Заключение

Адренорецепторы и, особенно, 2АР находятся практически на всех клетках, участвующих в иммунном ответе. Сейчас мы понимаем, что иммунная система и автономная нервная система связаны друг с другом. Интерпретация полученных данных необходимо проводить с осторожностью, так как большинство информации было получено в ходе исследований in vitro, во время которых использовались клетки на различных стадиях дифференцировки и активации в сочетании с разными адренергическими препаратами различной концентрации. Несмотря на это, полученные данные свидетельствуют о роли 2АР в модулировании иммунного ответа.

При исследовании массы данных можно предположить, что стимуляция 2АР ингибирует клеточный иммунитет и стимулирует гуморальный. Является ли действие адренергической системы на иммунный ответ пагубной в отношении клеточных микробов и полезной в сфере внеклеточных агентов? Являются ли некоторые аутоиммунные заболевания, возникающие вследствие продукции антигенов к собственным белкам, следствием неадекватной автономной регуляции функции В лимфоцитов? Можно ли перенести эффекты 2АР на практику при лечении таких заболеваний как сепсис и СДР, возникающие, как считается, вследствие патологии иммунного ответа? На эти вопросы еще предстоит дать ответы.

Дополнительные материалы

1. Ramer-Quinn D, Baker R, Sanders V: Activated T helper 1 and T helper 2 cells differentially express the 2- adrenergic receptor. J Immunol 159:4857-4867, 1997

2. Maestroni G: Sympathetic nervous system influence on the innate immune response. Ann NY Acad Sci 1069: 195-207, 2006

3. Kin N, Sanders V: It takes nerve to tell T and B cells what to do. J Leukoc Biol 79:1093-1104, 2006

4. Perkins G, McAuley D, Richter A, et al: Bench-to-bed­ side review: j32-agonists and the acute respiratory distress syndrome. Crit Care 8:25-32, 2004

5. Maestroni G: Sympathetic nervous system influence on the innate immune response. Ann NY Acad Sci 1069: 195-207, 2006

6. Sanders V: Interdisciplinary research: noradrenergic reg­ ulation of adaptive immunity. Brain Behavior Immunity 20:1-8, 2006

7. Sanders V, Straub R: Norepinephrine, the B-adrenergic receptor, and immunity. Brain Behavior Immunity 16: 290-332, 2002

8. Moynihan J, Kruszewska B, Madden K, et al: Sympa­ thetic nervous system regulation of immunity. J Neuro - immunol 147:87-90, 2004

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