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SECOND EDITION
The American Psychiatric Association Publishing
TEXTBOOK of
MOOD DISORDERS
EDITED BY
Charles B. Nemeroff, M.D., Ph.D.
Natalie Rasgon, M.D., Ph.D.
Alan F. Schatzberg, M.D.
Stephen M. Strakowski, M.D.
The American Psychiatric Association Publishing
TEXTBOOK OF
MOOD
D
SECOND EDITION
ISORDERS
The American Psychiatric Association Publishing
TEXTBOOK OF
MOOD
D
SECOND EDITION
Charles B. Nemeroff, M.D., Ph.D.
ISORDERS
EDITED BY
Natalie Rasgon, M.D., Ph.D.
Alan F. Schatzberg, M.D.
Stephen M. Strakowski, M.D.
Note: The authors have worked to ensure that all information in this book is accurate at the
https://t.me/med1917
time of publication and consistent with general psychiatric and medical standards, and that in formation concerning drug dosages, schedules, and routes of administration is accurate at the time of publication and consistent with standards set by the U.S. Food and Drug Administra tion and the general medical community. As medical research and practice continue to ad­vance, however, therapeutic standards may change. Moreover, specific situations may require a specific therapeutic response not included in this book. For these reasons and because human and mechanical errors sometimes occur, we recommend that readers follow the advice of phy sicians directly involved in their care or the care of a member of their family.
Books published by American Psychiatric Association Publishing represent the findings, con­clusions, and views of the individual authors and do not necessarily represent the policies and opinions of American Psychiatric Association Publishing or the American Psychiatric Associ ation.
If you wish to buy 50 or more copies of the same title, please go to www.appi.org/specialdis­counts for more information.
Copyright © 2022 American Psychiatric Association Publishing
ALL RIGHTS RESERVED
Second Edition
Manufactured in the United States of America on acid-free paper
26 25 24 23 22 5 4 3 2 1
American Psychiatric Association Publishing 800 Maine Avenue SW Suite 900 Washington, DC 20024-2812 www.appi.org
Library of Congress Cataloging-in-Publication Data
A CIP record is available from the Library of Congress.
British Library Cataloguing in Publication Data
A CIP record is available from the British Library.
-
-
-
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To Gayle, Gigi, Ross, Mandy, Michael, Emily, Callie, Rylie, and Finn,
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for your support during the long hours, which made this volume possible.
C.B.N
To Alex, for all your love and support.
To the loving memory of my parents.
N.R.
To my wife,
Nancy,
and my daughters,
Melissa Dassori and Lindsey Cedillos.
A.F.S.
To Stacy, Andy, Alexis, Lucas, and Sue,
for all your love and support.
S.M.S.
https://t.me/med1917
Contents
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Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xv
Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . xxvii
PART I
Symptomatology and Epidemiology
1 Historical Aspects of Mood Disorders . . . . . . . . . . . . 3
Dean F. MacKinnon, M.D.
J. Raymond DePaulo Jr., M.D.
2 Classifications of Mood Disorders . . . . . . . . . . . . . . 15
Darrel A. Regier, M.D., M.P.H.
3 Epidemiology and Burden of Mood Disorders . . . . . 31
Ronald C. Kessler, Ph.D.
Andrew A. Nierenberg, M.D.
Brenda W.J.H. Penninx, M.D., Ph.D.
Philip S. Wang, M.D., Dr.P.H.
Hans-Ulrich Wittchen, Ph.D.
Hannah N. Ziobrowski, Ph.D., M.P.H.
4 Rating Scales and Structured Diagnostic
Interviews for Mood Disorders . . . . . . . . . . . . . . . . . 55
David V. Sheehan, M.D., M.B.A.
PART II
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Pathogenesis of Mood Disorders
5 Neurochemistry of Mood Disorders . . . . . . . . . . . . . 93
Charles F. Gillespie, M.D., Ph.D.
6 Psychoneuroendocrinology of Mood Disorders . . . 105
Luca Sforzini, M.D.
Maria Antonietta Nettis, M.D., Ph.D.
Frances Isabella Weston, B.Sc.
Carmine Maria Pariante, M.D., Ph.D., FRCPsych
7 Role of the Immune System in Mood Disorders. . . 133
Marisa Toups, M.D.
Charles B. Nemeroff, M.D., Ph.D.
8 Evolutionary Contributions to the Understanding
of Mood and Mood Disorders
Martin Brüne, M.D.
Daniel R. Wilson, M.D., Ph.D.
. . . . . . . . . . . . . . . . . 145
PART III
Investigating Mood Disorders
9 Anatomical Pathology. . . . . . . . . . . . . . . . . . . . . . . 165
Grazyna Rajkowska, Ph.D.
10 Molecular and Cellular Neurobiology . . . . . . . . . . . 177
Marianne Seney, Ph.D.
David A. Lewis, M.D.
11 Brain Imaging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 191
Michele A. Bertocci, Ph.D.
Jorge Renner Cardoso de Almeida, M.D., Ph.D.
Stephen M. Strakowski, M.D.
Mary L. Phillips, M.D., M.D. (Cantab)
12 Genetics of Mood Disorders. . . . . . . . . . . . . . . . . . 205
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Wade Berrettini, M.D., Ph.D.
13 Epigenetics of Mood Disorders . . . . . . . . . . . . . . . 217
Melissa P.H. Miller, M.Sc.
Caroline Symcox, B.Sc.
Frances A. Champagne, Ph.D.
PART IV
Somatic Interventions for Mood Disorders
14 Tricyclics, Tetracyclics, and Monoamine
Oxidase Inhibitors . . . . . . . . . . . . . . . . . . . . . . . . . 231
Matthew Macaluso, D.O., DFAPA
15 Selective Serotonin Reuptake Inhibitors
and Related Antidepressants
Richard C. Shelton, M.D.
. . . . . . . . . . . . . . . . . 239
16 Lithium and Mood Stabilizers . . . . . . . . . . . . . . . . . 271
Keming Gao, M.D., Ph.D.
Yuanhan Bai, M.D., M.S.
Joseph R. Calabrese, M.D.
17 Role of Antipsychotics in Mood Disorder
Treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 285
Ilang M. Guiroy, M.D.
Tyler Wright, M.D., M.P.H.
Brian W. Wu, M.D., Ph.D.
Henry A. Nasrallah, M.D.
18 Electroconvulsive Therapy . . . . . . . . . . . . . . . . . . . 297
William McDonald, M.D.