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CLINICAL TOPICS

COMPETENCE AND REFERRAL IN ULTRASOUND EXAMINATION

The ethical obligation to provide competent obstetric ultrasound examinations derives from both beneficence and respect for autonomy. Either principle alone, and certainly both in combination, requires physicians to provide patients with accurate and reliable clinical information. To meet this ethical obligation, the cli­nician must address the following ethical considerations. First, ensuring an appro­priate level of competence imposes a rigorous standard of training and continuing education. Two problems result when physicians do not maintain this baseline level of competence in the techniques and interpretation of ultrasound imaging. First, they may cause unnecessary harm to the woman or fetal patient, e.g. from mistaken diagnosis of fetal anomalies, thus violating beneficence-based obliga­tions. Second, incomplete or inaccurate reporting of results by the physician to the pregnant woman undermines the informed consent process regarding the management of pregnancy. This constitutes an unacceptable ethical violation of autonomy-based obligations of the physician to the pregnant woman. Because physicians may rely on them, the general competence of obstetric sonographers is essential to avoiding these ethically unacceptable consequences for the exercise of the pregnant woman's autonomy.
Second, these obligations have important implications for physicians who employ a sonographer. Such physicians are ethically obligated to adequately super­vise the sonographer's clinical work. To do this properly, the physician should know more than the sonographer, especially about the application of sonographic findings to the diagnosis of anomalies. This more advanced fund of clinical and scientific knowledge is essential for the physician to fulfill his or her additional ethical obligation to regularly review the sonographer's work. In addition, physi­cians should provide the opportunity for continuing education of obstetric sonog­raphers. This is an especially important consideration for achieving strandards of quality, e.g. in nuchal translucency measurement in the first trimester.
In medical care, patients properly rely for their protection on the personal and professional integrity of their clinicians. A crucial aspect of that integrity is will­ingness on the part of physicians to refer to specialists when the limits of their own knowledge are being approached. Like other virtues, such as self-sacrifice and compassion, integrity directs physicians to focus primarily on the patient's interests, as a way to blunt mere self-interest.
44
47
Ethics and patient information

ROUTINE ULTRASOUND SCREENING AND RISK ASSESSMENT OF PREGNANT WOMEN

The clinical ethical issues here focus on the physician's responsibilities under informed consent, an autonomy-based concern. This process includes disclosure of and discussion about what obstetric ultrasound examinations can and cannot detect, the level of sophistication of the ultrasound techniques employed, and the incomplete and sometimes uncertain interpretation of ultrasound images.
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In the face of medical uncertainty about the clinical goods and harms of routine ultrasound, it is obligatory to inform pregnant patients about that uncertainty and to give them the opportunity to make their own choices about how that uncertainty should be managed. We have argued that prenatal informed consent for sonogram (PICS) should be an indication for the routine use of obstetric ultrasound.
The timing of routine ultrasound should be governed, as a rule, by the ethical principle of respect for autonomy, because the information obtained is relevant to the woman's decision about whether she will seek an abortion (assuming that is legally available to her). In pregnancies that will be taken to term, routine ultra­sound during the second trimester can enhance a pregnant woman's autonomy. If anomalies are detected and she does not choose abortion, she may begin to prepare herself for the decisions that she will confront later about the management of those anomalies in the intrapartum and postpartum periods. Providing this infor­mation early in pregnancy permits a pregnant woman ample time to deal with its psychological and other sequelae before she must confront such decisions.
Respect for autonomy has important implications for first-trimester ultra­sound screening for trisomy 21. First-trimester screening provides sophisticated
Ultrasound in obstetrics and gynaecology
information about risk to pregnant women that they can incorporate into their subsequent decisions about invasive testing.48 Many women prefer not to have an invasive test when provided with risk estimates based on first-trimester screening, which is reassuring.
11,62
Many women may find it important to have a diagnosis of an abnormal fetus early, in order to make an earlier decision about whether to continue or terminate their pregnancies.
12,13
Both of these aspects of first-trimester screening are important enhancements of the autonomy of pregnant women. To prevent information overload from presenting too many choices unnecessarily, all pregnant women in the first trimester should be offered risk assessment and invasive diagnosis. Physicians should be guided by the autonomous decisions of pregnant women in response to this offer.
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26,44
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DISCLOSURE OF RESULTS OF ULTRASOUND EXAMINATIONS

Significant clinical ethical issues arise about the disclosure of results of ultrasound examinations. The first clinical ethical topic here concerns the phenomenon of apparent bonding of pregnant women to their fetuses as a result of the woman seeing the ultrasound images.10 Such bonding can sometimes benefit pregnancies that will be taken to term but can also at other times complicate decisions to terminate a pregnancy. We recommend that these matters, like abnormal findings, should be discussed with the pregnant woman.
A second topic is a matter of ongoing debate: the disclosure of the fetus's gender. frankly to requests from the pregnant woman for information about the fetus's gender. The woman should be made aware of the uncertainties of ultrasound gen­der identification, as part of the disclosure process. The sonographer can use his or her own experience to help the pregnant woman understand those uncertainties.
Polaroid photography of ‘baby pictures’. There is nothing intrinsically wrong with
44,60
We propose that respect for maternal autonomy dictates responding
A third clinical topic may, at first, seem a non-issue, i.e. videotaping or the
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the practice if it is a side product of a legitimate ultrasound examination. In fact, it may help the bonding of the prospective parents to the fetal patient. However, when videotaping or Polaroid photography are performed to generate revenues, this practice trivializes the ultrasound examination and may result in harm because problems that could be diagnosed could be missed.
16

CONFIDENTIALITY OF FINDINGS

Confidentiality concerns the obligation of physicians to protect clinical informa­tion about patients from unauthorized access.44 The obligation of confidentiality derives from the principles of beneficence (patients will be more forthcoming) and respect for autonomy (the patient's privacy rights are protected). Others, including the pregnant woman's spouse, sex partner and family, should be under­stood as third parties to the patient relationship, in respect to information about the results of obstetric or gynaecological ultrasound. Diagnostic information about a woman's condition or pregnancy is confidential. It can therefore be jus­tifiably disclosed to third parties only with the pregnant woman's explicit permis- sion. This is because a potentially acceptable condition for releasing confidential information, avoiding grave harm to others, does not apply in this context. To avoid awkward situations, physicians should establish policies and procedures that reflect this analysis of the ethics of confidentiality.
19
5,44
Ethics and patient information

CONCLUSION

Ethics complements the scientific and technological aspects of obstetric and gynaecological ultrasound. In this chapter we have provided an ethical framework for clinical judgement and practice in communicating information about obstetric and gynaecological ultrasound and subsequent decision making. Implementing this framework on a daily basis is essential to creating and sustaining the physician– patient relationship in this important subspecialty of obstetrics and gynaecology. This framework emphasizes preventive ethics to clinical topics in obstetric and gynaecological ultrasound, i.e. an appreciation that the potential for ethical conflict is built into clinical practice and the use of effective communication and informed consent to prevent such conflict from occurring.

References

1. American College of Obstetricians and Gynecologists. Committee on Ethics. Patient choice: maternal–fetal conflict. American College of Obstetricians and Gynecologists, Washington, DC, 1987
2. American College of Obstetricians and Gynecologists. Technical bulletin. Ethical decision-making in obstetrics and gynecology. American College of Obstetricians and Gynecologists, Washington, DC,1989
3. Anderson G, Strong C. The premature breech: cesarean section or trial of labor? J Med Ethics 1988;14:18–24
4. Beauchamp TL, McCullough LB. Medical ethics: the moral responsibilities of physicians. Prentice-Hall, Englewood Cliffs, 1984
5. Beauchamp TL, Childress JF. Principles of biomedical ethics, 4th edn. Oxford University Press, New York, 1994
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6. Bopp J (ed). Restoring the right to life: the human life amendment. Brigham Young University, Provo, 1984
7. Bopp J (ed). Human life and health care ethics. University Publications of America, Frederick, 1985
8. Brett A, McCullough LB. When patients request specific interventions: refining the limits of the physician's obligations. N Engl J Med 1986;315:1347–1351
9. Callahan S, Callahan D (eds). Abortion: understanding differences. Plenum Press, New York, 1984
10. Campbell S, Reading AE, Cox DN et al. Ultrasound scanning in pregnancy: the short-term psychological effects of early real time scans. J Psychosom Obstet Gynecol 1986;1:57–161
11. Chasen ST, McCullough LB, Chervenak FA. Is nuchal translucency screening associated with different rates of invasive testing in an
Ultrasound in obstetrics and gynaecology
older obstetric population? Am J Obstet Gynecol 2004;190(3):769–774
12. Chasen ST, Skupski DW, McCullough LB, Chervenak FA. First-trimester nuchal translucency screening: reply. J Ultrasound Med 2002;21:483–487
13. Chasen ST, Skupski DW, McCullough LB, Chervenak FA. Prenatal informed consent for sonogram: the time for first-trimester translucency has come. J Ultrsound Med 2001;20:1147–1152
14. Chervenak FA, Farley MA, Walters L et al. When is termination of pregnancy during the third trimester morally justifiable? N Engl J Med 1984;310:501–504
15. Chervenak FA, McCullough LB. An ethically justified, clinically comprehensive management strategy for third-trimester pregnancies complicated by fetal anomalies. Obstet Gynecol 1990;75:311–316
16. Chervenak FA, McCullough LB. An ethical critique of boutique fetal imaging: the case for the medicalization of fetal imaging. Am J Obstet Gynecol 2006;192(1):31–33
17. Chervenak FA, McCullough LB. Clinical guides to preventing ethical conflicts between pregnant women and their physicians. Am J Obstet Gynecol 1990;162:303–307
18. Chervenak FA, McCullough LB. Does obstetric ethics have any role in the obstetrician's response to the abortion controversy? Am J Obstet Gynecol 1990;163:1425–1429
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19. Chervenak FA, McCullough L. Ethics in obstetric ultrasound. J Ultrasound Med 1989;8:493–497
20. Chervenak FA, McCullough LB, Campbell S. Is third trimester abortion justified? Br J Obstet Gynaecol, 1995;102:434–435
21. Chervenak FA, McCullough LB, Levene MI. An ethically justified, clinically comprehensive approach to peri-viability: gynaecological, obstetric, perinatal, and neonatal dimensions. J Obstet Gynaecol 2007;27:3–7
22. Chervenak FA, McCullough LB. Nonaggressive obstetric management: an option for some fetal anomalies during the third trimester. JAMA 1989;261:3439–3500
23. Chervenak FA, McCullough LB. Perinatal ethics: a practical method of analysis of obligations to mother and fetus. Obstet Gynecol 1985;66:442–446
24. Chervenak FA, McCullough LB, Sharma G, Davis J, Gross S. Enhancing patient autonomy with risk assessment and invasive diagnosis: an ethical solution to a clinical challenge. Am J Obstet Gynecol 2008; 199:19.e1–4
25. Chervenak FA, McCullough LB, Campbell S. Third trimester abortion: is compassion enough? Br J Obstet Gynaecol 1999;106:293–296
26. Chervenak FA, McCullough LB, Chervenak JL. Prenatal informed consent for sonogram (PICS): an indication for obstetrical ultrasound. Am J Obstet Gynecol 1989;161(4):857–860
27. Dunstan GR. The moral status of the human embryo. A tradition recalled. J Med Ethics 1984;10:38–44
28. Elias S, Annas GJ. Reproductive genetics and the law. Year Book Medical Publishers, Chicago, 1987
29. Engelhardt Jr HT. The foundations of bioethics, 2nd edn. Oxford University Press, New York, 1996
30. Evans MI, Fletcher JC, Zador IE et al. Selective first-trimester termination in octuplet and quadruplet pregnancies: clinical and ethical issues. Obstet Gynecol 1988;71:289–296
31. Faden RR, Beauchamp TL. A history and theory of informed consent. Oxford University Press, New York, 1986
32. Fleming L. The moral status of the fetus: a reappraisal. Bioethics 1987;1:15–34
33. Fletcher JC. The fetus as patient; ethical issues. JAMA 1981;246:772–773
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34. Ford NM. When did i begin? Conception of the human individual in history, philosophy and science. Cambridge University Press, Cambridge, 1988
35. Fost N, Chudwin D, Wikker D. The limited moral significance of fetal viability. Hastings Cent Rep 1980;10;10–13
36. Hack M, Fanaroff AA. Outcomes of extremely-low-birth-weight infants between 1982 and 1988. N Engl J Med 1989;321:1642–1647
37. Harrison MR, Golbus MS, Filly RA. The unborn patient. Grune and Stratton, New York, 1984
38. Hellegers AE. Fetal development. Theol Stud 1970;31:3–9
39. Liley AW. The foetus as a personality. Aust NZ J Psychiatry 1972;6:99–105
40. Macklin R. Abortion: contemporary ethical and legal aspects. In: Reich WT (ed) Encyclopedia of bioethics, 2nd edn. Macmillan, New York, 1995: 6–16
41. Mahoney MJ. Fetal–maternal relationship. In: Reich WT (ed) Encyclopedia of Bioethics. Macmillan, New York, 1978: 485–489
42. Mahoney MJ. The fetus as patient. West J Med 1989;150:517–540
43. Mahowald M. Beyond abortion: refusal of cesarean section. Bioethics 1989;3:106–121
44. McCullough LB, Chervenak FA. Ethics in obstetrics and gynecology. Oxford University Press, New York, 1994
45. Murray TH. Moral obligations to the not­yet born: the fetus as patient. Clin Perinatol 1987;14:313–328
46. Newton ER. The fetus as patient. Med Clin North Am 1989;73:517–540
47. Nicolaides KH. Nuchal translucency and other first-trimester sonographic markers of chromosomal anomalies. Am J Obstet Gynecol 2004;191:45–67
48. Nicolaides KH, Chervenak FA, McCullough LB. Evidence-based obstetric ethics and informed decision-making by pregnant women about invasive diagnosis after first­trimester assessment of risk for trisomy 21. Am J Obstet Gynecol 2005;193(2):322–326
49. Noonan JT (ed). The morality of abortion. Harvard University Press, Cambridge, MA, 1970
50. Noonan JT. A private choice. Abortion in America in the seventies. The Free Press, New York, 1979
51. Powderly KE. Patient consent and negotiation in the Brooklyn gynecological practice of Alexander J.C. Skene: 1863–1900. J Med Philos 2000;25:12–27
52. Pritchard JA, MacDonald PC, Gant NF. Williams' obstetrics, 17th edn. Appleton­Century-Crofts, Norwalk, CT, 1985: xi
53. Roe v. Wade, 410 US 113 (1973)
54. Ruddick W, Wilcox W. Operating on the fetus. Hastings Cent Report 1982;12:10–14
55. Shinn RL. The fetus as patient: a philosophical and ethical perspective. In: Milunsky A, Annas GJ (eds) Genetics and the law III. Plenum Press, New York, 1985: 317–324
56. Strong C. Ethical conflicts between mother and fetus in obstetrics. Clin Perinatol 1987;14:313–328
57. Strong C. Ethics in reproductive medicine: a new framework. Yale University Press, New Haven, CT, 1997
58. Strong C, Anderson G. The moral status of the near-term fetus. J Med Ethics 1989;15:25–27
59. Walters L. Ethical issues in intrauterine diagnosis and therapy. Fetal Ther 1986;1: 32–37
60. Warren MA. Gendercide. The implications of sex selection. Rowman and Littlefield, Totowa, NJ, 1985
61. Whyte HE, Fitzhardinge PM, Shennan AT et al. External immaturity: outline of 568 pregnancies of 23–26 weeks' gestation. Obstet Gynecol 1993;82:1–7
62. Zoppi MA, Ibba RM, Putzolu M, Floris M, Monni G. Nuchal translucency and the acceptance of invasive prenatal chrom­osomal diagnosis in women aged 35 and older. Obstet Gynecol 2001;97:916–920
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Test yourself – questions and answers

CHAPTER 2 BIOLOGICAL EFFECTS AND SAFETY ASPECTS

1. Which mode of operation can give the highest output intensity? a. B-mode b. Doppler imaging c. Spectral Doppler d. M-mode
2. Which of the following fetal tissues is likely to heat most during an
ultrasound examination?
a. skull bone b. brain c. eye d. myocardium
3. Which of the following safety indices is most appropriate for second- and
third-trimester scanning?
a. TIS b. MI c. TIC d. TIB
4. A diagnostic exposure that produces a maximum in situ temperature rise of
no more than
a. 1.5°C b. 2.5 °C c. 3.5°C
above normal physiological levels (37°C) may be used without reservation on thermal grounds.
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5. Which of the following statements are correct? Prenatal ultrasound exposure has been clearly shown to induce:
a. childhood malignancies b. hearing impairment c. reduced birthweight d. dyslexia
Select one choice from the following:
a. only a, b and c b. only a and c c. only b, c and d d. none of them
CHAPTER 3 SCANNING TECHNIQUES IN OBSTETRICS
AND GYNAECOLOGY
1. Transrectal scan can provide important information if transvaginal scanning is
Ultrasound in obstetrics and gynaecology
not feasible or contraindicated in the following cases except:
a. obesity b. ruptured membranes c. virginal patients d. senile atrophic vagina e. vaginal malformations
2. Which statements about orientation are true?
a. If the uterus is retroverted the bladder and the uterine fundus are on
opposite sides of the screen.
b. If the uterus is anteverted the uterine fundus and the bladder are on
opposite sides of the screen.
c. On a transverse section the right and left sides of the gynaecological
patient are matching those on an MRI picture.
d. On a transverse section the right and the left sides of the gynaecological
patient are the exact reverse of those on a CT picture. e. b and c are true. f. a and c are true.
3. The basic fetal ultrasound exam contains all features below except: a. document fetal number, presentation b. placental location and amniotic fluid volume c. survey of fetal anatomy including the brain d. evaluation of the adnexa of the patient e. documentation of fetal heartbeats
4. Which of the statements below is not correct regarding the endometrium? a. Endometrial thickness varies with the day in the menstrual cycle. b. Endometrial measurements should be done preferably on the transverse
section of the uterus.
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c. If fluid is in the cavity the anterior and posterior stripes should be
measured separately and then added up for a single number representing the total thickness.
d. In postmenstrual patients an echo less than 5 mm thick is usually
consistent with lack of significant tissue on sampling.
e. Saline infusion sonohysterography is the best tool to demonstrate
endocavitary findings.
5. A full urinary bladder is useful for the following except: a. chorionic villus sampling b. localizing the placenta and measuring its distance from the internal os c. in every gynaecological patient using transvaginal scanning d. evaluating placenta accreta close to the bladder wall

CHAPTER 4 INVESTIGATION OF EARLY PREGNANCY

(Note: more than one answer can be correct)
1. The following statements about multiple pregnancies are correct
except one.
a. The chorionicity of the multiple pregnancy is established before
5 LMP-based weeks.
b. The identification of the amnionicity is made earlier than the
chorionicity. c. In dichorionic pregnancies, the dividing wall consists of four layers. d. In the early second trimester, the lambda sign allows differentiation
between mono- and dichorionicity.
2. One of the following sonographic findings is suggestive for early pregnancy failure.
a. The crown–rump length (CRL) is twice the expected length. b. The diameter of the yolk sac is less than 6 mm. c. The heart rate of the embryo is less than 70 beats per minute (bpm). d. The diameter of the amniotic cavity is larger than the diameter of the
yolk sac.
3. Two of the following ultrasound findings are possible signs for an ectopic pregnancy (positive pregnancy test).
a. haemoperitoneum without an intrauterine gestational sac b. cyst in the ovary and an intrauterine trophoblast ring c. fluid in the uterine cavity and an extraovarian solid mass d. two yolk sacs in the gestational cavity without embryonic echo
4. Three of the following first-trimester findings are suspicious for a chromosomal disorder.
a. The placenta is large and contains cysts; the embryo is alive. b. The fetus at 12 weeks seems to have an oedema; there is a nuchal
translucency of >3 mm.
Test yourself – questions and answers
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c. The embryo has a CRL of 25 mm; the heart rate is as high as 185 bpm. d. The embryo has a CRL of 10 mm; the yolk sac diameter is 7 mm.
5. One of the following findings is probably consistent with a normal early pregnancy.
a. CRL 4 mm, diameter of yolk sac 5 mm, diameter of amniotic cavity
7 mm, heart rate 110 bpm
b. CRL 23 mm, diameter of yolk sac 5 mm, diameter of amniotic cavity
24 mm, heart rate 170 bpm
c. CRL 29 mm, diameter of yolk sac 5 mm, diameter of amniotic cavity
34 mm, heart rate 150 bpm
d. CRL 2 mm, diameter of yolk sac 3 mm, diameter of amniotic cavity
4 mm, heart rate 90 bpm
e. CRL 13 mm, diameter of yolk sac 9 mm, diameter of amniotic cavity
12 mm, heart rate 130 bpm

CHAPTER 5 NORMAL FETAL ANATOMY AT 18–22 WEEKS

Ultrasound in obstetrics and gynaecology
1. Basic guidelines by the American Institute of Ultrasound in Medicine include views of:
a. the great vessels of the heart b. hands and feet c. anterior abdominal wall d. face e. all of the above
2. A sequential segmental approach to the heart would include specifice views of all of the following except:
a. view of the upper abdomen to show normal solitus b. left and right ventricular outflow views c. four-chamber view d. ductus venosus e. pulmonary artery and ductal arch
3. Markedly echogenic bowel has been associated with what types of outcome?
a. normal b. aneuploidy c. fetal infection d. fetal demise e. all of the above
4. All of the following is true about the fetal anatomic survey except:
a. it is usually performed during the second trimester b. it is the ideal time for nuchal translucency evaluation c. it requires a systematic approach d. it gives the opportunity to provide important information about
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the fetus
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CHAPTER 6 AMNIOTIC FLUID AND PLACENTAL LOCALIZATION

1. The water content of amniotic fluid is: a. 50–60% b. 70–80% c. 98–99%
2. The normal amniotic fluid index ranges between: a. 5 and 25 cm b. 10 and 30 cm c. 20 and 40 cm
3. There is a high association with pulmonary hypoplasia when severe
oligohydramnios develops:
a. before 20–25 weeks of gestation b. at 30–35 weeks of gestation c. at 35–40 weeks of gestation
4. The association between chronic polyhydramnios and fetal anomalies is
approximately:
a. 1 in 25 b. 1 in 15 c. 1 in 5
Test yourself – questions and answers
CHAPTER 7 ASSESSMENT OF THE PLACENTA
AND UMBILICAL CORD
1. All the following statements concerning placenta accreta are correct except one. a. This anomaly is characterized by myometrial invasion by placental villous
tissue. b. It occurs when the decidua basalis is partially or completely absent. c. It is more common in primigravidae than multigravidae. d. Placentas accreta have an overall maternal and fetal mortality of around 10%. e. Caesarean hysterectomy is often needed.
2. The only statement about chorioangioma that is correct is: a. Chorioangiomas are malignant tumours characterized by a proliferation of
villous capillaries and trophoblastic tissue. b. Chorioangiomas are often diagnosed during the first trimester of pregnancy. c. Most chorioangiomas are large, single, round, encapsulated, near the cord
insertion. d. All chorioangiomas can be complicated by fetal hydrops, due to the
chronic shunting, and by polyhydramnios. e. The fetal risk depends more on the proportion of angiomatous versus
myxoid tissue inside the tumour than on its exact size.
3. The only ultrasound feature mentioned below that is specific to a triploid partial mole is:
a. fetal bilateral cerebral ventriculomegaly b. severe fetal growth restriction
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