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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_3908_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Foreword
- •Foreword
- •Foreword
- •Preface
- •Acknowledgments
- •About the Book
- •Contents
- •Contributors
- •References
- •2.3.1 Component Therapy
- •2.3.1.1 Tranexamic Acid
- •2.3.1.3 Factor Concentrate-Based Resuscitation Strategies
- •2.3.1.4 Factor VIIa
- •Conclusion
- •References
- •3.1 Blunt Cerebrovascular Injuries
- •3.4 Medical Treatment
- •3.5 Endovascular Treatment
- •3.6 Penetrating Cervical Vascular Injuries
- •References
- •4.1 Introduction
- •4.2 Initial Evaluation
- •4.3 Line Placement Considerations
- •4.5 Embolization Agents
- •4.6 Gelfoam
- •4.7 Particles
- •4.8 Metallic Coils
- •4.9 Amplatzer Vascular Plugs
- •4.10 Liver Endovascular Embolization
- •4.11 Spleen Endovascular Embolization
- •4.12 Kidney Endovascular Embolization
- •4.13 Pelvic Endovascular Embolization
- •4.14 Endovascular Stent Grafts
- •4.15 Axillosubclavian Injuries
- •4.16 Thoracic Endovascular Aortic Repair
- •Conclusion
- •Expert’s Comments by Yoram Kluger
- •References
- •5.1 Introduction
- •5.2 Endovascular Damage Control
- •5.3 Lower Extremity Vascular Injuries
- •5.3.1 Common Femoral Artery
- •5.3.2 Profunda Femoris
- •5.3.3 Superficial Femoral Artery
- •5.3.4 Popliteal Artery
- •5.3.5 Infrapopliteal Arteries
- •5.4 Venous Injuries
- •5.6 Upper Extremity Vascular Injuries
- •5.6.1 Axillo-subclavian Arteries
- •5.7 Postoperative Care
- •References
- •6.1 Introduction
- •6.2 History
- •6.3 Indications
- •6.4 Procedure
- •6.4.1 Arterial Access
- •6.4.3 Sheath Placement
- •6.4.5 Management While Occluded
- •6.4.6 Balloon Deflation
- •6.5 Current Research
- •Conclusion
- •Expert’s Comments by Catherine Arvieux
- •References
- •7: Partial REBOA
- •7.1 Introduction
- •7.2 Physiology
- •7.6 Feasibility
- •7.7 Future Directions
- •Conclusion
- •References
- •8.1 Introduction
- •8.2 Traumatic Brain Injury
- •8.2.1 Epidemiology
- •8.2.2 Normal Brain Physiology
- •8.2.3 Pathophysiology After Traumatic Brain Injury
- •8.4 Future Directions
- •Expert’s Comments by Edoardo Picetti
- •References
- •9.1 Introduction
- •9.4 Mitigation Strategies
- •9.4.2 Balloon Occlusion Time
- •9.4.3 Partial REBOA
- •9.4.4 Pharmacologic Interventions
- •9.4.5 Nitric Oxide Inhibitors
- •9.4.6 Valproic Acid
- •9.4.7 Adenosine
- •9.4.8 Heme Oxygenase
- •9.4.9 Statins
- •9.4.10 Hypothermia
- •Conclusion
- •References
- •10.1 Introduction
- •10.3.2 Clinical Evidence
- •References
- •10.2 Nontraumatic Cardiac Arrest
- •10.2.1 Epidemiology
- •10.2.2 Physiology
- •10.3.1 Preclinical Studies
- •10.3.1.1 Intermittent Occlusion
- •10.3.1.2 Continuous Occlusion
- •10.3.1.3 Selective Aortic Arch Perfusion
- •11.1 Introduction
- •11.3 Uterine Blood Supply
- •11.5 First Trimester
- •11.5.1 Ectopic Pregnancy
- •11.5.2 Molar Pregnancy
- •11.6.1 Placental Abruption
- •11.6.2 Trauma
- •11.6.3 Postpartum Hemorrhage
- •11.6.4 Placenta Accreta Spectrum
- •11.8 Massive Transfusion Protocols
- •11.9 Adjunctive Medications
- •11.9.1 Tranexamic Acid
- •11.9.2 Lyophilized Fibrinogen Concentrate
- •11.9.3 Prothrombin Complex Concentrates (PCCs)
- •11.9.4 Activated Recombinant Factor VII
- •11.10 Endovascular Balloon Occlusion
- •References
- •12.1 Introduction
- •12.2 Prehospital EVTM
- •12.3 Austere EVTM
- •Conclusion
- •Expert’s Comments by Miklosh Bala
- •References
- •13.1 Background
- •13.2 Categorizing Bleeding Severity
- •13.3.1 Emergency IR (EIR)
- •13.5 Trauma IR (TIR)
- •13.5.1 Overview
- •13.5.2 Preadmission
- •13.5.4 Trauma Imaging
- •13.5.5 Patient Selection
- •13.6.1 Overview
- •13.6.2 Procedure
- •13.6.2.3 Embolic Agents
- •13.7 Future Trends
- •13.7.1 Hybrid ER Room
- •13.8 Hybrid Trauma Specialist
- •Conclusion
- •References
- •14.1 Introduction
- •14.3 Communication
- •14.4 Crew Resource Management
- •14.5 REBOA Before or After Anesthesia?
- •14.6 Nonarterial Circulatory Access
- •14.9 Analgesia
- •14.10 Hemostatic Resuscitation
- •14.11 Afterload Reduction
- •14.12 Monitoring
- •14.13 Electrolyte Management
- •14.14 Balloon Deflation
- •Conclusion
- •References
- •15.2 VV ECMO
- •15.3 VV ECMO Circuit Management
- •15.3.1 VV ECMO Cannulation Strategies
- •15.3.2 Monitoring Targets
- •15.4 VV ECMO Patient Management
- •15.4.1 Anticoagulation Range
- •15.4.2 Ventilator Management
- •15.4.3 Sedation Strategies
- •15.4.4 Peri-procedural Management
- •15.5 VA ECMO
- •Conclusions
- •References
- •16.1 Introduction
- •16.4 Access-Related Complications
- •16.6 Fluid Resuscitation
- •16.8 Extracorporeal Membrane Oxygenation
- •16.9 Coagulation
- •16.11 Renal Function
- •Conclusions
- •Expert’s Comments by Andrew Kirkpatrick
- •References
- •17.1 Access Site Complications
- •17.1.1 Hematoma
- •17.1.2 Pseudoaneurysm
- •17.1.3 Acquired Arteriovenous Fistula
- •17.2 Intervention Complications
- •17.2.1 Dissection
- •17.2.2 Thrombosis/Embolization
- •17.2.3 Rupture
- •17.3 Post-procedure Complications
- •17.3.1 Infection
- •17.3.2 Contrast-Induced Nephropathy
- •17.3.3 Contrast Media Allergy
- •Conclusion
- •References
- •18.6.1 Simulators
- •18.6.2 Porcine Models
- •18.6.3 Cadaver
- •18.6.4 Cath-Lab Training
- •18.7 Summary
- •References

Hot Topics in Acute Care Sugery and Trauma
Endovascular
Resuscitation
and Trauma
Management
Tal Hörer
Joseph J. DuBose
Todd E. Rasmussen
Joseph M. White Editors
Bleeding and Haemodynamic Control

Hot Topics in Acute Care Surgery
and Trauma
Series Editors
FedericoCoccolini
Cesena,Italy
RaulCoimbra
Riverside,USA
AndrewW.Kirkpatrick
Calgary,Canada
SalomoneDiSaverio
Cambridge,UK
Editorial Board
Luca Ansaloni (Cesena, Italy); Zsolt Balogh (Newcastle, Australia); Walt Bif
(Denver, USA); Fausto Catena (Parma, Italy); Kimberly Davis (New Haven, USA);
Paula Ferrada (Richmond, USA); Gustavo Fraga (Campinas, Brazil); Rao Ivatury
(Richmond, USA); Yoram Kluger (Haifa, Israel); Ari Leppaniemi (Helsinki, Finland);
Ron Maier (Seattle, USA); Ernest E. Moore (Fort Collins, USA); Lena Napolitano
(Ann Arbor, USA); Andrew Peitzman (Pittsburgh, USA); Patrick Rielly (Philadelphia,
USA); Sandro Rizoli (Toronto, Canada); Boris Sakakushev (Plovdiv, Bulgaria);
Massimo Sartelli (Macerata, Italy); Thomas Scalea (Baltimore, USA); David Spain
(Stanford, USA); Philip Stahel (Denver, USA); Michael Sugrue (Letterkenny,
Ireland); George Velmahos (Boston, USA); Dieter Weber (Perth, Australia)

This series covers the most debated issues in acute care and trauma surgery, from
perioperative management to organizational and health policy issues.
Since 2011, the founder members of the World Society of Emergency Surgery’s
(WSES) Acute Care and Trauma Surgeons group, who endorse the series, realized
the need to provide more educational tools for young surgeons in training and for
general physicians and other specialists new to this discipline: WSES is currently
developing a systematic scientic and educational program founded on evidence-
based medicine and objective experience. Covering the complex management of
acute trauma and non-trauma surgical patients, this series makes a signicant
contribution to this program and is a valuable resource for both trainees and
practitioners in acute care surgery.
More information about this series at http://www.springer.com/series/15718

Tal Hörer • Joseph J. DuBose
Todd E. Rasmussen
Joseph M. White
Editors
Endovascular
Resuscitation and Trauma
Management
Bleeding and Haemodynamic Control

Editors
Tal Hörer
Department of Cardiothoracic and Vascular
Surgery, Örebro University Hospital
Örebro, Sweden
Department of Surgery, Örebro University
Hospital, Örebro, Sweden
Todd E. Rasmussen
F. Edward Hebert School
of Medicine – “America’s Medical School”
Uniformed Services University
of the Health Sciences
Bethesda, Maryland, USA
Walter Reed National Military Medical
Center, The National Institutes of Health
Clinical Center, Bethesda, Maryland, USA
Joseph J. DuBose
University of Maryland Medical Center
R Adams Cowley Shock Trauma Center
Baltimore, Maryland, USA
Joseph M. White
The Department of Surgery at Uniformed
Services
University of the Health Sciences
andWalter Reed National Military
Medical Center
Bethesda, Maryland, USA
ISSN 2520-8284 ISSN 2520-8292 (electronic)
Hot Topics in Acute Care Surgery and Trauma
ISBN 978-3-030-25340-0 ISBN 978-3-030-25341-7 (eBook)
https://doi.org/10.1007/978-3-030-25341-7
© Springer Nature Switzerland AG 2020
This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of
the material is concerned, specically the rights of translation, reprinting, reuse of illustrations, recita-
tion, broadcasting, reproduction on microlms or in any other physical way, and transmission or infor-
mation storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar
methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publica-
tion does not imply, even in the absence of a specic statement, that such names are exempt from the
relevant protective laws and regulations and therefore free for general use.
The publisher, the authors, and the editors are safe to assume that the advice and information in this book
are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the
editors give a warranty, expressed or implied, with respect to the material contained herein or for any
errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional
claims in published maps and institutional afliations.
This Springer imprint is published by the registered company Springer Nature Switzerland AG
The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

v
Research is fundamentally altering the daily practice of acute care surgery (Trauma,
Surgical Critical Care, and Emergency General Surgery) for the betterment of
patients around the world. Management for many diseases and conditions is radi-
cally different than it was just a few years ago. For this reason, concise up-to-date
information is required to inform busy clinicians. Therefore, since 2011 the World
Society of Emergency Surgery (WSES), in partnership with the American
Association for the Surgery of Trauma (AAST), endorses the development and pub-
lication of the “Hot Topics in Acute Care Surgery and Trauma,” realizing the need
to provide more educational tools for young in-training surgeons and for general
physicians and other surgical specialists. These new forthcoming titles have been
selected and prepared with this philosophy in mind. The books will cover the basics
of pathophysiology and clinical management, framed with the reference that recent
advances in the science of resuscitation, surgery, and critical care medicine have the
potential to profoundly alter the epidemiology and subsequent outcomes of severe
surgical illnesses and trauma.
Federico Coccolini
General Emergency and Trauma Surgery
Ospedale Maurizio Bufalini
Cesena, Italy
Raul Coimbra
Riverside University Health System - Med
Riverside, CA, USA
Andrew W. Kirkpatrick
Department of Surgery and Critical Care Medic
Foothills Medical Centre
Calgary, AB, Canada
Salomone Di Saverio
Department of Surgery (Addenbrooke)
Cambridge University Hospitals NHS Found
Cambridge, UK
Foreword

vii
Foreword
This is a textbook that is long overdue. The technology to change the paradigm in
the management of vascular trauma and critically ill patients has existed for quite
some time, yet its application as described in this textbook has had limited penetra-
tion. As a young vascular surgeon in the 1990s who also did a fair share of vascular
trauma, I experienced the endovascular revolution in vascular surgery rsthand. It
required rethinking the traditional open methods of vascular reconstructive surgery
and carefully and thoughtfully replacing or supplementing many open approaches
with endovascular techniques. Today, endovascular approaches have extended the
vascular surgeon’s scope of practice and at the same time increased the safety of
vascular interventions for the preservation of life and limb. It has always seemed
strange to me that the applications of endovascular techniques to vascular trauma
and bleeding have not occurred at the same rapid pace.
But now, the time has come, and I would anticipate the same endovascular revolu-
tion happening in the treatment of patients who sustain traumatic vascular injury or
are in need of hemorrhage control. Balloons, shunts, catheters, wires, coils, closure
devices, stents, and stentgrafts are now the new tools of the trade. How these tools
should be employed is the subject of this thorough and comprehensive book.
Furthermore, how to best integrate these tools with the tried and tested open approaches
to vascular injury and hemorrhage control is the very exciting challenge of the future.
Surgeons, vascular specialists, and critical care physicians will need to reinvent them-
selves if they are to take advantage of endovascular technology. Applications of endo-
vascular technology in the setting of vascular trauma and bleeding will require the
development of new paradigms of care. To have a state-of- the-art textbook is a neces-
sary foundation for expansion of endovascular techniques into this new arena.
I would like to congratulate the editors and authors for putting together this very
important and timely book. I look forward to seeing how this compendium will alter
the treatment of critically ill patients and extend the benets of the endovascular
approach to patients all over the world.
FredA.Weaver
Division of Vascular Surgery and Endovascular Therapy
USC CardioVascular Thoracic Institute
Keck Medical Center of USC
Los Angeles, CA, USA

ix
Foreword
Over the past several decades, endovascular technologies have continued to evolve
as valuable tools of modern vascular surgery. In my own career, I have been for-
tunate to play a role in this exciting evolution. In the context of this involvement,
our group was able to demonstrate that resuscitative endovascular balloon occlu-
sion of the aorta (REBOA) has the capacity to serve as a critical adjunct in the
salvage of some patients with a ruptured abdominal aortic aneurysm. In the wake
of this initial experience, endovascular aneurysm repair (EVAR) and selective
REBOA are now being used widely to treat this acute source of non-compressible
hemorrhage. It is of high interest to see this approach now expanding to other
sources of non- compressible hemorrhage following bleeding after trauma and
other entities. Endovascular tools continue to evolve in this regard, now being
employed actively alone or in combination with other procedures, to save life and
decrease morbidity.
The authors of this book summarize the current data and practice of the new
concept of endovascular resuscitation and trauma management (EVTM) in this
exciting new text. Trauma surgeons, surgeons, interventional radiologists, and
intensivists have worked collaboratively in this effort, reviewing and analyzing
advances in endovascular technologies as they apply to EVTM.Issues such as the
use of early vascular access, REBOA, embolization, endografts, and other endovas-
cular adjuncts are presented with current supporting data and research results as
well as clinically relevant information from active practitioners of EVTM princi-
ples. Central to their contribution is a superb collegial collaboration between vari-
ous disciplines and regions of the world, all built upon a foundational desire to
better dene the optimal application of endovascular technologies to benet the
patients who need them most.
Why is this book important? It summarizes our current understanding of a rap-
idly expanding fund of knowledge regarding endovascular and hybrid tools for
resuscitation and treatment. It also presents this knowledge in a unique and focused
platform which has never been done before. This evolution in care will undoubtedly
continue, and this textbook is an ideal source of information for the practitioner
regarding EVTM principles past, present, and future.

x
This volume is a “must have” for all the specialists involved in treating patients
subjected to trauma and in need of resuscitation.
FrankVeith
New York University–Langone Medical Center
New York, NY, USA
Cleveland Clinic Lerner College of Medicine
of Case Western Reserve University
Cleveland, OH, USA
The William J. von Liebig Chair in Vascular Surgery
The Cleveland Clinic Foundation
Cleveland, OH, USA
Foreword

xi
Preface
In February of 2017, more than 350 medical professionals, representing diverse
disciplines in surgery, trauma, anesthesia, cardiology, obstetrics, radiology, and
emergency medicine and critical care from around the world, met in Ӧrebro, Sweden,
at the inaugural Endovascular Hybrid Trauma and Bleeding Management (EVTM)
Symposium (#EVTM2017 http://www.jevtm.com/program-for-evtm-2017-sympo-
sium/). This international, multidisciplinary event aggregated an array of providers
experienced with the management of the critically injured, ill, or bleeding patients.
Through presentations, panel discussions, and moderator-led debates, the attendees
advanced their understanding of the capacity for catheter-based, endovascular
approaches and technologies (present and future) to improve the survival and recov-
ery of this challenging population. The size, diversity, and international composi-
tion of #EVTM2017 and the enthusiastic nature of the discussions surpassed the
projections of the event organizers. EVTM tapped and coalesced an underappreci-
ated momentum in the area of endovascular techniques for injury, hemorrhage con-
trol, and critical care, an interest that’s relatively overlooked by other, more
mainstream, professional organizations.
Beyond its clinical, scientic, and new technologies content, #EVTM2017 made
clear that interest in endovascular approaches to injury and critical care– compared
to those applied to age-related conditions– is at the margins of many clinical disci-
plines, their professional organizations, and their respective meetings and publica-
tions. EVTM exposed the challenge and provided a common, cross-disciplinary
forum to redress this critical gap. As an extension of the #EVTM2017, a new jour-
nal, called Journal of Endovascular Resuscitation and Trauma Management
(JEVTM), was commissioned as a platform on which to continue the global discus-
sion (www.jevtm.com). The JEVTM aims to capture and maintain the cross-
disciplinary momentum on display at the #EVTM2017 and serve as an electronic
and print forum by which to disseminate knowledge from clinical experiences as
well as that stemming from structured research, development, and innovation activi-
ties. Through the publication of case reports and results from original research and
by providing proles on new technology and innovation concepts, as well as mod-
ern reviews and commentaries in this space, JEVTM will establish itself as a com-
mon conduit for this topic area, a conduit which courses through the established, but
otherwise somewhat xed, disciplines of trauma, surgery, cardiology, obstetrics,
critical care, radiology, anesthesia, and emergency medicine. The previously held
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