Добавил:
Sekretar
kiopkiopkiop18@yandex.ru
t.me/Prokururor I Вовсе не секретарь, но почту проверяю
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_1267_Библиотеки_им_академика_М_И_Перельмана.pdf
X
- •Foreword
- •Foreword
- •Contents
- •References
- •2.1 Introduction
- •2.2.1 Crohn’s Disease
- •2.2.2 Ulcerative Colitis
- •References
- •3.2.1 Bacterial Sensing
- •3.2.1.2 Toll-Like Receptors, TLRs
- •3.2.2 Autophagy: Autophagy-Related 16-like 1, ATG16L1
- •3.1 Introduction
- •3.2.4.1 Interleukin-23 Receptor, IL-23R
- •3.2.4.2 Fractalkine Receptor 1, CX3CR1
- •3.2.4.3 Transforming Growth Factor Beta (TGF-β)
- •3.2.4.4 Angiotensinogen
- •3.2.4.5 Tumour Necrosis Factor Alpha (TNFα)
- •3.2.6 Cell Signalling: Janus Kinase 2 (JAK2)
- •3.2.8 Other Processes
- •References
- •4.1 Introduction
- •4.2 Genetics
- •4.3 Epigenetics
- •4.5 DNA Methylation
- •4.9 MicroRNA
- •4.12 Summary
- •References
- •5.1 Introduction
- •5.2.1 TNFα
- •5.2.2 Th1 Cytokines
- •5.2.3 IL-1 Cytokines
- •5.2.4 Th2 Cytokines
- •5.2.5 Th17 Cytokines
- •5.2.6 TL1A
- •5.3 “Regulatory” Cytokines
- •5.3.1 TGFβ
- •5.3.2 IL-10
- •5.4 Concluding Remarks
- •References
- •6.1.1.1 Collagens
- •6.1.1.3 Glycoproteins
- •6.2.1 Integrins
- •6.3.1 Extracellular Matrix Stiffness
- •6.3.1.1 Modeling Extracellular Matrix Stiffness
- •References
- •7.1 Introduction
- •7.5 Future Outlook
- •References
- •8.1 Introduction
- •8.2.1 Smoking
- •8.3 Conclusion
- •References
- •9.4 Conclusions
- •References
- •10.1 Ulcerative Colitis
- •10.1.1 Epidemiology
- •10.1.2 Etiology
- •10.2.1 Pathogenesis
- •References
- •11.4 Conclusion
- •References
- •12.1 Introduction
- •12.2 Clinical Biomarkers
- •12.3 Cellular Biomarkers
- •12.4 Serologic Biomarkers
- •12.5 Other Factors
- •12.6 Conclusions
- •References
- •13.1 Introduction
- •13.3 Bowel Ultrasound
- •13.4 Computed Tomography Enterography
- •13.5 Magnetic Resonance Imaging
- •13.5.2 Functional MR Imaging Techniques
- •13.5.3 Hybrid Imaging Techniques
- •13.6 Conclusion
- •References
- •14.1.1 Ultrasound Stiffness Imaging
- •14.1.2 Shear Wave Elastography
- •14.5 Conclusion
- •References
- •15.1 Introduction
- •15.2.1 Stricturing IBD
- •15.2.2 Stricturing CD
- •15.2.3 Stricturing UC
- •15.4.1 Steroids
- •15.4.2 5-ASA
- •15.4.3 Purine Analogs
- •15.4.4 Methotrexate
- •15.4.5 Anti-TNFs
- •15.4.6 Other Biologics
- •15.5 Other Measures
- •15.6 Conclusion
- •References
- •16.1 Introduction
- •17.2.4 Abscess
- •17.3 Stricturoplasty or Resection
- •17.4 Approach
- •16.6 Conclusion
- •References
- •17.1 Introduction
- •17.2.2 Fibrotic Phenotype
- •17.2.3 Fistulising Disease
- •17.4.1 Open
- •17.4.2 Handassisted
- •17.4.3 Multi-Port
- •17.4.4 Single-Port
- •17.4.5 Single Port versus Multi-Port
- •17.4.6 Decision Making
- •17.5 Anastomosis
- •17.7 Conclusion
- •References
- •18.1 Introduction
- •18.4.1 Initial Evaluation
- •18.5.1 Pre-IPAA (Afferent Limb/Ileostomy Closure Site)
- •18.5.2 The Fibrotic IPAA Body
- •18.5.3 Post-IPAA (Efferent Limb, Anal Canal)
- •18.6 Conclusion
- •References
- •19.2 Pathophysiology
- •19.3 Diagnosis
- •19.4 Surgical Approach
- •19.4.1 Resections
- •19.4.2 Strictureplasties
- •19.4.2.1 History
- •19.4.2.2 Indications
- •19.4.2.3 General Technique
- •19.4.2.4 Conventional Strictureplasties
- •Judd Strictureplasty
- •Moskel-Walske-Neumayer Strictureplasty
- •Jaboulay Strictureplasty
- •Poggioli Strictureplasty
- •19.4.2.6 Results
- •Short-Term Results
- •Long-Term Results
- •19.5 Future Perspectives
- •References
- •20.1 Introduction
- •20.6 Summary
- •References
- •21.1 Introduction
- •21.2 Wound Healing
- •21.3 Crohn’s Disease Fistula
- •21.7 Summary
- •References
- •22.1 Introduction
- •22.3 The Transforming Growth Factor-β (TGF-β) Pathways
- •22.4.1 Connective Tissue Growth Factor (CTGF/CCN2)
- •22.4.2 Platelet Derived Growth Factor
- •22.4.3 Wnt-Signaling
- •22.4.4 Hedgehog Signaling
- •22.4.5 Notch Signaling
- •22.6.1 Coagulation Stage
- •22.6.3 Fibrous Adhesion Stage
- •22.7.4 Material Barriers
- •22.7.5 Pharmaceutical Approaches
- •22.8.4 Smooth Muscle Cells
- •22.12 Conclusions
- •References
- •23.1 Introduction
- •23.2 Liver
- •23.2.1 Farnesoid X Receptor (FXR)
- •23.2.2 Lysyl Oxidase (LOXL2)
- •23.2.3 Statins
- •23.2.4 5-Hydroxytryptamine (5HT)
- •23.2.5 Caspase Inhibition
- •23.2.6 Chemokine Receptors CCR2/5
- •23.2.7 GR-MD-02
- •23.2.8 PPAR Gamma
- •23.3 Lung
- •23.3.1 Pirfenidone
- •23.3.2 Nintedanib/Tyrosine Kinase Inhibitors
- •23.3.3 Lysophospholipids
- •23.3.4 mTOR
- •23.3.5 Prostacyclin
- •23.3.6 Integrin αvβ6
- •23.3.7 Endothelin Receptor Antagonism
- •23.3.8 Interleukin (IL)-13
- •23.3.9 Connective Tissue Growth Factor
- •23.3.10 Serum Amyloid P
- •23.4 Kidney
- •23.4.2 Pyridoxamine
- •23.4.3 Janus Kinase (JAK)1/2
- •23.4.4 Bindarit-CCL (MCP) Inhibitor
- •23.4.5 Phosphodiesterase Inhibition
- •23.5 Skin
- •23.5.1 TGFβ Targeted Therapies
- •23.5.2 Thalidomide/Pomalidomide
- •23.5.3 Paquinimod
- •23.6 Heart
- •23.6.1 Renin Angiotensin Aldosterone System (RAAS)
- •23.6.2 Transforming Growth Factor (TGF)-β
- •23.7 Conclusion
- •References
- •Index

19 Stricturing Crohn’s Disease: Strictureplasty
genetic (NOD2/CARD 15, 5T5T in the MMP3 gene, rs 1,363,670), and serological
(antimicrobial antibodies) [7]. Diagnosis during childhood, jejuno-ileal location,
and stricturing behaviour are independent risk factors for elevated risk of surgery
and high surgical recurrence rates for small bowel CD [16]. In patients with multiple locations not all the diseased segments present with the same level of inammation or the same type of complication (stricture and brosis, perforation, or both).
The Montreal and Paris classications are useful tools and should be used in the
surgical reports, since they impact on the post-operative treatment and the longterm prognosis [2–4, 9, 10].
269
19.2 Pathophysiology
Extracellular matrix accumulation and mesenchymal cell expansion play a major
role in the mechanism of stricture formation and result in transmural thickening of
the bowel [7]. Inammation and brosis are closely intertwined injury pathways
and coexist in intestinal stenosis at varying degrees [7]. The brotic process, once
initiated by inammation, can progress independently from inammation. Currently
used anti-inammatory medications do not delay this development and are only
effective in limiting the inammatory component of the disease process [17]. For
that reason, the presence of on-going active inammation within a strictured segment increases the likelihood of response to anti-inammatory and immunomodulatory medications. However, even after the introduction of anti-TNF therapy since
1998, the global rates of surgery for CD remain essentially unchanged. All available
therapies are essentially unable to reverse the progression of brosis in the susceptible patient [18, 19].
19.3 Diagnosis
Radiologic and endoscopic evaluation play a major role in the work-up of patients
with brostenosing CD, providing information about disease activity and anatomical characteristics that will determine the actual therapy. Up to now, cross-sectional
computerized axial tomographic or magnetic resonance imaging (MRI) were basically unable to differentiate between inammatory and brotic stenosis [20].
However, MRI has recently gained an increasing role in the differential diagnosis of
CD stenosis [21]. Late images obtained with MRI enterography after intravenous
administration of a gadolinium chelate help distinguish between active (inammatory) and inactive (brotic) stenotic lesions. Predominant brostenotic lesions show
delayed enhancement, whereas active lesions show an early enhancement pattern
[22]. Patients who have delayed, homogeneous and full-thickness wall enhancement may be more likely to have a higher brotic component of their stricture. This
assumption has been recently veried in 41 patients with 44 small bowel strictures

270
who were scheduled for elective surgery. As result of the correlation between radiological images and histopathologic scores of the resected bowel segments, it was
possible to identify patients with severe degree of brosis [20].
G. Bislenghi and A. D’Hoore
19.4 Surgical Approach
After failure of medical therapy and endoscopic dilatation, or inability to perform
endoscopic dilatation, surgical resection of the affected segment is currently the most
commonly used treatment strategy [7]. Dilatation is indicated for short accessible
strictures in quiescent disease. Balloon enteroscopy facilitates dilatation anywhere in
the gastrointestinal tract but most procedure have been described in stenotic ileocolic
anastomoses. Multiple small series have demonstrated the safety and short-term efcacy of endoscopic dilatation for stenosis of 15–25mm length. Long strictures and
dilatation of nipple valve anastomosis (telescoped) are associated with technical failure. Balloon dilatation is impractical if multiple strictures are present [23].
19.4.1 Resections
Radical resections did not show a clear advantage compared with limited resections
in terms of recurrence. The microscopic presence of inammation at the resection
margin inuences the occurrence of postoperative recurrence [24–26]. The only randomized controlled trial from the group of Fazio published in 1994 [24], analyzing
data of 152 patients undergoing ileocolic resection for CD, found that extended resection margins (i.e., 12cm vs. 2cm for the limited resection) confer no advantage in
terms of cumulative recurrence rates (25.3% in the limited resection group and 17.9%
in the extended resection group with a median follow-up of 55.7months, p=0.31).
The presence of residual microscopic disease at the resection margins does not appear
to give signicantly increased recurrence rates compared with free margins (21.4%
for CD microscopic involvement and 17.8% for histologically normal, p = 0.91).
These ndings were conrmed in a retrospective study of 77 patients with CD undergoing resection (medium follow-up 5.6±2.8years), where the recurrence rate of the
resections with involved margins was 36% and 38% for free margins resections [25].
Hence, resections for CD should be as limited as possible. Considering the
relapsing behaviour of CD and the risk of short bowel syndrome caused by multiple
resections, it is common practice to limit the resection to the macroscopically
involved bowel, even accepting microscopic positive resection margins. However,
we recently published data showing that microscopic involvement of the resection
margin have a signicant impact on recurrence rates [27]. Further prospective
research is needed to further elucidate the importance of positive resection margins
for both clinical and surgical recurrence before a more aggressive approach is
adopted (Fig.19.2).

1.0
No
Positive
121
12
19 Stricturing Crohn’s Disease: Strictureplasty
0.9
0.8
0.7
0.6
0.5
0.4
0.3
Clinical recurrence (%)
0.2
0.1
271
Negative
Positive
12 24 36 48 60
0
Time after surgery (months)
. at risk
316
Negative
Fig. 19.2 Kaplan-Meier curves for surgical recurrence according to microscopic resection margin
involvement. P=0.010 (log rank test) from de Buck van Overstraeten A., BJS 2017
216781685614343117409634742460194815391232
72 84 96 108 120
The type of anastomosis does not seem to play a role in disease recurrence rate.
In a multicenter, randomized, controlled trial with 139 patients who underwent an
ileocolic resection [26] the recurrence rate was similar whether end-to-end anastomosis or side-to-side anastomosis was performed (42.5% in the end-to-end anastomosis group vs 37.9% in the side-to-side anastomosis group, p=0.55 and 21.9% in
the end-to-end group vs 22.7% in the side-to-side group, p= 0.92 for endoscopic
and clinical recurrence, respectively). A wide lumen stapled side-to-side anastomosis is found to be associated with decreased anastomotic leak rates and overall postoperative complications compared to end-to-end anastomosis. A meta-analysis
including 661 patients with ileocolic resection for CD reported an anastomotic leak
rate of 6.7% for end-to-end anastomosis versus 1.2% for side-to-side anastomosis
(p = 0.02) and overall postoperative complication rate of 21.2% for end-to-end
anastomosis versus 11.2% for side-to-side anastomosis, (p=0.2) [28]. No signicant difference with regard to peri-anastomotic recurrence rates was found [28, 29].
The same was found in a prospective cohort study showing no differences in safety
and recurrence rate between hand-sewn side-to-side and stapled side-to-side anastomosis. This may imply that a wide anastomotic luminal diameter is the discriminating factor affecting recurrence, rather than the suturing technique used [30].
A laparoscopic approach is preferable for ileocolonic resections in CD where
appropriate expertise is available [31–34].

272
G. Bislenghi and A. D’Hoore
19.4.2 Strictureplasties
19.4.2.1 History
Although the main goal of surgical interventions is to alleviate symptoms, limiting
bowel resection is critical to maintaining the absorbtive function of the small and large
intestines. Removing excessive lengths of intestine with traditional segmental resection can result in short bowel syndrome (SBS), in which patients suffer from malabsorptive symptoms and, in some cases, can lead to serious consequences, including a
profound decrease in life expectancy [35]. A retrospective analysis of postoperative
CD patients found that 8.5% had suffered intestinal failure within 20years after their
initial operation [36]. In attempting to preserve bowel length and to reduce the risk of
leak, patients with brostenosing jejuno-ileal involvement can be managed by means
of strictureplasty. Strictureplasty techniques were originally developed for the upper
gastrointestinal tract, where strictures arose from ulcer disease. Nonresective operative techniques were preferred in this region given the anatomical limitations of the
pancreaticobilliary system, which often led to unacceptably high rates of morbidity
with more traditional resection methods. The three most common procedures performed for stricturing peptic ulcer disease are the eponymous Heineke-Mikulicz,
Finney, and Jaboulay strictureplasties. Rather than undergoing resection or bypass,
these procedures allowed for increasing the luminal diameter of the bowel, while
avoiding segmental resection. The concept of using strictureplasty for multiple small
intestinal strictures was rst described by Katariya etal. in 1977. In an effort to avoid
segmental resection in treating multiple tandem tubercular strictures of the intestinal
tract, they demonstrated that the use of strictureplasty not only preserved the intestinal
absorptive capacity, but was also a safe alternative to segmental resection or bypass
[37]. This work was followed by Lee and Papaioannou from Oxford in 1982, who
published their use of strictureplasty for the treatment of Crohn strictures in nine
patients, eight of whom were successfully treated with either Heineke-Mikulicz or
Finney techniques with follow-up ranging from 8 to 42months [38].
19.4.2.2 Indications
The main indication for strictureplasty is the presence of multiple small bowel strictures within a long segment of bowel. Although the initial view was that strictureplasty should only be carried out for recurrent disease and in patients who have had
previous multiple resections [38], the consensus now is that any patient with a nonphlegmonous brotic lesion is suitable, depending on the length of the stricture
[39]. The most obvious advantage of strictureplasty over resection is that the risk of
short bowel syndrome is lowered.
General contraindications to performing strictureplasty are preoperative malnutrition, the presence of phlegmon/stula/perforation at the planned strictureplasty
site, a stricture next to an already planned resection site, multiple strictures within a
very short segment, and any suspicion of small bowel malignancy. Given the limits

19 Stricturing Crohn’s Disease: Strictureplasty
273
of preoperative imaging of the small intestine, specic planning for strictureplasty
is often made intraoperatively, and is typically based on the location of active disease. For instance, strictures located in the jejunoileal and ileocolonic anastomotic
regions have been shown to respond well to strictureplasty techniques, as opposed
to duodenal or colonic locations [40]. The presence of an enteric stula surrounded
by chronic inammation is not a contraindication in most cases.
19.4.2.3 General Technique
As with all Crohn’s disease patients, the operative approach should always begin
with examination of the entire small bowel from the ligament of Treitz to the ileocecal valve. This can be achieved either laparoscopically or via laparotomy. This allow
the surgeon to create a sort of “roadmap”. This is an essential step to design a surgical strategy based on the number, length, and relative location of CD lesions.
During the abdominal exploration at least one stricture site should be identied
and opened. Further strictures can be identied either by introducing the index nger into the lumen and passing the gut over the nger in a concertina fashion, or by
the use of the balloon ‘pull-through’ technique. This involves passing an 18-Fr
Foley catheter on an introducer into the original enterotomy (Fig.19.3). Most of
small bowel can be pulled over one introducer but sometimes a second enterotomy
is needed. If another stricture is detected and incised, this becomes a new entry point
for the catheter. Once the catheter is passed up to the duodenum or down through
the ileocaecal junction, the balloon is inated with 8ml water to give a balloon
diameter of 25mm. The balloon is then withdrawn and is held up wherever the
lumen is less than 25mm. If necessary the lumen can be sized by serial deation
(8ml=25mm, 6ml=20mm, 4ml=10mm). Most 25 and all 20mm or less strictures are incised longitudinally with diathermy [41].
Fig. 19.3 A typical
peroperative nding of a
localized stricture (short)
with creeping fat, luminal
narrowing and prestenotic
dilation

274
G. Bislenghi and A. D’Hoore
Table 19.1 Stricturoplasty
classication
Conventional strictureplasty
Heinecke-Mikulicz
Modied: Judd
Moskel-Walske-Neumayer
Finney
Modied: Jaboulay
Non-conventional strictureplasty
Side-to side isoperistaltic (Michelassi)
Modied: Poggioli
Sasaki
Adapted from Ambe R, J Gastrointestinal Surgery 2012
At the end of the procedure, small metal clips are used to mark the strictureplasty
site extraluminally for future identication in case of recurrent obstructive symptoms. Metal clips can be visualized radiographically on subsequent investigations or
intraoperatively at successive operations.
As mentioned above the use of the Heineke-Mikulicz and the Finney strictureplasty in Crohn’s stricture was rst described more than 30years ago [38, 42]. Since
then modications of the Heineke-Mikulicz strictureplasties and of the Finney strictureplasty as well as advanced strictureplasty techniques have been proposed [42].
All these techniques can be grouped into various categories: conventional versus
non-conventional, short versus long or based on technical difculty. Yet, the choice
of the technique ultimately rests on length, number, and location of strictures.
Campbell et al. classied these into conventional [Heineke-Mikulicz and
Finney] and non-conventional strictureplasties [43]. Up to now 15 different procedures have been proposed over the years in an attempt to provide more options to
patients and facilitate the possibility of preserving bowel length. As remarked by
Ambe et al. in their review there is much overlap and similarity between these
techniques; disparities can be better appreciated when they are classied into three
main groups including Heineke-Mikulicz like procedures (Heineke-Mikulicz,
Judd, Moskel-Walske-Neumayer, double Heineke-Mikulicz, ileocolic HeinekeMikulicz,), intermediate procedures (Finney, Jaboulay, combined HeinekeMikulicz and Finney) and entero-enterostomies (Michelassi: side-to-side
isoperistaltic and the modications of Poggioli and Sasaki) [42]. (Table19.1).
19.4.2.4 Conventional Strictureplasties
Heineke-Mikulicz Strictureplasty (Fig.19.4)
The Heineke-Mikulicz is the most commonly performed strictureplasty and best used
for short (≤7cm) strictures [42, 43]. A single longitudinal incision is made on the
antimesenteric side of the stricture extending approximately 2cm beyond the thickened segment of bowel, both proximally and distally. The enterotomy is then closed
transversely with a single or double layer closure with single stitches. To facilitate the
closure the index nger can be inserted through the incised stricture from an adjacent

19 Stricturing Crohn’s Disease: Strictureplasty
Fig. 19.4 Heineke-Mikulicz strictureplasty on a short segment stricture
275
opened stricture. The nger stents the anastomosis and helps the cut edges to be
everted. Seromuscular sutures are used, sparing the mucosa. The distance between
the stitches depends on the thickness of the gut wall.; it is always thinnest in the center of the suture line where there is also the most tension. If the gut is thickened or
there is some tension at the center of the suture line, a central mattress stay suture is
used. When this is tied, it indicates how much tension there is at the center of the
suture line and helps to hold the edges together while performing the remnant suture.
This strictureplasty enlarges the lumen of the diseased intestine and maintains
intestinal transit without creating a blind loop or intestinal stasis.
Finney Strictureplasty (Fig.19.5)
This is one of the conventional techniques used to manage medium-sized strictures
usually >10 and <25cm [44, 45]. Multiple adjacent or conuent strictures are all
opened longitudinally until normal gut is reached proximally and distally. The
incised gut is bent over in a loop, folding the strictured segment in a “U”-shape
manner. The posterior wall is sutured with a continuous seromuscular stitch. A stay
suture helps to approximate the apices of the long incision. When the posterior
suture meets the apical stay suture, they are knotted together and the suture is continued up the anterior wall.
Finney strictureplasty results in the creation of a lateral diverticulum and subsequent functional bypass while relieving obstruction. The lateral diverticulum can
result in luminal stasis and bacterial overgrowth and blind loop syndrome.
19.4.2.5 Modied: Conventional Strictureplasties
Judd Strictureplasty
In this technique, the strictured segment has an associated stulous opening at its
center. In this technique, the stulous site is excised, and the remainder of the short
segment (<10cm) stricture is then opened in a longitudinal manner, encompassing
the opening of the excised stula. The defect is then closed as in the HM technique.

276
Fig. 19.5 Finney strictureplasty
G. Bislenghi and A. D’Hoore
This technique confers the benets of HM strictureplasty, as it is technically easy to
perform with no signicant tension on the suture line [45].
Moskel-Walske-Neumayer Strictureplasty
This type is suited for short segment strictures (<10cm) in which there is dilatation of the proximal portion of the bowel. A Y-shaped longitudinal enterotomy is
made across the stricture with the fork of the “Y” pointing toward the dilated portion. The defect is then closed in the HM fashion (Fig.19.3). This technique nds
favor due to the fact that it is technically easy to perform and reduces proximal
dilatation of the bowel while conferring a gentle transition from dilated to nondilated bowel.
Jaboulay Strictureplasty
This technique was initially described back in the late nineteenth century by Mathieu
Jaboulay. It is very similar to the Finney procedure and consists in a side-to-side
enteroenterostomy. The Jaboulay strictureplasty is suitable for medium-sized (>10
and <25cm) strictures and can also be performed with the stapler technique. With
this technique, bowel length is spared; however, there is the creation of a lateral
diverticulum with resulting blind loop and stasis in the strictured segment.

19 Stricturing Crohn’s Disease: Strictureplasty
277
Limitations of the conventional strictureplasties is the length of stricture that can
be treated. Taking into account implications of geometry, sequential use of HM
stricutreplasty is limited to lesions at a distance of about 10cm from each other to
allow a 5 cm distance between strictureplasties. Furthermore, long Finney type
strictureplasties create a “diverticulum” on the small bowel and result in possible
stasis of content with bacterial overgrowth. This certainly is the case if the Jaboulay
strictureplasty bypasses longer segments of diseased bowel.
These shortcomings are addressed by the new non-conventional isoperistaltic
strictureplasties.
Side-to-Side Isoperistaltic Stricutreplasty (Referred toasMichelassi
Stricutreplasty) (Fig.19.6)
The Michelassi side-to-side isoperistaltic strictureplasty is indicated for signicantly long strictured segments (>20 cm) or a long portion of bowel containing
multiple short strictures in tandem, making the creation of multiple HM strictureplasties unsafe [46]. The mesentery of the small bowel loop to undergo the strictureplasty is rst divided at its center. The proximal small bowel loop is then moved
over the distal one in a side-to-side fashion. The stenotic segments of one loop are
placed adjacent to the dilated segments of the other loop. The two loops are then
approximated by a layer of interrupted seromuscular Lembert stitches with nonabsorbable 3-0 sutures. A longitudinal enterotomy is performed on both loops, with
the intestinal ends tapered to avoid blind ends. Hemostasis is achieved with suture
ligatures or electrocautery. The outer suture line is reinforced with an internal row
of running full-thickness 3-0 absorbable sutures, continued anteriorly as a running
Connell suture; this layer is reinforced by an outer layer of interrupted seromuscular
Lembert stitches with nonabsorbable 3-0 sutures. The benets of this technique
include relief of intestinal obstruction created by multiple strictures in sequence,
avoidance of resecting a long segment of bowel containing normal absorbing intestine in between strictures, and avoidance of blind and bypassed loops of bowel. This
technique may be challenging to perform in the presence of a thickened and shortened mesentery (Figs.19.7, 19.8, and 19.9).
Fig. 19.6 Judd stricutreplasty

278
Fig. 19.7 M-W-N stricutreplasty
G. Bislenghi and A. D’Hoore
Fig. 19.8 Jaboulay stricutreplasty
Poggioli Strictureplasty
A modied form of Michelassi’s side-to-side isoperistaltic enteroenterostomy has
been proposed and published by two groups: Poggioli etal. [47] and Di Abriola
etal. [48] respectively. These authors describe a technique whereby a long strictured
segment (>20cm) of bowel is plastied using a modication of the side-to-side isoperistaltic strictureplasty technique described by Michelassi. The technique begins
by severing the bowel and dividing the mesentery at the proximal junction of the
stricture. The non-diseased bowel is then advanced over the strictured segment. A
Соседние файлы в папке Библиотека им академика М.И. Перельмана
