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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5535_Библиотеки_им_академика_М_И_Перельмана.pdf
1306
Medical Laboratory Technology: Volume 3
Appendix i
drugs Affecting results of Blood studies, electrolytes, Blood
gAs AnAlyses, And isotope studies
Substances with an asterisk in this table reportedly inuence the laboratory test, but further study is
needed to determine the exact effect and mechanism of action.
Substance Determined Drugs Causing
Increased Values
False Positives
Acetoacetate decarboxylase Riboflavin Urea
Acid phosphatase Androgens (in women) Alcohol
Clofibrate Fluorides
Albumin Heparin Ascorbic acid
Phenazopyridine Penicillin
Alkaline phosphatase Acetohexamide Fluorides
Albumin Oxalates
Allopurinol Phosphates
Aluminium nicotinate Placebo
Amitriptyline Propranolol
Anabolic androgenic agents Vitamin D
Azathioprine
Bromsulphalein
Carbamazepine
Cephaloridine
Chlorpropamide
Clindamycin
Colchicine
Ergosterol
Erythromycin (Ilosone)
Estrogens
Flurazepam
Gold salts
N-hydroxyacetamide
Drugs Causing
Decreased Values
False Negatives
Arsenicals
Heparin
Oxalates
Phosphates
Salicylic acid
Sulphonamides
Contd.
Appendices
1307
Substance Determined Drugs Causing
Increased Values
False Positives
Imipramine
Indomethacin (rare)
Isoniazid
Lincomycin
Methyldopa
Methyltestosterone
Mithramycin
Nicotinic acid (large doses; 3–6 g/
day)
Nitrofurantoin
Novobiocin
Oxacillin
Oxyphenisatin
Papaverine (reversible)
PAS
Penicillamine
Petrofane
Phenothiazines
Phenylbutazone
Procainamide
Progestin-estrogen combinations
(oral contraceptives)
Propranolol
Rifampicin
Sulphonamides
Sulphamethoxazole
Sulfisoxazole
Tetracycline
Thiothixene
Tolazamide
Tolbutamide
Alpha aminonitrogen Sulphamethoxazole
Sulphonamides
Amino acids ACTH
Ampicillin
Bismuth
11-oxysteroids
Drugs Causing
Decreased Values
False Negatives
Contd.
1308
Medical Laboratory Technology: Volume 3
Substance Determined Drugs Causing
Increased Values
False Positives
Sulphonamides
Uric acid
Ammonia Acetazolamide (Diamox) Epinephrine
Ammonium salts (ammonium
chloride in cough preparations)
Asparagine Arginine
Barbiturates Diphenhydramine (Benadryl)
Colistimethate sodium (colistin
Sulphate)
Diuretics (oral) Glutamic acid
Chlorthalidone (Hygroton) Lactobacillus acidophilus
Clopamide
Ethacrynic acid (Edecrin) Methionine
Furosemide (Lasix)
Glucose Neomycin (Mycifradin)
Glutamine
Heparin Phosphates
Isoniazid (INH) Potassium salts
Lipomul (oil injection) Sodium salts
Methicillin (Dimocillin,
Staphcillin)
Morphine oral resins
Polymyxin B
Thiazide diuretics
Chlorothiazide (Diuril)
Tetracycline (large doses produce
hepatic damage with elevated
ammonia levels [+])
Urea
Drugs Causing
Decreased Values
False Negatives
Insulin
Acetohydroxamic acid (AHA:
urease inhibitor)
Glutamate sodium
Histidine
(Lactinex)
Monoamine oxidase inhibitors
Iproniazid
Tetracycline (reduces ammonia
production by gut bacteria [-1])
Tromethamine
Contd.
Appendices
1309
Substance Determined Drugs Causing
Increased Values
False Positives
Aminosalicylic acid (PAS) Diuretics (oral)
Bethanechol Ethacrynic acid
Chlorides Fluorides
*Codeine Oxalates
Corticosteroids
Cyproheptadine
Diatrizoate sodium
Diuretics (oral)
Chlorthalidone
Furosemide
Ethanol (gross intake)
Histamine
Hypaque
Indomethacin
Isoniazid
Lipemia
*Meperidine
Methylcholine
*Morphine
Oxyphenbutazone
Pancreatic extracts
Pentazocine
Phenylbutazone
Salicylates
Salicylazosulphapyridine
Sulphamethizole
Tetracycline
Thiazide diuretics
Chlorothiazide
Hydrochlorothiazide
Bicarbonate Aldosterone Metformin
Viomycin Phenformin Triamterene
Bilirubin (and icteric index) Acetaminophen (overdose) Barbiturates
Acetazolamide Chlorine
Acetohexamide Citrate
Allopurinol Dicophane
Drugs Causing
Decreased Values
False Negatives
Caffeine
Contd.
1310
Medical Laboratory Technology: Volume 3
Substance Determined Drugs Causing
Increased Values
False Positives
Aluminum nicotinate (rare) Ethanol (pregnant woman near
Aminosalicylic acid (PAS)
Amitriptyline Placebos*
Amphotericin B Protein
Anabolic/androgenic steroids
(reversible, conjugated)
Fluoxymesterone Sulfisoxazole and penicillin
Methandriol
Methandrostenolone urea
Norethandrolone
Norethisterone
Norethynodrel
Oxymetholone
Stanozolol
Ascorbic acid
Aspidium (unconjugated)
Azathioprine
Barbiturates
Carbamazepine
Carotin
Chlordiazepoxide
Chloroquine
Chlorpropamide
Clindamycin
Desipramine
Dextran
Diazepam
Diphenylhydantoin
Epinephrine
Erythromycin
Ethacrynic acid
Ethambutol
Ethionamide
Ethoxazene
Fluorouracil
Drugs Causing
Decreased Values
False Negatives
delivery)
Salicylates (large amounts)
Sodium chloride
Contd.
Appendices
1311
Substance Determined Drugs Causing
Increased Values
False Positives
Flurazepam
Gentamicin
Gold therapy (rare)
Halothane (rare)
Histidine
Idoxuridine
Imipramine
Indandione anitcoagulants
Indomethacin
Isoniazid
Isoproterenol
Levodopa
Lincomycin
Lipochrome
Menadiol sodium diphosphate
(large doses)
Menadione
Menadione sodium bisulfite
Mercaptopurine
Methimazole
Methotrexate
Methyldopa
Mithramycin
Monoamine oxidase inhibitors
Nicotinic acid (large doses)
Nitrofurans
Nitrofurantoin
Furazolidone
Novobiocin
Oxacillin
Oxyphenisatin
Papaverine
Penicillin and sulfisoxazole
combination
Phenacetin (rare)
Phenazopyridine
Phenelzine
Drugs Causing
Decreased Values
False Negatives
Contd.
1312
Medical Laboratory Technology: Volume 3
Substance Determined Drugs Causing
Increased Values
False Positives
Phenothiazines
(methotrimeprazine,
unconjugated)
Phenylbutazone
Phytonadione (high dose)
Piprobroman
Placebos*
Primaquine
Procainamide
Procarbazine
Progestin-estrogen combinations
(oral contraceptives)
Propylthiouracil
Protriptyline
Pyrazinamide
Quinacrine
Radiopaque contrast media
(sodium, calcium ipodates,
competition for excretion)
Rifampin (unconjugated)
Sulphonamides
Gantanol
Gantrisin
Sulphamethizole
Tetracyclines
Tolbutamide
Trifluperidol
Troleandomycin
Vitamin A
Vitamin K, K1
(large doses in newborn)
Xanthophyll
Blood urea nitrogen (BUN) Acetohexamide Chloramphenicol
Acetone Dextrose infusions
Alkaline antacids Phenothiazines (fluphenazine)
Aminosalicylic acid
Ammonium salts Thymol
Amphotericin B
Drugs Causing
Decreased Values
False Negatives
Contd.
Appendices
1313
Substance Determined Drugs Causing
Increased Values
False Positives
Antimony compound
Arginine
Arsenicals
Ascorbic acid
Bacitracin
Blood, whole
Capreomycin (reversible)
Cephaloridine (high doses)
Chloral hydrate
Chloramphenicol
Chlorobutanol
Chlorthalidone
Colistimethate sodium
Creatinine
Dextran
Doxapram
Ethacrynic acid
Fluid therapy
Fluorides
Furosemide
Gentamicin
Guanachlor
Guanethidine
Hydantoins
Hydroxyurea
Indomethacin
Kanamycin
Lipomul (oil injection)
Lithium carbonate
Mercury compounds
Methicillin
Methyldopa
Methysergide
Mithramycin
Morphine
Nalidixic acid
Neomycin
Drugs Causing
Decreased Values
False Negatives
Contd.
1314
Medical Laboratory Technology: Volume 3
Substance Determined Drugs Causing
Increased Values
False Positives
Nitrofurantoin
Pargyline
Polymyxin B
Propranolol
Radiopaque contrast media
Salicylates
Spectinomycin
Streptokinase-streptodornase
Sulphamethoxazole
Sulfisoxazole
Sulphonamides
Tetracyclines (doxycycline does
not gives significant increase)
Thiazide diuretics
Triamterene
Vancomycin
Bromsulphalein (BSP)
retention
Acetohexamide Albuminuria
Aluminium nicotinate Kanamycin
Amidone Phenazopyridine
Anabolic androgenic steroids Placebos
Fluoxymesterone
Methandriol
Methandrostenolone
Norethandrostenolone
Norethynodrel
Antifungal agents
Aspidium (if absorbed)
Barbiturates (stop drug 24 hr.
before test)
Capreomycin sulphate
Carbamazepine (Tegretol)
Cardiotonic glycosides
Chlorpropamide
(cholestatic jaundice)
Chlortetracycline
Choleretics
Clofibrate (hepatic damage;
cholestatic jaundice)
Drugs Causing
Decreased Values
False Negatives
Contd.
Appendices
1315
Substance Determined Drugs Causing
Increased Values
False Positives
Clomiphene citrate (Clomid)
Dehydrocholic acid (interferes
with hepatic uptake or biliary
excretion of BSP)
Diphenylhydantoin (Dilantin)
Estrogens (intrahepatic
cholestatic jaundice; depress
hepatic secretory transport)
Ethambutol
Ethoxazene
Guanoxan
Halogen compounds
Heparin
Hydroxyurea (suppresses renal
tubular function)
Indomethacin
Kanamycin*
Lipemia
Meperidine
Mercaptopurine
Metaxalone (jaundice)
Methadone
Methotrexate
Methyldopa (Aldomet)
Mithramycin
Monoamine oxidase inhibitors
Isocarboxazid
Nialamide
Phenelzine sulphate
Trancylpromine sulphate
Morphine
Nicotinic acid (Niacin; large
doses)
Novobiocin
Oxacillin
Phenazopyridine (Pyridium)
Phenolphthalein
PhenolSulphonphthalein (PSP)
Drugs Causing
Decreased Values
False Negatives
Contd.