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3 Relationships Between Traditional
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Persian/Iranian Medicine and Other
Traditional Medical Systems
Hartwig Schulz*
Consulting and Project Management for Medicinal and
Aromatic Plants, Stahnsdorf, Germany
Abstract
is chapter gives a detailed overview of the history of traditional Arab and Persian medical systems and their interactions with Ayurveda in India, Traditional Chinese Medicine (TCM), and Western trad itional medicine (the so-called ”monastic medicine”) that interacted with or emerged from Islamic medicine in the Middle Ages. e rst records of medicinal plants date back more than 5000 years to the time of the Sumerians in southern Mesopotamia, who prepared lists with various plant species. Furthermore, ancient Chinese and Egyptian papyrus writings dating back to 3000  also reveal the medicinal use of plants at that time. e “Ebers Papyrus” from ancient Egypt, for example, provides extensive information on more than 850 herbal medicines. Manuscripts of Traditional Persian/Iran­ian Medicine (TPM/TIM), written by Persian scholars especially in the Middle Ages, not only represent a treasure of traditional medical and pharmaceutical knowledge, but also provide a collection of ingeni­ous studies regarding the use of medicinal plants. In present days, herbal medicines are experiencing a renaissance and are extensively used for various therapeutic purposes. In this context, this chapter contains numerous references to various ethnobotanical studies and also gives a general overview of the intercultural exchange of traditional medical systems and the resulting gain in experiential know­ledge about the individual medicinal plants. Today, this traditional medical knowledge represents an important source of inspiration for the development of new ecient phytopharmaceutical drugs and new therapeutic strategies. Although traditional medicine continues to play an important role in Iran today, much of this traditional knowledge has not been adequately addressed by scientic research. erefore, it seems advisable to verify the eectiveness of traditional treatments using the new scien­tic tools available today, especially in cases where there is little or no supporting data in the literature.
-
Since ancient times, plants have been one of the first and most available resources usable for treating illnesses. There has always been a close relationship between man and plants, and the medicinal effects of plants and their
*Email: hs.consulting.map@t-online.de
Introduction
© CAB International 2023. Medicinal Plants Used in Traditional Persian Medicine
uses have been known more or less by every­body (UNESCO, 1996). In 2002, the World Health Organization (WHO) provided the following detailed description of the term “Traditional Medicine”: “Traditional medi­cine (TM) is a comprehensive term used to refer both to TM systems such as Traditional
(eds. H. Schulz, Seyed Ahmad Emami and Farsad Nadjafi)
DOI: 10.1079/9781800621671.0003 136
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Chinese Medicine, Indian Ayurveda, Islamic Traditional Medicine, and to various forms of indigenous medicine” (WHO, 2002) (Fig. 3.1).
Traditional medicine includes medica­tion therapies if they involve the application of herbal medicines, animal parts, and/or minerals; and non-medication therapies if they are carried out primarily without the use of medication, as in the case of acupunc­ture, manual therapies, and spiritual therapies (WHO, 1978, 2002).
In general, traditional medicine offers the enormous advantage that it is considered part of the culture and therefore cultural problems that could affect the application of the medicine can usually be avoided. More­over, it can be used in conjunction with con­ventional medicine and in this way often increase the healing success. The develop­ment and promotion of Traditional Medi­cine could also be seen as respecting and honoring the respective culture and heritage of people around the world. Thus, the exten­sive medical/pharmaceutical knowledge col­lected in ancient Persia is still successfully used today for the diagnosis, prevention, and therapy of various diseases. In this con­text, Traditional Persian/Iranian Medicine (TPM/TIM) is based exclusively on practical experience and observations that have been passed down from generation to generation.
Due to negligence, TPM/TIM has had a weak presence in the world for a long time.
However, in recent years, a variety of re­search activities and faculty centers have created awareness and a suitable platform to introduce and promote Persian medicine to the world.
Today, numerous scientific articles are published in international journals dealing with evidence-based complementary and al­ternative medicine, as well as basic concepts and historical aspects of TPM/TIM (Moeini and Gorji, 2016; Naghizadeh etal., 2020).
Pre-Islamic Period (c.8000 BC–6th
Century AD)
The roots of TPM/TIM go back more than 8000 years and today it is considered a branch, if not the root, of the so-called “Arabic Unani Medicine or Islamic Traditional Medicine (ITM)” (Mosaddegh and Naghibi,
2002). The earliest records describing the use of medicinal plants come from the As­syrians-Babylonians and the Egyptians, which developed in parallel. The clay tablets of the Sumerians already list hundreds of different medicinal plants such as myrrh (Commiphora myrrha) and opium (Papaver somniferum) (Sumner, 2000). The individual medical use of many plants is also described in more detail as early as 3000  in the pa­pyrus writings that have been handed down
Fig. 3.1. Development of medical systems from antiquity to present days.
Chinese/Kampo/
Ayurveda medicine
(from c.5000
BC)
Modern evidence-based
medicine
(
from 20th century AD)
Monastic medicine
(from 11th century
Medieval Islamic medicine
(7–10th century
Pre-Islamic and Greco-Arab
medicine
(c.8000 BC–6th century AD)
AD)
AD)
138 Hartwig Schulz
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from China and Egypt. One of the oldest and most important collections of these documents represent the book Papyrus Ebers (c.1550 ), which contains information how to use more than 850 herbal plants such as garlic (Allium sativum), juniper (Juniperus communis), can­nabis (Cannabis sativa), caraway (Carum carvi), coriander (Coriandrum sativum), fennel (Foe- niculum vulgare), anise (Pimpinella anisum), dill (Anethum graveolens), peppermint (Mentha ×
piperita), and mandrake (Mandragora officinar­um) (Sumner, 2000; Bryan, 2021) in order to
treat various diseases (Fig. 3.2).
Sumac (Rhus coriaria) was also exten-
sively used in folk medicine during ancient
times. Even today, this species is still col­lected and processed in mountain regions of Iran. The red fruits of sumac have a charac­teristic sour-salty taste, which makes them also a popular spice in the food industry in addition to their use as a herbal drug (Abdul­Jalil, 2020).
The English medical historian Cyril El­good even assumes that TPM/TIM was al­ready more advanced than the Assyrian one at that time and it can certainly also be as­sumed that several elements of this medical system were adopted by the Greeks (Elgood, 1979, 1992). Taking into account the defin­itions given by the WHO, Persian medicine
Fig. 3.2. Days of the Papyrus Ebers (1500 BC). The painting shows a head pharmacist dictating to a scribe and supervising the compounding of medicines in a temple drug room. (Artist: Robert A. Thom (1915–1979). Source: National Library of Medicine, Rockville Pike, Bethesda. Public Domain, https://
collections.nlm.nih.gov/catalog/nlm:nlmuid-101651536-img.)
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can be divided into a written part and an­other one consisting of orally transmitted, verbal traditional medicine (Naseri and Ardakani, 2004). The ancient manuscripts of Egyptian medicine from the middle of the 2nd millennium  initially refer mainly to various symptoms and diagnoses, and, in this context, describe different treatment approaches in which mineral, herbal, and animal substances were used. Mesopota­mian medicine, which is also documented by cuneiform texts on clay tablets, developed in parallel with Egyptian medicine. Surgical procedures as well as the treatment of bone fractures have also been proven to have been performed during this time. The Achaemen­ian kings of the Persian Empire in the 6th and 5th centuries  also employed phys­icians from Egypt at their courts.
It must be emphasized, however, that the Greek medicine of the 5th century  has some parallels to Mesopotamian medi­cine in terms of content, which can be ex­plained by the cultural and economic exchange between the Orient and the Medi­terranean region that already existed at that time. It can therefore be assumed that the medicine attributed to the Greek philoso­pher “Hippocrates of the island of Kos” was already influenced by elements of Mesopo­tamian culture. Evidence shows that even before the establishment of the famous medical schools of ancient Greece (Hippoc­rates, Homer, Asclepius) in the 5th to 6th century , at Cnidos in Asia Minor and on the nearby Aegean Island of Kos, different medical practices were already commonly applied in Mesopotamia, India, and Iran (Najmabadi, 2001). However, it is also un­disputed that the texts in Hippocrates’ handbook De medicina (Diller, 2021), trans­lated and written down by Aulus Cornelius Celsus at that time (Spencer, 1989), set a new standard for medical research and edu­cation until modern times. It was only with the emergence of scientific medicine in the 19th century that Hippocratic medicine fell more and more into the background. How­ever, the Hippocratic Oath survived into the 20th century and was only replaced in 1948 by the World Medical Association with the Geneva Declaration, to which many doctors
worldwide still feel committed today. In con­nection with traditional horticulture and the history of medicine in the 8th century , the Chaldean Marduk-apla-iddina II, who came from the Bit Yakin tribe, is also worth mentioning. At that time, the plants of the royal medicinal herb garden were listed on a clay tablet. From these cuneiform records it could later be learned, for example, that purslane (Portulaca oleracea) was already important as a remedy in ancient times (Jastrow, 1914). Marduk-apla-iddina II, who took advantage of the political unrest in the Assyrian Empire to conquer Babylonia in 721 , was first mentioned historically in 729 .
In ancient Persia, a vast area with great differences in climate and vegetation, the in­habitants were familiar with various medi­cinal plants from very early on. Several medicinal herbs such as basil (Basilicum ten- uiflorum), chicory (Cichorium intybus), violet (Viola spp.), and peppermint (M. × piperita) are already mentioned in the Avesta, the holy book of the Zoroastrian religion. Al­though the Avesta is one of the oldest reli­gious documents of mankind, it only became known in Europe through the French Orien­talist Abraham Anquetil-Dupperon, who traveled to the East Indies in  1755 to ob­tain a copy of the Avesta from the Parsi priests there. In addition, the names of 30 sacred plants are mentioned in the Bunda- hishn (Azizi, 2008; Azizi etal., 2008). In an­cient (pre-Islamic) Iran, many medicinal plants such as barberry (Berberis integerri-
ma), saffron (Crocus sativus), violet (Viola od- orata), white water-lily (Nymphaea alba), narcissus (Narcissus tazetta), myrtle (Myrtus communis), damask rose (Rosa × damascena),
citron (Citrus medica), pepper (Piper nigrum), agarwood (Aquilaria agallocha), haoma (Eph- edra spp.), pomegranate (Punica granatum), hemp (Cannabis sativa), olive (Olea euro- paea), Syrian rue (Peganum harmala), black mustard (Brassica nigra), asafoetida (Ferula
assa-foetida), gum tragacanth plant (Astrag­alus tragacantha), true indigo (Indigofera tinctoria), cumin (Cuminum cyminum), frank- incense (Boswellia sacra), cinnamon (Cin­namomum verum), and labdanum (Cistus ladanifer) were used; and the aromatherapy
140 Hartwig Schulz
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with aromatic drugs such as camphor (Cin­namomum camphora), sandalwood (Santalum album), and Arabian balsam (Commiphora gileadensis) was also practiced. Some min-
erals such as alum (K sulfur, lapis (lapis lazuli), and nushadir salt
SO 4·Al 2(SO 4) 3 ·24H 2 O),
2
(ammonium chloride) are among the drugs that were used in ancient Iranian medicine (Emami etal., 2017).
As part of the massive military expan­sion, the Islamized Arabs conquered Egypt, North Africa, Palestine, Syria, Mesopota­mia, and Persia by the middle of the 7th cen­tury . At the same time, at the beginning of the 9th century , some philosophical writings (written for example by Aristotle and Plato) as well as various scientific and medical Greek literature were translated into Arabic on a large scale. This allowed the cultural policy of the Abbasids to follow the example of the pre-Islamic Persian dynasty of the Sasanids ( 226–642). Greek manu­scripts had been very popular at that time and occasionally even reached Baghdad as a gift from a Byzantine emperor. The transla­tion of the mentioned books is due to the valuable and continuous efforts of some famous translators such as John Grammati­cus, Aaron Alexandrian, Sergius of Rechina, Issa ibn Sahar Boxt, Sabet ibn Qorrah, Qusta ibn Luqa of Heliopolis, Sahl ibn Shapur, Shapur ibn Sahl, Ibn Serapion, al-Kendy, and members of some families such as the Box­tishu (the servant of Christ), Massarjuyah, Hunayn, Karkhy, Massuyah, and Sinan fam­ilies (Tayarani-Najaran etal., 2014). Islamic polymaths and physicians such as Rhazes ( 850–923) and Avicenna ( 980–1037) adopted the writings of Hippocratic–Galian medicine that had become known to them in this way and systematically developed them further. Later, in the High Middle Ages, their works were translated into Latin.
Medicinal herbs are among the most important natural resources that may have a direct positive impact on people’s health. Even today, many of the medicines we use every day are derived directly or indirectly from medical herbs. The great importance of plant medicine was already recognized in an­tiquity; for example, the Egyptians had used the healing power of certain herbs since the
16th century . But the Israelites, too, used medicinal plants since ancient times and in India the most important and authentic classical work of Ayurveda (Charaka-Samhita) is originally written in Sanskrit. China’s old­est pharmacopoeia is attributed to one of its emperors named “Shinon” who lived around 2800 . From the 8th to 10th centuries , the famous Iranian scientists Avicenna and Rhazes (Razi) were leaders in this field of knowledge (Mah Van, 2002).
The culmination of Avicenna’s philo­sophical work is seen in his writing Kitāb al- Shifā (Book of Healing), in which he dealt intensively with the teachings of Aristotle. In addition, he summarized the state of knowledge of Islamic medicine at that time in his al-Qānūn fī al-Tibb (Canon of Medicine). In this context it was particularly important for him to dedicate a concrete and independ­ent place to medicine within the canon of the other sciences.
In Western countries, advances in this science date back to the Early Middle Ages and are still pursued today by scholars such as Constantine, Epitome Matthiol, and Dragen­dorff, and others (Mozaffarian, 1996; Zargari,
2014). In Iran, the most comprehensive study in this case was conducted by Ali Zargari and the result was published in five volumes (Jouri and Mahdavi, 2010). With regard to the different climatic conditions and soil quality, Iran offers optimal condi­tions for a high biodiversity of numerous different medicinal plant species, which often occur only in this country and can be considered endemic.
With an extent of 1,648,000 km
2
, Iran has a widely varied climate; it is a habitat for very different plant species. Nearly 190 fam­ilies of vascular plants are found in this country, containing 8500–9500 species, the endemic plants being relatively numerous. More details can be taken from the book The Endemic Phanerogams of the Flora of Iran, where 2324 species are mentioned, all of which belonging to Iranian Phanerogams (Emami and Aghazari, 2011).
In the Department of Natural Resources of Fars Province alone, more than 1600 me­dicinal plant species are found, of which more than 100 species are cultivated on an
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area of 600 ha. With an area of 133,000 km2, this province in Iran covers about 8.1% of the total area of the country.
The long-standing use of medicinal plants provides a valuable database regard­ing the safety and efficacy of individual plant species. Traditional Persian Medicine (TPM) has a solid theoretical basis, which is also supported by numerous evidences of clinical efficacy. Accordingly, the chance of being able to identify individual bioactive phytopharmaceuticals is comparatively high. In traditional medicine, there is a particular focus on medicines with cardiovascular ac­tivity, which were already listed by Avicenna (Abū ʿAlī al-Husayn ibn ʿAbd Allāh ibn Al- Hasan ibn Ali ibn Sīnā), a famous Persian physician of the 11th century , in his book entitled The Treatise on Cardiac Drugs dedi­cated to this special field. Here, Avicenna mentioned a total of 83 cardioactive drugs obtained from plant, animal, and mineral sources and described their therapeutic ef­fects and assumed mechanisms in the treat­ment of various cardiovascular diseases (Javadi and Emami, 2015). In recent years, most of these cardioactive plants proposed by Avicenna have been the subject of several pharmacologic and clinical studies (Park etal., 2011; Seo etal., 2020). Today, it is gen­erally accepted that loss of the sense of smell leads to a noticeable impairment of the gen­eral quality of life. However, only a small proportion of patients with olfactory loss re­spond to the currently available medica­tions. Therefore, there are various efforts to use the long-standing medical knowledge of TPM in this context as well. Such therapies were already developed in Avicenna’s time and it can be assumed that the olfactory changes or complete loss of the sense of smell observed in infections with COVID-19 viruses can be adequately treated in the near future by means of TPM/TIM (Sinaei etal.,
2017). Furthermore, in several cases the very high cost of synthetic pharmaceutical products, as well as the need for a sustain­able economy, is prompting the industry to pay more attention to the use of medicinal plants today (Noorhosseini etal., 2011).
Based on plant species recommended by Avicenna, for example, a link could be established
between TPM/TIM and relevant modern pharmacologic data to support the develop­ment of new efficient and safe cardiovascu­larly active drugs (Sobhani et al., 2017). Interestingly, some of these plant species showed significant cardiovascular activities via mechanisms such as calcium antagon­ism, angiotensin-converting enzyme inhib­ition, antiarrhythmic, anticoagulant and fibrinolytic activities, and reduction of car­diac fibrosis. In this context, phenolic com­pounds such as luteolin, rosmarinic acid, salvianolic acid A, cardamonin, cinnamic acid, punicalagin, punicalin, strictinin A, granatin B, ellagitannins, and anthocyanins were particularly responsible for cardioac­tive activity and are therefore considered to be promising candidates for the develop­ment of new cardiovascular drugs (Sobhani etal., 2017).
Today, however, more and more the preservation of this knowledge can no longer be guaranteed, as the transmission between generations no longer works as well as it did in the past (Anyinam, 1995). Yet the loss of this traditional knowledge in a rap­idly changing culture is as irreversible as the disappearance of plant species themselves (Joshi and Joshi, 2000). Considerable ef­forts must therefore be made to document the medicinal use of the related plant spe­cies before these traditional medicinal prac­tices are irreversibly lost (Joshi and Joshi,
2000).
Special attention is therefore paid to support the research of medicinal plants in Iran (Jivad etal., 2016; Parsaei etal., 2016; Rouhi-Boroujeni etal., 2016a). Phytothera­py has a long history in this country, so this topic has been extensively described in an­cient Iranian pharmacopoeias, such as the works of Avicenna. In addition, numerous studies have been published showing success­ful approaches to treat various diseases by applying Traditional Iranian Medicine (TIM) (Ibrar etal., 2007; Ahmadipour etal., 2016; Rouhi-Boroujeni etal., 2016b).
In Iran particularly a high diversity of species is found in the Lamiaceae (Labiatae) family and many of these species are also used in traditional folk medicine. Unfortu­nately, very often only few clear references
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concerning the ethnobotany and ethno­pharmacology of the Labiatae species are available, and most publications and historic documents are only available in Persian or Arabic (Naghibi et al., 2010; Amiri et al.,
2014).
Medieval Islamic Period
(7th–10th Century
AD)
TIM is a holistic and comprehensive medical school whose origins date back over 12 cen­turies. In this traditional medicine system, cancer was already a well-known disease with many treatment options. Especially, Razi (Rhazes;  865–925), Ahwazi (Hali Abbas;  930–994), Avicenna ( 980–
1037), Jorjāni ( 1042–1136), and Aqili Khorasani (18th century ) were among the most important doctors of their time who discussed various forms of cancer and their treatment in their books. They used many different types of plants in the treat­ment of the various tumours. In this con­text, Zakhireh Khārazmshāhi (The Treasure of Khārazmshāh) by Seyyed Esma’il Jorjāni ( 433–531/ 1041–1136) is known as the most important Persian medical book of TIM (Tayarani-Najaran etal., 2014).
Today, more than 80% of the world’s population apply traditional medicine, es­pecially medicinal plants, to treat the most common diseases and ailments. Especially in developing countries and rural areas, the use of medicinal plants represents an im­portant economical alternative within indi­vidual health systems (Alexiades and Sheldon, 1996; Robineau and Soejarto, 1996). In add­ition, traditional medicine provides a valu­able source of knowledge for research and development of new pharmaceutical prod­ucts. Therefore, in recent years the use of ethnobotanical information has become particularly important in medicinal plant re­search (Heinrich, 2000). Knowledge about the use and properties of medicinal plants was often acquired empirically and passed on from generation to generation (Lev and Amar, 2000). From the 9th century  on­ward, under the guidance of the Persians
and Arabs, who at this time were consider­ably more advanced than the inhabitants of medieval Europe, medical schools (so-called “Bimaristans”) emerged in the medieval Is­lamic world. As admirers of Greco-Roman culture, the Arabs translated numerous medical texts into Arabic for further studies (Castleman, 2001). As early as  600, the Nestorians (a Christian sect) founded trans­lator centers in Baghdad, Damascus, An­tioch, Basra, and Cairo in the Eastern Roman Empire, Syria, and Persia. The most import­ant achievement of these translators today is generally considered to be the translation of Galen’s very extensive writings into Arabic. On the basis of Galen’s theory of the four humors, numerous adaptations and in­dependent works were written later, such as Avicenna’s Canon medicinae (Canon of Medi- cine), which had a decisive influence on the development of medicine in the Western world for centuries (Figs 3.3 and 3.4).
In the dissemination of medical know­ledge, however, “cultural interfaces” also played a very important role again, and again at a later time. In this context, particular ref­erence should be made to the famous medi­eval medical school of Salerno (Civitas Hippocratica) and the scientific languages used there: Latin, Greek, Hebrew, and Arabic. Mention should be also made here of the translator “Constantine of Africa” ( 1010–
1087), to whom a collection of textbooks is attributed that later became known as Articel
-
la describing the central subject areas of
medieval medicine. In addition, the collection of recipes Antidotarium Nicolai is considered a very important work that also originated in Salerno and on which medicinal therapy was oriented until modern times (Sudhoff, 1930). The Iberian Peninsula also represented an­other important interface between “Orient” and “Occident” in medieval times, as the cul­tures of Islam and Christianity met there in close proximity. Of particular importance for the development of European medicine and science was the school of translators in To­ledo founded by Gerhard of Cremona ( 1134–1187), which translated a large num­ber of Arabic writings into Latin.
In addition, the Arabs had access to various plant raw materials due to their
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Fig. 3.3. Canon of Medicine, first page of the introduction to the first book (Arabic manuscript, 1597). (https://commons.wikimedia.org/wiki/File:Avicenna_canon_1597.jpg#/media/File:Avicenna_canon_1597.jpg.)
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org/w/index.php?curid=99757546.)
India. In this way, herbal books, medical textbooks, and translations of the classics of antiquity also reached them from both East and West. It must be emphasized, however, that Muslim botanists and physicians not only translated the traditional knowledge of materia medica, but considerably expanded
it. For example, al-Dinawari described more than 637 herbal drugs in the 9th century and Ibn al-Baytār d escribed more than 1400
different plant species in the 13th century, of which more than 300 were his own discoveries.
In medieval Islamic literature, in which the individual plant species are closely associated
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with medicine and agronomy, there are al­ready numerous references to the use of me­dicinal herbs. Furthermore, these plant species are described in various philosoph­ical, magical, and geographical contexts (de Vos, 2013). Especially three medieval pharmaceutical treatises, written by Yūhan­nā ibn Māsawayh, had an immense influ­ence on the development of pharmacy in early modern Europe at that time. Although these works had achieved great importance, they are relatively unknown in the history of pharmacy and medicine, and the exact iden
­tity of the author cannot be precisely proven even today, so that in principle it is also con­ceivable that the manuscripts were written under a pseudonym. The only thing that seems certain is that these treatises can be clearly assigned to the state of knowledge of the medieval Islamic world at that time. In any case, the writings contained numerous innovations that formed the basis for the theory and practice of Western pharmacy for centuries and probably also exerted a considerable influence on medical science in Europe (Troupeau, 1995; Cambra, 2001; Cárcer, 2001).
It has been reported that several plant species were already used for therapeutic purposes in the ancient Arab world as well as in other contemporary and earlier cultures. By the 10th century, the Oriental Islamic culture was able to develop a solid know­ledge of the effects of medicinal and spice plants. In particular, on the basis of the two writings, Kitāb Jawāhir al-tayb al-Mofradah (Essences of Simple Perfumes, written by Ibn Māsawayh) and Kitāb al-Adwiyah al-Mofra
-
dah (Simple Drugs, written by Ibn Wāfid),
this knowledge spread in Andalusia (now Spain) in the 11th century, which is con­sidered the so-called “Golden Age” of Anda­lusian pharmacology (Cárcer, 2001). Since the Muslim botanist al-Asma’i ( 740–828) wrote his famous work Kitāb al-Nabāt wa-’l- Shajar (Book of Plants and Trees), which be- came the standard work on Arabic plant names and botanical terms for later gener­ations of pharmacologists, some efforts were made to clarify or correct the botanical terms he used. Unfortunately, different bo­tanical systematics were in use at that time,
ranging from simple alphabetical sorting of individual plants to subdivisions according to their respective practical medicinal uses. However, subdivisions were also found in “trees, flowers and garden vegetables”, with the group of trees (including shrubs) and plants being further subdivided according to whether or not the fruits or other plant parts could be used as food (Bolens, 1977).
Some early Islamic works, such as those of al-Shaybāni, Ibn al-Arabi, al-Bahili, and Ibn as-Sikkit, have unfortunately been lost, but their works were extensively cited in later books by Abu Hanifah al-Dinawari, Ibn Sidah, and other authors. As a result of the further spread of Islam and the intensive ex
­change of information with Middle Eastern, Indian, and North African sources, a rich bo­tanical literature thus developed in which Muslim authors attempted to record the in­dividual significance of medicinal plants and stepwise develop a botanical systematics from this knowledge. In this context, the plant terminology of the older Arabic no­menclature was also gradually expanded (Bolens, 1977). In the treatises of Jabir ibn Hayyān, the herbs needed for the produc
­tion of medicinal plant extracts were de­scribed in more detail, while Abu Ubaid al-Bakri focused more on the plant and tree species growing in Andalusia (Nasr, 2003). Finally, in his book entitled Umdat al-Tabib fi
Mʿarifat al-Nabāt lia-kolle Labib (An Import­ant Botanical Book for Physicians, published
by Mohammad Arabi al-Khattabi in 1995), Abul Khair al-Ishbili attempted to obtain a more appropriate classification of medicinal plants according to their individual genera, species, and subspecies (Samso etal., 1996). Muslim botanists at that time already had an extensive knowledge regarding the culti­vation of different plant species and had also gained initial insights into how different types of fruit (e.g., different species of the genus Prunus) could be produced by grafting on the same tree. In addition, they were al­ready able to carry out first breeding experi­ments with wild rose species (e.g., Rosa × damascena) and almond trees (Prunus dulcis) occurring in Persia, in order to develop inter­esting subspecies with new quality charac­teristics in this way (Durant, 1950). The