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Contents

1 Introduction to Biotribology: A Science of Surface Interaction . . . . . 1
Abhishek Kumar, Avinash Kumar, Ashwani Kumar, Amit Choudhari, Ashish Kumar Gupta, and Sakib Faisal
2 Characterization of Hydrogel Properties in the Advancement
of Bio-Tribology. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27
Nusrat Chowdhury, Sakib Faisal, Abhishek Kumar, Amit Choudhari, Ashish Kumar Gupta, Avinash Kumar, and Ashwani Kumar
3 Recent Advancements in Developing Nanobiosensors
for Treating Inflammatory Diseases of Human:
A Comprehensive Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79
Ankita Chakraborty, Saubhik Mitra, Moytrey Chatterjee, Abhijit Dey, and Suprabhat Mukherjee
4 Biological Smart Materials: Materials for Cancer Treatment . . . . . . 113
Debasish Panda, Mansi Agarwal, Beauty Kumari, Prabhudutta Hota, and Ajay Agarwal
5 Tribological Measurements of Human Skin . . . . . . . . . . . . . . . . . . . . . 149
Ayushi Pal, Reetu Gour, Ashwani Kumar, Abhishek Kumar, Avinash Kumar, and Nusrat Chowdhury
6 Tribological Hurdles in Biomedical Manufacturing:
A Comprehensive Examination . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 167
Avinash Kumar, Pradipta Gajjar, Kavitha Sharanappa Gudadur, Abhishek Kumar, Ashish Kumar Gupta, Amit Choudhari, Nusrat Chowdhury, and Ashwani Kumar
xiii
xiv
Contents
7 Navigating the Landscape: Cutting-Edge Biomedical
Manufacturing Techniques . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 199
Milad Heidari, Sivasakthivel Thangavel, Pooyan Rahmanivahid, Morteza Khashehchi, Ashwani Kumar, Abhishek Kumar, and Avinash Kumar
8 Animal Tribology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 217
Reetu Gour, Nikki Baliyan, Ayushi Pal, Ashwani Kumar, Avinash Kumar, and Abhishek Kumar
9 Medical Devices Tribology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 235
Nipun Jain, Yusuf Olatunji Waidi, Saswat Chowdhury, Ranjit Barua, Samir Das, Arbind Prasad, and Sudipto Datta
10 Composites for Drug-Eluting Devices: Emerging Biomedical
Applications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 251
Ashish Kumar Gupta, Amit Choudhari, Abhishek Kumar, Avinash Kumar, Anamika Gupta, Sakib Faisal, and Ashwani Kumar
11 Biological Smart Biomaterials: Materials for Biomedical
Applications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 313
Saswat Chowdhury, Nipun Jain, Yusuf Olatunji Waidi, Ranjit Barua, Samir Das, Arbind Prasad, and Sudipto Datta
12 Bioresorbable Composite for Orthopedics and Drug Delivery
Applications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 327
Arbind Prasad, Sudipto Datta, Sriparna De, Pavitra Singh, and Bidyanand Mahto
13 Wear and Friction Mechanism Study in Knee and Hip
Rehabilitation: A Comprehensive Review . . . . . . . . . . . . . . . . . . . . . . 345
Amit Choudhari, Ashish Kumar Gupta, Abhishek Kumar, Avinash Kumar, Ashutosh Gupta, Nusrat Chowdhury, and Ashwani Kumar
14 Challenges and Perspective of Manufacturing Techniques
in Biomedical Applications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 433
Yusuf Olatunji Waidi, Nipun Jain, Saswat Chowdhury, Ranjit Barua, Samir Das, Arbind Prasad, and Sudipto Datta
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 447

Contributors

Ajay Agarwal RIMS Group, Indian Institute of Technology (I.I.T), Jodhpur,
Rajasthan, India
Department of Electrical Engineering, Indian Institute of Technology (I.I.T), Jodhpur, Rajasthan, India
MansiAgarwal Department of Bioscience and Bioengineering, Indian Institute of
Technology (I.I.T), Jodhpur, Rajasthan, India
NikkiBaliyan Chaudhary Charan Singh University, Meerut, Uttar Pradesh, India
RanjitBarua Centre for Healthcare Science and Technology, Indian Institute of
Engineering Science and Technology, Howrah, West Bengal, India
Ankita Chakraborty Integrative Biochemistry and Immunology Laboratory
(IBIL), Department of Animal Science, Kazi Nazrul University, Asansol, West Bengal, India
MoytreyChatterjee Department of Life Sciences, Presidency University, Kolkata,
West Bengal, India
AmitChoudhari Mechanical Engineering Department, Cleveland State University,
Cleveland, OH, USA
NusratChowdhury University of Illinois Urbana-Champaign, Urbana, IL, USA
SaswatChowdhury Department of Bioengineering, Indian Institute of Science,
Bangalore, Karnataka, India
SamirDas Biomaterials and Tissue Engineering Lab, School of Medical Science
and Technology Indian Institute of Technology, Kharagpur, West Bengal, India
SudiptoDatta Department of Materials Engineering, Indian Institute of Science,
Bangalore, Karnataka, India
Sriparna De Department of Allied Health Sciences, Brainware University,
Kolkata, West Bengal, India
xv
xvi
Contributors
Abhijit Dey Integrative and Immunology Laboratory (IBIL), Department of
Animal Science, Kazi Nazrul University, Asansol, West Bengal, India
SakibFaisal South Dakota State University, Brookings, SD, USA
Pradipta Gajjar Department of Mechanical Engineering, Indian Institute of
Information Technology Design and Manufacturing (IIITDM) Kancheepuram, Chennai, Tamil Nadu, India
Reetu Gour Department of Microbiology, IIMT University, Meerut, Uttar
Pradesh, India
KavithaSharanappaGudadur Department of Mechanical Engineering, Indian
Institute of Information Technology Design and Manufacturing (IIITDM) Kancheepuram, Chennai, Tamil Nadu, India
Anamika Gupta Department of General Surgery, Ganesh Shankar Vidyarthi
Memorial Medical College, Kanpur, Uttar Pradesh, India
Ashish Kumar Gupta School of Mechanical and Aerospace Engineering,
Oklahoma State University, Stillwater, OK, USA
Ashutosh Gupta Department of Zoology, Dayanand Vedic College, Orai, Uttar
Pradesh, India
Milad Heidari Mechanical Engineering Department, Global College of
Engineering and Technology, Muscat, Oman
PrabhuduttaHota Department of Biotechnology, National Institute of Technology
(N.I.T), Rourkela, Odisha, India
Nipun Jain Department of Materials Engineering, Indian Institute of Science,
Bangalore, Karnataka, India
Morteza Khashehchi Mechanical Engineering Department, Global College of
Engineering and Technology, Muscat, Oman
Abhishek Kumar J. Mike Walker ’66 Department of Mechanical Engineering,
Texas A&M University, College Station, TX, USA
Department of Mechanical Engineering, University of California, Merced, Merced, CA, USA
Ashwani Kumar Department of Mechanical Engineering, Technical Education
Department Uttar Pradesh (under Government of Uttar Pradesh), Kanpur, Uttar Pradesh, India
Avinash Kumar Department of Mechanical Engineering, Stanford University,
Stanford, CA, USA
Department of Mechanical Engineering, Indian Institute of Information Technology Design & Manufacturing (IIITDM), Kancheepuram, Chennai, Tamil Nadu, India
Contributors
xvii
BeautyKumari Department of Bioscience and Bioengineering, Indian Institute of
Technology (I.I.T), Jodhpur, Rajasthan, India
BidyanandMahto Government Engineering College, Vaishali (Under Department
of Science, Technology and Technical Education, Government of Bihar), Vaishali, Bihar, India
SaubhikMitra Department of Health and Family Welfare, Government of West
Bengal, Santipur Block, Nadia, West Bengal, India
Suprabhat Mukherjee Integrative Biochemistry and Immunology Laboratory
(IBIL), Department of Animal Science, Kazi Nazrul University, Asansol, West Bengal, India
Ayushi Pal Department of Microbiology, IIMT University, Meerut, Uttar
Pradesh, India
Debasish Panda RIMS Group, Indian Institute of Technology (I.I.T), Jodhpur,
Rajasthan, India
Department of Electrical Engineering, Indian Institute of Technology (I.I.T), Jodhpur, Rajasthan, India
Department of Biomedical Engineering, All Indian Institute of Medical Science (AIIMS), Jodhpur, Rajasthan, India
Arbind Prasad Mechanical Engineering Department, Katihar Engineering
College (Under Department of Science, Technology and Technical Education, Government of Bihar), Katihar, Bihar, India
PooyanRahmanivahid Mechanical Engineering Department, Global College of
Engineering and Technology, Muscat, Oman
PavitraSingh Foundry Technology, National Institute of Advanced Manufacturing
Technology (NIAMT), Hatia, Ranchi, Jharkhand, India
SivasakthivelThangavel Mechanical Engineering Department, Global College of
Engineering and Technology, Muscat, Oman
Yusuf Olatunji Waidi Department of Materials Engineering, Indian Institute of
Science, Bangalore, Karnataka, India

About the Editors

AbhishekKumar is currently working as a graduate assistant (PhD scholar) in the
J. Mike Walker ’66 Department of Mechanical Engineering at Texas A&M University, College Station. He received his MS in Mechanical Engineering (2023) from the University of California Merced, USA; MTech in Design Engineering (2016) from Indian Institute of Technology Delhi, India, in 2016; and Bachelor of Engineering degree (honors) in Mechanical Engineering (2014) from Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal. He has worked as an assistant professor at Jabalpur Engineering College, Jabalpur (2018–2020); Galgotias University, Greater Noida (2017); and Parul University, Vadodara (2016–2017). He was a summer visit­ing researcher at Indian Institute of Technology Kanpur (2018). He qualied GATE-2014 with 99.25 percentile in 2014 and was awarded GATE fellowship by the Government of India. His MTech thesis was based on the investigation of nano­wear in Mg-based composites in collaboration with National University of Singapore, Singapore. He has a very keen interest to work on the tribological char­acterization of interacting surfaces. He has experience of more than 8years as an assistant professor and a graduate student researcher to work with tribological sys­tems and their surface and wear characterization. He has gained hands-on experi­ence of working with sophisticated experimental equipment in the past 8.5years and has utilized his experimental skills to successfully complete more than ten research projects with reputed industrial partners such as Chevron Corporation, SpaceX, Chevron- Phillips, Lawrence Livermore National Laboratory, etc. and aca­demic collaborators such as National University of Singapore, Indian Institute of Technology Kanpur, California State University Chico, Illinois State University Normal, etc. He has utilized his exposure to demanding and challenging projects by publishing four peer-reviewed articles in peer-reviewed journals and presenting his work in ve international conferences and publishing articles in two conference proceedings. He has worked as book editor and book proposal reviewer for CRC Press, Taylor & Francis USA, and reviewed two book proposals, edited one book, and authored six book chapters. He has enthusiasm to learn about the advanced research, and he frequently volunteers as a peer- reviewer for more than six high impact journals (Journal of Magnesium and Alloys (IF = 17.6), Lubricants
xix
xx
About the Editors
(IF = 3.584), Journal of Composites Science (IF = 3.3), Tribology Transactions (IF=2.056), Inorganic Chemistry Communications (IF=3.8), and Materials Today: Proceedings (CS= 3.2), and has been recognized as a certied peer reviewer by Elsevier and MDPI.He has been selected as the Outstanding Reviewer twice by the Journal of Magnesium and Alloys (17.6 impact factor) due to his extraordinary con­tributions to the journal. He is also member of several professional societies such as the American Society of Mechanical Engineers (ASME), the Society of Tribologists and Lubrication Engineers (STLE), the American Ceramic Society (ACerS), the Association for Iron and Steel Technology (AIST), the Minerals, Metals and Materials Society (TMS), and ASM International (ASM). His research contribu­tions have been acknowledged by STLE, and he has been selected as the technical editor for Tribology and Lubrication Technology (TLT) magazine by STLE.He is also the recipient of several awards and honors, including 2024 Houston Section Scholarship by STLE.He is currently involved in the research that involves tribol­ogy, mechanical behavior of materials, material characterization, mechanical test­ing, mechanical properties, microstructure, nanomaterials, material characteristics, materials, and materials processing.
AvinashKumar is currently working as an assistant professor in the Department of Mechanical Engineering at the Indian Institute of Information Technology, Design and Manufacturing (IIITD&M), Kancheepuram, Chennai (an institute of national importance under Ministry of Education, Government of India). He is a visiting research professor, Stanford University California, USA.His research inter­ests include micro/nanofabrication, laser machining, surface engineering for micro­udics, and MEMS/micro/bio-devices. He has published more than 14 international journals, 12 chapters, 3 books, and 10 international conference papers. His google scholar ID is eiJdMdoAAAAJ, ORCID ID is 0000-0002-8071-5748, Scopus ID is 56564412000, and Web of Science Researcher ID is P-6124-2018. He is a reviewer in ASME Journal of Solar Energy Engineering, Journal of Engineering Applications
of Computational Fluid Mechanics, ASME Journal of Heat Transfer, Journal of Physics of Fluids, and many more. He worked as a post-doctoral fellow at Indian
Institute of Technology Kanpur until 2019. His post-PhD research experience includes early post-doctoral fellow in the Department of Mechanical Engineering, Indian Institute of Technology Delhi. He also worked as an assistant professor (TEQIP faculty) in a World Bank and MHRD-(Government of India) project (NPIU) for a semester (2018) at THDC- Institute of Hydropower Engineering and Technology Tehri (Uttarakhand). He obtained his PhD from the Department of Mechanical Engineering, Indian Institute of Technology, Delhi, in 2018. He received his Bachelor of Engineering in Mechanical Engineering from Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal in 2010 and M.Tech degree in Mechanical Engineering from Indian Institute of Technology Kanpur, India, in 2012. He was a research asso­ciate at the Bio-MEMS and Micro-uidics Laboratory, Indian Institute of Technology Kanpur, India, from August 2012 to November 2012. He worked as research associ­ate with Prof. G. K. Ananthsuresh and Prof. Ashitava Ghoshal in Robert Bosch Centre for Cyber Physical system, Mechanical Engineering Department, Indian
About the Editors
xxi
Institute of Science, Bangalore, for a year (2013). He qualied Indian Engineering Services in 2010. He qualify GATE-2010 with 98.20% in 2010. His PhD thesis was nominated for Best Thesis Award by the foreign and Indian examiner. He was selected in India–Sri Lanka Youth Exchange Program 2017, organized by the Ministry of Youth Affairs and Sports, Government of India. He was awarded DST­International Travel Fellowship in 2018 to visit Hawaii, USA.He is currently work­ing on the various research projects by CSIR and DST- GOI.He has coordinated and organized many conferences and workshops at IIITDM Kanchipuram- Chennai, IIT Delhi, IIT Kanpur, and AIIMS Delhi. He has delivered many talks in webinars, faculty development programs, and workshops in the institutes such as (a) BS Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, in asso­ciation with Tamilnadu State Council for Science and Technology, Chennai; (b) Sathyabama Institute of Science and Technology, Chennai; and (c) SRM University Chennai and VIT Chennai. He have examined many MTech. and PhD students at SRM University Chennai. He have guided more than 10 BTech, MTech, and PhD students for their thesis.
Ashwani Kumar earned his PhD in Mechanical Engineering, specializing in mechanical vibration and design. Currently, he is serving as a senior lecturer in Mechanical Engineering (Gazetted Ofcer Group B) at the Technical Education Department, Uttar Pradesh (under the Government of Uttar Pradesh) in Kanpur, India, since December 2013. Prior to this, he held the position of assistant professor in the Department of Mechanical Engineering at Graphic Era University, Dehradun, India (NIRF Ranking 55), from July 2010 to November 2013. With over 13years of extensive experience in research, academics, and administration, Dr. Kumar has taken on various roles, including coordinator for AICTE-Extension of Approval, nodal ofcer for PMKVY-TI Scheme (Government of India), internal coordinator for CDTP scheme (Government of Uttar Pradesh), industry academia relation of­cer, assistant centre superintendent (ACS) in the Institute Examination Cell, and zonal ofcer to conduct Joint Entrance Examination (JEE-Diploma), among others. As an esteemed academician and researcher, Dr. Kumar serves as the series editor for ve book series published by CRC Press (Taylor & Francis USA) and Wiley Scrivener Publishing, covering topics such as advances in manufacturing, design, computational intelligence techniques, renewable and sustainable energy develop­ments, smart innovations and technological advancements in mechanical and mate­rials engineering, and solar thermal energy systems. He is also a guest editor for a special issue titled “Sustainable Buildings, Resilient Cities and Infrastructure Systems” in Buildings (ISSN: 2075-5309, I.F. 3.8). Dr. Kumar holds the position of editor-in-chief for the International Journal of Materials and Manufacturing and
Sustainable Technologies (IJMMST, ISSN: 2583-6625) and editor of the International Journal of Energy Resources Applications (IJERA, ISSN: 2583-6617).
Additionally, he is a guest editor and editorial board member for 8 international journals and serves as a review board member for 20 prestigious international jour­nals indexed in SCI/SCIE/Scopus, including Applied Acoustics, Measurement, JESTEC, AJSE, SV-JME, and LAJSS. With a remarkable publication record, Dr.
xxii
About the Editors
Kumar has authored/co-authored and edited over 30 books in mechanical, materi­als, and renewable energy engineering. He has secured three patents and is actively involved in various research areas, including AI and ML in mechanical engineering, smart materials and manufacturing techniques, thermal energy storage, building efciency, renewable energy harvesting, sustainable transportation, and heavy vehi­cle dynamics. Recognized for his outstanding contributions, Dr. Kumar has been awarded as the Best Teacher for excellence in academic and research. He has suc­cessfully guided 15 BTech, MTech, and PhD theses and serves as an external doc­toral committee member at SRM University, New Delhi. Dr. Kumar continues to contribute signicantly to the eld through his participation as an invited speaker, session chair, advisory board member, review board member, and program commit­tee member in various international conferences. His Orcid is 0000-0003-4099-935X, and his research proles can be accessed via Google Scholar (https://scholar.google.
com/citations?hl=en&user=KOILpEkAAAAJ) and ResearchGate (https://www. researchgate.net/prole/Ashwani- Kumar- 45).
Chapter 1
Introduction toBiotribology: AScience ofSurface Interaction
AbhishekKumar , AvinashKumar , AshwaniKumar , AmitChoudhari , AshishKumarGupta , andSakibFaisal
Abstract Biotribology, the fascinating intersection of biology, materials science,
and engineering, delves into these interactions, unraveling the secrets of how bio­logical systems minimize friction, resist wear, and adapt to their environments. This chapter serves as an accessible introduction to the captivating world of biotribology. It embarks on a journey through diverse biological interfaces, exploring the inge­nious mechanisms employed by nature to achieve remarkable tribological feats. From the self-lubricating joints of lobsters to the adhesive prowess of gecko feet, we discover how these marvels inspire the development of novel biomimetic materials and technologies. Delving deeper, we investigate the tribological challenges faced by biological systems, such as biocompatibility, wear resistance, and lubrication under extreme conditions. We explore how these challenges are overcome through tailored surface structures, material properties, and ingenious biological uids. The chapter then highlights the burgeoning eld of bioinspired tribology, where insights from nature are harnessed to design innovative solutions for human applications. We delve into exciting areas like biomimetic implants, self-cleaning surfaces, and drag-reducing coatings, showcasing the immense potential of biotribology to revo­lutionize various elds. Finally, we ponder the future of biotribology, outlining cur­rent research frontiers and emerging trends. This chapter paves the way for further exploration, inviting readers to join the captivating quest to understand and harness the power of surface interactions in the biological world.
Keywords Biotribology · Surface interaction · Biomimetics · Bioinspiration · Lubrication · Wear · Biomaterials · Biointerfaces · Engineering
A. Kumar (*) J.Mike Walker ’66 Department of Mechanical Engineering, Texas A&M University, College Station, TX, USA
Department of Mechanical Engineering, University of California, Merced, Merced, CA, USA e-mail: akumar71@tamu.edu
A. Kumar et al. (eds.), Applications of Biotribology in Biomedical Systems,
https://doi.org/10.1007/978-3-031-58327-8_1
1© The Author(s), under exclusive license to Springer Nature Switzerland AG 2024