Добавил:
Sekretar
kiopkiopkiop18@yandex.ru
t.me/Prokururor I Вовсе не секретарь, но почту проверяю
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_861_Библиотеки_им_академика_М_И_Перельмана.pdf
X
- •Dedication
- •Contributors
- •Foreword
- •Preface
- •Contents
- •Indications/Contraindications
- •Surgery
- •Conclusion
- •Indications/Contraindications
- •Complications
- •Results
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Surgery
- •Complications
- •Results
- •Conclusion
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Introduction
- •Surgery
- •Conclusions
- •Surgery
- •Indications
- •Surgery
- •Complications
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Outcomes
- •Complications
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications
- •Contraindications
- •Surgery
- •Complications
- •Conclusion
- •Indications/Contraindications
- •Surgery
- •Complications
- •Cost
- •Results
- •Conclusions
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Introduction
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Introduction
- •Conclusions
- •Introduction
- •Indications/Contraindications
- •Surgery

MachadoM,NygrenJ,GoldmanS,LjungqvistO.Functionalandphysiologicassessmentofthe
colonicreservoirorside-to-endanastomosisafterlowanteriorresectionforrectalcancer:a
two-yearfollow-up.DisColonRectum2005;48(1):29–36.
McLemoreEC,HarnsbergerCR,BroderickRC,etal.Transanaltotalmesorectalexcision(taTME)
forrectalcancer:atrainingpathway.SurgEndosc2016;30(9):4130–5.
MilesWE.Amethodofperformingabdominoperinealexcisionofcarcinomaoftherectumandthe
terminalportionofthepelviccolon.Lancet1908;2:1812.
MohiuddinM,RegineWF,MarksGJ,MarksJW.High-dosepreoperativeradiationandthe
challengeofsphincter-preservationsurgeryforcancerofthedistal2cmoftherectum.IntJ
RadiatOncolBiolPhys1998;40(3):569–74.
MooreHG,RiedelE,MinskyBD,etal.Adequacyof1-cmdistalmarginafterrestorativerectal
cancerresectionwithsharpmesorectalexcisionandpreoperativecombined-modalitytherapy.
AnnSurgOncol2003;10(1):80–5.
OatesGD,WilliamsJA.Primaryclosureoftheperinealwoundinexcisionoftherectum.ProcR
SocMed1970;63(Suppl):128.
ParkJG,LeeMR,LimSB,etal.ColonicJ-pouchanalanastomosisafterultralowanterior
resectionwithuppersphincterexcisionforlow-lyingrectalcancer.WorldJGastroenterol
2005;11(17):2570–3.
PortierG,GhoutiL,KirzinS,GuimbaudR,RivesM,LazorthesF.Oncologicaloutcomeofultra-
lowcoloanalanastomosiswithandwithoutintersphinctericresectionforlowrectal
adenocarcinoma.BrJSurg2007;94(3):341–5.
RouanetP,Saint-AubertB,LemanskiC,etal.Restorativeandnonrestorativesurgeryforlow
rectalcancerafterhigh-doseradiation:long-termoncologicandfunctionalresults.DisColon
Rectum2002;45(3):305–13;discussion13–5.
RullierE,LaurentC,BretagnolF,RullierA,VendrelyV,ZerbibF.Sphincter-savingresectionfor
allrectalcarcinomas:theendofthe2-cmdistalrule.AnnSurg2005;241(3):465–9.
RullierE,LaurentC,GarrelonJL,MichelP,SaricJ,ParneixM.Riskfactorsforanastomotic
leakageafterresectionofrectalcancer.BrJSurg1998;85(3):355–8.
RullierE,LeTouxN,LaurentC,GarrelonJL,ParneixM,SaricJ.Loopileostomyversusloop
colostomyfordefunctioninglowanastomosesduringrectalcancersurgery.WorldJSurg
2001;25(3):274–7;discussion7–8.
SchiesselR,NoviG,HolzerB,etal.Techniqueandlong-termresultsofintersphinctericresection
forlowrectalcancer.DisColonRectum2005;48(10):1858–65;discussion65–7.
StevensonAR,SolomonMJ,LumleyJW,etal.Effectoflaparoscopic-assistedresectionvsopen
resectiononpathologicaloutcomesinrectalcancer:theALaCaRTrandomizedclinicaltrial.
JAMA2015;314(13):1356–63.
TekkisPP,CornishJA,RemziFH,etal.Measuringsexualandurinaryoutcomesinwomenafter
rectalcancerexcision.DisColonRectum2009;52(1):46–54.
TekkisPP,HeriotAG,SmithJ,ThompsonMR,FinanP,StamatakisJD.Comparisonof
circumferentialmargininvolvementbetweenrestorativeandnonrestorativeresectionsfor
rectalcancer.ColorectalDis2005;7(4):369–74.
TempleLK,RomanusD,NilandJ,etal.Factorsassociatedwithsphincter-preservingsurgeryfor
rectalcanceratnationalcomprehensivecancernetworkcenters.AnnSurg2009;250(2):260–
7.
TeramotoT,WatanabeM,KitajimaM.Peranumintersphinctericrectaldissectionwithdirect

coloanalanastomosisforlowerrectalcancer:theultimatesphincter-preservingoperation.Dis
ColonRectum1997;40(10Suppl):S43–7.
TilneyHS,TekkisPP.Extendingthehorizonsofrestorativerectalsurgery:intersphincteric
resectionforlowrectalcancer.ColorectalDis2008;10(1):3–15;discussion15–6.
TiretE,PoupardinB,McNamaraD,DehniN,ParcR.Ultralowanteriorresectionwith
intersphinctericdissection—whatisthelimitofsafesphincterpreservation?ColorectalDis
2003;5(5):454–7.
TranchartH,BenoistS,PennaC,JulieC,RougierP,NordlingerB.Cutaneousperianalrecurrence
onthesiteofLoneStarRetractorafterJ-pouchcoloanalanastomosisforrectalcancer:report
oftwocases.DisColonRectum2008;51(12):1850–2.
UenoM,OyaM,AzekuraK,YamaguchiT,MutoT.Incidenceandprognosticsignificanceoflateral
lymphnodemetastasisinpatientswithadvancedlowrectalcancer.BrJSurg2005;92(6):756–
63.
UlrichAB,SeilerC,RahbariN,WeitzJ,BuchlerMW.Divertingstomaafterlowanteriorresection:
moreargumentsinfavor.DisColonRectum2009;52(3):412–8.
UlrichAB,SeilerCM,Z’GraggenK,LofflerT,WeitzJ,BuchlerMW.Earlyresultsfroma
randomizedclinicaltrialofcolonJpouchversustransversecoloplastypouchafterlowanterior
resectionforrectalcancer.BrJSurg2008;95(10):1257–63.
WagmanR,MinskyBD,CohenAM,GuillemJG,PatyPP.Sphincterpreservationinrectalcancer
withpreoperativeradiationtherapyandcoloanalanastomosis:longtermfollow-up.IntJ
RadiatOncolBiolPhys1998;42(1):51–7.
WeiserMR,MilsomJW.Laparoscopictotalmesorectalexcisionwithautonomicnerve
preservation.SeminSurgOncol2000;19(4):396–403.
WeiserMR,QuahHM,ShiaJ,etal.Sphincterpreservationinlowrectalcancerisfacilitatedby
preoperativechemoradiationandintersphinctericdissection.AnnSurg2009;249(2):236–42.
WillisS,HolzlF,KronesCJ,TittelA,SchumpelickV.Evaluationofanastomoticmicrocirculation
afterlowanteriorrectalresection:anexperimentalstudywithdifferentreconstructionformsin
dogs.TechColoproctol2006;10(3):222–6.
WillisS,KasperkR,BraunJ,SchumpelickV.ComparisonofcolonicJ-pouchreconstructionand
straightcoloanalanastomosisafterintersphinctericrectalresection.LangenbecksArchSurg
2001;386(3):193–9.
YamadaK,OgataS,SaikiY,FukunagaM,TsujiY,TakanoM.Long-termresultsof
intersphinctericresectionforlowrectalcancer.DisColonRectum2009;52(6):1065–71.
YooJH,HasegawaH,IshiiY,NishiboriH,WatanabeM,KitajimaM.Long-termoutcomeofper
anumintersphinctericrectaldissectionwithdirectcoloanalanastomosisforlowerrectal
cancer.ColorectalDis2005;7(5):434–40.
Young-FadokTM,FanelliRD,PriceRR,EarleDB.Laparoscopicresectionofcurablecolonand
rectalcancer:anevidence-basedreview.SurgEndosc2007;21(7):1063–8.
ZeitelsJR,Fiddian-GreenRG,DentTL.Intersphinctericproctectomy.Surgery1984;96(4):617–
23.
Z’GraggenK,MaurerCA,MettlerD,StoupisC,WildiS,BuchlerMW.Anovelcolonpouchandits
comparisonwithastraightcoloanalandcolonJ-pouch—analanastomosis:preliminaryresults
inpigs.Surgery1999;125(1):105–12.

Chapter21
TransanalTotalMesorectal
Excision
ChayaShwaartzandPatriciaSylla
INTRODUCTION
In1982,Healdetal.firstdescribedtheconceptoftotalmesorectal
excision(TME)andestablishedthistechniqueasthegoldstandardfor
thesurgicaltreatmentofmiddleandlowerrectalcancer.Sharpenbloc
resectionoftherectumandmesorectum,includinghighligationofthe
inferiormesentericartery(IMA),wasshowntosignificantlyreducerates
ofpositivecircumferentialresectionmargins(CRMs),leadingtolower
riskoflocalrecurrenceandhighercancer-specificsurvival.
Minimallyinvasivesurgeryhasbeenshowntoachieveresultssimilarto
thoseofopensurgerywithrespecttooncologicresectionofrectalcancer.
Multiplerandomizedcontrolledtrials(RCTs)haveshownthat
laparoscopicTMEisassociatedwithsimilarperioperativemorbidity
comparedtoopensurgery,withlessbloodloss,rapidintestinalrecovery,
shorterhospitalstay,andnocompromiseofoncologicoutcomes.Despite
thefailureoftherecentAmericanCollegeofSurgeonsOncologyGroup
Z6051andAustralasianLaparoscopicCanceroftheRectumRCTsto
demonstratenon-inferiorityoflaparoscopicTMErelativetoopenTME,
long-termresultsfromseveralRCTscontinuetosupporttheuseof
laparoscopicsurgeryforrectalcancerandshownodifferenceregarding
oncologicoutcomes.Nevertheless,relativelyhighconversionratesto
opensurgerycontinuetobereported,evenwhenperformedinhighvolumeexpertcenters.RoboticTMEhasbeentoutedasassociatedwitha
shorterlengthofhospitalstay,andbetterrecoveryoutcomeswhen
comparedtoopensurgeryinpatientswithlowandmid-rectalcancer.
Laparoscopicandroboticsurgerieshaveimprovedtheapproachtothe
pelviswhenperformingTME,andhavebeenvalidatedfromanoncologic
standpoint.However,achievingacompleteTMEwithsphincter

preservationandnegativedistalandradialmarginsforlowrectaltumors,
whilepreservingautonomicnervesandavoidingconversion,canbe
extremelychallenging,eveninthehandsofexperiencedcolorectal
surgeons.Theanatomicconfigurationofthedistalrectumintight
appositiontotheprostate,sacrum,pelvicplexus,andpuborectalis,
especiallythenarrowmalepelvis,complicatesthemaneuveringrequired
tocompletesharpmesorectaldissectionandtransecttherectumwell
belowtherectaltumorunderdirectvisualization.
Byprovidingdirectandin-lineintraluminalandtransrectalaccessto
thelowrectumandmesorectum,atransanalnaturalorificetransluminal
endoscopicsurgery(NOTES)approach,firstdescribedinhuman
cadaversin2007,wasproposedasanovelminimallyinvasiveapproach
toovercometheanatomiclimitationofatransabdominalapproachtothe
lowpelvis.Transanalproctectomywithtotalmesorectalexcision(or
transanalTME)withlaparoscopicassistance,wherebyTMEis
undertakenfroma“bottoms-up”approachunderdirectvisualization
providedthroughtransanalendoscopicmultiportplatforms,wasfirst
describedinaclinicalcasein2009andhassincebecomeincreasingly
adoptedworldwideasanattractivealternativetostandardandminimally
invasiveTME.Benefitsofusingatransanalapproachtocompletethe
distal-mostdissectionofthemesorectumhadbeenwelldescribedfor
rectaltumorslocatedlessthan5cmfromtheanalverge,outofreach
fromatransabdominalapproach,andwhensphincterpreservationwas
attempted.
Thetransanal-transabdominaltechniquewithintersphincteric
resection(ISR)hasevolvedfromthenecessityofresectingpartorallof
theinternalanalsphinctermuscleincontinuitywiththedistalrectum
andmesorectum,toachievenegativedistalmarginsforlowrectal
tumors.Likewise,transanalendoscopicaccessnotonlypermitsearly
identificationandtransectionofthedistalrectalmarginwithorwithout
ISRbutalsoallowstaTMEtobecarriedoutentirelythroughatransanal
endoscopicplatform.Withimprovedvideoscopicvisualizationand
exposureachievedwithCO2insufflation,nerve-sparingandcomplete
dissectionofthemesorectalfasciaisgreatlyfacilitated.
p.187
p.188
OtherbenefitsprovidedbytaTMEincludethatdistalrectaltransection
isperformedtransanally,underdirectvision,anddoesnotrequire
laparoscopicstaplers.Anotheradvantageisthattransanalspecimen
extraction,whenfeasible,avoidstheneedforspecimenextractionsites
andreduceswound-relatedcomplications.Inaddition,taTME
proceduresperformedwithatwo-teamapproach,withbothabdominal

andtransanalteamsworkingsimultaneously,mayreduceoperatingtime
andintraoperativecomplicationsincludingconversiontoopensurgery.
Overall,despitethedemonstratedbenefitsinpostoperativerecovery
providedbytheuseofmulti-andsingle-portlaparoscopyandroboticsfor
rectalcancerresection,adoptionandconversionrateshaveplateaued,
whichreflectsthetechnicaldifficultiesandthelengthylearningcurve
requiredforperformingTMEusingtheseminimallyinvasivetechniques.
SinceourfirstreportoftaTMEperformedforamid-rectalcancerusinga
transanalendoscopicoperation(TEO)rigidplatform(KarlStorz,
Tubingen,Germany)andanearlycaseseriesreportedthefeasibilityof
thisapproachforrectalcancer,taTMEadoptionhasbeenfacilitatedby
increasedaccesstodisposabletransanalminimallyinvasivesurgery
(TAMIS)platformsandsupportedbypreliminarysmallandmid-sized
series,confirmingtheproceduralandpreliminaryoncologicsafetyof
taTME.Thusfar,thereportedfactorsdrivingtaTMEadoptionhavebeen
thehighsuccesswithtaTMEcompletionforlowrectaltumors,with
sphincterpreservationandexceedinglylowconversionrates.Inaddition,
oncologicresultshavedemonstratedhighratesofcompleteandnearcompleteTMEgradeachieved.Webelievethatinthehandsof
experiencedoperators,taTMEisbecomingthepreferredapproachfor
mid-andlowrectaltumors,particularlyinobesemalepatientsbecause
ofthesuperiorexposureprovided,forproceduresthatwouldotherwise
betechnicallydifficulttoapproachfromtheabdomen.
TheaimofthischapteristoprovideacomprehensivereviewontaTME
forrectalcancer,describetheprocedureindetail,andsummarizethe
preliminaryoutcomesofthisprocedurebasedonpublishedresultsfrom
thelargesttaTMEseries.

TRANSANALTOTALMESORECTAL
EXCISION:TRAININGAND
STANDARDIZATIONOFPROCEDURES
ThereisclearconsensusthattaTMEshouldbeperformedby
experienced,skilled,andwell-trainedsurgeonswhocanoutgrowthe
learningcurveinthemostefficientway.Arecentconsensusofanexpert
groupofsurgeonsfromaninternationaltaTMEconferencestatesthat
trainingisnecessarybeforesurgeonsundertakethisprocedure.
Furthermore,itstronglyrecommendsthatsurgeonsundertakeataTME
trainingcoursethatincludesdidacticlectures,mentoredcadaveric
dissection,livesurgery,anduneditedvideobeforeclinicalapplication.
Ideally,thisapproachshouldbeundertakenbyhigh-volumerectalcancer
surgeonswithexpertisenotonlyinlaparoscopicorroboticTMEbutalso
intransanalendoscopicmicrosurgery(TEM;RichardWolf,Knittlingen,
Germany),TEO,orTAMIS,andfamiliarwithISRtechniquesforverylow
rectaltumors.InstitutionscontemplatinginitiatingthetaTMEprogram
shoulddemonstratemultidisciplinaryexpertiseinthemanagementof
rectalcancerwithtumorboardreviewofallrectalcancers.Evenfor
surgeonswithallprerequisiteskillsfortaTME,in-depthprocedural
trainingismandatorybeforeclinicalpractice.Inaddition,proctorshipfor
thefirstfewclinicalcasesisstronglyrecommended,giventhelackof
familiaritywithanatomicallycorrectperinealdissectionplanesfroma
perinealendoscopicapproach.Theserecommendationsstemfromthe
factthattaTMEprocedurescalluponmasteryofseveralessential
technicalcompetencies,namely,laparoscopicsuturingthroughasingleincisionplatform,transanalendoscopicdissection,and,most
importantly,familiaritywiththeperinealanatomyandin-depth
understandingoftherelationshipbetweentherectum,analsphincters,
prostate,andurethra.
Theporcinemodelhasbeenextensivelyinvestigatedasatraining
modelfortransanalcolorectalNOTES.However,becauseofthebony
narrowporcinepelvisthatdoesnotallowdissectiontothebottomofthe
pelvicfloor,andgiventhelackofatruemesorectum,itwaslargely
abandonedasamodelfortaTMEtraining.Freshhumancadavers,onthe
otherhand,areanoptimalmodelfortaTMEtraining.Inthelargest
cadaverseriesoftransanalNOTEScolorectalresectionsperformedin32
freshmaleandfemalecadavers,ourgroupdemonstratedthatalthough
feasibleinafewcadaverswithfavorableanatomy,puretransanaland
combinedtransanalandtransgastricNOTEScolorectalresectionswere

limitedbythelackofspecializedinstrumentation,andthatlaparoscopic
assistancewasnecessarytocompletetransanalNOTESproceduressafely.
Withregardtotheprocedurallearningcurveanticipatedforthese
procedures,inthislargecadaverstudyoftransanalNOTEScolorectal
resections,asignificantdecreaseintheoperativetimeandincreaseinthe
lengthofrectosigmoidcolonmobilizedwasachievedafterperformanceof
thefirstfivecases.Althoughnoformalizedlearningcurveanalysishasyet
beenperformedfortaTME,severalmid-andlarge-sizedinstitutional
serieshavedemonstratedasignificantdecreaseinoperativetimewith
experience.In2013,Lacyetal.reportedtheirfirst20casesoftaTME
withameanoperatingroom(OR)timeof234minutes.In2015,thesame
groupreportedtheirexperiencewith140taTMEcaseswithameanOR
timeof166minutes.AlthoughthisdecreaseinORtimemayreflectthe
increaseduseofasynchronoustwo-teamapproach,itmayalsoreflectthe
impactofthelearningcurveforsurgicalteamsthathavebecome
experiencedwithtaTME.
p.188
p.189
In2014,Buscagliaetal.presentedanalternativetocadaverandanimal
training.TheyintroducedtransanalNOTESsigmoidectomytraining
usinganendoscopysimulationmodel.Fourparticipants(twocolorectal
surgeonsandtwogastroenterologists)performedsimulatedNOTES
sigmoidectomywithabaselinetest,mentoredtrainingsessions,anda
non-mentoredsimulatedfinaltesttothefinaltesting.Theyshoweda
42%reductioninoperativetimefromthebaselineperformance.This
preliminarydatasuggestthatsimulatorusebeforeperformingthe
procedureinanimalorcadavermodelsmayimprovethetrainingprocess.
Inarecentvideomanuscript,Mclemoreetal.proposedarigorous
trainingpathwayfortaTME.Thisincludedteamtraininginafresh
cadaverthedaybeforethefirstclinicalcasewiththesameoperativeteam
consistingofsurgeons,nurses,andoperativestaff.Inaddition,thecase
wasproctoredbyanexperiencedtaTMEsurgeon.Theauthorsreiterated
thekeyelementsforsuccessfuldevelopmentofataTMEprogram,
includingexpertiseinminimallyinvasiveandsphincter-preservingTME,
TES,andISRforverylowrectalinvasiveneoplasms.Experiencewiththis
firstcasereaffirmedtheimportanceofproceduralteamtrainingin
cadavers.
OneofthechallengesoftaTMEhasbeenthelackofstandardizationof
thetechnique.Publishedreportsandvideopresentationscontinuously
demonstratevariationsinoperativesetupandsequence,dissectionand
anastomotictechniques,andinstrumentationthatmayormaynot
impactoutcomes.Ongoingeffortsareunderwaytodefinestandardsteps

oftaTMEdissectionusingvideo-basedassessments,tostandardize
proceduresinpreparationforrandomizedcontrolledcomparisonof
taTMEtootherTMEapproaches.
Overall,prerequisiteexpertiseinrectalcancerresectionsand
appropriateproceduraltrainingintaTMEwillprofoundlyimpact
intraoperativeandpostoperativeoutcomes,especiallythequalityofthe
mesorectaldissectionachievedandhenceshort-andlong-termoncologic
outcomes.FormaltaTMEcadavertrainingcoursesincorporatevideobaseddidacticsandhands-ontrainingbyexperiencedproctors.Inthe
UnitedStates,thefirstAmericanSocietyofColonandRectalSurgery
(ASCRS)-sponsoredtaTMEhands-oncadavercourseandsymposiumwas
organizedinMay2016.
Theinternational(LowRectalCancerNationalDevelopmentProgram)
LORECtaTMEregistrycontains720taTMEcasesperformedforbenign
andmalignantindications.The(AmericanSocietyofColonandRectal
SurgeonsOptimizingtheSurgicalTreatmentofRectalCancer)ASCRS
OSTRiChtaTMEregistryusedbyUSsurgeonsisidenticaltotheLOREC
registry.WhileawaitingtheresultsoflargeprospectivephaseIItaTME
studiesorRCTcomparingtaTMEtoopenandorminimallyinvasive
TME,itishopedthattheseregistrieswillaccuratelyreflectcurrenttrends
withadoptionandoutcomesoftaTME,includingoperativetechniques,
indications,andprocedural,postoperative,oncologic,andfunctional
results.Large-scaledatacollectedfortheseregistriesmayalsohelp
standardizethetechnique.

INDICATIONS/CONTRAINDICATIONS
IndicationsforTransanalTotalMesorectalExcision
TherearenostrictindicationsforusingtaTMEratherthanopen,
laparoscopic,orroboticTMEatthistime.However,onthebasisofthe
unanimousreportsofenhancedvisualizationofandunobstructedin-line
accesstorectalandmesorectaldissectionplanesprovidedbythe
transanalapproach,taTMEisparticularlywellsuitedforasubsetof
rectaltumorsandforpatientswithrectalcancer.Performingrectal
resectioninamorbidlyobesemalepatientwithanarrowpelviscanbe
verychallengingevenforanexperiencedsurgeon,especiallywhen
oncologicresectionisthegoal.Asreflectedbythefactthatthelarge
majorityoftaTMEcasespublishedtodatehavebeenperformedfor
tumorslocated5cmorlessfromtheanalverge,thepatientswhowould
benefitthemostfromthisapproacharemaleswithanarrowanddeep
pelvis,particularlymaleswithsignificantvisceralobesity,anenlarged
prostate,withtumorslocated≤5cmfromtheanalverge.Thesearethe
sametumorandpatientcharacteristicsthatpredictamorechallenging
dissectionandahighriskofconversionwhenutilizingaminimally
invasivetransabdominalapproach.However,aswithanyotheroncologic
resection,carefulpatientselectionisessentialtooptimizeoutcomes
includingselectionofresectabletumorswithpredictednegative
circumferentialradialmarginsbasedonpreoperativemagneticresonance
imaging(MRI)staging.
p.189
p.190
taTMEisideallysuitedforverylowrectaltumorswhenthegoalsof
resectionincludesphincterpreservationalongwithacomplete
mesorectumandnegativemargins.Tumorslocatedwithin1–2cmofthe
dentatelinerequirepartialorcompleteISR.taTMEproceduresinthis
subsetoftumorsaremoretechnicallychallengingandrequirefamiliarity
withintersphinctericanatomyanddissectiontechniques.Itisstrongly
recommendedthat,earlyintheoperator’slearningcurve,ISRbe
performedusingatraditionalopentransanalapproachtoidentify
mesorectumandotheranatomiclandmarks.CompletionoftaTMEcan
thenbeperformedthroughthetransanalendoscopicplatform.Thesteep
learningcurveassociatedwiththesemorecomplexcasescanbe
overcomebyfirstmasteringthetaTMEtechniqueforlowandmid-rectal
tumors,and/orwhencombinedwithcompletionproctectomyforbenign

indications.
ContraindicationstoTransanalTotalMesorectal
Excision
TumorStage
Atthistime,therearenoabsolutecontraindicationsforthisprocedure.
However,taTMEisrelativelycontraindicatedinpatientswithpersistent
clinicalT4diseasedespitetreatmentwithneoadjuvanttherapy.taTME
canbecombinedwithenblocvaginectomy,prostatectomy,anterioror
posteriorexenterationwithtransabdominalassistance,andanyother
procedurerequiredtoachieveanR0resection;butinthose
circumstancessphincterpreservationmaynotbereasonable.Likewise,
taTMEisrelativelycontraindicatedinpatientswithpersistentpredicted
positiveCRMorinvolvementofthelevatoraniorexternalanalsphincter
basedonrestagingpelvicMRIfollowingneoadjuvanttherapy.Inthe
lattercase,standardopenorminimallyinvasiveabdominoperineal
resection(APR)orextralevatorabdominoperinealexcisionshouldbe
performedtoachieveanR0resection.Patientswithanalready
compromisedsphincterfunctionmaybeabletohavetaTME
anatomically,butthefunctionaloutcomewillbeunacceptable.
AnatomicFactorsandReoperation
taTMEhasbeenrelativelycontraindicatedinthereoperativepelvisand
inpatientswithpriorpelvicradiation,becauseofanticipateddifficulties
withdissectionofcorrectanatomicplaneswithincreasedriskofinjuryto
therectum,vagina,prostate,ureters,orurethra.Thepresenceofan
enlargedprostateandprostatecancer(afterpriortreatmentwith
radioactiveseeds)isconsideredarelativecontraindicationtotaTME
becauseofpotentialurethralinjury.Thetransanalapproachmay
facilitateredocolorectalandcoloanalanastomosesandsalvage
proctectomyfollowinganastomoticrecurrence.Borstlapetal.reported
theirexperiencewithtaTMEinredocolorectalanastomoses:14casesof
anastomoticreconstructionandthreecasesofcompletionproctectomy.
Overall,theyreporteda14%anastomoticleakrateand24%incidenceof
pelvicabscessrequiringreintervention.
RectalTumorLocation
ThereisastrongconsensusthatthereisminimalbenefitinusingtaTME
fortumor-specifictotalmesorectalexcision.Stapledanastomosisisnot
Соседние файлы в папке Библиотека им академика М.И. Перельмана
