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19 Transcranial Magnetic Stimulation . . . . . . . . . . . . . 317
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Andrew M. Fukuda, M.D., Ph.D.
Brian C. Kavanaugh, Psy.D.
Shiwen Yuan, M.D.
Linda L. Carpenter, M.D.
20 Vagus Nerve Stimulation and Deep Brain
Stimulation
Dora M. Meyer, M.Sc.
Hannah M. Kilian, M.Sc.
Thomas E. Schlaepfer, M.D.
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 335
21 Other Antidepressants: Bupropion, Mirtazapine,
and Trazodone
Charles DeBattista, M.D.
. . . . . . . . . . . . . . . . . . . . . . . . . . . . 365
22 Ketamine and Other Investigational Agents . . . . . . 375
Gerard Sanacora, M.D., Ph.D.
Brandon M. Kitay, M.D., Ph.D.
PART V
Psychotherapy of Mood Disorders
23 Cognitive and Behavior Therapies for
Depressive Disorders
W. Edward Craighead, Ph.D.
. . . . . . . . . . . . . . . . . . . . . . . 405
24 Interpersonal Psychotherapy for Depressive
Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 419
John C. Markowitz, M.D.
25 Psychoanalytic and Psychodynamic
Psychotherapy for Depressive Disorders . . . . . . . . 443
Glen O. Gabbard, M.D.

26 Psychotherapeutic Approaches to Bipolar
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Disorder
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 455
David J. Miklowitz, Ph.D.
Lisa A. O’Donnell, Ph.D.
27 Psychotherapy for Depression in Children
and Adolescents
Jennifer L. Hughes, Ph.D., M.P.H.
Martha C. Tompson, Ph.D.
Adora Choquette, B.A.
Joan R. Asarnow, Ph.D.
Integrative Management of Mood Disorders
. . . . . . . . . . . . . . . . . . . . . . . . . . . 473
PART VI
28 Practice Guidelines for Major Depressive
Disorder
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 495
Michael E. Thase, M.D.
29 Treatment Guidelines for Bipolar Disorder. . . . . . . 527
Jorge Renner Cardoso de Almeida, M.D., Ph.D.
Lakshmi N. Yatham, M.B.B.S., FRCPC
Benjamin Goldstein, M.D., Ph.D.
30 Understanding and Preventing Suicide . . . . . . . . . 543
J. John Mann, M.D.
Mina M. Rizk, M.B.B.Ch., M.Sc.
31 Suicide in Children and Adolescents . . . . . . . . . . . 559
Christine Yu Moutier, M.D.
Joan Asarnow, Ph.D.
32 Combination Strategies for the Pharmacological
Treatment of Major Depressive Disorder
Adel Farah, M.D., M.Sc.
Pierre Blier, M.D., Ph.D.
. . . . . . . . 583

33 Management of Treatment-Resistant
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Depression
Samuel J. Collier, M.D.
Charles B. Nemeroff, M.D., Ph.D.
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 609
PART VII
Subtypes of Mood Disorders
34 Seasonal Affective Disorder and Light Therapy . . . 633
Norman E. Rosenthal, M.D.
Dan A. Oren, M.D.
35 Atypical Depression, Dysthymia, and
Cyclothymia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 649
John T.P. Liggins, M.D., M.S.
William Coryell, M.D.
36 Major Depressive Disorder With Psychotic
Features
Alan F. Schatzberg, M.D.
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 665
37 Pediatric Mood Disorders . . . . . . . . . . . . . . . . . . . . 685
Manpreet K. Singh, M.D., M.S.
38 Geriatric Mood Disorders . . . . . . . . . . . . . . . . . . . . 703
Kristina F. Zdanys, M.D.
David C. Steffens, M.D., M.H.S.
PART VIII
Additional Perspectives on Mood Disorder
39 Depression in Primary Care . . . . . . . . . . . . . . . . . . 727
Larry Culpepper, M.D., M.P.H.

40 Depression in Medical Illness. . . . . . . . . . . . . . . . . 743
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James K. Rustad, M.D.
Vanessa Padilla, M.D.
Mitchell Rovner, M.D.
Dominique L. Musselman, M.D., M.S.C.R.
41 Mood Disorders and Substance Use . . . . . . . . . . . 769
Edward Nunes, M.D.
Eric Rubin, M.D., Ph.D.
Kenneth Carpenter, Ph.D.
Deborah Hasin, Ph.D.
42 Depression in Women . . . . . . . . . . . . . . . . . . . . . . 801
Alison Myoraku, M.S.
Lexi Nutkiewicz, B.A.
Teresa Lanza di Scalea, M.D., Ph.D.
Natalie Rasgon, M.D., Ph.D.
D. Jeffrey Newport, M.D., M.S.
43 Depression Across Cultures: An Ecosocial
Approach
Laurence J. Kirmayer, M.D.
G. Eric Jarvis, M.D.
Ana Gómez-Carrillo, M.D.
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 837
44 Mood Disorders and Sleep . . . . . . . . . . . . . . . . . . 869
Zhixing Yao, M.D.
Trevor Mooney, M.D.
William V. McCall, M.D., M.S.
45 Childhood Maltreatment and Mood Disorders . . . . 895
Elizabeth T.C. Lippard, Ph.D.
Charles B. Nemeroff, M.D., Ph.D.
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 909
Color Gallery

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Contributors
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Joan Asarnow, Ph.D.
Professor of Psychiatry and Biobehavioral Science, David Geffen School of Medicine,
Los Angeles, California
Yuanhan Bai, M.D., M.S.
Attending Physician, Division of Mood Disorders in Shenzhen Kangning Hospital,
Shenzhen, Guangdong, China; Research Fellow, Department of Psychiatry, University
Hospitals Cleveland Medical Center, Cleveland, Ohio
Wade Berrettini, M.D., Ph.D.
Karl E. Rickels Professor, Department of Psychiatry, Perelman School of Medicine,
University of Pennsylvania, Philadelphia, Pennsylvania
Michele A. Bertocci, Ph.D.
Research Assistant Professor of Psychiatry, Department of Psychiatry, University of
Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania
Pierre Blier, M.D., Ph.D.
Professor, Departments of Psychiatry and Cellular and Molecular Medicine, University
of Ottawa, Royal Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada
Martin Brüne, M.D., Ph.D.
Professor of Psychiatry, LWL University Hospital Bochum, Department of Psychiatry,
Psychotherapy and Preventive Medicine, Division of Social Neuropsychiatry and Evolutionary Medicine, Ruhr University Bochum, Bochum, Germany
Joseph R. Calabrese, M.D.
Emeritus Professor of Psychiatry, Former Director of Bipolar Disorder Research Center,
Case Western Reserve University; Former Director of Mood Disorders Program, Department of Psychiatry, University Hospitals Cleveland Medical Center, Cleveland, Ohio
Kenneth Carpenter, Ph.D.
Associate Professor of Clinical Psychology (in Psychiatry) Department of Psychiatry,
Columbia University Irving Medical Center and New York State Psychiatric Institute,
New York, New York
Linda L. Carpenter, M.D.
Professor, Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island
Frances A. Champagne, Ph.D.
Professor, Department of Psychology, The University of Texas at Austin
Adora Choquette, B.A.
Clinical Psychology doctoral student, Department of Psychology, University of Memphis, Memphis, Tennessee
xv

xvi The APA Publishing Textbook of Mood Disorders, Second Edition
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Samuel J. Collier, M.D.
Associate Professor, Department of Psychiatry, University of Texas Dell Medical
School, Austin, Texas
William Coryell, M.D.
George Winokur Professor of Psychiatry, Carver College of Medicine, University of
Iowa, Iowa City
W. Edward Craighead, Ph.D.
J. Rex Fuqua Professor and Endowed Chair, Vice Chair of Psychiatry and Behavioral
Sciences, Emory University, Atlanta, Georgia
Larry Culpepper, M.D., M.P.H.
Professor of Family Medicine, Boston University School of Medicine, Boston, Massachusetts
Jorge Renner Cardoso de Almeida, M.D., Ph.D.
Associate Professor, Department of Psychiatry and Behavioral Sciences, Dell Medical
School, The University of Texas at Austin
Charles DeBattista, M.D.
Professor of Psychiatry and Behavioral Sciences and Director, Depression Research
Clinic, Stanford University School of Medicine, Stanford, California
J. Raymond DePaulo Jr., M.D.
Professor, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
Adel Farah, M.D., M.Sc.
Psychiatry Resident, Departments of Psychiatry and Cellular and Molecular Medicine,
University of Ottawa, Royal Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada
Andrew M. Fukuda M.D., Ph.D.
Chief Resident of Psychiatry, Department of Psychiatry and Human Behavior, Brown
University, Providence, Rhode Island
Glen O. Gabbard, M.D.
Clinical Professor of Psychiatry, Baylor College of Medicine, Houston, Texas
Keming Gao, M.D., Ph.D.
Professor of Psychiatry, Director of Bipolar Disorder Research Center, Case Western
Reserve University; Director of the Mood Disorders Program, Medical Director of
Electroconvulsive Therapy, and Director of Ketamine Infusion and Repetitive Transcranial Stimulation in the Department of Psychiatry, University Hospitals Cleveland
Medical Center, Cleveland, Ohio
Charles F. Gillespie, M.D., Ph.D.
Assistant Professor, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia

Contributors xvii
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Benjamin Goldstein, M.D., Ph.D.
RBC Investments Chair in Children’s Mental Health & Developmental Psychopathology, Centre for Addiction and Mental Health, Professor of Psychiatry and Pharmacology, University of Toronto Faculty of Medicine, Toronto, Ontario, Canada
Ana Gómez-Carrillo, M.D.
Banting Post-Doctoral Fellow, Division of Social and Transcultural Psychiatry, McGill
University; Investigator, Culture and Mental Health Research Unit, Sir Mortimer B.
Davis—Jewish General Hospital, Montreal, Quebec, Canada
Ilang M. Guiroy, M.D.
Chief Resident Physician, University of Southern California, Los Angeles, California
Deborah Hasin, Ph.D.
Professor of Epidemiology (in Psychiatry), Mailman School of Public Health, Columbia University Irving Medical Center and New York State Psychiatric Institute, New
York, New York
Jennifer L. Hughes, Ph.D., M.P.H.
Psychologist and Clinical Scholar, Big Lots Behavioral Health Services, Nationwide
Children's Hospital, Columbus, Ohio; Associate Professor, Department of Psychiatry
and Behavioral Health, The Ohio State University, Columbus, Ohio; Adjunct Associate
Professor, Department of Psychiatry, UT Southwestern Medical Center, Dallas, Texas
G. Eric Jarvis, M.D.
Associate Professor of Psychiatry, Division of Social and Transcultural Psychiatry,
McGill University; Investigator, Culture and Mental Health Research Unit, Sir Mortimer B. Davis—Jewish General Hospital, Montreal, Quebec, Canada
Brian C. Kavanaugh, Psy.D.
Assistant Professor, Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island
Ronald C. Kessler, Ph.D.
McNeil Family Professor of Health Care Policy, Department of Health Care Policy,
Harvard Medical School, Boston, Massachusetts
Hannah M. Kilian, M.Sc.
Research Scientist, Division of Interventional Biological Psychiatry, Department of
Psychiatry and Psychotherapy Medical Center, University of Freiburg Faculty of Medicine, University of Freiburg, Germany
Laurence J. Kirmayer, M.D.
James McGill Professor and Director, Division of Social & Transcultural Psychiatry,
McGill University; Director, Culture and Mental Health Research Unit, Sir Mortimer
B. Davis—Jewish General Hospital, Montreal, Quebec, Canada
Brandon M. Kitay, M.D., Ph.D.
Assistant Professor of Psychiatry and Behavioral Sciences, Emory University, Atlanta,
Georgia

xviii The APA Publishing Textbook of Mood Disorders, Second Edition
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Teresa Lanza di Scalea, M.D., Ph.D.
Assistant Professor of Psychiatry and Women's Health, Department of Psychiatry, Dell
Medical School, The University of Texas at Austin
David A. Lewis, M.D.
Distinguished Professor of Psychiatry and Neuroscience, Thomas Detre Professor of
Academic Psychiatry, Translational Neuroscience Program, Department of Psychiatry,
University of Pittsburgh, Pittsburgh, Pennsylvania
John T.P. Liggins, M.D., M.S.
Staff Psychiatrist, Palo Verde Behavioral Health, Tucson, Arizona
Elizabeth T.P. Lippard, Ph.D.
Assistant Professor, Department of Psychiatry and Behavioral Sciences, Institute of
Early Life Adversity Research, Mulva Clinic for Neuroscience, Dell Medical School;
Assistant Professor of Psychiatry, Waggoner Center for Alcohol and Addiction Research, Department of Psychology, University of Texas, Austin, Texas
Matthew Macaluso, D.O., DFAPA
Bee McWane Reid Professor, Department of Psychiatry and Behavioral Neurobiology,
and Clinical Director, UAB Depression and Suicide Center, The University of Alabama
at Birmingham School of Medicine, Birmingham, Alabama
Dean F. MacKinnon, M.D.
Associate Professor, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
J. John Mann, M.D.
Paul Janssen Professor of Translational Neuroscience in Psychiatry and Radiology, Department of Psychiatry, Columbia University, New York, New York
John C. Markowitz, M.D.
Professor of Clinical Psychiatry, Columbia University; Research Psychiatrist, New
York State Psychiatric Institute, New York, New York
William V. McCall, M.D., M.S.
Professor and Case Distinguished University Chair, Department of Psychiatry and
Health Behavior, Medical College of Georgia, Augusta University, Augusta, Georgia
William McDonald, M.D.
J.B. Fuqua Chair and Professor of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia
Dora M. Meyer, M.Sc.
Research Scientist, Division of Interventional Biological Psychiatry, Department of
Psychiatry and Psychotherapy Medical Center, University of Freiburg Faculty of Medicine, University of Freiburg, Germany
David J. Miklowitz, Ph.D.
Distinguished Professor of Psychiatry and Biobehavioral Sciences, UCLA School of
Medicine, Los Angeles, California

xix Contributors
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Melissa P. H. Miller, M.Sc.
Doctoral Student, Department of Psychology & Interdisciplinary Life Sciences, The
University of Texas at Austin
Trevor Mooney, M.D.
Psychiatry Resident, Department of Psychiatry and Health Behavior, Medical College
of Georgia, Augusta University, Augusta, Georgia
Christine Yu Moutier, M.D.
Chief Medical Officer, American Foundation for Suicide Prevention, New York, New
Yo rk
Dominique Musselman, M.D., M.S.C.R.
Associate Professor, Department of Psychiatry and Behavioral Sciences, University of
Miami Leonard Miller School of Medicine, Miami, Florida
Alison Myoraku, M.S.
Clinical Research Coordinator Associate, Department of Psychiatry and Behavioral
Sciences, Stanford School of Medicine, Stanford, California
Henry A. Nasrallah, M.D.
Professor of Psychiatry, Neurology, and Neuroscience; Vice-Chair for Faculty Development and Mentorship; Director of Neuropsychiatry Program, University of Cincinnati College of Medicine, Cincinnati, Ohio
Charles B. Nemeroff, M.D., Ph.D.
Matthew P. Nemeroff Endowed Chair and Professor, Department of Psychiatry and
Behavioral Sciences, Mulva Clinic for the Neurosciences; Director, Institute of Early
Life Adversity Research, Dell Medical School, The University of Texas at Austin
Maria Antonietta Nettis, M.D., Ph.D.
Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College London; National Institute for Health and Research Biomedical
Research Centre at South London and Maudsley NHS Foundation Trust and King’s
College London, London, United Kingdom
D. Jeffrey Newport, M.D., M.S.
Professor and Associate Chair for Research, Department of Psychiatry, Dell Medical
School, The University of Texas at Austin, Texas
Andrew A. Nierenberg, M.D.
Thomas P. Hackett, MD, Endowed Chair in Psychiatry, Department of Psychiatry,
Massachusetts General Hospital, Boston, Massachusetts
Edward Nunes, M.D.
Professor of Psychiatry, Department of Psychiatry, Columbia University Irving Medical Center and New York State Psychiatric Institute, New York, New York
Lexi Nutkiewicz, B.A.
Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford, California
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