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Anticancer Eect of Aristolochia tagala and Curcuma caesia Acting Through Tumor Necrosis Factor-α
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008). Cancer-related inflammation. Nature,
454(7203), 436–444. doi:10.1038/nature07205 PMID:18650914
Marnett, L. J. (2000). Oxyradicals and DNA damage. Carcinogenesis, 21(3), 361–370. doi:10.1093/
carcin/21.3.361 PMID:10688856
Mataix, J., Quiles, J. L., Huertas, J. R., Battino, M., & Maña, M. (1998). Tissue specific interactions
of exercise, dietary fatty acids, and vitamin E in lipid peroxidation. Free Radical Biology & Medicine,
24(4), 511–521. doi:10.1016/S0891-5849(97)00288-8 PMID:9580480
Matés, J. M., & Sánchez-Jiménez, F. M. (2002). Role of reactive oxygen species in apoptosis: Implications for cancer therapy. The International Journal of Biochemistry & Cell Biology, 32(2), 157–170.
doi:10.1016/S1357-2725(99)00088-6 PMID:10687951
Maurya, H., Gandhi, S., Kumar, P., Upadhyay, G., & Kumar, T. (2014). Nephroprotective potential of
Curcuma caesia Roxb. in animal model. International Journal of Bioassays, 3(10), 3336–3341.
Mehta, R. (1995). The potential for the use of cell proliferation and oncogene expression as intermediate
markers during liver carcinogenesis. Cancer Letters, 93(1), 85–102. doi:10.1016/0304-3835(95)03790-4
PMID:7600546
Michels, G., Watjen, W., Niering, P., Steffan, B., Thi, Q. H., Chovolou, Y., Kampkotter, A., Bast, A.,
Proksch, P., & Kahl, R. (2005). Pro-apoptotic effects of the flavonoid luteolin in rat H4IIE cells. Toxicol-
ogy, 206(3), 337–348. doi:10.1016/j.tox.2004.07.022 PMID:15588924
Miller, J. A. (1970). Carcinogenesis by chemicals. Cancer Research, 30, 600. PMID:4915745
Mirvish, S. S. (1981) Ascorbic acid inhibition of N-nitroso compound formation in chemical, food, and
biological systems. In Inhibition of tumor induction and development. Springer.
Monkkonen, T., & Debnath, J. (2018). Inflammatory signaling cascades and autophagy in cancer. Au-
tophagy, 14(2), 190–198. doi:10.1080/15548627.2017.1345412 PMID:28813180
Mukunthan, K. S., Kumar, N. V. A., Balaji, S., & Trupti, N. P. (2014). Analysis of essential oil constituents in rhizome of Curcuma caesia Roxb. from South India. Journal of Essential Oil-Bearing Plants,
17(4), 647–651. doi:10.1080/0972060X.2014.884781
Muller-Ladner, U. (1996). Molecular and cellular interactions in rheumatoid synovium. Current Opinion
in Rheumatology, 8(3), 210–220. doi:10.1097/00002281-199605000-00008 PMID:8796980
Murugan, R., Shivanna, K. R., & Rao, R. R. (2006). Pollination biology of Aristolochia tagala, a rare
species of medicinal importance. Current Science, 91, 795–798.
Nakae, D., Kobayashi, Y., Akai, H., Andoh, N., Satoh, H., Ohashi, K., Tsutsumi, M., & Konishi, Y.
(1997). Involvement of 8-hydroxyguanine formation in the initiation of rat liver carcinogenesis by low
dose levels of N-nitrosodiethylamine. Cancer Research, 57, 1281–1287. PMID:9102214
Naugler, W. E., Sakurai, T., Kim, S., Maeda, S., Kim, K., Elsharkawy, A. M., & Karin, M. (2007). Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production. Science,
317(5834), 121–124. doi:10.1126cience.1140485 PMID:17615358
388
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use

Anticancer Eect of Aristolochia tagala and Curcuma caesia Acting Through Tumor Necrosis Factor-α
Newman, D. J., & Cragg, G. M. (2016). Natural products as sources of new drugs from 1981 to 2014.
Journal of Natural Products, 79(3), 629–661. doi:10.1021/acs.jnatprod.5b01055 PMID:26852623
Nordmann, R., Ribiere, C., & Rouach, H. (1992). Implication of free radical mechanisms in ethanolinduced cellular injury. Free Radicals In Biology and Medicine, 12(3), 219–240. doi:10.1016/08915849(92)90030-K PMID:1563648
Odyuo, M. M., & Sharan, R. N. (2005). Differential DNA strand breaking abilities of ·OH and ROS
generating radiomimetic chemicals and γ-rays: Study of plasmid DNA, pMTa4, invitro. Free Radical
Research, 39(5), 499–505. doi:10.1080/10715760500072305 PMID:16036325
Ohshima, H., Tazawa, H., Sylla, B. S., & Sawa, T. (2005). Prevention of human cancer by modulation of chronic inflammatory processes. Mutation Research, 591(1-2), 110–122. doi:10.1016/j.mrfmmm.2005.03.030 PMID:16083916
Ong, C. S., Tran, E., Nguyen, T. T., Ong, C. K., Lee, S. K., Lee, J. J., Ng, C. P., Leong, C., & Huynh,
H. (2004). Quercetin-induced growth inhibition and cell death in nasopharyngeal carcinoma cells are
associated with increase in Bad and hypophosphorylated retinoblastoma expressions. Oncology Reports,
11, 727–733. doi:10.3892/or.11.3.727 PMID:14767529
Papa, S., Bubici, C., Zazzeroni, F., & Franzoso, G. (2009). Mechanisms of liver disease: The crosstalk between the NF-κB and JNK pathways. Biological Chemistry, 390(10), 965–976. doi:10.1515/
BC.2009.111 PMID:19642868
Pfoze, N. L., Kumar, Y., & Myrboh, B. (2012). Survey and assessment of ethnomedicinal plants used in
Senapati district of Manipur state, Northeast India. Phytopharmacology, 2, 285–311.
Pikarsky, E., Porat, R. M., Stein, I., Abramovitch, R., Amit, S., Kasem, S., Gutkovich-Pyest, E., UrieliShoval, S., Galun, E., & Ben-Neriah, Y. (2004). NF-κB functions as a tumour promoter in inflammationassociated cancer. Nature, 431(7007), 461–466. doi:10.1038/nature02924 PMID:15329734
Pitot, H. C. (1991). Endogenous carcinogenesis: The role of tumor promotion. Proceedings of the
Society for Experimental Biology and Medicine, 198(2), 661–666. doi:10.3181/00379727-198-43304
PMID:1924401
Pitot, H. C., & Dragan, Y. P. (1991). Facts and theories concerning carcinogenesis. The FASEB Journal,
5(9), 2280–2286. doi:10.1096/fasebj.5.9.1860619 PMID:1860619
Plaa, G. L., & Hewitt, W. R. (1989). Detection and evaluation of chemically induced liver injury. In H.
A. Wallace (Ed.), Principles and Methods of Toxicology (pp. 399–628). Raven Press.
Porrini, M., Riso, P., Brusamolino, A., Berti, C., Guarnieri, S., & Visioli, F. (2005). Daily intake of a
formulated tomato drink affects carotenoid plasma and lymphocyte concentrations and improves cellular antioxidant protection. British Journal of Nutrition, 93(1), 93–99. doi:10.1079/BJN20041315
PMID:15705230
Prete, A. D., Allavena, P., Santoro, G., Fumarulo, R., Corsi, M. M., & Mantovani, A. (2011). Molecular
pathways in cancer-related inñammation. Biochemia Medica, 21(3), 264–275. doi:10.11613/BM.2011.036
PMID:22420240
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use
389

Anticancer Eect of Aristolochia tagala and Curcuma caesia Acting Through Tumor Necrosis Factor-α
Rathmell, J. C., & Thompson, C. B. (1999). The central effectors of cell death in the immune system.
Annual Review of Immunology, 17(1), 781–828. doi:10.1146/annurev.immunol.17.1.781 PMID:10358774
Recknagel, R. O., Glendek, E. A. Jr, Dolakk, J. A., & Waller, R. L. (1989). Mechanisms of carbon tetrachloride toxicity. Pharmacology & Therapeutics, 43(1), 139–154. doi:10.1016/0163-7258(89)90050-8
PMID:2675128
Reenu, J., Azeez, S., & Bhageerathy, C. (2015). In vitro antioxidant potential in sequential extracts of Cur-
cumacaesia Roxb. rhizomes. Indian Journal of Pharmaceutical Sciences, 77(1), 41–48. doi:10.4103/0250-
474X.151596 PMID:25767317
Remya, M., Bai, V. N., Murugesan, S., & Mutharaian, V. N. (2016). Changes in bioactive components
of Aristolochiatagala Cham, a rare species of medicinal importance during its in vitro development
through direct regeneration. bioRxiv, 1–25.
Rice-Evans, C. A., Miller, N. J., Bolwell, P. G., Bramley, P. M., & Pridham, J. B. (1995). The relative
antioxidant activities of plant-derived polyphenolic flavonoids. Free Radical Research, 22(4), 375–383.
doi:10.3109/10715769509145649 PMID:7633567
Risberg, B., Andreasson, S., & Eriksson, E. (1991). Disseminated intravascular coagulation. Acta An-
aesthesiologica Scandinavica. Supplementum, 95, 60–71. doi:10.1111/j.1399-6576.1991.tb03401.x
PMID:1927229
Rothe, M., Sarma, V., Dixit, V. M., & Goeddel, D. V. (1995). TRAF2-mediated activation of NF-κB by
TNF receptor 2 and CD40. Science, 269(5229), 1424–1427. doi:10.1126cience.7544915 PMID:7544915
Rothe, M., Wong, S. C., Henzel, W. J., & Goeddel, D. V. (1994). A novel family of putative signal
transducers associated with the cytoplasmic domain of the 75 kDa tumour necrosis factor receptor. Cell,
78(4), 681–692. doi:10.1016/0092-8674(94)90532-0 PMID:8069916
Sakurai, T., He, G., Matsuzawa, A., Yu, G., Maeda, S., Hardiman, G., & Karin, M. (2008). Hepatocyte
necroses induced by oxidative stress and IL-1a release mediate carcinogen-induced compensatory
proliferation and liver tumorigenesis. Cancer Cell, 14(2), 156–165. doi:10.1016/j.ccr.2008.06.016
PMID:18691550
Saybaşili, H., Yüksel, M., Haklar, G., & Yalçin, A. S. (2001). Effect of mitochondrial electron transport
chain inhibitors on superoxide radical generation in rat hippocampal and striatal slices. Antioxidants &
Redox Signaling, 3(6), 1099–1104. doi:10.1089/152308601317203602 PMID:11813983
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002). Release of chromatin protein HMGB1 by necrotic
cells triggers inflammation. Nature, 418(6894), 191–195. doi:10.1038/nature00858 PMID:12110890
Schieber, M., & Chandel, N. S. (2014). ROS function in redox signaling and oxidative stress. Current
Biology, 24(10), R453–R462. doi:10.1016/j.cub.2014.03.034 PMID:24845678
Schrader, M., & Fahimi, H. D. (2006). Peroxisomes and oxidative stress. Biochimica et Biophysica Acta.
Bioenergetics, 1763(12), 1755–1766. doi:10.1016/j.bbamcr.2006.09.006 PMID:17034877
390
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use

Anticancer Eect of Aristolochia tagala and Curcuma caesia Acting Through Tumor Necrosis Factor-α
Scott, O., & Roifman, C. M. (2019). NF-kB pathway and the Goldilocks principle: Lessons from human
disorders of immunity and inflammation. The Journal of Allergy and Clinical Immunology, 143(5),
1688–1701. doi:10.1016/j.jaci.2019.03.016 PMID:30940520
Selvendiran, K., Koga, H., Ueno, T., Yoshida, T., Maeyama, M., Torimura, T., Yano, H., Kojiro, M.,
& Sata, M. (2006). Luteolin promotes degradation in signal transducer and activator of transcription 3
in human hepatoma cells: An implication for the antitumour potential of flavonoids. Cancer Research,
66(9), 4826–4834. doi:10.1158/0008-5472.CAN-05-4062 PMID:16651438
Sen, R., & Baltimore, D. (1986). Multiple nuclear factors interact with the immunoglobulin enhancer
sequences. Cell, 46(5), 705–716. doi:10.1016/0092-8674(86)90346-6 PMID:3091258
Seol, G., Kang, P., Lee, H. S., & Seol, G. H. (2016). Antioxidant activity of linalool in patients with
carpal tunnel syndrome. BMC Neurology, 16(1), 17. doi:10.118612883-016-0541-3 PMID:26831333
Sethi, G., Sung, B., & Aggarwal, B. B. (2008). TNF: A master switch for inflammation to cancer. Fron-
tiers in Bioscience, 13(13), 5094–5107. doi:10.2741/3066 PMID:18508572
Shaikh, A. M., Shrivastava, B., Apte, K. G., Parab, P. B., Sharma, P., Navale, S. D., & Paygude, S. V.
(2016). In-vitro screening of some medicinal plants on breast, ovary and colon cancer cell lines. Inter-
national Journal of Pharmacy and Biological Sciences, 7(2), 11–17.
Sharan, R. N., Odyuo, M. M., & Purkayastha, S. (2011). Oxygen free radicals and its biomedical implications: A mini review, Solicited contribution. Organic Chemistry, 8, 372–376.
Sharan, R. N., & Wary, K. K. (1992). Study of unschedule DNA synthesis following exposure of human
cells to arecoline and extracts of betel nut in vitro. Mutation Research, 278(4), 271–276. doi:10.1016/
S0165-1218(10)80007-2 PMID:1373864
Shibutani, S., Takeshita, M., & Grollman, A. P. (1991). Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature, 349(6308), 431–434. doi:10.1038/349431a0
PMID:1992344
Shimizu, M., Deguchi, A., Lim, J. T., Moriwaki, H., Kopelovich, L., & Weinstein, I. B. (2005). (-)-Epigallocatechin gallate and polyphenon E inhibit growth and activation of the epidermal growth factor
receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells.
Clinical Cancer Research, 11(7), 2735–2746. doi:10.1158/1078-0432.CCR-04-2014 PMID:15814656
Singh, A. K. (2010). Probable agricultural biodiversity heritage sites in India: V. The Garo, Khasi, and
Jaintia Hills Region. Asian Agri-History, 14, 133–156.
Soreq, H. (1993). Coamplification of human acetylcholinesterase and butyrylcholinesterase genes in
blood cells: Correlation with various leukemias and abnormal megakaryocytopoiesis. Proceedings of
the National Academy of Sciences of the United States of America, 86, 4715–4719. PMID:2734315
St-Pierre, J., Buckingham, J. A., Roebuck, S. J., & Brand, M. D. (2002). Topology of superoxide production from different sites in the mitochondrial electron transport chain. The Journal of Biological
Chemistry, 277(47), 44784–44790. doi:10.1074/jbc.M207217200 PMID:12237311
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use
391

Anticancer Eect of Aristolochia tagala and Curcuma caesia Acting Through Tumor Necrosis Factor-α
Strieter, R. M., Kunkel, S. L., & Bone, R. C. (1993). Role of tumour necrosis factor-alpha in disease
states and inflammation. Critical Care Medicine, 21(Supplement), S447–S463. doi:10.1097/00003246-
199310001-00006 PMID:8403983
Strzelczyk, J. K., & Wiczkowski, A. (2012). Oxidative damage and carcinogenesis. Contemporary On-
cology (Poznan, Poland), 16(3), 230–233. doi:10.5114/wo.2012.29290 PMID:23788885
Sueoka, E., Sueoka, N., Okabe, S., Kozu, T., Komori, A., Ohta, T., Suganuma, M., Kim, S. J., Lim, I.
K., & Fujiki, H. (1997). Expression of the tumor necrosis factor-alpha gene and early response genes
by nodularin, a liver tumor promoter, in primary cultured rat hepatocytes. Journal of Cancer Research
and Clinical Oncology, 123(8), 413–419. PMID:9292703
Suganuma, M., Okabe, S., Kurusu, M., Iida, N., Ohshima, S., Saeki, Y., Kishimoto, T., & Fujiki, H.
(2002). Discrete roles of cytokines, TNF α, IL-1, IL-6 in tumor promotion and cell transformation. In-
ternational Journal of Oncology, 20(1), 131–136. doi:10.3892/ijo.20.1.131 PMID:11743653
Tandon, P., Kumaria, S., & Nongrum, L. (2009). Conservation and management of plant genetic resources
of Northeast India. Indian Journal of Traditional Knowledge, 8(1), 29–34.
Tang, G., Minemoto, Y., Dibling, B., Purcell, N. H., Li, Z., Karin, M., & Lin, A. (2001). Inhibition
of JNK activation through NF-κB target genes. Nature, 414(6861), 313–317. doi:10.1038/35104568
PMID:11713531
Tarao, K., Rino, Y., Ohkawa, S., Shimizu, A., Tamai, S., Miyakawa, K., Aoki, H., Imada, T., Shindo, K.,
Okamato, N., & Totsuka, S. (1999). Association between high serum alanine aminotransferase levels and
more rapid development and high rate incidence of hepatocellular carcinoma in patients with hepatitis C virus
associated cirrhosis. Cancer, 86(4), 589–595. doi:10.1002/(SICI)1097-0142(19990815)86:4<589::AID-
CNCR7>3.0.CO;2-K PMID:10440686
Tolba, R., Kraus, T., Liedtke, C., Schwarz, M., & Weiskirchen, R. (2015). Diethylnitrosamine
(DEN)-induced carcinogenic liver injury in mice. Laboratory Animals, 49(1_suppl, S1), 59–69.
doi:10.1177/0023677215570086 PMID:25835739
Trachootham, D., Alexandre, J., & Huang, P. (2009). Targeting cancer cells by ROS- mediated mechanisms: A radical therapeutic approach? Nature Reviews. Drug Discovery, 8(7), 579–591. doi:10.1038/
nrd2803 PMID:19478820
Tushar, B., Basak, S., Sarma, G. C., & Rangan, L. (2010). Ethnomedical uses of Zingiberaceous plants
of Northeast India. Journal of Ethnopharmacology, 132(1), 286–296. doi:10.1016/j.jep.2010.08.032
PMID:20727402
Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006). Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico-Biological Interactions, 160(1), 1–40. doi:10.1016/j.
cbi.2005.12.009 PMID:16430879
Van Leeuwen, I. M., & Zonneveld, C. (2001). From exposure to effect: A comparison of modeling
approaches to chemical carcinogenesis. Mutation Research, 489(1), 17–45. doi:10.1016/S13835742(01)00062-X PMID:11673088
392
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use

Anticancer Eect of Aristolochia tagala and Curcuma caesia Acting Through Tumor Necrosis Factor-α
Verna, L., Whysner, J., & Williams, G. M. (1996). N-nitrosodiethylamine mechanistic data and risk
assessment: Bioactivation, DNA adduct formation, mutagenicity, and tumour initiation. Pharmacology
& Therapeutics, 71(1-2), 57–81. doi:10.1016/0163-7258(96)00062-9 PMID:8910949
Wajant, H., Pfizenmaier, K., & Scheurich, P. (2003). Tumour necrosis factor signalling. Cell Death and
Differentiation, 10(1), 45–65. doi:10.1038j.cdd.4401189 PMID:12655295
Wang, J., Zhao, J., Liu, H., Zhou, L., Liu, Z., Wang, J., Han, J., Yu, Z., & Yang, F. (2010). Chemical
analysis and biological activity of the essential oils of two valerianaceous species from China: Nardostachys
chinensis and Valeriana officinalis. Molecules (Basel, Switzerland), 15(9), 6411–6422. doi:10.3390/
molecules15096411 PMID:20877232
Wary, K. K., & Sharan, R. N. (1988). Aqeous extract of betel-nut of North-East-India induces DNA
strand breaks and enhances rate of cell proliferation in vitro. Journal of Cancer Research and Clinical
Oncology, 114(6), 579–582. doi:10.1007/BF00398180 PMID:3204104
Wassermann, A. M., Lounkine, E., Hoepfner, D., Goff, G. L., King, F. J., Studer, C., Peltier, J. M.,
Grippo, M. L., Prindle, V., Tao, J., Schuffenhauer, A., Wallace, I. M., Chen, S., Krastel, P., Cobos-Correa, A., Parker, C. N., Davies, J. W., & Glick, M. (2015). Dark chemical matter as a promising starting
point for drug lead discovery. Nature Chemical Biology, 11(12), 958–966. doi:10.1038/nchembio.1936
PMID:26479441
Wenzel, U., Kuntz, S., Brendel, M. D., & Daniel, H. (2000). Dietary flavone is a potent apoptosis inducer
in human colon carcinoma cells. Cancer Research, 60, 3823–3831. PMID:10919656
Westwick, J. K., Weitzel, C., Minden, A., Karin, M., & Brenner, D. A. (1994). Tumour necrosis factor
alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. The Journal of Biologi-
cal Chemistry, 269(42), 26396–26401. doi:10.1016/S0021-9258(18)47207-9 PMID:7929360
Winterbourn, C. C. (1995). Toxicity of iron and hydrogen peroxide: The Fenton reaction. Toxicology
Letters, 82, 969–974. doi:10.1016/0378-4274(95)03532-X PMID:8597169
Wu, S., Zhu, W., Thompson, P., & Hannun, Y. A. (2018). Evaluating intrinsic and non-intrinsic cancer
risk factors. Nature Communications, 9(1), 3490. doi:10.103841467-018-05467-z PMID:30154431
Wu, W. S. (2006). The signaling mechanism of ROS in tumor progression. Cancer and Metastasis Re-
views, 25(4), 695–705. doi:10.100710555-006-9037-8 PMID:17160708
Yamada, K., Yamamiya, I., & Utsumi, H. (2006). In vivo detection of free radicals induced by diethylnitrosamine in rat liver tissue. Free Radical Biology & Medicine, 40(11), 2040–2046. doi:10.1016/j.
freeradbiomed.2006.01.031 PMID:16716904
Yang, C. S., Yoo, J. S., Ishizaki, H., & Hong, J. Y. (1990). Cytochrome P450IIE1: Roles in nitrosamine metabolism and mechanisms of regulation. Drug Metabolism Reviews, 22(2-3), 147–159.
doi:10.3109/03602539009041082 PMID:2272285
Yao, L. H., Jiang, Y. M., Shi, J., Tomas-Barberan, F. A., Datta, N., Singanusong, R., & Chen, S. S. (2004).
Flavonoids in food and their health benefits. Plant Foods for Human Nutrition (Dordrecht, Netherlands),
59, 113–122. doi:10.100711130-004-0049-7 PMID:15678717
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use
393

Anticancer Eect of Aristolochia tagala and Curcuma caesia Acting Through Tumor Necrosis Factor-α
Yoshida, Y., & Niki, E. (2003). Antioxidant effects of Phytosterol and its components. Journal of Nutritional Science and Vitaminology, 49(4), 277–280. doi:10.3177/jnsv.49.277 PMID:14598915
Zakut, H., Ehrlich, G., Ayalon, A., Prody, C. A., Malinger, G., Seidman, S., Ginzberg, D., Kehlenbach,
R., & Soreq, H. (1990). Acetylcholinesterase and butyrylcholinesterase genes coamplify in primary
ovarian carcinomas. The Journal of Clinical Investigation, 86(3), 900–908. doi:10.1172/JCI114791
PMID:2394839
Zhang, J., Wang, X., Vikash, V., Ye, Q., Wu, D., Liu, Y., & Dong, W. (2016). ROS and ROS-mediated
cellular signaling. Oxidative Medicine and Cellular Longevity. doi:10.1155/2016/4350965
Zhang, Q., Zhu, B., & Li, Y. (2017). Resolution of cancer-promoting inñammation: A new approach for
anticancer therapy. Frontiers in Immunology, 8, 71. doi:10.3389/fimmu.2017.00071 PMID:28210259
394
EBSCOhost - printed on 2/13/2023 11:18 AM via . All use subject to https://www.ebsco.com/terms-of-use

Chapter 20
Essential Oils and Their
Biological Applications:
Extraction methods, Types, Biological
Activities, Antimicrobial Fumes
Minky Mukhija
Ch. Devi Lal College of Pharmacy, India
395
Ankush Sundriyal
Sardar Bhagwan Singh University, India
Aanchal Loshali
Sardar Bhagwan Singh University, India
ABSTRACT
Essential oils are terpinoids and their oxygenated derivatives, which are widely used for antimicrobial,
fungicidal, antiparasitical, insecticidal uses. They are aromatic, hydrophobic, and volatile in nature and
frequently used in medicinal and cosmetic industries. Especially nowadays, volatile oils have a significant role in pharmaceutical, sanitary, cosmetic, agricultural, and food industries. Various conventional
and modern methods of extraction of volatile oil are available. Volatile oil can play an important role
in minimization of microbial load at primary stage and/or to prevent the growth of the microorganisms during various stages of product management. However, there is still the need more emphasis on
research regarding EO.
INTRODUCTION
Medicinal aromatic plant is a general term which is commonly used to refer spices, condiments, perfumes
and flavoring agents. These aromatic plants consist of essential oil (EO) or volatile oils due to which
they produce specific flavors or odors and used as spices or perfumery agents. Essential oils (EOs) are
natural, highly volatile, aromatic, hydrophobic liquid and compounded mixtures of low-molecular-weight
usually obtained in plants and used in ancient time for medicinal and health motive (Mahato et al., 2019).
EOs formed as secondary metabolites in aromatic plants as in reaction to attacks by herbivores, insects,
microorganism, and other entities (Raut & Karuppayil, 2014). Due to their volatile nature they can be
easily extract out by the steam distillation method from different natural sources (Mahato et al., 2019)
DOI: 10.4018/978-1-6684-5129-8.ch020
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Essential Oils and Their Biological Applications
and their antidepressant, detoxifying, stimulating, antimicrobial, and calming effects, EO gain huge admiration as a natural, secure an efficient therapy for health problems (Tongnuanchan & Benjakul, 2014).
EOs are complex, comprises of various chemicals, mostly present in liquid state but very few in solid
form also. At normal temperature, these volatile oils may appear colorless to light yellowish in color
and are readily absorbed through the skin. EO usually have lower density then water but few volatile
oils like cinnamon oil, clove oil, etc. possesses high density than water. They are miscible in vegetable
oils, fats, wax, and water and also soluble in diethyl ether, acetone, ethyl acetate, ethanol (SolórzanoSantos & Miranda-Novales, 2012). EOs of same plant may differ completely in aroma and properties
from part to part e.g. Geranium plant yields oil from flowers and the leaves, and both oils from different
parts differ in constituents, aroma and other properties (Veras et al., 2012; Rivera Calo et al., 2015). In
plants, generally volatile oil stored in glands, oil ducts, resin ducts, or glandular trichomes of the plants.
The quality of EOs usually affected by various interlinked factors, such as climatic conditions, seasonal
and geographical conditions, harvesting time and method of extraction (Pannizi et al., 1993). The oils
yield from the various parts of plants could be pretentious at the various stages of the plant growth.
EOs is generally used as flavoring ingredient such as in edible products, drinks, perfume industries,
pharmaceuticals, and cosmetics manufacturing.
Various compositions of EO make it potential to use them as potent antimicrobial agent with a low
risk of microbial resistance occurrence (Bakkali et al., 2008).
NATURAL SOURCES OF ESSENTIAL OILS
Around 3000 EOs is known till date, of which only 300 EOs are commercially valuable. Most of the
EOs is used in pharmaceuticals, sanitary, food, cosmetic, and perfume industries (Bakkali et al., 2008).
Plants producing EOs belongs to around 60 families which includes, Lamiaceae Alliaceae, Apiaceae,
Myrtaceae, Asteraceae, Poaceae, and Rutaceae (Carson et al., 2006). They may be originate in individual
portions of the plant such as leaves (mint), flower (rose), peel (orange), seed (Basil) berries (juniper),
rhizome (ginger, turmeric) bulb (garlic), root (jatamansi), bark (cinnamon), wood (sandal wood), resin
(frankincense), petals (marigold), etc. (Pannizi et al., 1993)
COMPONENTS OF ESSENTIAL OILS
EO is the mixture of various phytochemicals and obtained from the primary metabolites in the form of
secondary metabolites. EO is present in high concentration (approximately 20-70%) (Croteau et al., 2000;
Betts, 2001). Numerous compounds which belong from the family of terpenes have been recognized in
EOs. Majority of EO components alone show the biological properties (Veras et al., 2012) but occasion-
ally a combination of molecules changes biological activity (Carson et al., 2006; Bakkali et al., 2008).
The EO constituents of any specific plant depends on the plant part used, whether it be flowers, leaves,
stems, bark, wood, whole fruits, pericarp, seed, or roots (Rivera Calo et al., 2015).
Terpenoids and Phenylpropanoids originates by diverse precursors of the primary metabolism and
are synthesized by dispersed metabolic pathways and they are further classified into different groups,
such as functionalized derivatives of alcohols (geraniol, α-bisabolol), ketones (menthone, p-vetivone),
aldehydes (citronellal, sinensal), esters (γ-tepinyl acetate, cedryl acetate), and phenols (thymol) (Başer
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Essential Oils and Their Biological Applications
et al, 2007; Tabanca, 2007). EOs also contains non-terpenic composites biogenerated via the Phenylpropanoids pathway, such as eugenol, cinnamaldehyde, and safrole (Modzelewska, 2005).
TYPES OF ESSENTIAL OILS
Essential oils are classified into two chemical groups (1) Terpenoids and (2) Phenylpropanoids
Terpenoids
Terpenoids are naturally occurring hydrocarbons and basically consist of five carbon isoprene units.
Terpenoids are the terpenes obtained from the several kinds of plants and flowers in the form of primary
constituents of the EOs (Thimmappa, 2014). Within terpenoids; monoterpenoid and sesquiterpenoid
families are main because majority of most important components of EOs found in the plants (Ludwiczuk, 2017). Terpenoids are divided into hemeterpenes (C
diterpenes (C
terpenes (C
), triterpenes (C30) and tetraterpenes (C40) depending on its carbon units although mono-
20
) and sesquiterpenes (C15) are the major terpenoids (Bakkali et al., 2008).
10
Various Examples of EOs are turpentine, α and β-pinene isolated from Pinus species, geraniol isolated
from Rosa damascena, terpinen-4-ol from Melaleuca alternifolia (tea tree oil), linalool from Coriandrum
sativum, zingiberol from Zingiber officinale and cineol from Eucalyptus globulus, etc. (Bakkali et al,
2008; Sell, 2010; Chamorro et al., 2012).
), monoterpenes (C10), sesquiterpenes (C15),
5
Hemiterpenes
Hemiterpene are the type of terpene having C5 atom and formed from a single isoprene unit. Molecular
formula is C
. Eucalyptol, citronellol, limonene, humulene and Forskolin are the example of hemiter-
5H8
pene. These type of compounds used as a flavors, fragrances, food additives and pharmaceuticals and
possess various biological properties (Semih & Vasfiye, 2021).
Monoterpenes
Biosynthetically monoterpenes are synthesized from units of isopentenyl pyrophosphate, which is made
from acetyl-CoA via the intermediacy of mevalonic acid in HMG-CoA reductase pathway. The molecular
formula of monoterpenes is C
units. Monoterpenoids are characterized by oxygen-containing functional groups. Structural isomersacyclic (myrcene and ocimene are the type of acyclic monoterpene), monocyclic (α terpineol, limonene,
thymol, menthol, carvone, eucalyptol, and perillaldehyde are the type of monocyclic monoterpene), and
bicyclic monoterpenes (Carene, sabinene, camphene, and thujene are the type of bicyclic monoterpenes)
(Ajikumar et al., 2008). Geraniol, terpineol, limonene, myrcene, linalool or pinene is the examples of
monoterpenes (Breitmaier, 2006).
and comes under the class of terpenes and consists of two isoprene
10H16
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