
- •Destabilization of adherens junctions causes cellular de-differentiation
- •Signalling through the canonical WNT pathway
- •The discovery of the Wnt family of cytokines
- •Contribution of different species to the elucidation of the Wnt signal transduction pathway
- •Wnt target genes with a TCF-binding element
- •Wnt and Hedgehog
- •Wnt organizes the villous epithelium of the small intestine
- •Maintenance of the stem cell compartment requires Wnt signalling
- •Wnt aligns committed progenitor cells along the crypt–villus axis
- •Wnt and the asymmetric division of stem cells
- •Rho: regulator of the actin cytoskeleton
- •Non-canonical signal transduction pathways
- •A role for cadherin in contact inhibition
- •Other examples of signalling through adhesion molecules
- •Cadherin in the central nervous system
- •JAM and the regulation of differentiation
- •Occludin prevents Raf-1-mediated cell transformation
- •References

Signal Transduction
Abbreviation |
Full name/description |
SwissProt |
Other names/OMIM |
|
|
entry |
|
|
|
|
|
LRP6 |
LDL-receptor related protein-6 |
O75581 |
|
|
|
|
|
mDia1 |
mouse Diaphanous homologue-1 |
O08808 |
|
|
|
|
|
Pan |
pangolin (Drosophila) |
P91943 |
TCF |
|
|
|
|
PDZ |
domain found in PSD95, DlgA and |
|
|
|
ZO-1 |
|
|
|
|
|
|
PKC |
protein kinase C-iota |
P41743 |
atypical protein kinase C λ |
|
|
|
|
plakoglobin |
junctional plaque protein |
P14923 |
desmoplakin-3 |
|
|
|
|
PSD95 |
post-synaptic density protein-95 |
P78352 |
disc large homolog-4 |
|
|
|
|
Pygo1 |
pygopus homologue-1 |
Q9Y3Y4 |
|
|
|
|
|
ROCK |
Rho-associated coiled-coil |
Q13464 |
|
|
containing protein kinase-1 |
|
|
|
|
|
|
SCF |
ubiquitin protein E3-ligase complex |
|
|
|
comprising Skp1, cullin-1 and |
|
|
|
F-box protein |
|
|
|
|
|
|
Sgg |
shaggy (rough-haired) (Drosophila) |
P18431 |
zeste-white (GSK3 kinase) |
|
|
|
|
Smo |
smoothened homologue |
Q99835 |
Gx protein |
|
|
|
|
Snail |
|
O95863 |
SNAI1, SnaH |
|
|
|
|
TAF1 |
TBP-associated factor-1 |
Q15573 |
RNA polymerase subunit A |
|
|
|
|
TBP |
TATA-box binding protein |
P20226 |
TFIID TBP subunit |
|
|
|
|
TCF-4 |
T cell specific transcription factor-4 |
Q9NQB0 |
TCF7L2, MIM: 602228 |
|
|
|
|
TLE-1 |
transducin-like enhancer protein-1 |
Q04724 |
|
|
|
|
|
Wnt-3a |
wingless/int-3a |
P56704 |
|
|
|
|
|
ZONAB |
ZO-1 associated nucleic acid binding |
Q9N1Q2 |
DbpA (DNA binding protein-A) |
|
protein |
|
|
|
|
|
|
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