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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5446_Библиотеки_им_академика_М_И_Перельмана
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236 Index
R&D, see Research and Development
Raman spectroscopy, 146, 166, 203,
215–217
rapid prototyping (RP), 50, 121, 180
reactive diethyl fumarate, 75
recoating, 47–50, 69, 162
rectal dosage forms, 194–195
re-epithelisation/remodelling, 115–117,
122
regenerative medicine, 132–134, 137,
140
regulatory aspects, 81–83, 211–225
analysis, 215–218
clinical benefits, 202–203
current status, 212–213
customised/personalised products,
220–221
extrusion-based technologies,
214–221
hydrogels, 145
implantable scaffolds, 106–107
industrial adoption, 180–186
paediatric patients, 218–220
quality, 213–218
tailored drug release, 220–221
release modifiers, 18
release/real-time release testing (RTRT),
215
remodelling, wound healing, 115–117,
122
Research and Development (R&D), 121,
181, 184–185
resistance tests, 160
resolution to time-for-manufacturing
(RTM) ratio, 31–33
RESOMER
®
Filaments, 71, 79
resorbable polymers, 69–73, 83
rheology, 5–7, 140–141, 162–166, 217
risk-based strategies, 82–83
robotics, 32, 132
RP, see rapid prototyping
RTM, see resolution to time-for-manu-
facturing
RTRT, see release/real-time release
testing
Safety and Toxicity of Excipients for
Paediatrics (STEP), 220
sampling, 153–163, 166–171
scaffolds, 78–83, 89–108, 118–126,
132–133, 139
see also implantable scaffolds,
biodegradable systems, 92–93, 97–100
biomaterials, 79–83, 90–105, 124,
132–133, 139
biomimetics, 79, 83–84, 98
classification, 90–91
critical parameters, 94–100
drug release rates, 90–108
four-dimensional printing, 93–94
hydrogels, 93, 124, 132–133, 139
injectable, 92–93, 99
innovative, 93–94, 104–106
long-acting drug release, 89–108
non-biodegradable systems, 92,
98–100, 105
shape memory/smart polymers, 93–94
tissue engineering, 93, 132–133, 139
types of, 90–94
wound dressings/healing, 118–126
scaled up 3D printing processes, 104–
105, 145–146
scanning electron microscopy (SEM),
50, 54–55, 127, 166–168, 216–217
scanning speeds, 46–49, 52–54
selective laser sintering (SLS), 7–12,
43–66, 69–73, 76–80
see also powder bed fusion
advantages, 59–61
analysis, 152, 157
binder jetting, 43–46
clinical benefits, 189, 198–200
complex printing, 59
computer-aided design, 44
critical parameters, 47–48, 52–54
customised/personalised products, 44,
52–56, 59–61
device printing, 69–73, 76–80
disadvantages, 61
drug combinations, 52, 56–60
drug release, 43–66
https://t.me/med1917
Index 237
energy density, 50–51, 56–57
fused deposition modelling, 43–47, 61
history, 43–44
hydroxypropyl methylcellulose,
50–51, 56–58
implantable scaffolds, 101
Kollidon VA64, 50–57, 60
laser selection, 46, 48–49, 54–56
manufacturing challenges, 47–49
operational principles, 46–50, 69
oral solid dosage forms, 43–66
paracetamol, 50–55
polypills, 60–61
porosity, 50
powder materials, 7–10, 12, 19, 49–50
printing feature advantages, 59
quality, 47–48, 52–54
range of material advantages, 60
regulations, 214
scanning speeds, 46–49, 52–54
stereolithography, 43–45
surface property control, 59
thermal extrusion, 43–47, 59, 61
select laser melting (SLM), 48, 189
SEM, see scanning electron micros-
copy
semi-solid extrusion (SSE), 5–8, 14–19,
30–32, 190, 193–195, 198–199
shape memory polymers (SMP), 73–77,
80, 93–94
shear rheology, 162
shear-thinning, 141
SLA, see stereolithography
slicer software, 34, 67–68
SLM, see select laser melting
smart polymers, 73–75, 77, 80, 83, 93–94
SMP, see shape memory polymers
software packages,
computed microtomography, 167–168,
192–194, 217
computer-aided design, 34–35, 44,
67–68, 89, 106, 121, 211
solubility enhancement, 4, 18
Soluplus
®
, 16
solvent-casting, 101, 104
spatial-resolution to time-for-manufac-
turing ratio, 31–33
speeds,
hydrogel printing, 145
microstructured tailored release, 35–36
scanning, 46–49, 52–54
Sperogenix Therapeutics, 184–185
splints, 77–78
spreading,
hydrogels, 139–140
powder bed fusion, 7–11, 50
Spritam
®
, 9, 39, 44, 50, 180–181, 212
SSE, see semi-solid extrusion
STEP, see Safety and Toxicity of
Excipients for Paediatrics
stereolithography (SLA), 11–13, 67–69,
73–80
analysis, 152, 155, 163
clinical benefits, 189
device printing, 65–68, 73–80,
84, 101
hydrogels, 136–137, 144
implantable scaffolds, 101
microstructured tailored release,
30–33, 39
operational principles, 67–68
oral solid dosage forms, 43–45
overview, 11–13
processability considerations, 5,
11–13, 19
ultraviolet light, 11–13, 67–68, 74–78
stereomicroscopy, 166–168
sterilisation, 40, 145
stimuli responsive materials, 73–75, 77,
83, 93–94
stimulus-triggered technologies, see
binder jetting; selective laser
sintering; stereolithography
strain, 161–163
stress tests, 161–162
sulphonamide disaster, 219
suppositories, 194–195
surface properties,
scaffolds, 94, 96
selective laser sintering, 59
https://t.me/med1917
238 Index
swelling, 105–106
synthetic polymers, 70–72, 98–100,
133–136
tacrolimus suppositories, 194–195
tailored drug release, 29–42
binder jetting, 30–33, 39
challenges, 39–40
cleaning, 40
complex mechanisms, 35–36, 38–39
direct ink writing, 30–32
fused deposition modelling, 30–32,
34–35, 38–40
hot-melt extrusion, 39
influencing designs, 36–39
inkjet printing, 30–32, 35
microstructure design, 29–42
modified mechanisms, 38–39
parameter-based design, 35–39
polypills, 35–36
printing parameters, 35–39
regulatory aspects, 220–221
semi-solid extrusion, 30–32
software-based design, 34–35
stereolithography, 30–33, 39
sterilization, 40
vat polymerisation, 30–33, 39
tailor-made implantable scaffolds,
89–108
taste masking excipients, 18
TBM, see tracheobronchomalacia
TE, see thermal extrusion
Technical Considerations for Additive
Manufactured Medical Devices, 44
technology elevation, 181–186
temperature,
hydrogels, 132, 138, 143–144
microstructured tailored release, 35–36
ramp analysis, 163–165
temperature–composition phase
diagrams, 3–4
tensile strength, 52, 54, 160–161
terahertz pulsed imaging (TPI), 168–169
TGA, see thermogravimetric analysis
thermal analysis, 3–4, 153–155, 159,
163–165, 216–217
thermal extrusion (TE), 2–6, 14–19,
43–47, 59–61
hot-melt extrusion, 2–5, 14–16, 39,
101–102, 124–125, 159, 166
thermogravimetric analysis (TGA),
153–155, 159, 216
thermoplastics, 69, 73, 98–100
three-point bending test, 160
tissue engineering, 78–79, 89–108,
132–134, 137–140, 144–146
toxicity database, 220
TPI, see terahertz pulsed imaging
tracheobronchomalacia (TBM), 78
Triastek, 182–185
tuneable release, 16, 50, 70, 125–126,
133, 142
two-photon polymerisation, 30, 33, 76,
137
ultraviolet (UV) light, 11–13, 43, 46,
67–68, 74–78
unique quick response (QR) codes, 182,
201–203
vaginal dosage forms, 194–195
vascular repair devices, 77
vat polymerisation,
see also individual techniques
analysis, 152–155, 159, 162–163
clinical benefits, 189, 198–199
microstructured tailored release,
30–33, 39
oral solid dosage forms, 43
veterinary applications, 201–202
vinyl acetates, 14, 50–57, 60
viscoelasticity, 141, 162–165
viscosity, 140, 165–166
volumetric printing, 74, 189
warpage deformations, 58
water-insoluble nylon, 56
wettability, 94–96
wounds,
antibacterial dressings, 122–127
biomaterials, 115–127
case studies, 122–126
https://t.me/med1917
Index 239
classification, 117–120
diabetes, 116–118
dressings, 115–129
extrusion-based dressings, 121,
123–127
fabricating dressings, 118–127
granulation tissue, 115–119, 122–123,
127, 133
haemostasis, 115–117
healing, 115–129, 133, 145–146
hydrogel dressings, 124–126, 133,
145–146
injury, 115–118
polymers, 118–127
proliferation, 115–119, 122–123, 127,
133
re-epithelisation/remodelling, 115–
117, 122
scaffolds, 118–126
xanthan gum, 122
X-ray computed microtomography
(XµCT), 167–168, 192–194, 217
X-ray powder diffraction (XRPD),
156–157, 159, 216–217
yield stress, 6, 102, 141
zero-order release mechanisms, 36–37
ZipDose technology, 50, 189, 201, 212
https://t.me/med1917
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https://t.me/med1917
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