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Fig. 5.98 Proper layer of ller injection for perioral wrinkles correction is a supercial layer (deep dermis or subdermal layer) / (with kind permission of MANIAMIND)
5 Filler Procedures Based ontheFacial Area
lling the volume may look bumpy and awkward, so care should be taken to ensure the wrinkles are only slightly attened and made to look natural.
A needle is generally used more than a can­nula as an injection tool. Anesthesia before nee­dle injection is sufcient with topical anesthesia. Inject a soft ller with low viscosity into the sub­dermal layer or deep dermis (Fig.5.98).
There are several techniques for the injection method such as the retrograde serial threading technique, retrograde fanning technique, Mantoux test injection technique, and droplet technique (see Sect. 4.4.1 injection technique).
Treatment of Smoker’s Line
In the treatment of smoker’s lines, the injection depth is subdermal or intradermal. Inject a soft HA ller with low viscosity using 30G/31G nee­dles along the vermillion border of the upper and lower lip. Unlike lip augmentation, this does not require a large amount of ller. Conversely, a large amount injected along the vermillion border can lead to irregularities.
Treatment of smoker’s line requires combina­tion with toxin. Toxin can be used to weaken orbicularis oris muscles so that the skin is less folded and wrinkles less obvious, and the effect of ller treatment can be maximized. Toxin is injected 0.5units at approximately 1cm intervals along the vermillion border. If toxin injection is too much, orbicularis oris muscles may be exces-
sively relaxed, making it difcult to close the mouth, and saliva may leak out when brushing the teeth.
5.3.3.3 Precautions/Side Eects
Vascular Complication: Bruising
Bruising is caused by subdermal plexus injury when a subdermal needle is injected to treat wrin­kles around the mouth. Bleeding or bruising from capillary injury may occur, but there is little chance of injury to the facial artery and facial vein. However, there is a supercial course of the facial artery between the zygomaticus major and the risorius muscle outside the orbicularis oris muscle. In other words, the facial artery may reach the tissue below the skin at the area 1.5cm lateral of the oral commissure where the facial artery gives off the superior labial artery branch. If you palpate this area, you will feel an arterial pulse, and sometimes the pulsation is visible to the naked eye. Therefore, when injecting ller into the wrinkles around the oral commissure, the artery must be checked, and it is better to avoid the procedure in the subcutaneous fat layer (Fig.5.99).
Lump/Irregularity
Care should be taken when injecting too super­cially into the dermis, as a lump may occur. After injecting the ller, use a teaspoon or roller to massage sufciently to prevent lumps. In addition, it is helpful to prevent a lump or irregu-
5.3 Lower Face
a
b
Fig. 5.99 Cautions for vascular complication during perioral wrinkles correction. (a) Blue dotted circle: super­cial winding of the facial artery (with kind permission of MANIAMIND). (b) Rea dotted circle: pulsation of the facial artery is sometimes visible without palpation
larity by dividing the procedure into multiple ses­sions with small amounts injected rather than completing the procedure in one single session.
189
Fig. 5.100 Inverted S-line from lower lip to chin
to the chin look beautiful as an inverted-S line (Fig.5.100). In the lateral view, the chin should look beautiful just on the Ricketts line. The Ricketts line is the line from the nasal tip to the chin tip in the lateral view. In Korea, it is consid­ered that the upper and lower lip margins should be located on this line or 1–2mm behind the line to look harmonious. Correcting the chin with a ller to coincide with this line can harmonize the overall lateral contour (see Sect. 4.4.1).
• When correction is needed in the frontal view
5.3.4 Chin Augmentation andJaw
Line Contouring
If the chin is not fully developed or if the teeth are protruding, chin augmentation can produce excellent results. In the past, silicone implants were widely used, but nowadays, the ller has become a substitute for this. Since the chin is not complicated in structure, side effects are rare and even beginners can easily try.
5.3.4.1 Design
Western patients prefer treatments to make the mandibular angle and jaw lines look more distinct or to smoothen an uneven jawline. On the other hand, many Koreans (Asians) have short chins or retracted chins and prefer to correct them.
• When correction is needed in the lateral view
When the contour of the forehead-nose-chin is viewed in oblique views, the curves from the lips
On the frontal view, if the chin looks short or wide, one can make the chin slightly sharper or longer to make the jawline look slimmer.
Make the length from philtrum to chin about 1/3 of the total face length. In the West, the ratio of forehead to nose to chin is preferably 1:1:1, and in the East, the ratio 1:1:0.8 is preferred.
To summarize, to make a beautiful chin, the retracted chin is augmented to project slightly anteriorly and a short chin is augmented to elon­gate slightly downward (Fig.5.101).
However, in actual clinical practice, there are more important design principles to consider. Even if llers are injected into the chin to create an ideal prole based on the Ricketts line, the result must also be aesthetically pleasing from the frontal view. For individuals with smaller chins, particularly among Asians, elongating the chin to align with the Ricketts line can result in an overly prominent appearance when viewed from the front, leading to a very unnatural look. This type of unnatural appearance is quite common with
190
5 Filler Procedures Based ontheFacial Area
ller procedures. Therefore, the Ricketts line should be regarded merely as a reference, not an absolute guideline. It is more crucial to create a natural chin line when viewed from the front. If there is a discrepancy between the natural appear­ance of the chin line from the front and the ideal chin line according to the Ricketts line from the side, achieving a natural appearance from the frontal view is far more desirable.
5.3.4.2 Anatomy
The layers around the chin and jaw are divided into skin-subcutaneous tissue (supercial fat) and muscle-deep fat-bone (mental protuberance and mandibular body). At the tip of the chin, there is thin layer of deep fat under the muscle layer. In chin augmentation and jaw contouring, the injec­tion layer should be the supraperiosteum and subcutaneous fat.
Mentalis Muscle (Fig.5.102)
Asians tend to have a “cobble-stone” appearance due to the development of the mentalis muscles due to their oral structure. Fillers may not be suf­cient to correct the volume in an aesthetically pleasing manner. Combining with toxin treat­ment into the mentalis muscles has the advantage of smoothening the skin dimples and maintaining the corrected shape longer.
In addition to the chin shape, the mentalis muscle asymmetry must be checked before the procedure. When ller correction is satisfactory, but asymmetric muscle correction is not done properly, the physician may encounter com­plaints after the procedure.
Vasculature/Artery
Blood vessels around the chin include the mental artery from the mental foramen and the inferior labial artery. For midline injections, the blood vessels are located outside the treatment area, making the procedure relatively safe. The central branch of the submental artery can sometimes run into the midline, but due to its small diameter, the injection tool is unlikely to be inserted into the vessel. Also, since supercial fat is abundant, there is less risk of skin necrosis by extravascular compression.
5.3.4.3 Choice ofFiller
Chin augmentation and jaw line contouring can
Fig. 5.101 Aesthetic lines—Ricketts line
a
Fig. 5.102 Injection layer for chin augmentation. (a) Filler is injected into the supraperiosteum level. (b) Filler can be
additionally injected in the subcutaneous layer
be injected at two different depths and using dif-
b
5.3 Lower Face
ferent llers selected accordingly. Use HA or CaHA llers which have high viscoelasticity and good shape when injected into the deep layer. Inject a medium viscosity ller into the super­cial layer.
5.3.4.4 Injection Technique forChin Augmentation
Check with the patient whether to project the jaw forward or elongate downward before the procedure.
In addition, the hypertrophy of mentalis mus­cle needs to be checked along with the asymme­try of the chin.
In the case of chin augmentation, most of the procedure can be performed without any major discomfort by just applying topical anesthetic agent or inject local anesthesia at the entry point. However, pain-sensitive patients need to be anes­thetized through a mental nerve block.
Needle Injection (Fig.5.103a)
In general, needles are more frequently used than cannulas for chin augmentation. Use a needle with 25/27G to inject high viscoelastic llers. Since there is little risk of vascular accident, it can be performed relatively safely. Inject the nee­dle vertically in the midline, touch the bone, retract slightly, and inject the ller. In other words, inject into the supraperiosteum level below the muscle layer. Inject using the bolus technique and adjust the bevel direction of the needle in the cephalic direction when projecting and in the caudal direction when elongating. If deep injection alone does not provide satisfactory correction, additional medium viscoelastic ller can be injected into the supercial fat layer over the muscle layer.
Cannula Injection (Fig.5.103b)
It is better to use a cannula for evenly spreading over a wider range. Using retrograde fanning techniques, a cannula with 21/23G can be used to inject into the supraperiosteum layers and subcu­taneous layers.
The entry point can be made on the midline or on both sides of the midline.
191
Fig. 5.103 Entry point for chin augmentation. (a) Entry point for needle injection, (b) entry point for cannula injection
Fig. 5.104 Toxin injection points in the mentalis muscle
Inject the cannula deep until it touches the bone, retract slightly, and inject it into the supra­periosteum layer below the muscle.
Immediately after the chin augmentation pro­cedure, it may appear to be uniformly injected due to the edema, but if you carefully palpate, you may feel the uneven areas. In such a case, massage with your hands and inject additional llers into areas with irregularities or depressions so that you can maintain a smooth shape without bumps after edema is resolved.
Botulinum Toxin Injection into the Mentalis Muscle (Fig.5.104)
Many patients undergoing chin augmentation due to their micrognathia have mentalis muscle hypertrophy resulting in skin dimpling. Injecting
192
5 Filler Procedures Based ontheFacial Area
toxin in the mentalis muscle not only eliminates dimples but also relaxes the tension of the mus­cles so that the corrected shape maintains longer after ller injection below the muscles.
Inject into the muscle at points 0.5cm lateral of the midline of the chin, two-third the distance between the vermillion border of lower lip and the end of the chin. The proper injection layer is when the needle is slightly retracted after it touches the bone. Inject botulinum toxin 2–4U per side.
Patients with severe cobble stone appearance can obtain satisfactory results with botulinum toxin pretreatment.
If the left and right muscles are not symmetri­cally corrected after the rst procedure, a second touch-up procedure will be needed.
5.3.4.5 Injection Technique forJaw
Line Contouring
Jaw line contouring can be performed for both old and young patients. In older patients, sagging produces a pre-jowl sulcus, and the jaw line is not smooth, so ller correction is necessary. In young patients, the jawline may be depressed on both sides of the chin after chin augmentation. It occurs at the boundary of the chin (mental protu­berance) and mandible body, which requires additional jaw line contouring after chin augmentation.
Needle Injection (Fig.5.105)
Insert a 25/27G needle vertically or obliquely into the boundary of the chin and mandible body. Penetrate into the depressor anguli oris muscle and platysma muscle, an then inject into the supraperiosteum level.
Cannula Injection (Fig.5.106)
When injecting with a cannula, two entry points can be created. The rst is to make an entry point medial to the boundary of the chin and mandible body and then insert the cannula toward the mandible body. The second is to make an entry point below the anterior border of the masseter muscle and then insert the cannula toward the chin. At this time, spe­cial care is needed not to damage the facial artery when creating the entry point with the needle.
A 5cm cannula with 21/23G can be injected into both the supraperiosteum level and subcutane­ous fat layer. Subcutaneous fat of the mandibular body is thinner than that of the chin. The mandibu­lar ligament is attached to the skin and holds the skin rmly, so it may not be smooth when entering with the cannula. Slowly insert the cannula while touching the bone and inject ller using the retro­grade linear technique. When injecting into the subcutaneous layer, retract the tool without remov­ing from the entry point then advance it into the subcutaneous layer for injection.
a
Fig. 5.105 Jawline contouring—needle injection. (a) Needle penetrate into the depressor anguli oris muscle and pla- tysma muscle. (b) Filler is injected into the supraperiosteum level
b
5.3 Lower Face
193
a
Fig. 5.106 Jawline contouring—cannula injection. (a)
Two entry points for cannula insertion. The rst entry point is made medial to the boundary of the chin and man­dible body, and then the cannula is inserted toward the mandible body. The second entry point is made below the
b
c
anterior border of the masseter muscle, and then the can­nula is inserted toward the chin. (b) Filler is injected into the supraperiosteum level. (c) Filler can be additionally injected in the subcutaneous layer
Combination with Toxin (Jaw Line Lifting- Nefertiti Lift) (Fig.5.107)
By paralyzing and releasing the platysma muscle along the jaw line, it can improve the sagging jaw.
Injecting too shallowly will not be effective. Therefore, it should be injected deeper than the subcutaneous layer. Intradermal and subdermal injections are all possible. The dose is about 10–15U per side, divided into multiple points on the jawline at 1.0–1.5cm intervals.
5.3.4.6 Precaution/Side Eect
Vascular Complication
• Chin augmentation procedures are relatively
safe from vascular complications.
• Be careful not to damage the facial artery
when injecting into the subcutaneous layer
during jaw line contouring.
Fig. 5.107 Jawline lifting using botulinum toxin­Nefertiti lift. Blue dots, toxin injection points
Nodule/Depression
• When the amount of subcutaneous fat is too small or the skin is thin during chin augmenta­tion, a nodule may occur after subcutaneous
194
5 Filler Procedures Based ontheFacial Area
injection. Therefore, it is recommended to rst inject at the supraperiosteum level if possible and to inject into the subcutaneous layer in small amounts only when necessary.
• After the chin augmentation, the jawline may be depressed at the boundary of the chin and the mandible body. Additional ller injection for the jawline contouring can be performed to create a harmonious jawline.
Migration
• During chin augmentation, special attention is needed as it may enter the oral cavity rather than the mental protuberance when the injec­tion is too close to the lower lip.
• When elongating the chin downward, if the injection direction is too downward or amount is too much, the ller may migrate toward the platysma muscle. Since the ller can move downward along the plane of the platysma muscle, direct the injection tool above the tip of the chin, and use your thumb and index n­ger of the opposite hand to prevent the ller from migrating.

5.4 Skin Booster Procedures

Rather than aiming to add volume to a specic area, skin booster procedures are primarily intended to introduce llers throughout the facial skin to improve overall skin quality. Unlike tradi­tional llers that focus on volumization, skin boosters are designed to rejuvenate the skin by delivering various substances through microin­jections. These substances may include PDRN (polydeoxyribonucleotide), PRP, EGF, and other growth factors, all of which serve as skin boost­ers. In this chapter, we will focus specically on the llers used for skin boosters.
Skin boosters are commonly injected into the
dermal layer, where they are slowly absorbed and effectively hydrate the skin over time, enhancing its texture and elasticity. By retaining moisture, the skin appears rmer and more luminous.
Recent advancements in drug delivery techniques have allowed for more effective and even distri­bution of these substances, leading to sustained skin improvement.
There are various forms of skin boosters, some of which use a polymer matrix to gradually release active ingredients over time. For example, free hyaluronic acid (HA) can be used to deeply hydrate and improve skin tone. However, due to its fast absorption, HA may not provide long- lasting effects, necessitating repeated treat­ments. To address this, more advanced products have been developed that release HA gradually or combine it with other substances for sustained results. This technique is particularly useful for patients with early signs of aging who seek mini­mal downtime.
For rmer, longer-lasting results, other bios­timulatory materials like PLA (poly L-lactic acid) are often used. PLA, introduced under the brand name Sculptra in 2004 and approved by the FDA, has gained popularity as a ller for colla­gen stimulation. By triggering the body’s natural collagen production, PLA treatments provide gradual and long-lasting improvements in skin texture and elasticity.
PLA may be mixed with other components to further enhance its effectiveness. Some formula­tions include additives such as H2O2, which enhance the efcacy of the treatment by facilitat­ing deeper penetration and reducing inamma­tion. In recent years, other biocompatible and biostimulatory materials like PLLA (poly L-lactic acid) and PCL (polycaprolactone) have been introduced. These substances not only stimulate collagen production but also provide long-lasting volumization and are used frequently in modern skin booster procedures.
These advancements in skin booster treat­ments have made them a popular choice for patients looking to improve skin quality without signicant downtime. The gradual, natural­looking results have broadened the appeal of these procedures among patients seeking subtle and effective skin rejuvenation.
5.4 Skin Booster Procedures
195

5.4.1 Manual Injection Techniques

When injecting hyaluronic acid llers manually, a ne needle (typically 30–34G) is used to intro­duce the ller into the supercial dermis. To apply llers across the entire face, injections are typically administered at intervals of approxi­mately 1.5–2cm. Cannulas, such as those used for procedures requiring deeper injection (e.g., mesotherapy), are generally avoided in favor of needles, which allow for greater control and pre­cision. This method utilizes the smallest possible amount of ller in each entry point, which facili­tates even distribution across the facial area.
For areas that require delicate handling, nee­dles no longer than 5 mm are recommended. Shorter needles are preferable, especially when injecting into the supercial dermal layer, as they minimize the risk of tissue trauma and allow for precise ller placement. Injectors should employ a variety of techniques, including adjusting the angle of entry and needle depth based on the patient’s specic skin condition. For instance, needles may be inserted at a 45° angle in certain areas to avoid vascular complications and achieve uniform distribution of the ller.
Due to the manual nature of this procedure, there are multiple injection techniques available, each suited to specic areas of the face and levels of patient sensitivity. Each injector has a pre­ferred technique, though the ultimate goal is to achieve an even and natural appearance across the treated area. For certain procedures that require high precision, injecting in a multilayered or fan-like pattern ensures that the ller disperses evenly without creating lumps or irregularities.
One major consideration is the patient’s facial symmetry. While llers should be injected evenly, injectors must also account for each patient’s unique anatomical structure. Special attention should be paid to areas that are more prone to asymmetry or volume loss to achieve a balanced appearance. Furthermore, due to the risk of over­correction in some areas, injectors should gradu­ally build up volume, especially in sensitive or delicate zones, to avoid an unnatural result.
Fillers not based on hyaluronic acid, such as those containing PLLA (poly L-lactic acid), require a different approach. Due to PLLA’s unique biostimulatory properties, they should be injected at a deeper level, targeting areas with substantial collagen loss. Additionally, PLLA llers may cause transient swelling, so patients should be informed about the expected recovery process.
By tailoring the injection technique to the spe­cic ller type and treatment area, practitioners can provide patients with more natural, long­lasting results and reduce the risk of adverse effects.
5.4.2 Automated Injection
Techniques
Automated injection devices typically use a method where a needle tip is placed close to the skin, and the device rhythmically injects the ller into the dermis. Among the most commonly used devices for automated injection is the dermal injector. This device allows for consistent, con­trolled doses in multiple points across the skin. Some devices are equipped with multiple nee­dles, allowing for several tiny punctures in a sin­gle application, thereby enabling a broad distribution of the ller. Automated devices typi­cally use a 34G needle, which is small enough to minimize discomfort while ensuring precise ller placement.
These devices can deliver up to 720 injections per minute, making them highly efcient for skin booster procedures. The fast, repetitive injections effectively enhance skin hydration and elasticity, producing an overall rejuvenating effect. While these devices provide reliable results for skin boosters and similar treatments, care must be taken when using automated devices on patients with sensitive skin or specic needs.
The use of automated injectors also requires a thorough understanding of skin anatomy to avoid potential risks. For instance, if the needle pene­trates too deeply or at an incorrect angle, there is
196
5 Filler Procedures Based ontheFacial Area
a risk of tissue trauma or irregular ller distribu­tion. Furthermore, automated devices should only be handled by trained professionals, as incorrect usage can lead to overcorrection or inadequate results. It is especially important to avoid areas where ller accumulation could lead to lumps or unevenness.
In addition to standard dermal injectors, devices such as mesotherapy guns with pneu­matic gas systems are also frequently used. These tools are advantageous for treatments requiring rapid, uniform application across a wide area. They are often employed with substances like PDLA (poly D, L-lactic acid) or PDRN (poly­deoxyribonucleotide) in rejuvenating procedures, allowing for enhanced control and precision.
By selecting the appropriate device and tech­nique, practitioners can achieve consistent, safe, and effective outcomes, even with automated ller injections.

Further Reading

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3. Hetzler L, etal. The brow and forehead in periocu­lar rejuvenation. Facial Plast Surg Clin North Am. 2010;18:375–84.
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6. Yoo DB, et al. Effacing the orbitoglabellar groove with transposed upper eyelid fat. Ophthalmic Plast Reconstr Surg. 2013;29:220–4.
7. Goldberg RA, et al. Eyelid anatomy revisited. Dynamic high-resolution magnetic resonance images of Whitnall’s ligament and upper eyelid structures with the use of a surface coil. Arch Ophthalmol. 1992;110:1598–600.
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18. Mendelson BC, etal. Surgical anatomy of the mid­cheek: facial layers, spaces, and the mid cheek seg­ments. Clin Plastic Surg. 2008;35:395.
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21. Zhang HM, etal. Anatomical structure of the buccal fat pad and its clinical adaptations. Plast Reconstr Surg. 2002;109:2509–18: discussion 2519.
22. Pessa JE, Rohrich RJ.The cheek. In: Facial topogra­phy: clinical anatomy of the face. St. Louis: Quality Medical Publishing; 2012. p.47–93.
23. Pessa JE, etal. Concertina effect and facial aging: nonlinear aspects of youthfulness and skeletal remod­eling, and why, perhaps, infants have jowls. Plast Reconstr Surg. 1999;103:635–44.
24. Pilsl U, et al. Anatomy of the cheek: implications for soft tissue augmentation. Dermatologic Surg. 2012;38:1254–62.
25. Swanson E. Malar augmentation assessed by magnetic resonance imaging in patients after face lift and fat injection. Plast Reconstr Surg. 2011;127:2057–65.
26. Gosain AK, et al. A volumetric analysis of soft­tissue changes in the aging midface using high­resolution MRI: Implications for facial rejuvenation. Plast Reconstr Surg. 2005;115:1143–52: discussion 1153–5.
27. Mendelson BC, etal. Surgical anatomy of the mid­cheek and malar mounds. Plast Reconstr Surg. 2002;110:885–96: discussion 897.
28. Wang W, etal. Facial contouring by targeted restora­tion of facial fat compartment volume: the midface. Plast Reconstr Surg. 2017;139:563.
29. Wan D, et al. The differing adipocyte morpholo­gies of deep versus supercial midfacial compart­ments: a cadaveric study. Plast Reconstr Surg. 2013;133:615e–25e.
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31. Pessa JE, etal. The malar septum: the anatomic basis of malar mounds and malar edema. Aesthet Surg J. 1997;17:11–7.
32. Lin TM, et al. Application of microautologous fat transplantation in the correction of sunken upper eye­lid. Plast Reconstr Surg Glob Open. 2014;2:e259.
33. Liew S. Nonsurgical volumetric upper periorbital rejuvenation: a plastic surgeon’s perspective. Aesth Plast Surg. 2011;35:319.
34. Park SK, etal. Correction of superior sulcus defor­mity with orbital fat anatomic repositioning and fat graft applied to retro-orbicularis oculi fat for Asian eyelids. Aesth Plast Surg. 2011;35:162.
35. Lambros V.Observations on periorbital and midface aging. Plast Reconstr Surg. 2007;120:1367–76: dis­cussion 1377.
36. Rohrich RJ, et al. The anatomy of suborbicularis fat: implications for periorbital rejuvenation. Plast Reconstr Surg. 2009;124:946–51.
37. Surek CK, et al. Deep pyriform space: anatomical clarications and clinical implications. Plast Reconstr Surg. 2016;138:59–64.
38. Zufferey J.Anatomic variations of the nasolabial fold. Plast Reconstr Surg. 1992;89:225–31.
39. Gardetto A, etal. Does a supercial musculoaponeu­rotic system exist in the face and neck? An anatomi­cal study by the tissue plastination technique. Plast Reconstr Surg. 2003;111(2):664–72.
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