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13 Botulinum Toxin Aided Hernia Repair
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novel approach to posterior component separation during complex abdominal wall reconstruc­tion. Am J Surg. 2012;204(5):709–16.
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of giant incisional hernias: a study of 41 patients. Br J Surg. 1990;77(3):306–7.
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sion in abdominal wall restoration following abdominal compartment syndrome. Am Surg. 2002;68(5):491–6.
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24. Rodriguez-Acevedo O, Elstner KE, Jacombs ASW, et al. Preoperative botulinum toxin
a enabling defect closure and laparoscopic repair of complex ventral hernia. Surg Endosc. 2018;32(2):831–9.
25. Farooque F, Jacombs AS, Roussos E, et al. Preoperative abdominal muscle elonga-
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Ibarra R, Bravo-Cuéllar L.Effect of botulinum toxin type a in lateral abdominal wall muscles thickness and length of patients with midline incisional hernia secondary to open abdomen management. Hernia. 2014;18(5):647–52.
27. Elstner KE, Read JW, Jacombs ASW, et al. Single port component separation: endoscopic
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28. Weissler JM, Lanni MA, Tecce MG, Carney MJ, Shubinets V, Fischer JP.Chemical component
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T. Tejirian and L. Yeung

Pneumoperitoneum Aided Hernia Repair

YohannRenard, CheryneHammoutene, andJean-PierrePalot

14.1 Introduction

Most incisional hernias are classied according to the size of the hernia defect, in particular to their width [13] and not by the difculties in reduction of the herni­ated content. However, some of them, 5% in our experience [4], cannot be restored into the abdominal cavity. These giant incisional hernias with loss of domain (IHLD) imply that a proportion of the abdominal content, 20% according to Kingsnorth [5], lls permanently the extraperitoneal hernia sac [6, 7], thereby leading to a “second abdominal cavity” [8] (Fig.14.1).
Recently, a group of expert surgeons has proposed loss of intra-abdominal domain as a common criterion to dene a complex ventral hernia [9]. In case of IHLD, the massive visceral protrusion presents a major therapeutic challenge due to the difculty to restore the volume of the herniated content into the abdomen and complete closure of the abdominal wall myofascial layers [10, 11]. Further, IHLD development is associated with lateral wall shortening and oblique muscle atrophy with decreased extensibility and compliance [12]. The replacement of the viscera within an unyielding and stiff abdominal wall may compromise the perfusion of the intestines, elevate the diaphragm [13] and may lead to subsequent intra-abdominal hypertension [14]. This situation may induce acute pulmonary complications and even a postoperative abdominal compartment syndrome [1517].
14
Y. Renard (*) · C. Hammoutene · J.-P. Palot Department of General, Digestive and Endocrine Surgery, Robert-Debre University Hospital, University of Reims Champagne-Ardenne, Reims, France
© Springer Nature Switzerland AG 2019 K. A. LeBlanc (ed.), Robotic Assisted Hernia Repair,
https://doi.org/10.1007/978-3-030-23025-8_14
243
244
Fig. 14.1 Example of giant incisional hernias with loss of domain (IHLD), leading to a real “sec­ond abdominal cavity”
Y. Renard et al.
14.1.1 Preoperation Treatment Options
Several techniques have been described to increase the abdominal cavity volume [18], including tissue expanders, botulinum toxin, component separation techniques (CST) and progressive preoperative pneumoperitoneum (PPP).
The different component separation techniques (CST) are extensively reported and well described for the surgical treatment of IHLD [1928] and are rapidly becoming the technique of choice in complex ventral hernia repair, even sometimes considered as a standard for the repair of all midline incisional hernias [25, 2931]. The rst technique described was anterior CST, reported by Ramirez etal. [32, 33]. In this technique, the external oblique muscle aponeurosis is sectioned near the semilunar line, allowing advancement of the composite ap of the ipsilateral rectus muscle medially to the midline. More recently, Novitsky etal. [19] described the transversus abdominis release (TAR). This technique consists in an extension of the Rives-Stoppa technique where the transversus abdominis muscle insertion is sec­tioned near the semilunar line, allowing the creation of a plane laterally between the transversus abdominis muscle and the transversalis fascia. The TAR, also called “perforator preserving CST” [29], is a safe alternative to the posterior component separation described by Carbonell et al. [20] where the lateral plane is created between the internal oblique and the transversus abdominis muscle, thus affecting the abdominal perforator nerves and vessels.
14 Pneumoperitoneum Aided Hernia Repair
245
Anterior CST seems more able than the TAR to achieve the objective of closure of the midline since it allows an advancement of the rectus muscle medially up to 10cm in length on both sides [32]. It has also been shown to increase the abdominal cavity volume by an average of 7% [13]. Of note, however, comparable outcomes of TAR and anterior CST have been reported in meta-analysis [30].
Nevertheless, anterior CST requires the lateral dissection of the subcutaneous space, leading to an increased risk devascularized skin aps and impairment of the wound healing process with the subsequent risk of skin necrosis [24]. Further, both the anterior CST and TAR signicantly alter the normal anatomy of the abdominal wall since these methods intentionally disrupt the integrity of the musculofascial components of the abdominal wall [13]. These factors may explain why CST is associated with a rate of wound complications as great as 26–42% and a recurrence rate up to 30% in large series [11, 19, 20, 34].

14.2 Progressive Preoperative Pneumoperitoneum (PPP)

First described in 1947 by Moreno [35], PPP represents an interesting alternative for surgical repair of IHLD without permanent alteration of the musculo-aponeurotic integrity of the abdominal wall [4]. It involves the progressive insufation of the abdominal cavity. Prior to the surgical repair of IHLD.This is undertaken with the purpose of the complete reduction of the hernia content without division of any muscle or its associated aponeuroses, thus achieving a reduction of the post­operative complication rate [4, 18, 36, 37].
Contrary to CST, PPP involves a long preoperative preparation of the patients before IHLD repair, also called “Goni Moreno protocol”. Indeed, we think that the preparation of these patients, including careful pulmonary, cardiac and anesthesio­logic evaluations, as well as appropriate skin preparation, is essential and should be, in fact, as crucial as the operation itself [4, 27, 36].
This technique has been used for a long time by specialized teams [3845] but is still not extensively performed in the majority of hospitals. Nevertheless, special­ized teams have reported good results with acceptable risk rate [4, 11, 36, 44, 46,
47]. Even if their series included limited number of patients [4, 11, 48], they have
recently published objective data. However, no recommendation has been published until now about the indication of PPP, neither the precise protocol nor the method of repair.
14.2.1 Prior Evaluation oftheLoss ofDomain
The indication of PPP is usually based on clinical examination, ie, any incisional hernia that could not be reduced on physical exam [4, 44]. Nevertheless, it is some­times difcult to clinically estimate the exact size of the incisional hernia, due to bowel adhesion or obesity [4]. Preoperative CT measurements of hernia defect sizes and abdominal wall thickness is mandatory for all complex incisional hernia [49].
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Y. Renard et al.
In addition, in case of IHLD, preoperative CT-scan, with valsalva maneuver when­ever possible, allows objective measures of the volume of the incisional hernia. Tanaka etal. [47] were the rst team to report an objective method to calculate the exteriorized volume of the abdominal content on CT-scan. The hernia sac volume (VIH) and the abdominal cavity volume (VAC) were approximated by using their diameter within the three planes of space and using the mathematical formula of an ellipse (4/3×π×r1×r2×r3), considering the shape of the two abdominal compart- ments as elliptic (Fig. 14.2). Using the Archimedes theory in the rat model, the efciency of this method has been validated [50]. The exact VIH and VAC are now routinely calculated directly on CT-scan using volumetric software, as it is per­formed for hepatic volumetry (Fig.14.3). The volume of the peritoneal cavity is calculated as the sum of VAC+VIH.The ratio of the volume of the hernia content was calculated according to the ratio VIH/(VAC+VIH), representing 45% on the specic example in Fig.14.3.
a
b
cde
Fig. 14.2 Method to calculate VIH and VAC according to Tanaka on CT-scan (a, b) from a patient with median IHLD (c, d). VIH=4/3×π×a×b×c. VAC=4/3×π×A×B×C. (e) Result after PPP and surgery
14 Pneumoperitoneum Aided Hernia Repair
aceg
247
b
dfh
ijk
Fig. 14.3 CT volumetric measurements before PPP (a, b: Axial CT slide; c, d: Sagittal CT slice) in a patient presenting with a median giant IHLD (i, j). The VIH was measured at 3820mL.The VAC was measured at 4653mL.The ratio of the exteriorized visceral volume was calculated at 45% in this patient before surgery. CT volumetric measurements after progressive preoperative pneumoperitoneum and before surgery (e, f: Axial CT slide; g, h: Sagittal CT slice). The VAC was measured at 6951mL which represented a mean VAC increase of 49%. (k) Results 6months after surgery
14.2.2 Is There aPercentage ofHerniated Volume fromWhich
aPPP Is Indicated?
This exact determination is not clearly dened. Tanaka et al. [47] suggested that PPP should be performed when the ratio was at least 25%. Kingsnorth etal. [5] considered that a respiratory prehabilitation (smoking cessation, respiratory adapta­tion with intensive respiratory physiotherapy) should be performed in patients with a ratio of 15–20%. However, abdominal volumetry was not performed in the latter study. We consider that a IHLD with an exteriorized ratio of 20% should be pre­pared using PPP since recent prospective studies have shown that an exteriorized volume <20% of the entire peritoneal volume was predictive of a relative
248
Y. Renard et al.
tension- free fascia closure and was associated with less postoperative pulmonary complications [9, 48, 51].
14.2.3 Objectives ofthePPP
PPP has many potential and/or theoretical advantages [4, 18, 36, 37], including:
– The progressive distension of the lateral abdominal wall muscle will enlarge the
abdominal cavity and allow the complete reduction of the herniated content and
subsequent ability to close the defect completely.
– The PPP will cause progressive abdominal hypertension thereby resulting in dia-
phragmatic rehabilitation before surgery to improve ventilatory function. In
other words, this can act as a pre-operative respiratory tolerance test. Some
authors argue that PPP should be contraindicated in patients suffering from car-
diac and pulmonary insufciency without evidence-based data [38, 5255]. In
our experience, this pre-operative test will allow a surgical repair for patients
with high comorbidities, without cardiac or respiratory failure [4].
– The resultant increase in the volume of the abdominal cavity can allow the com-
plete reduction of the herniated organs without alteration of the abdominal wall
(i.e. no CST necessary).
– The consequent pneumatic dissection of visceral adhesions facilitates the
required dissection during the operation.
14.2.4 PPP Protocol
PPP can be either performed by repetitive percutaneous punctures with a Palmer needle under local anesthesia or with a percutaneous catheter implanted into the peritoneal cavity [4, 36, 43, 52, 5658]. The use of a permanent catheter facilitates the entire process until the surgical intervention, but leads to the increased risk of infection of the catheter that may delay the operation for several months if this occurs. Repeated punctures lead to less infection rate but increase the risk of perfo­ration of any of the contents of the abdominal cavity. Mougin published a complica­tion rate of 20% during the PPP procedure [59]. The majority of these were minor events, without difference between the use of a catheter or repetitive puncture. More recently, catheter placement under ultrasound or CT-scan guidance has been described, which may provide better control over localization but requires good, available and motivated radiologists [60].
Each PPP procedure consists in the injection of ambient air into the peritoneal cav­ity through a microporous antibacterial lter after skin disinfection (Fig.14.4ad). A 3-way valve attached to a 60ml syringe is a very effective and accurate method to inltrate the air into the abdominal cavity. The procedure should be repeated every 1–3days for 15–30days. The volume of air injection during each procedure (500– 2000ml) and the duration of the entire procedure will depend upon the volume of the
a
ce
14 Pneumoperitoneum Aided Hernia Repair
249
bd f
Fig. 14.4 PPP procedure using iterative puncture with a palmer needle. (a) Skin disinfection. (b) Local anesthesia. (c) Insertion of the palmer needle. (d) Insufations of the cavity with ambient air. (e) Plain abdominal X-Ray showing the pneumoperitoneum under the diaphragm. (f) From the rst session and until the day of the operation, all patients are equipped with an abdominal belt
VIH [47] and patient tolerance to each instillation. This will be manifested by either scapular or abdominal pain and/or dyspnea which can limit the amount of air and/or result in the need for administration of an analgesic agent [4].
After the initial procedure, a plain abdominal x-ray should be performed to check the presence of a pneumoperitoneum indicated by free air under both hemidia­phragms. (Fig.14.4e). During the PPP and until the day of the operation, all patients should be equipped with an abdominal belt for active respiratory therapy in attempt to tolerate the progressive abdominal hypertension and to increase the respiratory capacity (Fig.14.4f). In case of any dermatologic or septic skin condition, every attempt was made using detergent and antiseptic topical agents to eradicate and prevent further infectious complications. This can oftimes be avoided the use of skin lubricants or creams on the abdominal skin.
The protocol should include prophylactic subcutaneous anticoagulation start­ing at the time of the rst PPP; the prophylactic dose may need to be increased in cases of obesity [4]. The administration of a broad spectrum antibiotic therapy should be evaluated on a case-by-case basis [36]. The rst two or three procedures can be performed during conventional hospitalization to evaluate the initial toler­ance to PPP [42, 61] but the subsequent ones can be performed in a outpatient surgery setting [4].
To the best of our knowledge, there is no consensus published regarding the quantity of air to insufate, nor the length of time for this preparation. Some argue that the PPP should be stopped when excessive abdominal tension is observed [35,
41, 58]. Tanaka etal. insufated the volume equivalent to the VIH calculated on
pre-operative CT-scan [47] whereas Bueno-Lledo etal. insufated three times this
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Y. Renard et al.
volume in consideration that, at least, some of the injected air is partially resorbed [36]. The preparation time varies greatly among the series published, ranging from 4 to 64 days, allowing the nal insufation total volume to range from 1400 to 38,000cc (Table14.1). Future studies are needed to clarify this precise aspect of the method. Regardless, once the selected time or volume has been achieved it is gener­ally recommended that a new CT-scan is performed so that calculations of the new volumetry and hernia size after the procedure can be calculated. This should be done before surgery to verify the signicant and sufcient increase of the VAC [4,
36, 41, 44, 46, 47].
14.2.5 Efficacy ofPPP
As noted above, the pre-operative CT-scan allows calculation of objective data regarding the efcacy of the PPP [4, 36, 44, 46]. Dumont etal. [46] have reported an increase of the length of the right and left anterolateral muscles by an average of 83mm on each side. Most importantly, the efcacy of PPP might be assessed by the increase of the VAC, by comparing pre- and post-PPP CT-scan volumetries, which might also be predictive of the success of the hernia repair. Sabbagh etal. [44, 48] and our team [4] reported an increase of the VAC by 22% and 53% respectively. These objective data may explain that PPP can lead to the spontaneous reduction of the herniated viscera, as shown on the post-PPP CT-scan (Figs.14.3e and 14.5). For comparative purposes, the increase of VAC has also been reported after anterior CST in two series of 19 and 10 patients: the mean increase of VAC was 6% and 10%, respectively, which appears modest compared to PPP results.
Individual and pooled data of the three main studies that reported the volumetric results and efcacy of PPP in patients with giant IHLD are reported in Table14.2 [4, 44, 47].

14.3 Surgical Repair: Minimally Invasive

To the best of our knowledge, no recommendation can be performed to date about the surgical technique. For an incisional hernia repair, the retromuscular sublay pro­cedure (Rives-Stoppa), has been demonstrated by several authors to have a lower recurrence rate (3–7%) and is considered by many to be the gold standard technique [68]. For this reason, we advise this technique for the repair of an IHLD whenever possible [4].
To date, large series reporting minimally invasive approach of IHLD repair has not been published yet. It has been recently shown that transabdominal preperito­neal repair (TAPP), intraperitoneal onlay mesh (IPOM) or posterior CST can be easily accomplished using robotic surgery [69]. Nevertheless, application of laparo­scopic or robotic ventral hernia repair is often limited by hernia morphology [70]. We argue that a minimally invasive repair of IHLD does not allow the complete closure of the defect to be guaranteed. If this cannot be accomplished there will be