Добавил:
Sekretar
kiopkiopkiop18@yandex.ru
t.me/Prokururor I Вовсе не секретарь, но почту проверяю
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5632_Библиотеки_им_академика_М_И_Перельмана.pdf
336 S. Gul et al.
Beer B, Bartolome MJ, Berndorfer L, Bochmann G, Guebitz GM, Nyanhongo GS (2020) Con-
trolled enzymatic hydrolysis and synthesis of lignin cross-linked chitosan functional hydrogels.
Int J Biol Macromol 161:1440–1446
Beheshtizadeh N, Gharibshahian M,
Commercialization and regulation of regenerative medicine products: promises, advances and
challenges. Biomed Pharmacother 153:113431
Bhattarai N, Gunn J, Zhang M (2010) Chitosan-based hydrogels for controlled, localized drug
delivery. Adv Drug Deliv Rev 62(1):83–99
Blackwell J (1988) Physical methods for the determination of chitin structure and conformation.
Methods Enzymol 161:435–442
Blagodatskikh IV, Vyshivannaya OV, Tishchenko NA, Orlov VN, Tikhonov VE, Bezrodnykh EA
et al (2023) Complexation between chitosan and carboxymethyl cellulose in weakly acidic,
neutral, and weakly alcaline media. Int J Biol Macromol 243:125277
Brasselet C, Pierre G, Dubessay P, Dols-Lafargue M, Coulon J, Maupeu J et al (2019) Modification
of chitosan for the generation of functional derivatives. Appl Sci 9(7):1321
Busuioc C, Isopencu GO, Deleanu I-M (2023) Bacterial cellulose–polyvinyl alcohol based complex
composites for controlled drug release. Appl Sci 13(2):1015
Chen J-P, Chang G-Y, Chen J-K (2008) Electrospun collagen/chitosan nanofibrous membrane as
wound dressing. Colloids Surf A Physicochem Eng Asp 313:183–188
de Sousa Victor R, da Cunha M, Santos A, Viana de Sousa B, de Araújo Neves G, de Lima N,
Santana L, Rodrigues Menezes R (2020) A review on Chitosan’s uses as biomaterial: tissue
engineering, drug delivery systems and cancer treatment. Materials 13(21):4995
Desai N, Rana D, Salave S, Gupta R, Patel P, Karunakaran B et al (2023) Chitosan: A potential
biopolymer in drug delivery and biomedical applications. Pharmaceutics 15(4):1313
Díez-Pascual AM (2019) Synthesis and applications of biopolymer composites, vol 20. MDPI,
p 2321
Dilamian M, Montazer M, Masoumi J (2013) Antimicrobial electrospun membranes of chitosan/
poly (ethylene oxide) incorporating poly (hexamethylene biguanide) hydrochloride. Carbohydr
Polym 94(1):364–371
Dimassi S, Tabary N, Chai F, Blanchemain N, Martel B (2018) Sulfonated and sulfated chitosan
derivatives for biomedical applications: a review. Carbohydr Polym 202:382–396
Elieh-Ali-Komi D, Hamblin MR (2016) Chitin and chitosan: production and application of versatile
biomedical nanomaterials. Int J Adv Res 4(3):411–427
Etale A, Onyianta AJ, Turner SR, Eichhorn SJ (2023) Cellulose: a review of water interactions,
applications in composites, and water treatment. Chem Rev 123(5):2016–2048
Farhadnejad H, Mortazavi SA, Jamshidfar S, Rakhshani A, Motasadizadeh H, Fatahi Y et al (2022)
Montmorillonite-famotidine/chitosan bio-nanocomposite hydrogels as a mucoadhesive/
gastroretentive drug delivery system. Iran J Pharm Res: IJPR 21(1):e127035
Gaur M, Maurya S, Akhtar MS, Yadav AB (2023) Synthesis and evaluation of BSA-loaded PLGA–
Chitosan composite nanoparticles for the protein-based drug delivery system. ACS omega
8(21):18751–18759
Gopi S, Balakrishnan P, Chandradhara D, Poovathankandy D, Thomas S (2019) General scenarios
of cellulose and its use in the biomedical field. Mater Today Chem 13:59–78
Guo T, Pei Y, Tang K, He X, Huang J, Wang F (2017) Mechanical and drug release properties of
alginate beads reinforced with cellulose. J Appl Polym Sci 134(8):44495
He S, Zhong S, Meng Q, Fang Y, Dou Y, Gao Y, Cui X (2021) Sonochemical preparation of folate-
decorated reductive-responsive carboxymethylcellulose-based nanocapsules for targeted drug
delivery. Carbohydr Polym 266:118174
Hegyesi D
and physicochemical characterization of matrix pellets containing APIs with different solubility
via extrusion process. Drug Dev Ind Pharm 43(3):458–464
Heinze T (2016) Cellulose: structure and properties. In: Rojas OJ (ed) Cellulose chemistry and
properties: fibers, nanocelluloses and advanced materials. Springer, pp 1–52
hommes M, Kleinebudde P, Sovány T, Kása P Jr, Kelemen A et al (2017) Preparation
, T
Pazhouhnia Z, Rostami M, Zangi AR, Maleki R et al (2022)
13 Cellulose, Chitin, and Chitosan Composite-Based Sustainable Biomaterials 337
Hong H-J, Kim J, Kim D-Y, Kang I, Kang HK, Ryu BG (2019) Synthesis of carboxymethylated
nanocellulose fabricated ciprofloxacine–montmorillonite composite for sustained delivery of
antibiotics. Int J Pharm 567:118502
Hou J, Aydemir BE, Dumanli AG (2021) Understanding
versatile biomaterial. Phil Trans R Soc A 379(2206):20200331
Husain S, Al-Samadani KH, Najeeb S, Zafar MS, Khurshid Z, Zohaib S, Qasim SB (2017) Chitosan
biomaterials for current and potential dental applications. Materials 10(6):602
Ibrahim H, El-Zairy E (2015) Chitosan as a biomaterial—structure, properties, and electrospun
nanofibers. In: Bobbarala V (ed) Concepts, compounds and the alternatives of antibacterials.
InTech, pp 81–101
Jaafar J, Siregar JP, Tezara C, Hamdan MHM, Rihayat T (2019) A review of important
considerations in the compression molding process of short natural fiber composites. Int J
Adv Manuf Technol 105:3437–3450
Jiang A, Patel R, Padhan B, Palimkar S, Galgali P, Adhikari A et al (2023) Chitosan based
biodegradable composite for antibacterial food packaging application. Polymers 15(10):2235
Kargarzadeh H, Huang J, Lin N, Ahmad I, Mariano M, Dufresne A et al (2018) Recent
developments in nanocellulose-based biodegradable polymers, thermoplastic polymers, and
porous nanocomposites. Prog Polym Sci 87:197–227
Kaur M, Sharma A, Puri V, Aggarwal G, Maman P, Huanbutta K et al (2023) Chitosan-based
polymer blends for drug delivery systems. Polymers 15(9):2028
Kestur GS (2010) Biodegradable polymer composites based on Brazilian lignocellulosic. Matéria
(Rio de Janeiro) 15:88–95
Khalili Z, Kazemi NM, Azar ZJ, Mosavi Z, Hasanzadeh M (2024) Fabrication and characterization
of a Bi2O3-modified chitosan@ ZIF-8 nanocomposite for enhanced drug loading-releasing
efficacy. Int J Biol Macromol 263:130295
Kim J, Kim Y, Jeong J-P, Kim J-M, Kim MS, Jung S (2023) A pH-sensitive drug delivery using
biodegradable succinoglycan/chitosan hydrogels with synergistic antibacterial activity. Int J
Biol Macromol 242:124888
Kochkina NE, Lukin ND (2020) Structure and properties of biodegradable maize starch/chitosan
composite films as affected by PVA additions. Int J Biol Macromol 157:377–384
Kostag M, El Seoud OA (2021) Sustainable biomaterials based on cellulose, chitin and chitosan
composites-A review. Carbohydr. Polym. Technol. Appl. 2:100079
Kulshreshtha AK, Vasile C (2002) Handbook of polymer blends and composites, vol vol.
1. iSmithers Rapra Publishing
Kumar A, Yadav S, Pramanik J, Sivamaruthi BS, Jayeoye TJ, Prajapati BG, Chaiyasut C (2023)
Chitosan-based composites: development and perspective in food preservation and biomedical
applications. Polymers 15(15):3150
Kuzgun NK, İnanlı AG (2013) Kitosan üretimi ve özellikleri ile kitosanın kullanım alanları. Türk
Bilimsel Derlemeler Dergisi 6(2):16–21
Lakhundi S, Siddiqui R, Khan NA (2015) Cellulose degradation: a therapeutic strategy in the
improved treatment of Acanthamoeba infections. Parasit Vectors 8:1–16
Leonard TE, Liko AF, Gustiananda M, Putra ABN, Juanssilfero AB, Hartrianti P (2023) Thiolated
pectin-chitosan composites: Potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer. Int J Biol Macromol 225:1–12
Li R, Wang Y, Xu J, Ahmed S, Liu Y (2019) Preparation and characterization of ultrasound treated
polyvinyl alcohol/chitosan/DMC antimicrobial films. Coatings 9(9):582
Ma Q, Gao X, Bi X, Han Q, Tu L, Yang Y et al (2020) Dissolution and deacetylation of chitin in
ionic liquid tetrabutylammonium hydroxide and its cascade reaction in enzyme treatment for
chitin recycling. Carbohydr Polym 230:115605
Mao D,
Li Q, Bai N, Dong H, Li D (2018) Porous stable poly (lactic acid)/ethyl cellulose/
hydroxyapatite composite scaffolds prepared by a combined method for bone regeneration.
Carbohydr Polym 180:104–111
the structural diversity of chitins as a
338 S. Gul et al.
McNamara JT, Morgan JL, Zimmer J (2015) A molecular description of cellulose biosynthesis.
Annu Rev Biochem 84:895–921
Methacanon P, Prasitsilp M, Pothsree T,
of squid chitin in alkaline solution. Carbohydr Polym 52(2):119–123
Mıyazakı S, Ishıı K, Nadaı T (1981) The use of chitin and chitosan as drug carriers. Chem Pharm
Bull 29(10):3067–3069
Mokhena TC,
processing of PLA/cellulose nanomaterials composites. Polymers 10(12):1363
Morishima R, Bokuda K (2021) Hydroxypropyl cellulose-induced fixed drug eruption as an adverse
effect of generic drugs. Contact Derm 85(1):90–91
Muhamad II, Selvakumaran S, Lazim NAM (2014) Designing polymeric nanoparticles for targeted
drug delivery system. Nanomed 287:287
Murugan SS, Anil S, Sivakumar P, Shim MS, Venkatesan J (2021) 3D-printed chitosan composites
for biomedical applications. In: Jayakumar R, Prabaharan M (eds) Chitosan for biomaterials IV:
biomedical applications, pp 87–116
Mushtaq S, Khan JA, Rabbani F, Latif U, Arfan M, Yameen MA (2017) Biocompatible biodegrad-
able polymeric antibacterial nanoparticles for enhancing the effects of a third-generation
cephalosporin against resistant bacteria. J Med Microbiol 66(3):318–327
Nadeem H, Naseri M, Shanmugam K, Dehghani M, Browne C, Miri S et al (2020) An energy
efficient production of high moisture barrier nanocellulose/carboxymethyl cellulose films via
spray-deposition technique. Carbohydr Polym 250:116911
Nicolay VK, Nina S, Yuliya K, Galina B (2020) Formation of polyelectrolyte complexes from
chitosan and alkaline gelatin. KnE Life Sci 2020:109–119
Nicolle L, Journot CM, Gerber-Lemaire S (2021) Chitosan functionalization: covalent and
non-covalent interactions and their characterization. Polymers 13(23):4118
Oldal DG, Topuz F, Holtzl T, Szekely G (2023) Green electrospinning of biodegradable cellulose
acetate nanofibrous membranes with tunable porosity. ACS Sustain Chem Eng 11(3):994–1005
Omrani Z, Pourmadadi M, Yazdian F, Rashedi H (2023) Preparation and characterization of
pH-sensitive chitosan/starch/MoS2 nanocomposite for control release of curcumin
macromolecules drug delivery; application in the breast cancer treatment. Int J Biol Macromol
250:125897
Pal K, Bharti D, Sarkar P, Anis A, Kim D, Chałas R et al (2021) Selected applications of chitosan
composites. Int J Mol Sci 22(20):10968
Parvaneh S, Pourmadadi M, Abdouss M, Pourmousavi SA, Yazdian F, Rahdar A, Díez-Pascual AM
(2023) Carboxymethyl cellulose/starch/reduced graphene oxide composite as a pH-sensitive
nanocarrier for curcumin drug delivery. Int J Biol Macromol 241:124566
Pattnaik S, Swain K (2022) Cellulose-Based composites and their biomedical applications. Cellul
Chem Technol 56(1–2):115–122
Pattnaik S, Swain K, Rao JV, Varun T, Mallick S (2015) Temperature influencing permeation
pattern of alfuzosin: an investigation using DoE. Medicina 51(4):253–261
Pavinatto FJ, Caseli L, Oliveira ON Jr (2010) Chitosan in nanostructured thin films.
Biomacromolecules 11(8):1897–1908
Peng X, Fan M, Hartley J, Al-Zubaidy M (2012) Properties of natural fiber composites made by
pultrusion process. J Compos Mater 46(2):237–246
Peng S, Liang Y, Xiao W, Liu Y, Yu M, Liu L (2022) Anaphylaxis induced by intra-articular
injection of chitosan: a case report and literature review. Clin Case Reports 10(12):e6596
Petrova VA, Gofman IV, Dubashynskaya NV, Golovkin AS, Mishanin AI, Ivan’kova EM et al
(2023) Chitosan composites with bacterial cellulose nanofibers doped with nanosized cerium
oxide: characterization and cytocompatibility evaluation. Int J Mol Sci 24(6):5415
Phan VG,
cross-linked alginate-chitosan core-shell hydrogel beads for oral delivery of insulin. Int J Biol
Macromol 222:262–271
Sefadi JS,
Mathiyalagan R, Nguyen M-T, Tran T-T, Murugesan M, Ho T-N et al (2022) Ionically
Sadiku ER, John MJ, Mochane MJ, Mtibe A (2018) Thermoplastic
Pattaraarchachai J (2003) Heterogeneous N-deacetylation
13 Cellulose, Chitin, and Chitosan Composite-Based Sustainable Biomaterials 339
Pillai CK, Paul W, Sharma CP (2009) Chitin and chitosan polymers: chemistry, solubility and fiber
formation. Prog Polym Sci 34(7):641–678
Przypis M, Wawoczny A, Gillner D (2023) Biomass and Cellulose Dissolution—The Important
Issue in
Qin Y, Li P (2020) Antimicrobial chitosan conjugates: current synthetic strategies and potential
Qin Y, Li P, Guo Z (2020) Cationic chitosan derivatives as potential antifungals: a review of
Quero F, Nogi M, Yano H, Abdulsalami K, Holmes SM, Sakakini BH, Eichhorn SJ (2010)
Ramezani G, Stiharu I, van de Ven TG, Nerguizian V (2024) Advancements in hybrid cellulose-
Rehman KU, Hollah C, Wiesotzki K, Heinz V, Aganovic K, Rehman RU et al (2023) Insect-
Rizvi M, Gerengi H, Gupta P (2022) Functionalization of nanomaterials: synthesis and
Román-Doval R, Torres-Arellanes SP, Tenorio-Barajas AY, Gómez-Sánchez A, Valencia-Lazcano
Rui Q, Gao J, Yin Z-Z, Li J, Cai W, Wu D, Kong Y (2023) A biodegradable pH and glutathione
Sahu R, Singh MK, Singh G, Agarwal N, Yadav AS, Chincholkar P et al (2024) Optimization
Said HA, Noukrati H, Mahdi I, Oudadesse H, Barroug A (2023) In situ precipitated hydroxyapatite-
Salavati M (2023) Mechanical properties of α-Chitin and chitosan biocomposite: a molecular
Sankarganesh P, Parthasarathy V, Ganesh Kumar A, Ragu S, Saraniya M, Udayakumari N,
Sanmugam A, Abbishek S, Kumar SL, Sairam AB, Palem VV, Kumar RS et al (2023) Synthesis of
Sarmento B, Goycoolea FM, Sosnik A, das Neves J (2011) Chitosan and chitosan derivatives for
Shariatinia Z (2019) Pharmaceutical applications of chitosan. Adv Colloid Interf Sci 263:131–194
Silva-Castro I
Kumar P,
Renewable Materials Treatment. Appl Sci 13(2):1055
applications. Int J Mol Sci 21(2):499
structural optimization and applications. Carbohydr Polym 236:116002
Optimization of the mechanical performance of bacterial cellulose/poly (L-lactic) acid
composites. ACS Appl Mater Interfaces 2(1):321–330
based films: Innovations and applications in 2D nano-delivery systems. J Funct Biomater 15(4):
93
derived chitin and chitosan: A still unexploited resource for the edible insect sector. Sustain For
15(6):4864
characterization. In: Functionalized nanomaterials for corrosion mitigation: synthesis, characterization, and applications. ACS Publications, pp 1–26
AA (2023) Chitosan: properties and its application in agriculture in context of molecular weight.
Polymers 15(13):2867
dual-triggered drug delivery system based on mesoporous silica, carboxymethyl chitosan and
oxidized pullulan. Int J Biol Macromol 224:1294–1302
techniques in compression moulding: a comprehensive review. Mater Sci Forum 1112:41–48
chitosan composite loaded with ciprofloxacin: formulation, mechanical, in vitro antibiotic
uptake, release, and antibacterial properties. Mater Chem Phys 294:127008
dynamic study. Journal of Composites Science 7(11):464
Anbarasan R (2024) Preparation of cellulose-PVA blended hydrogels for wound healing
applications with controlled release of the antibacterial drug: an in vitro anticancer activity.
Biomass Convers Biorefinery 14(3):3385–3395
chitosan based reduced graphene oxide-CeO2 nanocomposites for drug delivery and
antibacterial applications. J Mech Behav Biomed Mater 145:106033
biological applications: chemistry and functionalization. Int J Carbohydr Chem. https://doi.org/
10.1155/2011/802693
, M
J (2017) Eco-friendly nanocomposites of chitosan with natural extracts, antimicrobial agents,
and nanometals. In: Thakur VK, Thakur MK, Kessler MR (eds) Handbook of composites from
renewable materials. Wiley, pp 35–60
encapsulated silica-chitosan composite for drug release study. Bulg Chem Commun 55, Special
Issue A:102–108
artín-Ramos P, Matei PM, Fernandes-Correa M, Hernánez-Navarro S, Martín-Gil
Khan N, Kumar D, Ali M, Tandon R (2023) Microwave-assisted synthesis of curcumin-
340 S. Gul et al.
Snyman D, Hamman J, Kotze J, Rollings J, Kotze A (2002) The relationship between the absolute
molecular weight and the degree of quaternisation of N-trimethyl chitosan chloride. Carbohydr
Polym 50(2):145–150
Song Y, Wu T, Bao J, Xu M,
with super piezoelectric properties for energy harvesting. Carbohydr Polym 288:119407
Stephen AM, Phillips GO (2016) Food polysaccharides and their applications. CRC Press
Sun X, Liu C, Omer A, Lu W, Zhang S, Jiang X et al (2019a) pH-sensitive ZnO/carboxymethyl
cellulose/chitosan bio-nanocomposite beads for colon-specific release of 5-fluorouracil. Int J
Biol Macromol 128:468–479
Sun X, Shen J, Yu D, Ouyang X-K (2019b) Preparation of pH-sensitive Fe3O4@ C/carboxymethyl
cellulose/chitosan composite beads for diclofenac sodium delivery. Int J Biol Macromol 127:
594–605
Tao F, Cheng Y, Shi X, Zheng H, Du Y, Xiang W, Deng H (2020) Applications of chitin and
chitosan nanofibers in bone regenerative engineering. Carbohydr Polym 230:115658
Thakur VK, Thakur MK, Gupta RK (2014) Raw natural fiber–based polymer composites. Int J
Polym Anal Charact 19(3):256–271
Trzeciak K, Chotera-Ouda A, Bak-Sypien II, Potrzebowski MJ (2021) Mesoporous silica particles
as drug delivery systems—the state of the art in loading methods and the recent progress in
analytical techniques for monitoring these processes. Pharmaceutics 13(7):950
Tsigos I, Martinou A, Kafetzopoulos D, Bouriotis V (2000) Chitin deacetylases: new, versatile tools
in biotechnology. Trends Biotechnol 18(7):305–312
Ul-Islam M, Alabbosh KF, Manan S, Khan S, Ahmad F, Ullah MW (2023) Chitosan-based
nanostructured biomaterials: synthesis, properties, and biomedical applications. Adv Ind Eng
Polym Res 7:79–99
Vaca-Medina G, Jallabert B, Viet D, Peydecastaing J, Rouilly A (2013) Effect of temperature on
high pressure cellulose compression. Cellulose 20:2311–2319
Vallittu PK (2018) An overview of development and status of fiber-reinforced composites as dental
and medical biomaterials. Acta biomaterialia odontologica Scandinavica 4(1):44–55
Volk M, Yuksel O, Baran I, Hattel JH, Spangenberg J, Sandberg M (2022) Cost-efficient,
automated, and sustainable composite profile manufacture: A review of the state of the art,
innovations, and future of pultrusion technologies. Compos Part B 246:110135
Wang L, Ishihara S, Hikima Y, Ohshima M, Sekiguchi T, Sato A, Yano H (2017) Unprecedented
development of ultrahigh expansion injection-molded polypropylene foams by introducing
hydrophobic-modified cellulose nanofibers. ACS Appl Mater Interfaces 9(11):9250–9254
Wilson MR, Jones DS, Andrews GP (2017) The development of sustained release drug delivery
platforms using melt-extruded cellulose-based polymer blends. J Pharm Pharmacol 69(1):32–42
Wohlert M, Benselfelt T, Wågberg L, Furó I, Berglund LA, Wohlert J (2022) Cellulose and the role
of hydrogen bonds: not in charge of everything. Cellulose 29:1–23
Xu Q, Ji Y, Sun Q, Fu Y, Xu Y, Jin L (2019) Fabrication of cellulose nanocrystal/chitosan hydrogel
for controlled drug release. Nano 9(2):253
Yadav M, Kaushik B, Rao GK, Srivastava CM, Vaya D (2023) Advances and challenges in the use
of chitosan and its derivatives in biomedical fields: a review. Carbohydr Polym Technol Appl 5:
100323
Yan H, Chen X, Feng M, Shi Z, Zhang W, Wang Y et al (2019) Entrapment of bacterial cellulose
nanocrystals stabilized Pickering emulsions droplets in alginate beads for hydrophobic drug
delivery. Colloids Surf B: Biointerfaces 177:112–120
Yang Y, Wu H, Fu Q, Xie X, Song Y, Xu M, Li J (2022) 3D-printed polycaprolactone-chitosan
based drug delivery implants for personalized administration. Mater Des 214:110394
Yari K
Younes I, Rinaudo M (2015) Chitin and chitosan preparation from marine sources. Structure,
harati G, Akbari I (2023) Evaluating effect of salt leaching method on release and swelling
, G
rate of metformin nanoparticles loaded-chitosan/polyvinyl alcohol porous composite. Int J Biol
Macromol 227:1282–1292
properties and applications. Mar Drugs 13(3):1133–1174
Yang Q, Zhu L et al (2022) Porous cellulose composite aerogel films
13 Cellulose, Chitin, and Chitosan Composite-Based Sustainable Biomaterials 341
Zhang H, Neau SH (2001) In vitro degradation of chitosan by a commercial enzyme preparation:
effect of molecular weight and
degree of deacetylation. Biomaterials 22(12):1653–1658
Zhang A, Zou Y, Xi Y, Wang P, Zhang Y, Wu L, Zhang H (2021) Fabrication and characterization
of bamboo shoot cellulose/sodium alginate composite aerogels for sustained release of
curcumin. Int J Biol Macromol 192:904–912
Sultan Gul graduated from Necmettin Erbakan University with a
degree in Molecular Biology and Genetics in 2017. She continued
her academic journey with a master’s degree in Medical Biology
and Genetics at Medipol University. During this time, she
participated in several projects as a TÜBİTAK project grantee
and completed her master’s degree in November 2021 at Istanbul
Medipol University. Her thesis focused on “Microbiome Changes
during Axolotl Limb Regeneration” and resulted in a related
publication. Currently pursuing a master’s degree in Biotechnology at Yıldız Technical University, Sultan Gül has been leading
the TÜBİTAK 1512 project titled “Plant Growth Regulators
Containing Metabolites Produced by Bene ficial Microorganisms
(Antibiotics, Hormones, and Plant Nutrients)” since 2023. She is
also the founder and CEO of Microhobist Biotechnology, actively
involved in patenting the product MHOne developed under the
company’s auspices.
Yesim Karahan is currently pursuing her second PhD in the
Bioengineering department at Yıldız Technical University. Previously, she obtained a PhD in Physical Chemistry from the same
institute in 2022, with a thesis titled “Obtaining and Characterization of Hesperetin Microrods Stabilized by Different Biomaterials
from Various Hesperetin Nanosuspensions.” As part of her studies, she participated in the ERASMUS+ program at the Department of Pharmacy, Biopharmaceuticals and Pharmaceutical
Technologies, Saarland University, Saarbrücken, Germany, during the 2018–2019 academic year. She got her master’s degree in
Physical Chemistry with a focus on in silico research from
Eskişehir OsmanGazi University in 2015 and graduated from the
Chemistry department at Abant İzzet Baysal University in 1999.
Additionally, she has three articles and delivered numerous oral
presentations at both national and international conferences.
Ozan Baris Kurtur is currently a PhD student at Yıldız Techni-
cal University, Department of Bioengineering. He received his
master’s degree from Çanakkale Onsekiz Mart University,
Department of Biology, in 2018. His current research area is on
nanotechnology, polymeric nanoparticles, controlled release system and drug delivery systems. In addition to disease diagnosis,
prophylaxis and treatment, he works as a researcher in projects
within the scope of development of polymeric-based controlled
release systems for soil fertility and fertilization.
342 S. Gul et al.
Yasemin Budama-Kilinc is currently an Assistant Professor at
Yıldız Technical University, Faculty of Chemical and Metallurgical Engineering, Department of Bioengineering. She received her
master’s degree in bioengineering in 2006 and her doctorate
degree in 2013. The focus of his research topics are a wide range
of topics such as polymeric nanoparticles with prophylactic and
therapeutic properties, nanoemulsions, phytotherapeutic
nanoformulations, controlled release systems, specific antibody
production, lateral flow rapid diagnostic kit development, cosmeceutical nanoformulation production. She has authored many
research articles published in various journals within the scope
of SCI/SCI-Ex. and chapters in many books within the scope of
the Book Citation Index. She has led many nationally supported
projects.
Sustainable Synthesis of Cellulose-Derived Hydrogels for Tissue Engineering
Ainil Hawa Jasni, Azlin Suhaida Azmi, Noor Illi Puad Mohamad Puad,
Fathilah Ali, and Yusilawati Ahmad Nor
Abstract
The demand for environmentally friendly and sustainable materials has led to an
increased interest in green synthesis methods for biomaterials used in tissue
engineering applications. Cellulose obtained from renewable sources is considered a promising option because of its abundance, biocompatibility, and biodegradability. Hydrogels, with their capacity to mimic the extracellular matrix and
support biological processes, are an adaptable biomaterial for tissue engineering
scaffolds. This chapter gives a thorough overview of green synthesis methods for
cellulose-derived hydrogels and their potential uses in tissue engineering . The
synthesis of cellulose-based hydrogels using ecologically friendly methods
include minimizing harmful compounds, lowering energy usage, and employing
safe solvents. Such approaches include microwave-assisted synthesis, sonication,
and enzymatic transformation. These methods not only reduce environmental
effect, but they also increase the biocompatibility and functionality of the produced hydrogel. Cellulose-based hydrogels have various advantages in tissue
engineering applications. Their innate biocompatibility and resemblance to the
extracellular matrix promote cell adhesion, proliferation, and differentiation. In
bone tissue engineering, cellulose nanofibril hydrogels have been found to
stimulate the proliferation and differentiation of mesenchymal stem cells. Furthermore, hydrogel features such as tensile strength, porosity, and degradation
rate can be tailored to fulfill tissue-specific requirements. For example, genipin
cross-linked carboxymethylcellulose hydrogels have been engineered to have
tunable mechanical characteristics ideal for cartilage tissue engineering. Furthermore, adding bioactive chemicals into cellulose-based hydrogels will enhance
14
A. H. Jasni (✉) · A. S. Azmi · N. I. P. M. Puad · F. Ali · Y. A. Nor
Department of Chemical Engineering and Sustainability Kulliyyah of Engineering, International
Islamic University Malaysia, Kuala Lumpur, Malaysia
#
T
he Author(s), u
R. Malviya, S. Sundram (eds.), Sustainable Green Biomaterials As Drug Delivery
Systems, Biomaterials, Bioengineering and Sustainability 1,
https://doi.org/10.1007/978-3-031-79062-1_14
nder exclusive license to Springer Nature Switzerland AG 2025
343
344 A. H. Jasni et al.
their therapeutic potential. In skin tissue engineering, cellulose-based hydrogels
incorporating growth factors or nanoparticles have demonstrated encouraging
results in stimulating angiogenesis and wound healing. The biodegradability of
cellulose-derived hydrogels is anothe r critical component of tissue engineering.
These hydrogels gradually degrade in the body, allowing regenerated tissues to
integrate and reducing unwanted immune responses. Oxidi
hydrogels, for example, have been show
tissue-engineered constructs to remodel more easily. In conclusion, the green
manufacture of cellulose-derived hydrogels shows great promise for tissue engineering applications. Advanced hydrogel scaffolds can be created for various
tissue regeneration strategies by utilizing sustainable production methods and
leveraging cellulose’s unique features, such as biocompatib
radabi
biodeg
function even more, opening the door to creative solutions in biomedical engineering and regenerative medicine.
Keywords
Cellulose-derived hydrogels · Drug-delivery system · Renewable resources ·
Sustainable synthesis · Tissue engineering
lity.
Research
in
this fi
eld
n to degrade over time, allowing
will
enable cellulose-based hydrogels to
zed cellulose
ility, t
ailorability, and
14.1 Introduction
14.1.1 Overview of Cellulose-Derived Hydrogels
Cellulose-derived hydrogels are a rapidly developing subject at the crossroads of
material science, biology, and sustainability. These hydrogels, made from the
plentiful and renewable polymer cellulose, have a diverse range of characteristics
and applications, especially in tissue engineering and regenerative medicine. This
chapter presents an in-depth review of cellulose-derived hydrogels, including their
structure, synthesis methods, and many applications.
Cellulose-based hydrogels, which are made up of diverse organic biopolymers
like cellulose, chitin, and chitosan, have hydrophilic qualities. They are capable of
absorbing and retaining large volumes of water inside the interstitial gaps of their
structures (Kabir et al. 2018) The self-assembly of tiny or macr omolecular polymers
results in the porous three-dimensional network structure known as hydrogels.
Usually, precursor molecules undergo covalent, non-covalent, or physical crosslinking to form them (Wang et al. 2023).
14.1.2 The Significance of Sustainability in Tissue Engineering
Materials
Tissue engineering has emerged as a transformative field with the capacity to alter
healthcare by delivering treatments for tissue repair, regeneration, and transplantation (Melecio 2024) The progress of tissue engineering techniques is dependent on
ustainable Synthesis of Cellulose-Derived Hydrogels for Tissue Engineering 345
14 S
the development of biomaterials that resemble the native extracellular matrix and
create a favorable milieu for cell proliferation and tissue creation. Recently, there has
been a rising realization of the significance of sustainability in the development and
production of tissue engineering materials (Jasni et al.
2023).
The significance of sustainability in tissue engineering materials is broad, involving environmental, economic, and ethical factors. As the science of tissue engineering evolves, integrating sustainable techniques and materials is vital for various
reasons in Table 14.1:
Table 14.1 Justifications for sustainability’s significance in tissue engineering materials
Reason Specific reason Justification Citation
1. Environmental
impact
2. Biocompatibility
and safety
Resource
depletion
Pollution The manufacturing processes for
Carbon footprint The production and transportation of
Toxicity Synthetic materials can sometimes
Chronic health
concerns
Traditional materials used in tissue
engineering, such as synthetic
polymers, are often derived from
non-renewable petroleum sources.
The extraction and processing of
these materials contribute to
depletion of finite
synthetic polymers can generate
significant environmental pollutants.
Additionally, the disposal of
non-biodegradable materials can lead
to long-term environmental
contamination
traditional biomaterials can result in
high carbon emissions. Sustainable
materials, like cellulose-derived
hydrogels, often have a lower carbon
footprint due to more eco-friendly
production processes and the use of
renewable resources.
release toxic byproducts during
degradation, posing risks to human
health and the environment.
Sustainable materials, particularly
those derived from natural sources,
tend to be biocompatible and degrade
into non-toxic byproducts.
Non-biodegradable materials can
persist in
leading to chronic inflammation or
other long-term health issues.
Biodegradable materials, on the other
hand, minimize these risks by
breaking down into harmless
substances.
the body,
natural resources
potentially
the
Chen et al.
(2020a)
Smith and
Jones
(2018a)
Lee et al.
(2019a, b)
Wang et al.
(2021a, b)
Brown
et al.
(2022)
(continued)