinical outcomes and risk factors of post- polypectomy coagulation syndrome:a multicenter,
retrospective, case- control study. Endoscopy. 203;45:202– 207. Doi:0.055/ s- 0032- 32604.
3. A. Endoscopic retrograde cholangiopancreatography (ERCP) for jaundice
secondary to a hilar cholangiocarcinoma
• Some endoscopic interventions may cause bacteraemia; however, complications from
bacteraemia are fortunately uncommon
• Antibiotics are no longer routinely required for the prevention of infective endocarditis
• Antibiotics are required in ERCP when adequate biliary decompression is unlikely to be achieved

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There are specic situations in endoscopy where antibiotics are indicated. These are summarized in
Table 10.1.
Allison MC, Sandow JAT etal. Antibiotic prophylaxis in gastrointestinal endoscopy. Gut. 2009;58:869–
880. Doi:0.36/ gut.2007.36580.
Table10.1 Summary ofprophylactic antibiotic regimens recommended forgastrointestinal
endoscopy
Scenario Rationale Antibiotics Dose/ route
1. Patients with valvular heart
disease, valve replacement,
and/ or surgically constructed
systemic– pulmonary shunt or
conduit or vascular graft
2. ERCP in the following:
a. Ongoing cholangitis or
sepsis elsewhere
b. Biliary obstruction and/ or
CBD stones
c. When complete biliary
drainage is unlikely to be
achieved (e.g. PSC, hilar
cholangiocarcinoma)
(may need to consider
alternative antibiotic
prophylaxis if repeated
procedures are needed)
d. Communicating pancreatic
cyst or pseudocyst
e. Biliary complications
following liver transplant
3. EUS in the following:
a. FNA solid lesions
b. FNA cystic lesions in or
near the pancreas or
drainage of a cystic cavity
4. PEG Prevention of
Prevention of infective
endocarditis or
conduit/ graft infection
Prevention of
procedure- related
bacteraemia
Prevention of
cholangitis
Prevention of
cholangitis
Reducing risk of
introducing infection
into cavity
Prevention of
cholangitis
Prevention of local
infections
Prevention of cyst
infections
peristomal infection
Possible reduction in
risk of other infections,
such as aspiration
pneumonia
Not indicated
Guide by culture results.
Patients should already be
established on antibiotics
Not indicated unless biliary
decompression is not achieved.
If biliary decompression is not
achieved during the procedure,
a full course of antibiotics is
indicated
Ciprooxacin
or
Gentamycin
As (c)
As (c)+ amoxicillin
or
vancomycin
Not indicated
Co- amoxiclav
or
Ciprooxacin
Co- amoxiclav
or
Cefuroxime
Microbiology advice
750 mg PO 60– 90
mins before procedure
1.5 mg/ kg IV over
2– 3 mins
As (c)
1 g IV single dose
20 mg/ kg IV infused
over at least 1 hour
1.2 g IV single dose
750 mg PO single dose
1.2 g IV injection or
infusion just before
procedure
750 mg IV injection or
infusion just before
procedure
(continued)
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Table10.1 Continued
Scenario Rationale Antibiotics Dose/ route
Teicoplanin can be used if
there is a past history of
anaphylaxis or angioedema
with penicillin/ cephalosporin
5. Variceal bleeding
(not strictly prophylaxis)
6. Profound immunocompromise
(e.g. neutropenia <0.5 × 109/
L or advanced haematological
malignancy)
CBD, common bile duct; PO, by mouth; IV, intravenous; PSC, primary sclerosing cholangitis; ERCP, endoscopic retrograde
cholangiopancreatography; EUS, endoscopic ultrasound; FNA, ne- needle aspiration; PEG, percutaneous endoscopic gastrostomy.
Prevention of infections
such as spontaneous
bacterial peritonitis
Prevention of
procedure- related
bacteraemia
Piperacillin/ tazobactam
or
Third- generation cephalosporin
Seek microbiology or regional
liver unit advice in cases of
penicillin allergy
Only indicated in procedures
with a high rate of bacteraemia
(e.g. sclerotherapy, dilatation,
ERCP with obstructed system)
400 mg IV for adults
4.5 g IV 3 times a day
e.g. cefotaxime 2 g IV
3 times a day
Discuss with
haematologist and/ or
clinical microbiologist
4. B. Grade II A
• Gastroscopy should be performed between 12 and 48 hours post caustic ingestion
• Zargar’s classication is the most common endoscopic tool for assessing caustic injury
• There is a ninefold increase in morbidity and mortality with every increased injury grade
Gastroscopy is an important diagnostic and prognostic tool in the evaluation of a caustic injury,
especially during the rst 12– 48 hours of caustic ingestion. It is contraindicated in patients with
haemodynamic instability, severe respiratory compromise, and suspected perforations. In the
absence of symptoms, signicant lesions are typically not seen endoscopically. Emergent endoscopy is
recommended in symptomatic individuals and in those with intentional ingestions of caustic substances.
Endoscopy is the gold standard in diagnosis and prognostication in caustic ingestions. It also guides
management. Zargar’s classication (Table 10.2) is most commonly used to grade severity of caustic
injury. Grades 0– II Agenerally recover without sequelae. Grades IIB– III eventually develop oesophageal
or gastric scarring, which may result in stricture formation. The degree of oesophageal injury
endoscopically is a predictor of morbidity and mortality with a ninefold increase with each injury grade.
Table10.2 Zargar classication
Zargar classication Endoscopic description
Grade 0 Normal mucosa
Grade I Oedema and erythema of the mucosa
Grade II A Haemorrhage, erosions, blisters, supercial ulcers
Grade II B Circumferential lesions
Grade III A Focal deep grey or brownish- black ulcers
Grade III B Extensive deep grey or brownish- black ulcers
Grade IV Perforation
De Lusong MAA, Tombol ABG, Tuazon DJS. Management of esophageal caustic injury. World J
Gastrointest Pharmacol Ther. 207 May 6;8(2):90– 98. Doi:0.4292/ wjgpt.v8.i2.90.

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283
5. D. Obesity
• Sedation- related complication is the leading factor in endoscopy- related mortality
• Assessment of risk factors for sedation- related complications is paramount
• Opiates and benzodiazepines have a synergistic eect
Conscious sedation is dened as the use of medication to depress the central nervous system without
the loss of verbal communication. Sedation is the leading factor in endoscopy- related mortality.
Risk factors for complications of sedation include the following:
• Advanced age
• Obesity
• Comorbidities including cirrhosis, cardiac disease, respiratory disease, renal disease
• Prior administration of sedation or opiates
• Known drug allergies
• Low resting oxygen saturations
• Emergency endoscopy
Complications of sedation include over- sedation, paradoxical excitement, respiratory depression,
aspiration, cardiac arrhythmias, acute coronary events, hypertension, hypotension, cerebrovascular
events, nausea, vomiting, and ushing (Table 10.3). Risk factors for complications should warrant
discussion of un- sedated endoscopy and, if sedation is undertaken, adjustment of doses should be
considered.
6. C. Bile duct cannulation rate in at least 90%
The ESGE and United European Gastroenterology have identied quality of endoscopy as a major
priority. They recommend that endoscopy services adopt the following key performance measures
for ERCP and EUS:
1. Adequate antibiotic prophylaxis before ERCP (key performance measure, at least 90%)
2. Antibiotic prophylaxis before EUS- guided puncture of cystic lesions (key performance
measure, at least 95%)
3. Bile duct cannulation rate (key performance measure, at least 90%)
4. Tissue sampling during EUS (key performance measure, at least 85%)
5. Appropriate stent placement in patients with biliary obstruction below the hilum (key
performance measure, at least 95%)
6. Bile duct stone extraction (key performance measure, at least 90%)
7. Post- ERCP pancreatitis (key performance measure, less than 10%)
Minor performancemeasure
8. Adequate documentation of EUS landmarks (at least 90%)
Domagk D, Oppong KW etal. Performance measures for ERCP and endoscopic ultrasound:a
European Society of Gastrointestinal Endoscopy (ESGE) quality improvement initiative. Endoscopy.
208;50:6– 27. Doi:0.055/ a- 0749- 8767.
7. D. The formal consent process should be completed before entry into the
procedure room
• All endoscopic procedures require written consent, except in an emergency

Table10.3 Sedatives, analgesics and adjuncts used inendoscopy
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Drug Eect Contra- indications Side eects (SE) Onset
Benzodiazepines
e.g. Midazolam
Opiates
e.g. Pethidine*,
Fentanyl
Buscopan Relief of smooth
Xylocaine Throat
Spray (Topical
lidocaine)
Sedation with
amnesia, and no
analgesic eect
Prevention,
reduction, and
relief of pain
Opiates have
a synergistic
eect with
benzodiazepines
Give 3 minutes
before
benzodiazepines,
as doses may
need to be
reduced by up to
fourfold
muscle spasm
Analgesia of
oropharynx
Neuromuscular
respiratory weakness
Severe respiratory
depression
Acute respiratory
depression
Phaeochromocytoma
Myasthenia gravis, acute
closed- angle glaucoma
Unsafe swallow
(Relative)
Confusion
Paradoxical excitement
or agitation
Nausea
Vomiting
Reduced respiratory
eort
Hypoxia
Hypotension
Cardiac or respiratory
arrest
Confusion
Nausea
Vomiting
Decreased
responsiveness
Reduced respiratory
eort
Hypoxia
Hypotension
Cardiac or respiratory
arrest
Tachycardia
Arrhythmias
Anti- muscarinic side
eects
Risk of aspiration Peak:1
(minutes)
Initial:1
Peak:1- 2
Initial:1- 2
Peak:3
Peak:4
Duration of
action (hours):5
Duration of
action:15– 60
Dose Reversal agent
<70 yrs:0– 2 mg,
increment 0– 1 mg,
max 5 mg
>70years:0– 1 mg,
increment 0– 0.5 mg,
max 2 mg
<70years old:
Pethidine:initial dose
25 mg, increment
25 mg, max
50 mg
Fentanyl:initial dose
50 mg, increment
25 mg, max 100 mg
>70years old:
Pethidine:initial dose
12.5 mg, increment
12.5 mg, max 25 mg
Fentanyl:initial dose
25 mg, increment
12.5 mg, max 50 mg
20 mg can be repeated
every 30 minutes up
to a max of 100 mg in
24 hours.
Max 20 applications
(200 mg lidocaine
base)
Flumazenil:0.2– 0.5 mg,
increment 0.1 mg, peak
eect in up to 1 minute,
duration of action 1– 2 hours
SE:ushing, seizures, and late
re- sedation.
Naloxone:
Dosage 0.1– 0.2 mg,
maximum 10 mg, peak eect
in 1– 2 minutes, duration of
action 1– 3 hours
SE: Pain, agitation,
arrhythmias, pulmonary
oedema, and late
re- sedation.
-
-
*Pethidine is metabolized to fentanyl and therefore has less predictable eects, including a higher risk of hypotension, and hallucinations
Dumonceau JM, Riphaus Aetal. European Society of Gastrointestinal Endoscopy, European Society of Gastroenterology and Endoscopy Nurses and Associates, and the European Society of
Anaesthesiology Guideline:Non- anesthesiologist administration of propofol for GI endoscopy. Endoscopy. 200 Nov;42():960- 74. Doi:0.055/ s- 0030- 255728

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• Abest interest decision should be taken for those who lack capacity
• The consent process should be completed before entry into the procedure room
All endoscopic procedures require written consent, except in an emergency. The endoscopist
performing the procedure is ultimately responsible for ensuring that the consent process is
appropriate for the procedure being undertaken. The endoscopist performing the procedure
should assess capacity to consent. If a patient lacks capacity, delaying the procedure to allow the
patient to regain capacity may be appropriate. If the patient is unlikely to regain capacity or the
procedure is an emergency, the endoscopist should make a decision to proceed in the patient’s
best interests. In such instances, where possible, the next of kin should be informed. However,
this should not delay emergency treatment. Patients who lack capacity may have a proxy decision
maker (e.g. Lasting Power of Attorney) or may require appointment of an Independent Mental
Capacity Advocate. In non- emergency cases where the patient lacks capacity, the decision regarding
endoscopy is best decided in a multi- disciplinary discussion with best interests in mind. Patients
physically unable to sign their consent may have their consent countersigned by a witness (relative
or healthcare professional (not the consenting healthcare professional).
All patients should receive written information explaining the procedure, and its intended benets
and risks, in a format that they can understand. Written information should be provided in advance
of the procedure. The consent process should be performed by a suitably trained individual before
entry into the procedure room. Final validation of the consent process should be completed
before the procedure starts. Endoscopic photo- and video- documentation as part of routine
clinical care does not require additional consent. If a patient, with capacity, withdraws consent
during an endoscopic procedure, the procedure should be stopped. The person’s concerns should
be explored. If they clearly indicate a wish for the procedure to be discontinued, this must occur
without delay unless doing so would result in a risk of serious harm to the patient.
Everett SM, Griths H etal. Guideline for obtaining valid consent for gastrointestinal endoscopy
procedures. Gut. 206;65(0):585– 60. Doi:0.36/ gutjnl- 206- 3904.
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8. D. Neoplastic lesions account for two- thirds of cases
• Intussusception is a rare cause of intestinal obstruction in adults
• It typically occurs in the small bowel and is associated with structural lesions in 90% of which
two- thirds are neoplastic
Intussusception is the invagination of one segment of bowel into an immediately adjacent segment.
It is most commonly found in children and represents the second most common cause of intestinal
obstruction in this group after pyloric stenosis. The majority of paediatric intussusception is
idiopathic (90%) and is usually ileocolic. Conversely, adult intussusception is rare, accounting for
1– 5% of cases of bowel obstruction and usually occurs in the ileum. Ninety per cent of adult cases
will have an underlying structural cause, two- thirds of which will be due to benign or malignant
neoplasms. The remainder are caused by infections, adhesions, intestinal ulceration, and congenital
abnormalities such as Meckel’s diverticulum. These lesions act as a focal area of traction, or ‘lead
point’, which draws the proximal bowel within the peristalsing distal bowel, which can ultimately
lead to bowel ischaemia and perforation. Intussusception in adults is usually diagnosed on CT, which
classically demonstrates a concentric hyperdense double ring or ‘target- sign’. In children, most
ileocolic intussusception is successfully managed with ultrasound or uoroscopy guided pneumatic/
hydrostatic enema. In adults, because of the majority of cases arising from structural pathology in
the small bowel, surgery remains the mainstay of treatment.
Marsicovetere P, Ivatury SJ, White B etal. Intestinal intussusception:etiology, diagnosis, and treatment.
Clin Colon Rectal Surg. 207 Feb;30():30– 39. Doi:0.055/ s- 0036- 593429.

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9. D. Rubber band ligation (RBL)
• RBL is currently the rst- line intervention in Grades I– III haemorrhoids, with a long- term
success rate of >80%
• Surgical haemorrhoidectomy is associated with the lowest rate of recurrence but should be
reserved for when RBL has failed because of higher complication rates (pain, anal stenosis,
incontinence)
Haemorrhoids are dened as the symptomatic enlargement and displacement of the anal cushions
which are prominences of anal mucosa formed by connective tissue, smooth muscle, and blood
vessels. Contributing factors include lack of dietary bre, chronic straining, excess time on the
commode, constipation, and pregnancy. Haemorrhoids can be classied as internal (covered by
columnar epithelium) or external (covered by squamous epithelium), and internal haemorrhoids
can be graded from I– IV depending on the degree of prolapse during defecation. Conservative
management of haemorrhoids includes lifestyle advice (adequate uid and bre intake, reduce
straining, good anal hygiene), and treatment with laxatives and topical analgesics.
RBL is currently rst- line therapy in Grade I– III haemorrhoids with a long- term success rate of
>80%. Pain is the most common complication of RBL but can be minimized by proximal placement
and single banding at a session. Sclerotherapy and heater probe coagulation can be used in Grade
I– II haemorrhoids with variable success and higher complication rates respectively, when compared
to RBL. While surgical haemorrhoidectomy is more eective than RBL in the treatment of Grade
III haemorrhoids, it is associated with higher rates of complications, pain, and disability, and should
therefore be reserved for cases when band ligation has failed. Lord’s procedure involves anal dilation
to decrease sphincteric pressure but is now an outdated technique because of high rates of postprocedural incontinence.
Ganz RA etal. The evaluation and treatment of hemorrhoids:a guide for the gastroenterologist. Clin
Gastroenterol Hepatol 203;(6):593– 603. Doi:0.06/ j.cgh.202.2.020.
10. C. Topical diltiazem
• Topical diltiazem and GTN have a similar ecacy for chronic anal ssures
• Topical diltiazem has a superior side eect prole
• Surgical options, including sphincterotomy, are reserved for cases refractory to conservative
and medical therapy
Following the initial development of an anal ssure, passage of subsequent stool will continue to
irritate the area. The internal sphincter may be involved and can go into spasm, causing further
pain. It also pulls the edges of the ssure further apart, impairing wound healing, leading to the
development of a chronic ssure.
Although conservative treatment may be sucient for some acute ssures, other patients will need
medical or surgical therapy. Stool softeners may reduce the pain and progression of a ssure, warm
baths may relax the sphincter, and topical anaesthetic gel can provide pain relief. Topical diltiazem
would be the next treatment of choice. This has the same ecacy as GTN— however with a
superior side eect prole (30% of patients who use topical GTN suer from headache). Topical
diltiazem has been associated with healing rates of 65%– 95%. Fifty per cent of patients treated with
topical GTN may experience recurrent ssures. Treatment with botulinum toxin has a similar ecacy
to that of GTN and diltiazem. However, it is more expensive and therefore may be used in patients
whose ssures do not heal with topical (diltiazem or GTN) therapy or in cases of recurrence.
With regard to surgical treatment, lateral internal sphincterotomy has consistently superior
healing rates and less recurrence when compared with medical therapy. However, there is
a higher rate of faecal incontinence following treatment. In general, sphincterotomy and the

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various alternative surgical techniques available should only be used if the patient does not
respond to medical treatment.
Stewart D, Gaertner W etal. Clinical Practice Guideline for the management of anal ssures. Dis Colon
Rectum. 207;60():7– 4. Doi:0.097/ DCR.0000000000000735
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11. B. Rectal bleeding on defaecation is a hallmark feature
• SRUS is a chronic, benign disorder in young adults
• Only 20% of patients have a solitary ulcer
• Patient education and conservative measures, including biofeedback, are the mainstay of
treatment
SRUS is a rare, benign disorder characterized by a combination of clinical, endoscopic, and
histological ndings. Although denoted as a ‘solitary rectal ulcer’, only 20% of patients have a single
ulcer endoscopically. It is a rare and often underdiagnosed disorder, with an annual prevalence of 1
in 100,000 persons. Adisorder of young adults, occurring most commonly in the third and fourth
decade in men and women respectively. Men and women are aected equally, however. The
aetiology is not well understood but is thought to be multifactorial. Characterized by single or multiple
ulcerations of the rectal mucosa, symptoms include rectal bleeding and mucus discharge, usually
associated with excessive straining or abnormal defaecation. The passage of blood during defaecation
is a hallmark feature. However, over a quarter of patients are asymptomatic, diagnosed incidentally.
According to anorectal manometry studies, dyssynergic defaecation is associated with SRUS in
25%– 82% of patients. Defaecatory disorders with excessive straining are signicantly associated
with SRUS. Diagnosis is made on clinical features, endoscopy, and histology. Proctosigmoidoscopy
reveals shallow rectal ulcer(s) of varying sizes covered by white or yellow slough. Surrounding
rectal mucosa may appear hyperemic. Key histological features include bromuscular obliteration
of the lamina propria, hypertrophied muscularis mucosa, and glandular crypt abnormalities.
Defaecatory proctogram and/ or anorectal manometry are useful for determining the presence
of intussusception, rectal prolapse, or dyssynergic defaecation. Several treatment options include
conservative measures (high- bre diet, patient education), biofeedback, medical therapy (topical
sucralfate, mesalazine), and surgery (in presence of prolapse). Conservative measures and
biofeedback are the mainstays of treatment.
Zhu Q, Shen R etal. Solitary rectal ulcer syndrome:clinical features, pathophysiology, diagnosis and
treatment strategies. World J Gastroenterol. 204;20(3):738– 744. Doi:0.3748/ wjg.v20.i3.738.
12. A. Chlamydia lymphogranuloma venereum (LGV)
• LGV proctitis may mimic Crohn’s disease
• All patients with LGV proctitis should be screened for HIV
• Treatment is with macrolides— doxycycline or erythromycin
All the infections listed can cause proctitis, and often there will be coexisting infections. Patients
should be tested for HIV, especially in cases of LGV, syphilis, and herpes simplex virus (Table 10.4).
Where positive, contact tracing should be instigated.
LGV has re- emerged among European MSM in the past decade and is a relatively common cause
of proctitis in this population. Anorectal LGV is generally a symptomatic infection, although
asymptomatic infection does occur. Proctitis is the primary manifestation of LGV infection, usually
occurring within a few weeks of sexual contact. It is characterized by symptoms of anorectal pain,
mucopurulent discharge, bleeding per rectum, tenesmus, and constipation. Endoscopic examination
may reveal distal granular or haemorrhagic proctitis with purulent exudate, inammatory inltrate,
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