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6TH EDITION
THE CARDIAC
CATHETERIZATION
HANDBOOK

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6TH EDITION
https://t.me/med1917
THE CARDIAC
CATHETERIZATION
HANDBOOK
Morton J. Kern, MD, MSCAI, FAHA, FACC
Professor of Medicine
University of California, Ir vine
Orange, California;
Chief of Medicine
Long Beach Veterans Health Care System
Long Beach, California
Paul Sorajja, MD, FACC, FAHA, FSCAI
Director, Center for Valve and Structural Heart Disease
Minneapolis Heart Institute
Abbott Northwestern Hospital
Minneapolis, Minnesota
Michael J. Lim, MD
Co-Director, Center for Comprehensive Cardiovascular Care (C4)
Director, Division of Cardiology
Professor of Internal Medicine
Jack Ford Shelby Endowed Professor in Cardiology
Director, Cardiac Catheterization Laboratory
Director, Cardiovascular Diseases and Interventional Cardiovascular
Diseases Fellowship Programs
Saint Louis University School of Medicine
St. Louis, Missouri

1600 John F. Kennedy Blvd.
https://t.me/med1917
Ste 1800
Philadelphia, PA 19103-2899
THE CARDIAC CATHETERIZATION
HANDBOOK, SIXTH EDITION
Copyright © 2016 by Elsevier, Inc. All rights reserved.
No part of this publication may be reproduced or transmitted in any form or by
any means, electronic or mechanical, including photocopying, recording, or any
information storage and retrieval system, without permission in writing from the
publisher. Details on how to seek permission, further information about the
Publisher’s permis sions policies and our arrangements with organizations such as
the Copyright Clearance Center and the Copyright Licensing Agency, can be
found at our website: ww w.elsevier.com/permissions.
This book and the individual contributions contained in it are protected under
copyright by the Publisher (other than as may be noted herein).
Notices
Knowledge and best practice in this field are constantly changing. As new
research and experience broaden our understanding, changes in research
methods, professional practices, or medical treatment may become
necessary.
Practitioners and researchers must always rely on their own experience
and knowledge in evaluating and using any information, methods,
compounds, or experiments described herein. In using such information or
methods they should be mindful of their own safety and the safety of others,
including parties for whom they have a professional responsibility.
With respect to any drug or pharmaceutical products identified, readers are
advised to check the most current information provided (i) on procedures
featured or (ii) by the manufacturer of each product to be administered, to
verify the recommended dose or formula, the method and duration of
administration, and contraindications. It is the responsibility of practitioner s,
relying on their own experience and knowledge of their patients, to make
diagnoses, to determine dosages and the best treatment for each individual
patient, and to take all appropriate safety precautions.
To the fullest extent of the law, neither the Publisher nor the authors,
contributors, or editors, assume any liability for any injury and/or damage to
persons or property as a matter of products liability, negligence or other wise,
or from any use or operation of any methods, products, instructions, or ideas
contained in the material herein.
ISBN: 978-0 -323-34039 -7
Previous editions copyrighted 2011, 20 03, 1999, 1995, and 1991.
Librar y of Congress Cataloging-in-Publication Data
The cardiac catheterization handbook / [edited by] Mor ton J. Kern, Paul Sorajja,
Michael J. Lim.—Sixth edition.
p. ; cm.
Preceded by The cardiac catheterization handbook / edited by Morton J. Kern.
Includes bibliographical references.
ISBN 978 -0 -323-34039-7 (pbk. : alk. paper)
I. Kern, Morton J., editor. II. Sorajja, Paul, editor. III. Lim, Michael J., editor.
[DNLM: 1. Cardiac Catheterization. WG 141.5.C2]
RC683.5.C25
616.1’20754– dc23
International Standard Book Number: 978-0-323-34039-7
Content Strategist: Dolores Meloni
Content Development Specialist: Lauren Boyle
Publishing Services Manager: Catherine Jackson
Senior Project Manager: Rachel E. McMullen
Design Direction: Ryan Cook
Printed in China
Last digit is the print number: 9 8 7 6 5 4 3 2 1
2015006020

I thank my wife, Margaret, and daughter,
https://t.me/med1917
Anna Rose, who are the ever-stronger systole
of my life.
Morton J. Kern
To my children, Parker and Taylor. May
all who read and learn from these pages
remember that all of our patients are
somebody’s family and deserve everything
we would do for our own.
Michael J. Lim
To my loving daughters, Natali and Amalin,
who inspire me every day.
Paul Sorajja

Contributors
https://t.me/med1917
Subhash Banerjee, MD
VA North Texas Healthcare System and University of Texas
Southwestern Medical Center
Dallas, Texas
Barry A. Borlaug, MD, FACC
Consultant, Cardiovascular Diseases
Cardiology
Mayo Clinic;
Associate Professor of Medicine
Mayo Medical School
Mayo Clinic;
Director, Circulatory Failure Research
Cardiology
Mayo Clinic
Rochester, Minnesota
Charles Chambers, MD
Professor of Medicine and Radiology
Heart and Vascular Institute
Penn State Hershey Medical Center
Hershey, Pennsylvania
Douglas Emmet Drachman, MD
Director, Cardiology Fellowship Program
Division of Cardiology
Massachusetts General Hospital
Boston, Massachusetts
Scott W. Ferreira, MD, MSE
Assistant Professor
Internal Medicine/Cardiology
Saint Louis University
St. Louis, Missouri
Michael Forsberg, MD
Assistant Professor of Medicine
Cardiology
Saint Louis University;
Staff Physician
Cardiology
John Cochran VA Medical Center
St. Louis, Missouri
Joerg Herrmann, MD
Department of Internal Medicine
Division of Cardiovascular Diseases
Mayo Clinic
Rochester, Minnesota
vivi

Contributors vii
https://t.me/med1917
Navin K. Kapur, MD
Interventional Cardiologist
The Cardiovascular Center
The Molecular Cardiology Research Institute
Tufts Medical Center
Boston, Massachusetts
Morton J. Kern, MD, MSCAI, FAHA, FACC
Professor of Medicine
University California, Irvine
Orange, California;
Chief of Medicine
Long Beach Veterans Health Care System
Long Beach, California
Andrew John Klein, MD, FACC, FSCAI
Staff Interventional Cardiologist
Endovascular and Vascular Medicine
Director of Endovascular Services
Director of Cardiovascular Research
Medicine, Division of Cardiology
John Cochran VAMC, Saint Louis VA Healthcare System;
Assistant Professor of Medicine
Medicine, Division of Cardiology
Saint Louis University School of Medicine
St. Louis, Missouri
Chad Kliger, MD, MS, FACC
Assistant Professor of Cardiology
Hofstra School of Medicine
Attending Physician
Division of Structural and Congenital Heart Disease
Lenox Hill Heart and Vascular Institute, North Shore-LIJ Health
System
Hempstead, New York
Michael Lee, MD
Assistant Professor
Division of Cardiology
University of California Los Angeles Medical Center
Los Angeles, California
Michael J. Lim, MD
Co-Director, Center for Comprehensive Cardiovascular Care (C4)
Director, Division of Cardiology
Professor of Internal Medicine
Jack Ford Shelby Endowed Professor in Cardiology
Director, Cardiac Catheterization Laboratory
Director, Cardiovascular Diseases and Interventional
Cardiovascular Diseases Fellowship Programs
Saint Louis University School of Medicine
St. Louis, Missouri
Ali A. Mehdirad, MD, FACC
Marvin and Harlene Wool Professor and Director of EP Services
Center for Comprehensive Cardiovascular Care
Saint Louis University
St. Louis, Missouri
Pranav M. Patel, MD
Chief of Cardiology Director, Cardiac Catheterization Laboratory
Associate Director, Cardiovascular Medicine Fellowship
Assistant Professor of Medicine Division of Cardiology
University of California, Ir vine
Orange, California

viii
https://t.me/med1917
Contributors
Carlos E. Ruiz, MD, PhD
Professor of Cardiology in Pediatrics and Medicine
Director, Structural and Congenital Heart
North Shore Health System and Lenox Hill Heart and Vascular
Institute of New York
New York, New York
Kimberly A. Skelding, MD
Interventional Cardiologist
Cardiology
Geisinger Health System
Danville, Pennsylvania
Paul Sorajja, MD, FACC, FAHA, FSCAI
Director, Center for Valve and Structural Heart Disease
Minneapolis Heart Institute
Abbott Northwestern Hospital
Minneapolis, Minnesota
Jennifer A. Tremmel, MD, MS
Assistant Professor
Medicine (Cardiovascular)
Stanford University Medical Center
Stanford, California
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