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19 Stricturing Crohn’s Disease: Strictureplasty
genetic (NOD2/CARD 15, 5T5T in the MMP3 gene, rs 1,363,670), and serological (antimicrobial antibodies) [7]. Diagnosis during childhood, jejuno-ileal location, and stricturing behaviour are independent risk factors for elevated risk of surgery and high surgical recurrence rates for small bowel CD [16]. In patients with multi­ple locations not all the diseased segments present with the same level of inamma­tion or the same type of complication (stricture and brosis, perforation, or both). The Montreal and Paris classications are useful tools and should be used in the surgical reports, since they impact on the post-operative treatment and the long­term prognosis [2–4, 9, 10].
269

19.2 Pathophysiology

Extracellular matrix accumulation and mesenchymal cell expansion play a major role in the mechanism of stricture formation and result in transmural thickening of the bowel [7]. Inammation and brosis are closely intertwined injury pathways and coexist in intestinal stenosis at varying degrees [7]. The brotic process, once initiated by inammation, can progress independently from inammation. Currently used anti-inammatory medications do not delay this development and are only effective in limiting the inammatory component of the disease process [17]. For that reason, the presence of on-going active inammation within a strictured seg­ment increases the likelihood of response to anti-inammatory and immunomodu­latory medications. However, even after the introduction of anti-TNF therapy since 1998, the global rates of surgery for CD remain essentially unchanged. All available therapies are essentially unable to reverse the progression of brosis in the suscep­tible patient [18, 19].

19.3 Diagnosis

Radiologic and endoscopic evaluation play a major role in the work-up of patients with brostenosing CD, providing information about disease activity and anatomi­cal characteristics that will determine the actual therapy. Up to now, cross-sectional computerized axial tomographic or magnetic resonance imaging (MRI) were basi­cally unable to differentiate between inammatory and brotic stenosis [20]. However, MRI has recently gained an increasing role in the differential diagnosis of CD stenosis [21]. Late images obtained with MRI enterography after intravenous administration of a gadolinium chelate help distinguish between active (inamma­tory) and inactive (brotic) stenotic lesions. Predominant brostenotic lesions show delayed enhancement, whereas active lesions show an early enhancement pattern [22]. Patients who have delayed, homogeneous and full-thickness wall enhance­ment may be more likely to have a higher brotic component of their stricture. This assumption has been recently veried in 41 patients with 44 small bowel strictures
270
who were scheduled for elective surgery. As result of the correlation between radio­logical images and histopathologic scores of the resected bowel segments, it was possible to identify patients with severe degree of brosis [20].
G. Bislenghi and A. D’Hoore

19.4 Surgical Approach

After failure of medical therapy and endoscopic dilatation, or inability to perform endoscopic dilatation, surgical resection of the affected segment is currently the most commonly used treatment strategy [7]. Dilatation is indicated for short accessible strictures in quiescent disease. Balloon enteroscopy facilitates dilatation anywhere in the gastrointestinal tract but most procedure have been described in stenotic ileocolic anastomoses. Multiple small series have demonstrated the safety and short-term ef­cacy of endoscopic dilatation for stenosis of 15–25mm length. Long strictures and dilatation of nipple valve anastomosis (telescoped) are associated with technical fail­ure. Balloon dilatation is impractical if multiple strictures are present [23].

19.4.1 Resections

Radical resections did not show a clear advantage compared with limited resections in terms of recurrence. The microscopic presence of inammation at the resection margin inuences the occurrence of postoperative recurrence [24–26]. The only ran­domized controlled trial from the group of Fazio published in 1994 [24], analyzing data of 152 patients undergoing ileocolic resection for CD, found that extended resec­tion margins (i.e., 12cm vs. 2cm for the limited resection) confer no advantage in terms of cumulative recurrence rates (25.3% in the limited resection group and 17.9% in the extended resection group with a median follow-up of 55.7months, p=0.31). The presence of residual microscopic disease at the resection margins does not appear to give signicantly increased recurrence rates compared with free margins (21.4% for CD microscopic involvement and 17.8% for histologically normal, p = 0.91). These ndings were conrmed in a retrospective study of 77 patients with CD under­going resection (medium follow-up 5.6±2.8years), where the recurrence rate of the resections with involved margins was 36% and 38% for free margins resections [25].
Hence, resections for CD should be as limited as possible. Considering the relapsing behaviour of CD and the risk of short bowel syndrome caused by multiple resections, it is common practice to limit the resection to the macroscopically involved bowel, even accepting microscopic positive resection margins. However, we recently published data showing that microscopic involvement of the resection margin have a signicant impact on recurrence rates [27]. Further prospective research is needed to further elucidate the importance of positive resection margins for both clinical and surgical recurrence before a more aggressive approach is adopted (Fig.19.2).
1.0
No
Positive
121
12
19 Stricturing Crohn’s Disease: Strictureplasty
0.9
0.8
0.7
0.6
0.5
0.4
0.3
Clinical recurrence (%)
0.2
0.1
271
Negative Positive
12 24 36 48 60
0
Time after surgery (months)
. at risk
316
Negative
Fig. 19.2 Kaplan-Meier curves for surgical recurrence according to microscopic resection margin involvement. P=0.010 (log rank test) from de Buck van Overstraeten A., BJS 2017
216781685614343117409634742460194815391232
72 84 96 108 120
The type of anastomosis does not seem to play a role in disease recurrence rate. In a multicenter, randomized, controlled trial with 139 patients who underwent an ileocolic resection [26] the recurrence rate was similar whether end-to-end anasto­mosis or side-to-side anastomosis was performed (42.5% in the end-to-end anasto­mosis group vs 37.9% in the side-to-side anastomosis group, p=0.55 and 21.9% in the end-to-end group vs 22.7% in the side-to-side group, p= 0.92 for endoscopic and clinical recurrence, respectively). A wide lumen stapled side-to-side anastomo­sis is found to be associated with decreased anastomotic leak rates and overall post­operative complications compared to end-to-end anastomosis. A meta-analysis including 661 patients with ileocolic resection for CD reported an anastomotic leak rate of 6.7% for end-to-end anastomosis versus 1.2% for side-to-side anastomosis (p = 0.02) and overall postoperative complication rate of 21.2% for end-to-end anastomosis versus 11.2% for side-to-side anastomosis, (p=0.2) [28]. No signi­cant difference with regard to peri-anastomotic recurrence rates was found [28, 29]. The same was found in a prospective cohort study showing no differences in safety and recurrence rate between hand-sewn side-to-side and stapled side-to-side anas­tomosis. This may imply that a wide anastomotic luminal diameter is the discrimi­nating factor affecting recurrence, rather than the suturing technique used [30]. A laparoscopic approach is preferable for ileocolonic resections in CD where appropriate expertise is available [31–34].
272
G. Bislenghi and A. D’Hoore

19.4.2 Strictureplasties

19.4.2.1 History
Although the main goal of surgical interventions is to alleviate symptoms, limiting bowel resection is critical to maintaining the absorbtive function of the small and large intestines. Removing excessive lengths of intestine with traditional segmental resec­tion can result in short bowel syndrome (SBS), in which patients suffer from malab­sorptive symptoms and, in some cases, can lead to serious consequences, including a profound decrease in life expectancy [35]. A retrospective analysis of postoperative CD patients found that 8.5% had suffered intestinal failure within 20years after their initial operation [36]. In attempting to preserve bowel length and to reduce the risk of leak, patients with brostenosing jejuno-ileal involvement can be managed by means of strictureplasty. Strictureplasty techniques were originally developed for the upper gastrointestinal tract, where strictures arose from ulcer disease. Nonresective opera­tive techniques were preferred in this region given the anatomical limitations of the pancreaticobilliary system, which often led to unacceptably high rates of morbidity with more traditional resection methods. The three most common procedures per­formed for stricturing peptic ulcer disease are the eponymous Heineke-Mikulicz, Finney, and Jaboulay strictureplasties. Rather than undergoing resection or bypass, these procedures allowed for increasing the luminal diameter of the bowel, while avoiding segmental resection. The concept of using strictureplasty for multiple small intestinal strictures was rst described by Katariya etal. in 1977. In an effort to avoid segmental resection in treating multiple tandem tubercular strictures of the intestinal tract, they demonstrated that the use of strictureplasty not only preserved the intestinal absorptive capacity, but was also a safe alternative to segmental resection or bypass [37]. This work was followed by Lee and Papaioannou from Oxford in 1982, who published their use of strictureplasty for the treatment of Crohn strictures in nine patients, eight of whom were successfully treated with either Heineke-Mikulicz or Finney techniques with follow-up ranging from 8 to 42months [38].
19.4.2.2 Indications
The main indication for strictureplasty is the presence of multiple small bowel stric­tures within a long segment of bowel. Although the initial view was that stricture­plasty should only be carried out for recurrent disease and in patients who have had previous multiple resections [38], the consensus now is that any patient with a non­phlegmonous brotic lesion is suitable, depending on the length of the stricture [39]. The most obvious advantage of strictureplasty over resection is that the risk of short bowel syndrome is lowered.
General contraindications to performing strictureplasty are preoperative malnu­trition, the presence of phlegmon/stula/perforation at the planned strictureplasty site, a stricture next to an already planned resection site, multiple strictures within a very short segment, and any suspicion of small bowel malignancy. Given the limits
19 Stricturing Crohn’s Disease: Strictureplasty
273
of preoperative imaging of the small intestine, specic planning for strictureplasty is often made intraoperatively, and is typically based on the location of active dis­ease. For instance, strictures located in the jejunoileal and ileocolonic anastomotic regions have been shown to respond well to strictureplasty techniques, as opposed to duodenal or colonic locations [40]. The presence of an enteric stula surrounded by chronic inammation is not a contraindication in most cases.
19.4.2.3 General Technique
As with all Crohn’s disease patients, the operative approach should always begin with examination of the entire small bowel from the ligament of Treitz to the ileoce­cal valve. This can be achieved either laparoscopically or via laparotomy. This allow the surgeon to create a sort of “roadmap”. This is an essential step to design a surgi­cal strategy based on the number, length, and relative location of CD lesions.
During the abdominal exploration at least one stricture site should be identied and opened. Further strictures can be identied either by introducing the index n­ger into the lumen and passing the gut over the nger in a concertina fashion, or by the use of the balloon ‘pull-through’ technique. This involves passing an 18-Fr Foley catheter on an introducer into the original enterotomy (Fig.19.3). Most of small bowel can be pulled over one introducer but sometimes a second enterotomy is needed. If another stricture is detected and incised, this becomes a new entry point for the catheter. Once the catheter is passed up to the duodenum or down through the ileocaecal junction, the balloon is inated with 8ml water to give a balloon diameter of 25mm. The balloon is then withdrawn and is held up wherever the lumen is less than 25mm. If necessary the lumen can be sized by serial deation (8ml=25mm, 6ml=20mm, 4ml=10mm). Most 25 and all 20mm or less stric­tures are incised longitudinally with diathermy [41].
Fig. 19.3 A typical peroperative nding of a localized stricture (short) with creeping fat, luminal narrowing and prestenotic dilation
274
G. Bislenghi and A. D’Hoore
Table 19.1 Stricturoplasty classication
Conventional strictureplasty
Heinecke-Mikulicz Modied: Judd Moskel-Walske-Neumayer Finney Modied: Jaboulay
Non-conventional strictureplasty
Side-to side isoperistaltic (Michelassi) Modied: Poggioli Sasaki
Adapted from Ambe R, J Gastrointestinal Surgery 2012
At the end of the procedure, small metal clips are used to mark the strictureplasty site extraluminally for future identication in case of recurrent obstructive symp­toms. Metal clips can be visualized radiographically on subsequent investigations or intraoperatively at successive operations.
As mentioned above the use of the Heineke-Mikulicz and the Finney stricture­plasty in Crohn’s stricture was rst described more than 30years ago [38, 42]. Since then modications of the Heineke-Mikulicz strictureplasties and of the Finney stric­tureplasty as well as advanced strictureplasty techniques have been proposed [42]. All these techniques can be grouped into various categories: conventional versus non-conventional, short versus long or based on technical difculty. Yet, the choice of the technique ultimately rests on length, number, and location of strictures.
Campbell et al. classied these into conventional [Heineke-Mikulicz and Finney] and non-conventional strictureplasties [43]. Up to now 15 different proce­dures have been proposed over the years in an attempt to provide more options to patients and facilitate the possibility of preserving bowel length. As remarked by Ambe et al. in their review there is much overlap and similarity between these techniques; disparities can be better appreciated when they are classied into three main groups including Heineke-Mikulicz like procedures (Heineke-Mikulicz, Judd, Moskel-Walske-Neumayer, double Heineke-Mikulicz, ileocolic Heineke­Mikulicz,), intermediate procedures (Finney, Jaboulay, combined Heineke­Mikulicz and Finney) and entero-enterostomies (Michelassi: side-to-side isoperistaltic and the modications of Poggioli and Sasaki) [42]. (Table19.1).
19.4.2.4 Conventional Strictureplasties
Heineke-Mikulicz Strictureplasty (Fig.19.4)
The Heineke-Mikulicz is the most commonly performed strictureplasty and best used for short (≤7cm) strictures [42, 43]. A single longitudinal incision is made on the antimesenteric side of the stricture extending approximately 2cm beyond the thick­ened segment of bowel, both proximally and distally. The enterotomy is then closed transversely with a single or double layer closure with single stitches. To facilitate the closure the index nger can be inserted through the incised stricture from an adjacent
19 Stricturing Crohn’s Disease: Strictureplasty
Fig. 19.4 Heineke-Mikulicz strictureplasty on a short segment stricture
275
opened stricture. The nger stents the anastomosis and helps the cut edges to be everted. Seromuscular sutures are used, sparing the mucosa. The distance between the stitches depends on the thickness of the gut wall.; it is always thinnest in the cen­ter of the suture line where there is also the most tension. If the gut is thickened or there is some tension at the center of the suture line, a central mattress stay suture is used. When this is tied, it indicates how much tension there is at the center of the suture line and helps to hold the edges together while performing the remnant suture.
This strictureplasty enlarges the lumen of the diseased intestine and maintains intestinal transit without creating a blind loop or intestinal stasis.
Finney Strictureplasty (Fig.19.5)
This is one of the conventional techniques used to manage medium-sized strictures usually >10 and <25cm [44, 45]. Multiple adjacent or conuent strictures are all opened longitudinally until normal gut is reached proximally and distally. The incised gut is bent over in a loop, folding the strictured segment in a “U”-shape manner. The posterior wall is sutured with a continuous seromuscular stitch. A stay suture helps to approximate the apices of the long incision. When the posterior suture meets the apical stay suture, they are knotted together and the suture is con­tinued up the anterior wall.
Finney strictureplasty results in the creation of a lateral diverticulum and subse­quent functional bypass while relieving obstruction. The lateral diverticulum can result in luminal stasis and bacterial overgrowth and blind loop syndrome.
19.4.2.5 Modied: Conventional Strictureplasties
Judd Strictureplasty
In this technique, the strictured segment has an associated stulous opening at its center. In this technique, the stulous site is excised, and the remainder of the short segment (<10cm) stricture is then opened in a longitudinal manner, encompassing the opening of the excised stula. The defect is then closed as in the HM technique.
276
Fig. 19.5 Finney strictureplasty
G. Bislenghi and A. D’Hoore
This technique confers the benets of HM strictureplasty, as it is technically easy to perform with no signicant tension on the suture line [45].
Moskel-Walske-Neumayer Strictureplasty
This type is suited for short segment strictures (<10cm) in which there is dilata­tion of the proximal portion of the bowel. A Y-shaped longitudinal enterotomy is made across the stricture with the fork of the “Y” pointing toward the dilated por­tion. The defect is then closed in the HM fashion (Fig.19.3). This technique nds favor due to the fact that it is technically easy to perform and reduces proximal dilatation of the bowel while conferring a gentle transition from dilated to nondi­lated bowel.
Jaboulay Strictureplasty
This technique was initially described back in the late nineteenth century by Mathieu Jaboulay. It is very similar to the Finney procedure and consists in a side-to-side enteroenterostomy. The Jaboulay strictureplasty is suitable for medium-sized (>10 and <25cm) strictures and can also be performed with the stapler technique. With this technique, bowel length is spared; however, there is the creation of a lateral diverticulum with resulting blind loop and stasis in the strictured segment.
19 Stricturing Crohn’s Disease: Strictureplasty
277
Limitations of the conventional strictureplasties is the length of stricture that can be treated. Taking into account implications of geometry, sequential use of HM stricutreplasty is limited to lesions at a distance of about 10cm from each other to allow a 5 cm distance between strictureplasties. Furthermore, long Finney type strictureplasties create a “diverticulum” on the small bowel and result in possible stasis of content with bacterial overgrowth. This certainly is the case if the Jaboulay strictureplasty bypasses longer segments of diseased bowel.
These shortcomings are addressed by the new non-conventional isoperistaltic strictureplasties.
Side-to-Side Isoperistaltic Stricutreplasty (Referred toasMichelassi Stricutreplasty) (Fig.19.6)
The Michelassi side-to-side isoperistaltic strictureplasty is indicated for signi­cantly long strictured segments (>20 cm) or a long portion of bowel containing multiple short strictures in tandem, making the creation of multiple HM stricture­plasties unsafe [46]. The mesentery of the small bowel loop to undergo the stricture­plasty is rst divided at its center. The proximal small bowel loop is then moved over the distal one in a side-to-side fashion. The stenotic segments of one loop are placed adjacent to the dilated segments of the other loop. The two loops are then approximated by a layer of interrupted seromuscular Lembert stitches with nonab­sorbable 3-0 sutures. A longitudinal enterotomy is performed on both loops, with the intestinal ends tapered to avoid blind ends. Hemostasis is achieved with suture ligatures or electrocautery. The outer suture line is reinforced with an internal row of running full-thickness 3-0 absorbable sutures, continued anteriorly as a running Connell suture; this layer is reinforced by an outer layer of interrupted seromuscular Lembert stitches with nonabsorbable 3-0 sutures. The benets of this technique include relief of intestinal obstruction created by multiple strictures in sequence, avoidance of resecting a long segment of bowel containing normal absorbing intes­tine in between strictures, and avoidance of blind and bypassed loops of bowel. This technique may be challenging to perform in the presence of a thickened and short­ened mesentery (Figs.19.7, 19.8, and 19.9).
Fig. 19.6 Judd stricutreplasty
278
Fig. 19.7 M-W-N stricutreplasty
G. Bislenghi and A. D’Hoore
Fig. 19.8 Jaboulay stricutreplasty
Poggioli Strictureplasty
A modied form of Michelassi’s side-to-side isoperistaltic enteroenterostomy has been proposed and published by two groups: Poggioli etal. [47] and Di Abriola etal. [48] respectively. These authors describe a technique whereby a long strictured segment (>20cm) of bowel is plastied using a modication of the side-to-side iso­peristaltic strictureplasty technique described by Michelassi. The technique begins by severing the bowel and dividing the mesentery at the proximal junction of the stricture. The non-diseased bowel is then advanced over the strictured segment. A