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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5535_Библиотеки_им_академика_М_И_Перельмана.pdf
1336
Medical Laboratory Technology: Volume 3
Substance Determined Drugs Causing
Increased Values
False Positives
Ethanol Phenylmercuric acetate
Fructose Piperazine
Furosemide Potassium oxalate
Gentamicin Salicylates (large doses)
Glucose Saline infusions
Griseofulvin Sodium oxalate
Hydralazine Sulfinpyrazone
Hydroxyurea Thiazide diuretics
Ibufenac
Lead intoxication
Levodopa Triamterne*
Lipomul (oil injection)
Mecamylamine
Mercaptopurine
Methicillin
Methotrexate
Methyldopa
Norepinephrine
Nicotinic acid
Nitrogen mustards
Penicillin
Phenacetin
Phenelzine
Phenothiazines
Potassium salts
Probenecid
Propylthiouracil antimetabolites
Azathioprine
6-Mercaptopurine
6-Thioguanine
Pyrazinamide
Quinethazone
Reducing substances
Rifampin
Salicylates (low doses)
Salicylic acid
Drugs Causing
Decreased Values
False Negatives
(chlorothiazide, 500 mg. IV)
Contd.
Appendices
1337
Substance Determined Drugs Causing
Increased Values
False Positives
Spironolactone
Thiazide diuretics (Chlorothiazide,
1.5 gm in divided doses)
Triamterene*
Vincristine
Drugs Causing
Decreased Values
False Negatives
Drugs Affecting results of urine stuDies
Substances with an asterisk in this table reportedly inuence the laboratory test, but further study is
needed to determine the exact effect and mechanism of action.
Substance Determined Drugs Causing Increased Values
False Positives
Acetone (ketones) Aspirin
BSP (colour interference on
nitroprusside test, Ketostix, Labstix,
Acetest, Bili-Labstix)
Ether anaesthesia
Inositol or methionine
Insulin (excessive doses)
Isoniazid intoxication (produces
acetonuria)
Isopropyl alcohol
Levodopa (L-Dopa, brown on
Ketostix or Labstix)
Metformin
Methyldopa
Paraldehyde
Increased acetaldehyde;
nitroprusside reaction, Acetest
Phenazopyridine (Pyridium)
Interfering colours on
Ketostix
Phenacetin
Phenformin
Phenothiazines
PSP (possible colour interference on
nitroprusside test, Ketostix, Labstix,
Acetest, Bili-Labstix)
Aldosterone Progesterone
Drugs Causing Decreased Values
False Negatives
Contd.
1338
Medical Laboratory Technology: Volume 3
Substance Determined Drugs Causing Increased Values
False Positives
Alkaline phosphatase Ethionamide
Alpha amino nitrogen Sulphonamides
Amino acids ACTH Epinephrine
Amphetamine Insulin
Ampicillin (false-positive spots on
paper chromatograms)
Amino acids continued Cephalexin
Colistin
Cortisone
Dopamine
Ephedrine
Epinephrine
Gentamicin
Kanamycin
Levarterenol
Levodopa
Mafenide
Methamphetamine
Methyldopa
Neomycin
Penicillamine
Phenacetin
Phenylephrine
Phenylpropanol
Polymyxin
Sulphonamide
Tetracycline
Amino levulinic acid Penicillin
Bacteria Phenazopyridine
Benzidine Bromides
Copper
Ferricyanide
Formalin
Iodides
Permanganate
Bile Aminosalicylic acid
Aspirin
Drugs Causing Decreased Values
False Negatives
Nitrofurantoin
Contd.
Appendices
1339
Substance Determined Drugs Causing Increased Values
False Positives
Chlorpromazine
Chlorprothixene
Chloroxazone
Flufenamic acid
Mefenamic acid
Phenazopyridine
Phenothiazines
Thymol
Aspirin
Chlorprothixine
Ethoxazene reddish colour (BiliLabstix)
Flufenazine
Mefenamic acid (Ponstel)
Perphenazine
Phenazopyridine (Pyridium; false
positive)— “foam test.” atypical
colour reaction on talc-diskFouchet-spot test and Franklin’s
tablet-Fouchet test; red colour—
Ictotest, Bili-Labstix)
Phenothiazines
Chlorpromazine (Bili-Labstix;
Ictotest is unaffected)
Calcium Cholestyramine Alkaline urine
Dihydrotachysterol Phosphates
Nandrolone (in some cancer
patients)
Parathyroid injection Viomycin
Vitamin D
Catecholamines Aminophylline Bethanedine
Aspirin Chlorpromazine
Caffeine
Carbon tetrachloride
Chloral hydrate
Demeclocycline
Dopamine
Drugs Causing Decreased Values
False Negatives
Sodium phytate
Thiazide diuretics
Guanethidine (Ismelin),
elevated epinephrine
decreased norepinephrine
Contd.
1340
Medical Laboratory Technology: Volume 3
Substance Determined Drugs Causing Increased Values
False Positives
Epinephrine inhalation (Dylephrin,
Mehaler-Epinephrine,
Micronephrine, Vaponephrine)
Erythromycin
Ethanol
Formaldehyde
Gaunethidine (Ismelin;
elevated epinephrine, decreased
norepinephrine)
Hydralazine (Aspresoline)
Hydroquinone
Hypertensive agents
Imipramine (Tofranil)
Isoproterenol
Levodopa (L-dopa)
Methenamine
Methyldopa (Aldomet)
Niacin
Nitroglycerin
Phenothiazines
Quinidine
Quinine
Tetracyclines
Chlortetracycline
Oxytetracycline
B complex vitamins (nicotinic acid,
riboflavin)
Reserpine (large dose)
Chloride Bromides
Cortisol Quinacrine Dextran
Spironolactone Ethacrynic acid
Creatine and creatinine Androgens Thiazide diuretics
Corticosteroids
Histidine
Levodopa
Methyldopa
Nitrofuran derivatives
Drugs Causing Decreased Values
False Negatives
Guanoxan
Reserpine
Hydrochlorothiazide
Contd.
Appendices
1341
Substance Determined Drugs Causing Increased Values
False Positives
Nitrofurazone
Urea
Crystals Acetazolamide
Aminosalicylic acid
Ampicillin
Methenamine mandelate
Sulphonamides
Thiabendazole
Diacetic acid Acetate* Acetate*
Antipyrine* Antipyrine*
Sodium bicarbonate* Sodium bicarbonate
Cyanate* Cyanate*
Coaltar drugs*
Levodopa (L-dopa)
Phenazopyridine (Pyridium)
Phenothiazines
Salicylates
Diagnex blue Aluminium salts Caffeine sodium benzoate
Antacids
Cremomycin Phenazopyridine
Donnagel
Kaolin
Kaopectate
Atabrine
Barium
B complex vitamins
Nicotinic acid
Riboflavin
Calcium
Iron
Magnesium
Methylene blue
Phenazopyridine
Potassium salts (larger amounts)
Quinacrine (Mepacrine)
Quinidine
Quinine
Sodium salts (large amounts)
Drugs Causing Decreased Values
False Negatives
Contd.
1342
Medical Laboratory Technology: Volume 3
Substance Determined Drugs Causing Increased Values
False Positives
Triamterene
Estradiol Levodopa Cascara
Crystals (probable for drug) Methotrexate
Estriol Aspirin
Estrogens Anthraquinone Acetazolamide
Cascara Cascara
Chlortetracycline Danthron
Levodopa Glucose
Methenamine Hydrochlorothiazide
Phenothiazines* (prochlorperazine,
Kober method)
Tetracyclines* Tetracyclines
Vitamins Vitamins*
Estrone Senna
Ferric chloride test Aminosalicylic acid
Antipyretics
Aspirin
Levodopa
Methotrimeprazine
Methyldopa
Perphenazine
Phenothiazines
Salicylates
Fouchet test FPN Aspirin
Aminosalicylic acid
Chlorpromazine
Fluphenazine
Methdilazine
Perphenazine
Prochlorperazine
Promazine
Promethazine
Thiopropazate
Thioridazine
Drugs Causing Decreased Values
False Negatives
Glucose
Hydrochlorothiazide
Methenamine
Methenamine
Phenothiazines (prochlorperazine)
Contd.
Appendices
1343
Substance Determined Drugs Causing Increased Values
False Positives
Trifluoperazine
Triflupromazine
Glucose Acetanilid (Benedict’s) Ampicillin
Amino acids Ascorbic acid
Aminopyrine Aspirin
Aminosalicylic acid (PAS), reducing
agent (Benedict’s; glucose oxidase
not affected)
Antipyrine Dipyrone
Ascorbic acid (large doses produce
false positive with Benedict’s or
Clinitest)
Aspedium oleoresin Hydroquinone
Aspirin Levodopa (L-dopa)
Bismuth Meralluride sodium
Carbamazepine (Tegretol)
Carinamide
Cephalexin Mercurial diuretics
Cephaloglycin
Cephaloridine Oxytetracycline
Cephalothin
Clinitest-black brown, interpreted as
positive glucose or as false negative)
Chloral betaine Phenobarbital
Chloral hydrate (Noctec; Benedict’s
large doses, positive Clinitest;
glucose oxidase not affected)
Drugs Causing Decreased Values
False Negatives
Bisacodyl
Cephaloridine
Cephalothin
Chloral hydrate
Epinephrine
Flurazepam
Furosemide
Glucose
Phenazopyridine (Pyridium; glucose
oxidase negative, Tes-Tape positive;
copper reduction test not affected)
Prednisone
Propoxyphene
Salicylates (glucose oxidase
negative)
Contd.
1344
Medical Laboratory Technology: Volume 3
Substance Determined Drugs Causing Increased Values
False Positives
Chloramphenicol (Chloromycetin;
Benedict’s, Clinitest)
Chloroform
Chlortetracycline
Cinchophen
Corticosteroids (increased
production of glucose, lower renal
threshold)
Corticotropin
Creatinine
Dextrothyroxine
Edathamil (EDTA)
Ephedrine (large doses)
Ethacrynic acid
Formaldehyde
Gluconates
Glucuronic acid
Hippuric acid
Histidine
Homogentisic acid
Hydrogen peroxide (Benedict’s
glucose oxidase)
Hypochlorites (Benedict’s glucose
oxidase)
Indomethacin
Isoniazid (INH; Benedict’s,Clinitest,
or glucose oxidase not affected;
hyperglycemic, may produce true
glucosuria)
Levodopa (L-dopa; Clinitest
positive, glucose oxidase negative)
Lithium carbonate
Methaproterenol
Metaxalone Skelarin; reducing
subs tance interferes-(Benedict’s
Clini test-glucose oxidase not
affected)
Methenamine products
Methyldopa (Aldomet)
Methyprylon
Morphine (Benedict’s)
Drugs Causing Decreased Values
False Negatives
Tetracycline
Contd.
Appendices
1345
Substance Determined Drugs Causing Increased Values
False Positives
Nalidixic acid
Neocinchophen
Niacin
Nicotinic acid (large doses)
Nitrofurans
Nitrofurantoin (Furadantin)
Furazolidine (Furoxone) metabolite
(Benedict’s)
Furazolidone histidine
Nitrofurazone
Nucleoproteins
Oxalic acid
Oxazepam
Oxytetracycline
Penicillin (Benedict’s) Clinitest)
Phenacetin
Phenazopyridine
(Pyridium; glucose oxidase negative,
Tes-Tape positive; copper reduction
test not affected)
Phenols
Phenothiazines
Probenecid (reducing substance
in the urine; Benedict’s, Clinitest;
glucose oxidase not affected)
Protein
Pyrazolones
Quinethazone (glucosuria)
Salicylates (Clinitest positive, large
doses)
Streptomycin (Benedict’s, Clinitest;
glucose oxidase not affected)
Sulphamethoxazole
Sulphathiazole
Sulphonamides (Sulphanilamide;
Benedict’s, Clinitest; large doses
interfere with copper reduction test)
Drugs Causing Decreased Values
False Negatives
Contd.