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Chapter21
TransanalTotalMesorectal Excision
ChayaShwaartzandPatriciaSylla

INTRODUCTION

In1982,Healdetal.firstdescribedtheconceptoftotalmesorectal excision(TME)andestablishedthistechniqueasthegoldstandardfor thesurgicaltreatmentofmiddleandlowerrectalcancer.Sharpenbloc resectionoftherectumandmesorectum,includinghighligationofthe inferiormesentericartery(IMA),wasshowntosignificantlyreducerates ofpositivecircumferentialresectionmargins(CRMs),leadingtolower riskoflocalrecurrenceandhighercancer-specificsurvival.
Minimallyinvasivesurgeryhasbeenshowntoachieveresultssimilarto thoseofopensurgerywithrespecttooncologicresectionofrectalcancer. Multiplerandomizedcontrolledtrials(RCTs)haveshownthat laparoscopicTMEisassociatedwithsimilarperioperativemorbidity comparedtoopensurgery,withlessbloodloss,rapidintestinalrecovery, shorterhospitalstay,andnocompromiseofoncologicoutcomes.Despite thefailureoftherecentAmericanCollegeofSurgeonsOncologyGroup Z6051andAustralasianLaparoscopicCanceroftheRectumRCTsto demonstratenon-inferiorityoflaparoscopicTMErelativetoopenTME, long-termresultsfromseveralRCTscontinuetosupporttheuseof laparoscopicsurgeryforrectalcancerandshownodifferenceregarding oncologicoutcomes.Nevertheless,relativelyhighconversionratesto opensurgerycontinuetobereported,evenwhenperformedinhigh­volumeexpertcenters.RoboticTMEhasbeentoutedasassociatedwitha shorterlengthofhospitalstay,andbetterrecoveryoutcomeswhen comparedtoopensurgeryinpatientswithlowandmid-rectalcancer.
Laparoscopicandroboticsurgerieshaveimprovedtheapproachtothe pelviswhenperformingTME,andhavebeenvalidatedfromanoncologic standpoint.However,achievingacompleteTMEwithsphincter
preservationandnegativedistalandradialmarginsforlowrectaltumors, whilepreservingautonomicnervesandavoidingconversion,canbe extremelychallenging,eveninthehandsofexperiencedcolorectal surgeons.Theanatomicconfigurationofthedistalrectumintight appositiontotheprostate,sacrum,pelvicplexus,andpuborectalis, especiallythenarrowmalepelvis,complicatesthemaneuveringrequired tocompletesharpmesorectaldissectionandtransecttherectumwell belowtherectaltumorunderdirectvisualization.
Byprovidingdirectandin-lineintraluminalandtransrectalaccessto thelowrectumandmesorectum,atransanalnaturalorificetransluminal endoscopicsurgery(NOTES)approach,firstdescribedinhuman cadaversin2007,wasproposedasanovelminimallyinvasiveapproach toovercometheanatomiclimitationofatransabdominalapproachtothe lowpelvis.Transanalproctectomywithtotalmesorectalexcision(or transanalTME)withlaparoscopicassistance,wherebyTMEis undertakenfroma“bottoms-up”approachunderdirectvisualization providedthroughtransanalendoscopicmultiportplatforms,wasfirst describedinaclinicalcasein2009andhassincebecomeincreasingly adoptedworldwideasanattractivealternativetostandardandminimally invasiveTME.Benefitsofusingatransanalapproachtocompletethe distal-mostdissectionofthemesorectumhadbeenwelldescribedfor rectaltumorslocatedlessthan5cmfromtheanalverge,outofreach fromatransabdominalapproach,andwhensphincterpreservationwas attempted.
Thetransanal-transabdominaltechniquewithintersphincteric resection(ISR)hasevolvedfromthenecessityofresectingpartorallof theinternalanalsphinctermuscleincontinuitywiththedistalrectum andmesorectum,toachievenegativedistalmarginsforlowrectal tumors.Likewise,transanalendoscopicaccessnotonlypermitsearly identificationandtransectionofthedistalrectalmarginwithorwithout ISRbutalsoallowstaTMEtobecarriedoutentirelythroughatransanal endoscopicplatform.Withimprovedvideoscopicvisualizationand exposureachievedwithCO2insufflation,nerve-sparingandcomplete
dissectionofthemesorectalfasciaisgreatlyfacilitated.
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OtherbenefitsprovidedbytaTMEincludethatdistalrectaltransection isperformedtransanally,underdirectvision,anddoesnotrequire laparoscopicstaplers.Anotheradvantageisthattransanalspecimen extraction,whenfeasible,avoidstheneedforspecimenextractionsites andreduceswound-relatedcomplications.Inaddition,taTME proceduresperformedwithatwo-teamapproach,withbothabdominal
andtransanalteamsworkingsimultaneously,mayreduceoperatingtime andintraoperativecomplicationsincludingconversiontoopensurgery.
Overall,despitethedemonstratedbenefitsinpostoperativerecovery providedbytheuseofmulti-andsingle-portlaparoscopyandroboticsfor rectalcancerresection,adoptionandconversionrateshaveplateaued, whichreflectsthetechnicaldifficultiesandthelengthylearningcurve requiredforperformingTMEusingtheseminimallyinvasivetechniques. SinceourfirstreportoftaTMEperformedforamid-rectalcancerusinga transanalendoscopicoperation(TEO)rigidplatform(KarlStorz, Tubingen,Germany)andanearlycaseseriesreportedthefeasibilityof thisapproachforrectalcancer,taTMEadoptionhasbeenfacilitatedby increasedaccesstodisposabletransanalminimallyinvasivesurgery (TAMIS)platformsandsupportedbypreliminarysmallandmid-sized series,confirmingtheproceduralandpreliminaryoncologicsafetyof taTME.Thusfar,thereportedfactorsdrivingtaTMEadoptionhavebeen thehighsuccesswithtaTMEcompletionforlowrectaltumors,with sphincterpreservationandexceedinglylowconversionrates.Inaddition, oncologicresultshavedemonstratedhighratesofcompleteandnear­completeTMEgradeachieved.Webelievethatinthehandsof experiencedoperators,taTMEisbecomingthepreferredapproachfor mid-andlowrectaltumors,particularlyinobesemalepatientsbecause ofthesuperiorexposureprovided,forproceduresthatwouldotherwise betechnicallydifficulttoapproachfromtheabdomen.
TheaimofthischapteristoprovideacomprehensivereviewontaTME forrectalcancer,describetheprocedureindetail,andsummarizethe preliminaryoutcomesofthisprocedurebasedonpublishedresultsfrom thelargesttaTMEseries.
TRANSANALTOTALMESORECTAL EXCISION:TRAININGAND STANDARDIZATIONOFPROCEDURES
ThereisclearconsensusthattaTMEshouldbeperformedby experienced,skilled,andwell-trainedsurgeonswhocanoutgrowthe learningcurveinthemostefficientway.Arecentconsensusofanexpert groupofsurgeonsfromaninternationaltaTMEconferencestatesthat trainingisnecessarybeforesurgeonsundertakethisprocedure. Furthermore,itstronglyrecommendsthatsurgeonsundertakeataTME trainingcoursethatincludesdidacticlectures,mentoredcadaveric dissection,livesurgery,anduneditedvideobeforeclinicalapplication. Ideally,thisapproachshouldbeundertakenbyhigh-volumerectalcancer surgeonswithexpertisenotonlyinlaparoscopicorroboticTMEbutalso intransanalendoscopicmicrosurgery(TEM;RichardWolf,Knittlingen, Germany),TEO,orTAMIS,andfamiliarwithISRtechniquesforverylow rectaltumors.InstitutionscontemplatinginitiatingthetaTMEprogram shoulddemonstratemultidisciplinaryexpertiseinthemanagementof rectalcancerwithtumorboardreviewofallrectalcancers.Evenfor surgeonswithallprerequisiteskillsfortaTME,in-depthprocedural trainingismandatorybeforeclinicalpractice.Inaddition,proctorshipfor thefirstfewclinicalcasesisstronglyrecommended,giventhelackof familiaritywithanatomicallycorrectperinealdissectionplanesfroma perinealendoscopicapproach.Theserecommendationsstemfromthe factthattaTMEprocedurescalluponmasteryofseveralessential technicalcompetencies,namely,laparoscopicsuturingthroughasingle­incisionplatform,transanalendoscopicdissection,and,most importantly,familiaritywiththeperinealanatomyandin-depth understandingoftherelationshipbetweentherectum,analsphincters, prostate,andurethra.
Theporcinemodelhasbeenextensivelyinvestigatedasatraining modelfortransanalcolorectalNOTES.However,becauseofthebony narrowporcinepelvisthatdoesnotallowdissectiontothebottomofthe pelvicfloor,andgiventhelackofatruemesorectum,itwaslargely abandonedasamodelfortaTMEtraining.Freshhumancadavers,onthe otherhand,areanoptimalmodelfortaTMEtraining.Inthelargest cadaverseriesoftransanalNOTEScolorectalresectionsperformedin32 freshmaleandfemalecadavers,ourgroupdemonstratedthatalthough feasibleinafewcadaverswithfavorableanatomy,puretransanaland combinedtransanalandtransgastricNOTEScolorectalresectionswere
limitedbythelackofspecializedinstrumentation,andthatlaparoscopic assistancewasnecessarytocompletetransanalNOTESproceduressafely. Withregardtotheprocedurallearningcurveanticipatedforthese procedures,inthislargecadaverstudyoftransanalNOTEScolorectal resections,asignificantdecreaseintheoperativetimeandincreaseinthe lengthofrectosigmoidcolonmobilizedwasachievedafterperformanceof thefirstfivecases.Althoughnoformalizedlearningcurveanalysishasyet beenperformedfortaTME,severalmid-andlarge-sizedinstitutional serieshavedemonstratedasignificantdecreaseinoperativetimewith experience.In2013,Lacyetal.reportedtheirfirst20casesoftaTME withameanoperatingroom(OR)timeof234minutes.In2015,thesame groupreportedtheirexperiencewith140taTMEcaseswithameanOR timeof166minutes.AlthoughthisdecreaseinORtimemayreflectthe increaseduseofasynchronoustwo-teamapproach,itmayalsoreflectthe impactofthelearningcurveforsurgicalteamsthathavebecome experiencedwithtaTME.
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In2014,Buscagliaetal.presentedanalternativetocadaverandanimal training.TheyintroducedtransanalNOTESsigmoidectomytraining usinganendoscopysimulationmodel.Fourparticipants(twocolorectal surgeonsandtwogastroenterologists)performedsimulatedNOTES sigmoidectomywithabaselinetest,mentoredtrainingsessions,anda non-mentoredsimulatedfinaltesttothefinaltesting.Theyshoweda 42%reductioninoperativetimefromthebaselineperformance.This preliminarydatasuggestthatsimulatorusebeforeperformingthe procedureinanimalorcadavermodelsmayimprovethetrainingprocess.
Inarecentvideomanuscript,Mclemoreetal.proposedarigorous trainingpathwayfortaTME.Thisincludedteamtraininginafresh cadaverthedaybeforethefirstclinicalcasewiththesameoperativeteam consistingofsurgeons,nurses,andoperativestaff.Inaddition,thecase wasproctoredbyanexperiencedtaTMEsurgeon.Theauthorsreiterated thekeyelementsforsuccessfuldevelopmentofataTMEprogram, includingexpertiseinminimallyinvasiveandsphincter-preservingTME, TES,andISRforverylowrectalinvasiveneoplasms.Experiencewiththis firstcasereaffirmedtheimportanceofproceduralteamtrainingin cadavers.
OneofthechallengesoftaTMEhasbeenthelackofstandardizationof thetechnique.Publishedreportsandvideopresentationscontinuously demonstratevariationsinoperativesetupandsequence,dissectionand anastomotictechniques,andinstrumentationthatmayormaynot impactoutcomes.Ongoingeffortsareunderwaytodefinestandardsteps
oftaTMEdissectionusingvideo-basedassessments,tostandardize proceduresinpreparationforrandomizedcontrolledcomparisonof taTMEtootherTMEapproaches.
Overall,prerequisiteexpertiseinrectalcancerresectionsand appropriateproceduraltrainingintaTMEwillprofoundlyimpact intraoperativeandpostoperativeoutcomes,especiallythequalityofthe mesorectaldissectionachievedandhenceshort-andlong-termoncologic outcomes.FormaltaTMEcadavertrainingcoursesincorporatevideo­baseddidacticsandhands-ontrainingbyexperiencedproctors.Inthe UnitedStates,thefirstAmericanSocietyofColonandRectalSurgery (ASCRS)-sponsoredtaTMEhands-oncadavercourseandsymposiumwas organizedinMay2016.
Theinternational(LowRectalCancerNationalDevelopmentProgram) LORECtaTMEregistrycontains720taTMEcasesperformedforbenign andmalignantindications.The(AmericanSocietyofColonandRectal SurgeonsOptimizingtheSurgicalTreatmentofRectalCancer)ASCRS OSTRiChtaTMEregistryusedbyUSsurgeonsisidenticaltotheLOREC registry.WhileawaitingtheresultsoflargeprospectivephaseIItaTME studiesorRCTcomparingtaTMEtoopenandorminimallyinvasive TME,itishopedthattheseregistrieswillaccuratelyreflectcurrenttrends withadoptionandoutcomesoftaTME,includingoperativetechniques, indications,andprocedural,postoperative,oncologic,andfunctional results.Large-scaledatacollectedfortheseregistriesmayalsohelp standardizethetechnique.

INDICATIONS/CONTRAINDICATIONS

IndicationsforTransanalTotalMesorectalExcision
TherearenostrictindicationsforusingtaTMEratherthanopen, laparoscopic,orroboticTMEatthistime.However,onthebasisofthe unanimousreportsofenhancedvisualizationofandunobstructedin-line accesstorectalandmesorectaldissectionplanesprovidedbythe transanalapproach,taTMEisparticularlywellsuitedforasubsetof rectaltumorsandforpatientswithrectalcancer.Performingrectal resectioninamorbidlyobesemalepatientwithanarrowpelviscanbe verychallengingevenforanexperiencedsurgeon,especiallywhen oncologicresectionisthegoal.Asreflectedbythefactthatthelarge majorityoftaTMEcasespublishedtodatehavebeenperformedfor tumorslocated5cmorlessfromtheanalverge,thepatientswhowould benefitthemostfromthisapproacharemaleswithanarrowanddeep pelvis,particularlymaleswithsignificantvisceralobesity,anenlarged prostate,withtumorslocated≤5cmfromtheanalverge.Thesearethe sametumorandpatientcharacteristicsthatpredictamorechallenging dissectionandahighriskofconversionwhenutilizingaminimally invasivetransabdominalapproach.However,aswithanyotheroncologic resection,carefulpatientselectionisessentialtooptimizeoutcomes includingselectionofresectabletumorswithpredictednegative circumferentialradialmarginsbasedonpreoperativemagneticresonance imaging(MRI)staging.
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taTMEisideallysuitedforverylowrectaltumorswhenthegoalsof resectionincludesphincterpreservationalongwithacomplete mesorectumandnegativemargins.Tumorslocatedwithin1–2cmofthe dentatelinerequirepartialorcompleteISR.taTMEproceduresinthis subsetoftumorsaremoretechnicallychallengingandrequirefamiliarity withintersphinctericanatomyanddissectiontechniques.Itisstrongly recommendedthat,earlyintheoperator’slearningcurve,ISRbe performedusingatraditionalopentransanalapproachtoidentify mesorectumandotheranatomiclandmarks.CompletionoftaTMEcan thenbeperformedthroughthetransanalendoscopicplatform.Thesteep learningcurveassociatedwiththesemorecomplexcasescanbe overcomebyfirstmasteringthetaTMEtechniqueforlowandmid-rectal tumors,and/orwhencombinedwithcompletionproctectomyforbenign
indications.
ContraindicationstoTransanalTotalMesorectal Excision
TumorStage
Atthistime,therearenoabsolutecontraindicationsforthisprocedure. However,taTMEisrelativelycontraindicatedinpatientswithpersistent clinicalT4diseasedespitetreatmentwithneoadjuvanttherapy.taTME canbecombinedwithenblocvaginectomy,prostatectomy,anterioror posteriorexenterationwithtransabdominalassistance,andanyother procedurerequiredtoachieveanR0resection;butinthose circumstancessphincterpreservationmaynotbereasonable.Likewise, taTMEisrelativelycontraindicatedinpatientswithpersistentpredicted positiveCRMorinvolvementofthelevatoraniorexternalanalsphincter basedonrestagingpelvicMRIfollowingneoadjuvanttherapy.Inthe lattercase,standardopenorminimallyinvasiveabdominoperineal resection(APR)orextralevatorabdominoperinealexcisionshouldbe performedtoachieveanR0resection.Patientswithanalready compromisedsphincterfunctionmaybeabletohavetaTME anatomically,butthefunctionaloutcomewillbeunacceptable.
AnatomicFactorsandReoperation
taTMEhasbeenrelativelycontraindicatedinthereoperativepelvisand inpatientswithpriorpelvicradiation,becauseofanticipateddifficulties withdissectionofcorrectanatomicplaneswithincreasedriskofinjuryto therectum,vagina,prostate,ureters,orurethra.Thepresenceofan enlargedprostateandprostatecancer(afterpriortreatmentwith radioactiveseeds)isconsideredarelativecontraindicationtotaTME becauseofpotentialurethralinjury.Thetransanalapproachmay facilitateredocolorectalandcoloanalanastomosesandsalvage proctectomyfollowinganastomoticrecurrence.Borstlapetal.reported theirexperiencewithtaTMEinredocolorectalanastomoses:14casesof anastomoticreconstructionandthreecasesofcompletionproctectomy. Overall,theyreporteda14%anastomoticleakrateand24%incidenceof pelvicabscessrequiringreintervention.
RectalTumorLocation
ThereisastrongconsensusthatthereisminimalbenefitinusingtaTME fortumor-specifictotalmesorectalexcision.Stapledanastomosisisnot