Добавил:
kiopkiopkiop18@yandex.ru t.me/Prokururor I Вовсе не секретарь, но почту проверяю Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз: Предмет: Файл:
Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5929_Библиотеки_им_академика_М_И_Перельмана.pdf
Скачиваний:
0
Добавлен:
15.09.2026
Размер:
13 Мб
Скачать
☆
Anticancer Eect of Aristolochia tagala and Curcuma caesia Acting Through Tumor Necrosis Factor-α
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008). Cancer-related inflammation. Nature, 454(7203), 436–444. doi:10.1038/nature07205 PMID:18650914
Marnett, L. J. (2000). Oxyradicals and DNA damage. Carcinogenesis, 21(3), 361–370. doi:10.1093/ carcin/21.3.361 PMID:10688856
Mataix, J., Quiles, J. L., Huertas, J. R., Battino, M., & Maña, M. (1998). Tissue specific interactions of exercise, dietary fatty acids, and vitamin E in lipid peroxidation. Free Radical Biology & Medicine, 24(4), 511–521. doi:10.1016/S0891-5849(97)00288-8 PMID:9580480
Matés, J. M., & Sánchez-Jiménez, F. M. (2002). Role of reactive oxygen species in apoptosis: Implica­tions for cancer therapy. The International Journal of Biochemistry & Cell Biology, 32(2), 157–170. doi:10.1016/S1357-2725(99)00088-6 PMID:10687951
Maurya, H., Gandhi, S., Kumar, P., Upadhyay, G., & Kumar, T. (2014). Nephroprotective potential of Curcuma caesia Roxb. in animal model. International Journal of Bioassays, 3(10), 3336–3341.
Mehta, R. (1995). The potential for the use of cell proliferation and oncogene expression as intermediate markers during liver carcinogenesis. Cancer Letters, 93(1), 85–102. doi:10.1016/0304-3835(95)03790-4 PMID:7600546
Michels, G., Watjen, W., Niering, P., Steffan, B., Thi, Q. H., Chovolou, Y., Kampkotter, A., Bast, A., Proksch, P., & Kahl, R. (2005). Pro-apoptotic effects of the flavonoid luteolin in rat H4IIE cells. Toxicol- ogy, 206(3), 337–348. doi:10.1016/j.tox.2004.07.022 PMID:15588924
Miller, J. A. (1970). Carcinogenesis by chemicals. Cancer Research, 30, 600. PMID:4915745
Mirvish, S. S. (1981) Ascorbic acid inhibition of N-nitroso compound formation in chemical, food, and biological systems. In Inhibition of tumor induction and development. Springer.
Monkkonen, T., & Debnath, J. (2018). Inflammatory signaling cascades and autophagy in cancer. Au- tophagy, 14(2), 190–198. doi:10.1080/15548627.2017.1345412 PMID:28813180
Mukunthan, K. S., Kumar, N. V. A., Balaji, S., & Trupti, N. P. (2014). Analysis of essential oil constitu­ents in rhizome of Curcuma caesia Roxb. from South India. Journal of Essential Oil-Bearing Plants, 17(4), 647–651. doi:10.1080/0972060X.2014.884781
Muller-Ladner, U. (1996). Molecular and cellular interactions in rheumatoid synovium. Current Opinion in Rheumatology, 8(3), 210–220. doi:10.1097/00002281-199605000-00008 PMID:8796980
Murugan, R., Shivanna, K. R., & Rao, R. R. (2006). Pollination biology of Aristolochia tagala, a rare species of medicinal importance. Current Science, 91, 795–798.
Nakae, D., Kobayashi, Y., Akai, H., Andoh, N., Satoh, H., Ohashi, K., Tsutsumi, M., & Konishi, Y. (1997). Involvement of 8-hydroxyguanine formation in the initiation of rat liver carcinogenesis by low dose levels of N-nitrosodiethylamine. Cancer Research, 57, 1281–1287. PMID:9102214
Naugler, W. E., Sakurai, T., Kim, S., Maeda, S., Kim, K., Elsharkawy, A. M., & Karin, M. (2007). Gen­der Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production. Science, 317(5834), 121–124. doi:10.1126cience.1140485 PMID:17615358
388
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use
Anticancer Eect of Aristolochia tagala and Curcuma caesia Acting Through Tumor Necrosis Factor-α
Newman, D. J., & Cragg, G. M. (2016). Natural products as sources of new drugs from 1981 to 2014. Journal of Natural Products, 79(3), 629–661. doi:10.1021/acs.jnatprod.5b01055 PMID:26852623
Nordmann, R., Ribiere, C., & Rouach, H. (1992). Implication of free radical mechanisms in ethanol­induced cellular injury. Free Radicals In Biology and Medicine, 12(3), 219–240. doi:10.1016/0891­5849(92)90030-K PMID:1563648
Odyuo, M. M., & Sharan, R. N. (2005). Differential DNA strand breaking abilities of ·OH and ROS generating radiomimetic chemicals and γ-rays: Study of plasmid DNA, pMTa4, invitro. Free Radical Research, 39(5), 499–505. doi:10.1080/10715760500072305 PMID:16036325
Ohshima, H., Tazawa, H., Sylla, B. S., & Sawa, T. (2005). Prevention of human cancer by modula­tion of chronic inflammatory processes. Mutation Research, 591(1-2), 110–122. doi:10.1016/j.mrfm­mm.2005.03.030 PMID:16083916
Ong, C. S., Tran, E., Nguyen, T. T., Ong, C. K., Lee, S. K., Lee, J. J., Ng, C. P., Leong, C., & Huynh, H. (2004). Quercetin-induced growth inhibition and cell death in nasopharyngeal carcinoma cells are associated with increase in Bad and hypophosphorylated retinoblastoma expressions. Oncology Reports, 11, 727–733. doi:10.3892/or.11.3.727 PMID:14767529
Papa, S., Bubici, C., Zazzeroni, F., & Franzoso, G. (2009). Mechanisms of liver disease: The cross­talk between the NF-κB and JNK pathways. Biological Chemistry, 390(10), 965–976. doi:10.1515/ BC.2009.111 PMID:19642868
Pfoze, N. L., Kumar, Y., & Myrboh, B. (2012). Survey and assessment of ethnomedicinal plants used in Senapati district of Manipur state, Northeast India. Phytopharmacology, 2, 285–311.
Pikarsky, E., Porat, R. M., Stein, I., Abramovitch, R., Amit, S., Kasem, S., Gutkovich-Pyest, E., Urieli­Shoval, S., Galun, E., & Ben-Neriah, Y. (2004). NF-κB functions as a tumour promoter in inflammation­associated cancer. Nature, 431(7007), 461–466. doi:10.1038/nature02924 PMID:15329734
Pitot, H. C. (1991). Endogenous carcinogenesis: The role of tumor promotion. Proceedings of the Society for Experimental Biology and Medicine, 198(2), 661–666. doi:10.3181/00379727-198-43304 PMID:1924401
Pitot, H. C., & Dragan, Y. P. (1991). Facts and theories concerning carcinogenesis. The FASEB Journal, 5(9), 2280–2286. doi:10.1096/fasebj.5.9.1860619 PMID:1860619
Plaa, G. L., & Hewitt, W. R. (1989). Detection and evaluation of chemically induced liver injury. In H. A. Wallace (Ed.), Principles and Methods of Toxicology (pp. 399–628). Raven Press.
Porrini, M., Riso, P., Brusamolino, A., Berti, C., Guarnieri, S., & Visioli, F. (2005). Daily intake of a formulated tomato drink affects carotenoid plasma and lymphocyte concentrations and improves cel­lular antioxidant protection. British Journal of Nutrition, 93(1), 93–99. doi:10.1079/BJN20041315 PMID:15705230
Prete, A. D., Allavena, P., Santoro, G., Fumarulo, R., Corsi, M. M., & Mantovani, A. (2011). Molecular pathways in cancer-related inñammation. Biochemia Medica, 21(3), 264–275. doi:10.11613/BM.2011.036 PMID:22420240
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use
389
Anticancer Eect of Aristolochia tagala and Curcuma caesia Acting Through Tumor Necrosis Factor-α
Rathmell, J. C., & Thompson, C. B. (1999). The central effectors of cell death in the immune system. Annual Review of Immunology, 17(1), 781–828. doi:10.1146/annurev.immunol.17.1.781 PMID:10358774
Recknagel, R. O., Glendek, E. A. Jr, Dolakk, J. A., & Waller, R. L. (1989). Mechanisms of carbon tetra­chloride toxicity. Pharmacology & Therapeutics, 43(1), 139–154. doi:10.1016/0163-7258(89)90050-8 PMID:2675128
Reenu, J., Azeez, S., & Bhageerathy, C. (2015). In vitro antioxidant potential in sequential extracts of Cur- cumacaesia Roxb. rhizomes. Indian Journal of Pharmaceutical Sciences, 77(1), 41–48. doi:10.4103/0250- 474X.151596 PMID:25767317
Remya, M., Bai, V. N., Murugesan, S., & Mutharaian, V. N. (2016). Changes in bioactive components of Aristolochiatagala Cham, a rare species of medicinal importance during its in vitro development through direct regeneration. bioRxiv, 1–25.
Rice-Evans, C. A., Miller, N. J., Bolwell, P. G., Bramley, P. M., & Pridham, J. B. (1995). The relative antioxidant activities of plant-derived polyphenolic flavonoids. Free Radical Research, 22(4), 375–383. doi:10.3109/10715769509145649 PMID:7633567
Risberg, B., Andreasson, S., & Eriksson, E. (1991). Disseminated intravascular coagulation. Acta An- aesthesiologica Scandinavica. Supplementum, 95, 60–71. doi:10.1111/j.1399-6576.1991.tb03401.x PMID:1927229
Rothe, M., Sarma, V., Dixit, V. M., & Goeddel, D. V. (1995). TRAF2-mediated activation of NF-κB by TNF receptor 2 and CD40. Science, 269(5229), 1424–1427. doi:10.1126cience.7544915 PMID:7544915
Rothe, M., Wong, S. C., Henzel, W. J., & Goeddel, D. V. (1994). A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumour necrosis factor receptor. Cell, 78(4), 681–692. doi:10.1016/0092-8674(94)90532-0 PMID:8069916
Sakurai, T., He, G., Matsuzawa, A., Yu, G., Maeda, S., Hardiman, G., & Karin, M. (2008). Hepatocyte necroses induced by oxidative stress and IL-1a release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell, 14(2), 156–165. doi:10.1016/j.ccr.2008.06.016 PMID:18691550
Saybaşili, H., Yüksel, M., Haklar, G., & Yalçin, A. S. (2001). Effect of mitochondrial electron transport chain inhibitors on superoxide radical generation in rat hippocampal and striatal slices. Antioxidants & Redox Signaling, 3(6), 1099–1104. doi:10.1089/152308601317203602 PMID:11813983
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002). Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature, 418(6894), 191–195. doi:10.1038/nature00858 PMID:12110890
Schieber, M., & Chandel, N. S. (2014). ROS function in redox signaling and oxidative stress. Current Biology, 24(10), R453–R462. doi:10.1016/j.cub.2014.03.034 PMID:24845678
Schrader, M., & Fahimi, H. D. (2006). Peroxisomes and oxidative stress. Biochimica et Biophysica Acta. Bioenergetics, 1763(12), 1755–1766. doi:10.1016/j.bbamcr.2006.09.006 PMID:17034877
390
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use
Anticancer Eect of Aristolochia tagala and Curcuma caesia Acting Through Tumor Necrosis Factor-α
Scott, O., & Roifman, C. M. (2019). NF-kB pathway and the Goldilocks principle: Lessons from human disorders of immunity and inflammation. The Journal of Allergy and Clinical Immunology, 143(5), 1688–1701. doi:10.1016/j.jaci.2019.03.016 PMID:30940520
Selvendiran, K., Koga, H., Ueno, T., Yoshida, T., Maeyama, M., Torimura, T., Yano, H., Kojiro, M., & Sata, M. (2006). Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: An implication for the antitumour potential of flavonoids. Cancer Research, 66(9), 4826–4834. doi:10.1158/0008-5472.CAN-05-4062 PMID:16651438
Sen, R., & Baltimore, D. (1986). Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell, 46(5), 705–716. doi:10.1016/0092-8674(86)90346-6 PMID:3091258
Seol, G., Kang, P., Lee, H. S., & Seol, G. H. (2016). Antioxidant activity of linalool in patients with carpal tunnel syndrome. BMC Neurology, 16(1), 17. doi:10.118612883-016-0541-3 PMID:26831333
Sethi, G., Sung, B., & Aggarwal, B. B. (2008). TNF: A master switch for inflammation to cancer. Fron- tiers in Bioscience, 13(13), 5094–5107. doi:10.2741/3066 PMID:18508572
Shaikh, A. M., Shrivastava, B., Apte, K. G., Parab, P. B., Sharma, P., Navale, S. D., & Paygude, S. V. (2016). In-vitro screening of some medicinal plants on breast, ovary and colon cancer cell lines. Inter- national Journal of Pharmacy and Biological Sciences, 7(2), 11–17.
Sharan, R. N., Odyuo, M. M., & Purkayastha, S. (2011). Oxygen free radicals and its biomedical impli­cations: A mini review, Solicited contribution. Organic Chemistry, 8, 372–376.
Sharan, R. N., & Wary, K. K. (1992). Study of unschedule DNA synthesis following exposure of human cells to arecoline and extracts of betel nut in vitro. Mutation Research, 278(4), 271–276. doi:10.1016/ S0165-1218(10)80007-2 PMID:1373864
Shibutani, S., Takeshita, M., & Grollman, A. P. (1991). Insertion of specific bases during DNA syn­thesis past the oxidation-damaged base 8-oxodG. Nature, 349(6308), 431–434. doi:10.1038/349431a0 PMID:1992344
Shimizu, M., Deguchi, A., Lim, J. T., Moriwaki, H., Kopelovich, L., & Weinstein, I. B. (2005). (-)-Epi­gallocatechin gallate and polyphenon E inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells. Clinical Cancer Research, 11(7), 2735–2746. doi:10.1158/1078-0432.CCR-04-2014 PMID:15814656
Singh, A. K. (2010). Probable agricultural biodiversity heritage sites in India: V. The Garo, Khasi, and Jaintia Hills Region. Asian Agri-History, 14, 133–156.
Soreq, H. (1993). Coamplification of human acetylcholinesterase and butyrylcholinesterase genes in blood cells: Correlation with various leukemias and abnormal megakaryocytopoiesis. Proceedings of the National Academy of Sciences of the United States of America, 86, 4715–4719. PMID:2734315
St-Pierre, J., Buckingham, J. A., Roebuck, S. J., & Brand, M. D. (2002). Topology of superoxide pro­duction from different sites in the mitochondrial electron transport chain. The Journal of Biological Chemistry, 277(47), 44784–44790. doi:10.1074/jbc.M207217200 PMID:12237311
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use
391
Anticancer Eect of Aristolochia tagala and Curcuma caesia Acting Through Tumor Necrosis Factor-α
Strieter, R. M., Kunkel, S. L., & Bone, R. C. (1993). Role of tumour necrosis factor-alpha in disease states and inflammation. Critical Care Medicine, 21(Supplement), S447–S463. doi:10.1097/00003246- 199310001-00006 PMID:8403983
Strzelczyk, J. K., & Wiczkowski, A. (2012). Oxidative damage and carcinogenesis. Contemporary On- cology (Poznan, Poland), 16(3), 230–233. doi:10.5114/wo.2012.29290 PMID:23788885
Sueoka, E., Sueoka, N., Okabe, S., Kozu, T., Komori, A., Ohta, T., Suganuma, M., Kim, S. J., Lim, I. K., & Fujiki, H. (1997). Expression of the tumor necrosis factor-alpha gene and early response genes by nodularin, a liver tumor promoter, in primary cultured rat hepatocytes. Journal of Cancer Research and Clinical Oncology, 123(8), 413–419. PMID:9292703
Suganuma, M., Okabe, S., Kurusu, M., Iida, N., Ohshima, S., Saeki, Y., Kishimoto, T., & Fujiki, H. (2002). Discrete roles of cytokines, TNF α, IL-1, IL-6 in tumor promotion and cell transformation. In- ternational Journal of Oncology, 20(1), 131–136. doi:10.3892/ijo.20.1.131 PMID:11743653
Tandon, P., Kumaria, S., & Nongrum, L. (2009). Conservation and management of plant genetic resources of Northeast India. Indian Journal of Traditional Knowledge, 8(1), 29–34.
Tang, G., Minemoto, Y., Dibling, B., Purcell, N. H., Li, Z., Karin, M., & Lin, A. (2001). Inhibition of JNK activation through NF-κB target genes. Nature, 414(6861), 313–317. doi:10.1038/35104568 PMID:11713531
Tarao, K., Rino, Y., Ohkawa, S., Shimizu, A., Tamai, S., Miyakawa, K., Aoki, H., Imada, T., Shindo, K., Okamato, N., & Totsuka, S. (1999). Association between high serum alanine aminotransferase levels and more rapid development and high rate incidence of hepatocellular carcinoma in patients with hepatitis C virus associated cirrhosis. Cancer, 86(4), 589–595. doi:10.1002/(SICI)1097-0142(19990815)86:4<589::AID- CNCR7>3.0.CO;2-K PMID:10440686
Tolba, R., Kraus, T., Liedtke, C., Schwarz, M., & Weiskirchen, R. (2015). Diethylnitrosamine (DEN)-induced carcinogenic liver injury in mice. Laboratory Animals, 49(1_suppl, S1), 59–69. doi:10.1177/0023677215570086 PMID:25835739
Trachootham, D., Alexandre, J., & Huang, P. (2009). Targeting cancer cells by ROS- mediated mecha­nisms: A radical therapeutic approach? Nature Reviews. Drug Discovery, 8(7), 579–591. doi:10.1038/ nrd2803 PMID:19478820
Tushar, B., Basak, S., Sarma, G. C., & Rangan, L. (2010). Ethnomedical uses of Zingiberaceous plants of Northeast India. Journal of Ethnopharmacology, 132(1), 286–296. doi:10.1016/j.jep.2010.08.032 PMID:20727402
Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006). Free radicals, metals and anti­oxidants in oxidative stress-induced cancer. Chemico-Biological Interactions, 160(1), 1–40. doi:10.1016/j. cbi.2005.12.009 PMID:16430879
Van Leeuwen, I. M., & Zonneveld, C. (2001). From exposure to effect: A comparison of modeling approaches to chemical carcinogenesis. Mutation Research, 489(1), 17–45. doi:10.1016/S1383­5742(01)00062-X PMID:11673088
392
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use
Anticancer Eect of Aristolochia tagala and Curcuma caesia Acting Through Tumor Necrosis Factor-α
Verna, L., Whysner, J., & Williams, G. M. (1996). N-nitrosodiethylamine mechanistic data and risk assessment: Bioactivation, DNA adduct formation, mutagenicity, and tumour initiation. Pharmacology & Therapeutics, 71(1-2), 57–81. doi:10.1016/0163-7258(96)00062-9 PMID:8910949
Wajant, H., Pfizenmaier, K., & Scheurich, P. (2003). Tumour necrosis factor signalling. Cell Death and Differentiation, 10(1), 45–65. doi:10.1038j.cdd.4401189 PMID:12655295
Wang, J., Zhao, J., Liu, H., Zhou, L., Liu, Z., Wang, J., Han, J., Yu, Z., & Yang, F. (2010). Chemical analysis and biological activity of the essential oils of two valerianaceous species from China: Nardostachys chinensis and Valeriana officinalis. Molecules (Basel, Switzerland), 15(9), 6411–6422. doi:10.3390/ molecules15096411 PMID:20877232
Wary, K. K., & Sharan, R. N. (1988). Aqeous extract of betel-nut of North-East-India induces DNA strand breaks and enhances rate of cell proliferation in vitro. Journal of Cancer Research and Clinical Oncology, 114(6), 579–582. doi:10.1007/BF00398180 PMID:3204104
Wassermann, A. M., Lounkine, E., Hoepfner, D., Goff, G. L., King, F. J., Studer, C., Peltier, J. M., Grippo, M. L., Prindle, V., Tao, J., Schuffenhauer, A., Wallace, I. M., Chen, S., Krastel, P., Cobos-Cor­rea, A., Parker, C. N., Davies, J. W., & Glick, M. (2015). Dark chemical matter as a promising starting point for drug lead discovery. Nature Chemical Biology, 11(12), 958–966. doi:10.1038/nchembio.1936 PMID:26479441
Wenzel, U., Kuntz, S., Brendel, M. D., & Daniel, H. (2000). Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells. Cancer Research, 60, 3823–3831. PMID:10919656
Westwick, J. K., Weitzel, C., Minden, A., Karin, M., & Brenner, D. A. (1994). Tumour necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. The Journal of Biologi- cal Chemistry, 269(42), 26396–26401. doi:10.1016/S0021-9258(18)47207-9 PMID:7929360
Winterbourn, C. C. (1995). Toxicity of iron and hydrogen peroxide: The Fenton reaction. Toxicology Letters, 82, 969–974. doi:10.1016/0378-4274(95)03532-X PMID:8597169
Wu, S., Zhu, W., Thompson, P., & Hannun, Y. A. (2018). Evaluating intrinsic and non-intrinsic cancer risk factors. Nature Communications, 9(1), 3490. doi:10.103841467-018-05467-z PMID:30154431
Wu, W. S. (2006). The signaling mechanism of ROS in tumor progression. Cancer and Metastasis Re- views, 25(4), 695–705. doi:10.100710555-006-9037-8 PMID:17160708
Yamada, K., Yamamiya, I., & Utsumi, H. (2006). In vivo detection of free radicals induced by dieth­ylnitrosamine in rat liver tissue. Free Radical Biology & Medicine, 40(11), 2040–2046. doi:10.1016/j. freeradbiomed.2006.01.031 PMID:16716904
Yang, C. S., Yoo, J. S., Ishizaki, H., & Hong, J. Y. (1990). Cytochrome P450IIE1: Roles in nitro­samine metabolism and mechanisms of regulation. Drug Metabolism Reviews, 22(2-3), 147–159. doi:10.3109/03602539009041082 PMID:2272285
Yao, L. H., Jiang, Y. M., Shi, J., Tomas-Barberan, F. A., Datta, N., Singanusong, R., & Chen, S. S. (2004). Flavonoids in food and their health benefits. Plant Foods for Human Nutrition (Dordrecht, Netherlands), 59, 113–122. doi:10.100711130-004-0049-7 PMID:15678717
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use
393
Anticancer Eect of Aristolochia tagala and Curcuma caesia Acting Through Tumor Necrosis Factor-α
Yoshida, Y., & Niki, E. (2003). Antioxidant effects of Phytosterol and its components. Journal of Nutri­tional Science and Vitaminology, 49(4), 277–280. doi:10.3177/jnsv.49.277 PMID:14598915
Zakut, H., Ehrlich, G., Ayalon, A., Prody, C. A., Malinger, G., Seidman, S., Ginzberg, D., Kehlenbach, R., & Soreq, H. (1990). Acetylcholinesterase and butyrylcholinesterase genes coamplify in primary ovarian carcinomas. The Journal of Clinical Investigation, 86(3), 900–908. doi:10.1172/JCI114791 PMID:2394839
Zhang, J., Wang, X., Vikash, V., Ye, Q., Wu, D., Liu, Y., & Dong, W. (2016). ROS and ROS-mediated cellular signaling. Oxidative Medicine and Cellular Longevity. doi:10.1155/2016/4350965
Zhang, Q., Zhu, B., & Li, Y. (2017). Resolution of cancer-promoting inñammation: A new approach for anticancer therapy. Frontiers in Immunology, 8, 71. doi:10.3389/fimmu.2017.00071 PMID:28210259
394
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use
Chapter 20
Essential Oils and Their
Biological Applications:
Extraction methods, Types, Biological
Activities, Antimicrobial Fumes
Minky Mukhija
Ch. Devi Lal College of Pharmacy, India
395
Ankush Sundriyal
Sardar Bhagwan Singh University, India
Aanchal Loshali
Sardar Bhagwan Singh University, India
ABSTRACT
Essential oils are terpinoids and their oxygenated derivatives, which are widely used for antimicrobial, fungicidal, antiparasitical, insecticidal uses. They are aromatic, hydrophobic, and volatile in nature and frequently used in medicinal and cosmetic industries. Especially nowadays, volatile oils have a signifi­cant role in pharmaceutical, sanitary, cosmetic, agricultural, and food industries. Various conventional and modern methods of extraction of volatile oil are available. Volatile oil can play an important role in minimization of microbial load at primary stage and/or to prevent the growth of the microorgan­isms during various stages of product management. However, there is still the need more emphasis on research regarding EO.
INTRODUCTION
Medicinal aromatic plant is a general term which is commonly used to refer spices, condiments, perfumes and flavoring agents. These aromatic plants consist of essential oil (EO) or volatile oils due to which they produce specific flavors or odors and used as spices or perfumery agents. Essential oils (EOs) are natural, highly volatile, aromatic, hydrophobic liquid and compounded mixtures of low-molecular-weight usually obtained in plants and used in ancient time for medicinal and health motive (Mahato et al., 2019). EOs formed as secondary metabolites in aromatic plants as in reaction to attacks by herbivores, insects, microorganism, and other entities (Raut & Karuppayil, 2014). Due to their volatile nature they can be easily extract out by the steam distillation method from different natural sources (Mahato et al., 2019)
DOI: 10.4018/978-1-6684-5129-8.ch020
Copyright © 2022, IGI Global. Copying or distributing in print or electronic forms without written permission of IGI Global is prohibited.
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use
Essential Oils and Their Biological Applications
and their antidepressant, detoxifying, stimulating, antimicrobial, and calming effects, EO gain huge ad­miration as a natural, secure an efficient therapy for health problems (Tongnuanchan & Benjakul, 2014). EOs are complex, comprises of various chemicals, mostly present in liquid state but very few in solid form also. At normal temperature, these volatile oils may appear colorless to light yellowish in color and are readily absorbed through the skin. EO usually have lower density then water but few volatile oils like cinnamon oil, clove oil, etc. possesses high density than water. They are miscible in vegetable oils, fats, wax, and water and also soluble in diethyl ether, acetone, ethyl acetate, ethanol (Solórzano­Santos & Miranda-Novales, 2012). EOs of same plant may differ completely in aroma and properties from part to part e.g. Geranium plant yields oil from flowers and the leaves, and both oils from different parts differ in constituents, aroma and other properties (Veras et al., 2012; Rivera Calo et al., 2015). In plants, generally volatile oil stored in glands, oil ducts, resin ducts, or glandular trichomes of the plants. The quality of EOs usually affected by various interlinked factors, such as climatic conditions, seasonal and geographical conditions, harvesting time and method of extraction (Pannizi et al., 1993). The oils yield from the various parts of plants could be pretentious at the various stages of the plant growth. EOs is generally used as flavoring ingredient such as in edible products, drinks, perfume industries, pharmaceuticals, and cosmetics manufacturing.
Various compositions of EO make it potential to use them as potent antimicrobial agent with a low risk of microbial resistance occurrence (Bakkali et al., 2008).
NATURAL SOURCES OF ESSENTIAL OILS
Around 3000 EOs is known till date, of which only 300 EOs are commercially valuable. Most of the EOs is used in pharmaceuticals, sanitary, food, cosmetic, and perfume industries (Bakkali et al., 2008). Plants producing EOs belongs to around 60 families which includes, Lamiaceae Alliaceae, Apiaceae, Myrtaceae, Asteraceae, Poaceae, and Rutaceae (Carson et al., 2006). They may be originate in individual portions of the plant such as leaves (mint), flower (rose), peel (orange), seed (Basil) berries (juniper), rhizome (ginger, turmeric) bulb (garlic), root (jatamansi), bark (cinnamon), wood (sandal wood), resin (frankincense), petals (marigold), etc. (Pannizi et al., 1993)
COMPONENTS OF ESSENTIAL OILS
EO is the mixture of various phytochemicals and obtained from the primary metabolites in the form of secondary metabolites. EO is present in high concentration (approximately 20-70%) (Croteau et al., 2000; Betts, 2001). Numerous compounds which belong from the family of terpenes have been recognized in EOs. Majority of EO components alone show the biological properties (Veras et al., 2012) but occasion- ally a combination of molecules changes biological activity (Carson et al., 2006; Bakkali et al., 2008). The EO constituents of any specific plant depends on the plant part used, whether it be flowers, leaves, stems, bark, wood, whole fruits, pericarp, seed, or roots (Rivera Calo et al., 2015).
Terpenoids and Phenylpropanoids originates by diverse precursors of the primary metabolism and are synthesized by dispersed metabolic pathways and they are further classified into different groups, such as functionalized derivatives of alcohols (geraniol, α-bisabolol), ketones (menthone, p-vetivone), aldehydes (citronellal, sinensal), esters (γ-tepinyl acetate, cedryl acetate), and phenols (thymol) (Başer
396
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use
Essential Oils and Their Biological Applications
et al, 2007; Tabanca, 2007). EOs also contains non-terpenic composites biogenerated via the Phenyl­propanoids pathway, such as eugenol, cinnamaldehyde, and safrole (Modzelewska, 2005).
TYPES OF ESSENTIAL OILS
Essential oils are classified into two chemical groups (1) Terpenoids and (2) Phenylpropanoids
Terpenoids
Terpenoids are naturally occurring hydrocarbons and basically consist of five carbon isoprene units. Terpenoids are the terpenes obtained from the several kinds of plants and flowers in the form of primary constituents of the EOs (Thimmappa, 2014). Within terpenoids; monoterpenoid and sesquiterpenoid families are main because majority of most important components of EOs found in the plants (Ludwic­zuk, 2017). Terpenoids are divided into hemeterpenes (C diterpenes (C terpenes (C
), triterpenes (C30) and tetraterpenes (C40) depending on its carbon units although mono-
20
) and sesquiterpenes (C15) are the major terpenoids (Bakkali et al., 2008).
10
Various Examples of EOs are turpentine, α and β-pinene isolated from Pinus species, geraniol isolated from Rosa damascena, terpinen-4-ol from Melaleuca alternifolia (tea tree oil), linalool from Coriandrum sativum, zingiberol from Zingiber officinale and cineol from Eucalyptus globulus, etc. (Bakkali et al, 2008; Sell, 2010; Chamorro et al., 2012).
), monoterpenes (C10), sesquiterpenes (C15),
5
Hemiterpenes
Hemiterpene are the type of terpene having C5 atom and formed from a single isoprene unit. Molecular formula is C
. Eucalyptol, citronellol, limonene, humulene and Forskolin are the example of hemiter-
5H8
pene. These type of compounds used as a flavors, fragrances, food additives and pharmaceuticals and possess various biological properties (Semih & Vasfiye, 2021).
Monoterpenes
Biosynthetically monoterpenes are synthesized from units of isopentenyl pyrophosphate, which is made from acetyl-CoA via the intermediacy of mevalonic acid in HMG-CoA reductase pathway. The molecular formula of monoterpenes is C units. Monoterpenoids are characterized by oxygen-containing functional groups. Structural isomers­acyclic (myrcene and ocimene are the type of acyclic monoterpene), monocyclic (α terpineol, limonene, thymol, menthol, carvone, eucalyptol, and perillaldehyde are the type of monocyclic monoterpene), and bicyclic monoterpenes (Carene, sabinene, camphene, and thujene are the type of bicyclic monoterpenes) (Ajikumar et al., 2008). Geraniol, terpineol, limonene, myrcene, linalool or pinene is the examples of monoterpenes (Breitmaier, 2006).
and comes under the class of terpenes and consists of two isoprene
10H16
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use
397