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P O RTA L S / E X P O S U R ES
P I T F A L L S
• Improper incision placement can make the disk excision and instrumentation very difficult to perform and may compromise implant insertion.
• Be aware of the correct disk level to be addressed in cases in which there is transitional lumbosacral anatomy.
• Avoidance of electrocautery may reduce the incidence of retrograde ejaculation. Bipolar cautery or other means to achieve hemostasis is recommended.
P O RTA L S / E X P O S U R ES
I N S T RU M E N T A T I O N
• Smooth-edged retractors are important to avoid inadvertent vessel injuries.
• Proper illumination into the abdominal cavity is crucial. A headlight or direct fiberoptic lighting is helpful.
Procedure 32  | Anterior Lumbar Interbody Fusion    299
FIGURE 32-4 
P O RTA L S / E X P O S U R ES
C O N T RO V E R S IE S
• The use of a cosurgeon (general or vascular surgeon) during the anterior lumbar approach is dependent upon the individual surgeon’s training and expertise.
C-arm
FIGURE 32-5 
A
B
FIGURE 32-6 
C-arm
300    Procedure 32| Anterior Lumbar Interbody Fusion
n
P O RTA L S / E X P O S U R ES
P E A R LS
• If the L5-S1 disk lies low in the pelvis and is at an acute angle, the incision will need to be lower on the abdomen to allow the proper trajectory for disk excision and graft placement.
• Always confirm the disk level with fluoroscopy or radiographs to avoid wrong-level surgery.
Blunt dissection is performed down to the anterior disk space.
n
Retractors are placed appropriately, depending on the disk space being
addressed. At L4-5, the aorta and inferior vena cava are retracted left to right. At L5-S1, the middle sacral artery and vein are ligated (see Figure 32-4), and the iliac veins are retracted laterally.

Procedure

Step 1
n
The anterior disk is incised with a long-handled no. 10 scalpel.
n
An end-plate elevator is used to develop the interval between the subchondral
bone and the cartilaginous end plate (Figure 32-7).
n
S T E P 1 P EA R L S
• Properly developing the interval between the subchondral bone and the cartilaginous end plate with a disk elevator is crucial for efficient and complete disk excision.
• If the end plates are sclerotic, a bone hook can be used to perforate the subchondral bone in several areas to expose bleeding bone.
Disk rongeurs are used to remove large disk fragments (Figure 32-8).
n
Long-handled curettes are used to gently scrape the end plates of any remaining
pieces of cartilage and to expose bleeding bone.
S T E P 1 P IT FA L L S
• When incising the disk margins, the sharp edge of the blade should always point away from the vascular structures.
• When exiting and entering the disk space during excision, maintain an awareness of the location of the vascular structures. Veins can easily slip beneath the edges of retractors.
• Be aware of the orientation of the end plates when excising the disk to avoid disruption of the subchondral bone.
FIGURE 32-7 
FIGURE 32-8 
Procedure 32  | Anterior Lumbar Interbody Fusion    301
S T E P 2 P EA R L S
• Slowly distract the collapsed disk spaces to allow for viscoelastic expansion and restoration of disk height. Paddled distractors of progressive heights are inserted and rotated in the interbody space to restore segmental lordosis.
• Ensure that the implant is inserted parallel to the end plates.
S T E P 2 P IT FA L L S
• Inserting the implant at an angle not parallel to the end plates will fracture the subchondral bone and result in implant settling and loss of lordosis.
• Overaggressive insertion or impaction of the implant can cause fracture and displacement of the posterior vertebral body and subsequent thecal sac or nerve root impingement.
S T E P 2
I N S T RU M E N T A T I O N /
I M P L AN TAT IO N
• Various anterior lumbar interbody implants are available, including allograft, titanium, polyether ether ketone (PEEK), and absorbable. They come in many shapes and sizes.
Step 2
n
Distraction is applied to the disk space to restore proper disk space height.
n
A trial implant or sizing device is used to determine the appropriate-sized graft
or cage.
n
An implant is selected that corresponds to the correct trial implant.
n
The implant is packed with bone graft material and inserted into the disk space
in an anterior to posterior direction (Figures 32-9 and 32-10). The insertion device distracts the disk space as the implant is inserted.
FIGURE 32-9 
FIGURE 32-10 
302    Procedure 32| Anterior Lumbar Interbody Fusion
n
S T E P 2 C ON T R O V ER S I E S
• The use of an anterior plate for interspace fixation or buttressing of the implant is surgeon dependent.
• Many interbody implants now incorporate screw fixation into the implant itself, obviating the need for plate fixation.
• Many surgeons believe anterior implants alone are not stable enough to obtain a successful fusion. However, recent studies (Burkus, 2005) using bone morphogenetic protein (BMP) in conjunction with standalone devices have reported a fusion rate of up to 99%.
Fluoroscopic imaging is used to ensure correct positioning of the implant.
n
If used, anterior instrumentation is applied across the disk space (Figures 32-11,
32-12, and 32-13).
n
Interbody implants that incorporate screw holes for internal fixation are inserted
in a similar manner with the insertion device (Figure 32-14).
n
Following insertion, a drill guide is attached to the implant and drill holes are
made for screw insertion (Figure 32-15).
n
The screws are then inserted through the implant, through the superior and
inferior end plates and into the vertebral body (Figures 32-16 and 32-17).
FIGURE 32-11 
FIGURE 32-12 
FIGURE 32-13 
Procedure 32  | Anterior Lumbar Interbody Fusion    303
FIGURE 32-14  FIGURE 32-15 
FIGURE 32-16 
FIGURE 32-17 

Postoperative Care and Expected Outcomes

n
Patients are started on clear liquids, and their diets are advanced as tolerated.
n
Patients are mobilized on postoperative day 1 and encouraged to ambulate as
tolerated.
n
A simple lumbar corsette brace may be recommended for 6 weeks postopera-
tively, but many surgeons do not routinely use bracing.
n
If the procedure is a standalone anterior lumbar interbody fusion, patients are
typically discharged on postoperative day 2 or 3.
n
A successful fusion rate in the 90% range can be expected with an anterior
lumbar interbody fusion when combined with a posterior stabilizing procedure or when BMP is used in conjunction with an implant stabilized anteriorly.
304    Procedure 32| Anterior Lumbar Interbody Fusion

Evidence

Brau SA. Mini-open approach  to  the  spine for anterior lumbar interbody  fusion: 
description of the procedure,  results  and  complications. Spine J 2002;2:216-23.
This is a review of the complications of the anterior lumbar approach using a mini-open technique (Level IV evidence).
Burkus JK, Gornet MF, Schuler TC, Kleeman TJ,  Zdeblick TA. Six-year  outcomes of 
anterior lumbar interbody arthrodesis  with  use  of interbody fusion cages and  recombinant human bone morphogenetic  protein-2.  J  Bone Joint Surg Am  2009;91:1181-9.
A 98% fusion rate was achieved with standalone tapered titanium cylinder cages and rh-BMP2. Improvements in Oswestry Disability Index and SF-36 scores were maintained at the 6-year follow-up (Level II evidence).
Burkus JK, Sandhu HS,  Gornet  MF, Longley MC. Use of  rhBMP-2 in combination 
with structural cortical allografts:  clinical  and  radiographic outcomes in anterior  lumbar spinal surgery. J Bone Joint Surg Am 2005;87:1205-12.
This is a prospective investigational device exemption study evaluating the use of BMP in anterior lumbar fusion with cortical allograft dowels. The fusion rate was 99% (Level I evidence).
Sasso RC, Kitchel SH,  Dawson  EG.  A prospective randomized controlled clinical 
trial of anterior lumbar  interbody  fusion  using a titanium cylindrical threaded  fusion device. Spine 2004;29:113-22.
Titanium cylinder cages had better results when used alone than did femoral allograft implants (Level II evidence).
P R O C ED U R E 3 3
Transforaminal Lumbar
Interbody Fusion
Kamal R.M. Woods, Eli M. Baron, Neel Anand, and
Alexander R. Vaccaro
I N D I CAT I O NS P I T F A L L S
• Osteoporosis or severe osteopenia: may easily fracture end plates during surgery or have telescoping of cage into vertebra
• Severe disk space collapse: may be difficult to achieve adequate disk space height without injuring end plates

I N D I CAT I O NS

C O N T RO V E R S IE S
• Multilevel (>3 levels) degenerative disk disease
• Lytic and high-grade spondylolisthesis
T R E A T M E N T OP T I O N S
• Anterior lumbar interbody fusion (ALIF)
• Posterior lumbar interbody fusion (PLIF)
• Lateral transpsoas interbody fusion (extreme lateral interbody fusion [XLIF], direct lateral interbody fusion [DLIF])
• Posterolateral fusion
• Axial transsacral lumbar interbody fusion (AxiaLIF)
• Laminoforaminotomy
Indications
n
Spondylolisthesis (particularly isthmic and degenerative etiology)
n
Symptomatic degenerative disk disease
n
Recurrent disk herniation
n
Radiculopathy caused by foraminal stenosis from loss of disk height
n
Augmentation of distal end of long posterior scoliosis fusion constructs
n
Segmental coronal collapse and tilt with unilateral radiculopathy

Examination/Imaging

n
Pertinent preoperative history and physical are essential to the diagnosis and
surgical decision making. The most symptomatic side (right versus left) is selected for the transforaminal lumbar interbody fusion (TLIF) approach.
n
Plain radiographs are obtained to assess for listhesis, other deformities, osteo-
penia, and spina bifida occulta. Dynamic studies should be performed to rule out dynamic instability. Figure 33-1, A to C shows anteroposterior (AP) and flexion extension films demonstrating a grade I degenerative spondylolisthesis at L4-5 in a 60-year-old male who had undergone laminoforaminotomy and facet cyst excision years earlier and then presented with recurrent leg and back pain.
n
Magnetic resonance imaging (MRI) is done to identify degenerated interverte-
bral disks and possible compression of neuronal elements. Figure 33-2 shows T2-weighted sagittal MRI in the same patient, showing facet cyst and severe stenosis at the level of L4-5 spondylolisthesis.
n
Computed tomography (CT) is done to exclude pars defect in cases of spondy-
lolisthesis. CT also helps to assess bone quality and anatomy in preparation for instrumentation.
n
Plain lateral radiograph or fluoroscopic imaging is done after patient positioning.
Often, a preoperative degenerative spondylolisthesis will reduce with the patient positioned prone with the hips extended.
306    Procedure 33| Transforaminal Lumbar Interbody Fusion
A
C
FIGURE 33-1, A-C 
B
Procedure 33  | Transforaminal Lumbar Interbody Fusion    307
FIGURE 33-2 
Pedicle
screws
A
FIGURE 33-3, A-B 
L4 pedicle
A
C
B
L4-5 disc
L5 pedicle
B
A
B

Surgical Anatomy

n
It is important to expose the ipsilateral spinous process, lamina, facet, and
transverse process. The working zone for the TLIF approach is bounded medially by the traversing nerve root and thecal sac, superiorly by the exiting nerve root, and inferiorly by the pedicle of the vertebra below the disk space. Note that the exiting root hugs the undersurface of the superior pedicle, allowing for a safe work zone.
n
Figure 33-3 shows lateral (A) and cross-sectional (B) schematics demonstrating
working zone for TLIF and the relationship of exiting and traversing roots to the disk space.
308    Procedure 33| Transforaminal Lumbar Interbody Fusion
P O S I TI O N I N G PI T FA L L S
• The hip-flexed position will open the posterior interbody space and may improve access to the disk; however, this position reduces lumbar lordosis and can lead to fixed sagittal imbalance. Therefore the authors do not recommend it.
• High-grade isthmic spondylolisthesis or significant kyphosis at the level of the slip may necessitate a bilateral PLIF rather than a TLIF, if a posterior interbody approach is being taken.
P O S I TI O N I N G EQ U I P M EN T
• Jackson table
S T E P 1 P EA R L S
• Thinning the planned resection area of the pars and facet joints with a high-speed burr makes removal easy and less traumatic.
• All local bone resected, including bone dust from drilling, is harvested for use as autograft.
• The ligamentum flavum is not removed in the absence of central stenosis.
• Similarly, the traversing nerve root is not exposed, and the vascular sleeve and fat over the exiting nerve are maintained.
• Use fluoroscopy to confirm appropriate placement of the osteotome for the initial transverse cut, to ensure that this is low enough to avoid injuring the exiting nerve root. At L5-S1, the authors recommend using a burr over an osteotome, because the L5 root lies lower in the foramen, and use of the osteotome may have a theoretically higher risk of injuring the L5 dorsal root ganglion. Because the spinal canal is wider at this level, a variant of the TLIF can be performed here without a true inferior facetectomy and is recommended, if possible, to prevent any inadvertent injury to the exiting L5 nerve root.

Positioning

n
The patient is prone with the abdomen free of any compression to reduce
venous congestion.
n
The thigh is neutral or slightly extended.
n
Check the final positioning on the operating room table with a plain radiograph
or fluoroscopy.

Portals/Exposures

n
The standard midline incision with subperiosteal exposure of the pertinent
posterior osseous elements may be performed.
n
Alternatively, the surgical exposure may be achieved by the Wiltse paraspinal
approach.
n
Some minimally invasive approaches (e.g., with tubular retractors) use a muscle-
splitting technique.
n
If no central decompression is being performed, the midline posterior ligamen-
tous and osseous structures are preserved.

Procedure

Step 1
n
A subperiosteal exposure is performed. The facet complex corresponding to the
disk space being fused is exposed in its entirety. The transverse process and pars interarticularis of the caudal level are also exposed. The pars and transverse process of the rostral level are exposed, while making sure the supraadjacent facet capsule is not violated.
n
The inferior facet is removed from the cephalad level using a
should be done by making a transverse cut in the pars interarticularis just above the lower vertebrae’s pedicle. Although this usually corresponds to the top of the superior articular facet of the lower vertebrae, one must be cautious while doing this in the degenerative spine, because one may be pushed upward by the osteophyte and inadvertently make the cut higher along the pars, which could injure the exiting nerve root. The authors confirm the position on fluoros­copy before making the cut. Figure 33-4 is an intraoperative fluoroscopic image showing the position of the osteotome at the level of the top of the lower
1
osteotome. This
4
S T E P 1 P IT FA L L S
• Epidural bleeding can decrease visualization and potentially increase the risk of inadvertent nerve root injury. The authors use low-power bipolar cautery over the disk space as needed.
FIGURE 33-4