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A. Dardeer et al.
26.7 Obstructive Sleep Apnea (OSA)
andPostoperative Complications
According to a recent meta-analysis, patients having OSA who are undergoing non- cardiac surgery are more prone to cardiorespiratory complications compared to non-OSA patients. These complications include, but are not limited to, desatura­tion in the postoperative phase, respiratory failure, cardiac events, and unplanned transferals to ICUs [84]. It is the effect of the hypnotic sedative agents used in general anesthesia or sedation that causes these patients to have such complica­tions. The pharyngeal muscles are prone to collapse, closing the airway, which might be augmented by the sedative effect of anesthesia, leading to respiratory complications. This periodic collapse/reopening of the airway causes hypoventila­tion and acidosis, sympathetic activation, and hypoxia, which eventually leads to the various cardiovascular complications associated with OSA [8284]. The risk of OSA may not normalize for several nights postoperatively, with the greatest risk on postoperative night three. Later, the disturbance and rebound in Rapid Eye Movement (REM) sleep, caused by administration of high doses of opioids in the postoperative period, which suppress REM, causes sleep deprivation and related consequences [85].
26.8 Conclusion
OSA is associated with a number of upper airway anatomical and physiological changes that pose a signicant challenge to perioperative care. The effects of seda­tives, analgesics, and anesthetics can worsen OSA airway and ventilation. OSA has a three-to-four-fold higher risk of DI when compared to non-OSA patients. Acute and chronic pathologies of the epiglottis that cause OSA, despite being uncommon, mandate attention from both anesthetist and surgeon, as they impose certain chal­lenges to both diagnosis and management. The golden rule in an OSA patient is the maintenance of airway control either by the patient or by the anesthetist. Extubation is a critical time in the management of OSA patients and should be well planned ahead with multiple layers of safety.
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Future Directions
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27
MohamedAbdelwahab, RakhaAbdelwahab, andRobsonCapasso
27.1 Introduction
27.1.1 The Problem
Obstructive sleep apnea (OSA) is a prevalent yet treatable chronic condition affect­ing over a billion subjects globally [1]. Subjects with OSA are reported to be up to 38% of the US population [2]. However, when we evaluated subjects with insurance coverage, this percentage was only 4.34% of all enrolled subjects, indicating that over 80% of the population likely remain undiagnosed [3]. Beyond debilitating quality of life daytime symptoms and possible partner sleep issues, associated oxy­gen desaturations seem to lead to worsened cardiovascular outcomes, including sys­temic hypertension, increased incidence of stroke, heart failure, atrial brillation, and coronary heart disease [48].
Managing OSA can be difcult, as phenotyping respiratory drive and airway col-
lapsibility remains a challenge [5, 6]. Anatomical (including the craniofacial
Supplementary Information The online version contains supplementary material available at
https://doi.org/10.1007/978-3-031-34992-8_27. The videos can be accessed individually by click-
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M. Abdelwahab Sleep Surgery Division, Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA
R. Abdelwahab Department of Otolaryngology, Head and Neck Surgery, School of Medicine, Mansoura University, Mansoura, Egypt
R. Capasso (*) Division of Sleep Surgery, Department of Otolaryngology-Head & Neck Surgery, Stanford University Medical Center, Stanford, CA, USA e-mail: rcapasso@stanford.edu
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2023 M. Delakorda, N. de Vries (eds.), The Role of Epiglottis in Obstructive Sleep Apnea, https://doi.org/10.1007/978-3-031-34992-8_27
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skeleton, neck dimensions, and airway soft tissue anatomy) [9, 10] and physiologi­cal (including the loop gain, arousal threshold, and transmural pressure) [11] phe­notypes of OSA have been extensively studied. [12, 13] While our group has dened and continued to improve the comprehensive approach to OSA management since 1986 [1416], an important step is to dene the pattern, level, and triggers of airway collapse. This collapse occurs most commonly at the level of the Velum, but may involve the Oropharynx (lateral pharyngeal wall), tongue base and less commonly the Epiglottis (therefore the acronym VOTE), or a combination of any of the above [1719]. The VOTE classication based on drug-induced sleep endoscopy (DISE), describing the dynamic airway obstruction, has guided and warranted reproducibil­ity of our understanding of airway collapse during sleep.
Laryngeal obstruction in OSA results from collapse of the laryngeal inlet, formed by the epiglottis, aryepiglottic folds, the arytenoids, and the overlying mucosa. This may be primary (also known as “oppy epiglottis”) (Fig.27.1) or secondary, when the epiglottis is retro-displaced by the tongue base (Fig.27.2). Epiglottic collapse may be difcult to treat with conservative therapies, such as oral appliances [20]
Fig. 27.1 An example of a oppy epiglottis on sleep endoscopy
Fig. 27.2 An example of a retrodisplaced epiglottis on sleep endoscopy
27 Future Directions
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and CPAP, [21] and has shown to be a predictor of OSA persistence after surgical treatments [22].
However, prior to considering a surgical intervention, it is important to investi­gate the following: when does the epiglottic collapse (based on DISE) requires treatment beyond positional measures, and the type of intervention required that could minimize risks of immediate and long-term swallowing dysfunction and aspi­ration due to a modied supraglottic anatomy.
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27.1.2 Relevant Anatomy
The epiglottis is a leaf-like sheet of elastic brocartilage that is curled-out and later­ally attached to the aryepiglottic folds. The laryngeal inlet is usually wide to avoid its collapse with inspiration according to the Bernoulli’s phenomenon. The lower narrow part, the petiole, is attached to the posterior surface of the thyroid alae at their junction just above the anterior commissure. The anterior surface is separated from the hyoid and thyrohyoid membrane by pre-epiglottic space. It projects upwards and backwards behind the tongue and the hyoid bone, separated from the tongue by the vallecula. The aryepiglottic ligaments and overlying mucosa (folds) form the sides of the laryngeal inlet between the apex of arytenoid & the upper free edge of epiglottis on both sides [23, 24].
The shape can be classied into: (1) omega-shaped (sharply curved if the angle between its lateral parts was less than 90° at the central portion) epiglottis; (2) normally curved epiglottis shape; and (3) at epiglottis. An epiglottis was classied as at if its medial part lacked the characteristic anterior convexity [25]. In most cases of obstruction at epiglottis and/or tongue base, the epiglottis was at (type 3), where it was lacking the typical anterior convexity in its upper part. The hypothesis was that the change of its shape is a result of degeneration of the suspensory apparatus that maintains the convexity of the epiglottis and maintains it in position. This may help identify patients with narrowing at this level [25]. Another nding was that subjects with isolated epiglottic collapse have lower mandibular plane to hyoid distance and tend to have a bigger angle of their epiglotic curvature [26]. For full details on anatomy, please review Chap. 5. Epiglottic collapse can vary based on the phenotype from a oppy epiglottis (primary) to a retro-displaced epiglottis by the tongue base (secondary) and from partial to complete collapse. The epiglottis can also collapse into two different patterns: one where it is retro-displaced in an antero- posterior (AP) direction, thereby obstructing the laryngeal inlet. This is also known as the trapdoor phe­nomenon. Alternatively, it can collapse in a lateral direction (omega-shaped pat­tern), thereby resulting in obstructing at the level of the hypopharynx or laryngeal inlet [1719].
In pediatric cases with laryngomalacia, the epiglottis is omega-shaped, and the aryepiglottic folds are medially posed resulting in a narrow laryngeal inlet (Fig.27.3). This narrow inlet results in collapse with inspiration presenting with
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Fig. 27.3 An example of an endoscopic view of an omega shaped epiglottis in a 2-day old newborn with laryngomalacia
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stridor and/or OSA.The former being the main symptom due to increasing negative pressure according to Bernoulli’s effect [23, 24, 27, 28].
27.1.3 Diagnosis
Non-invasive imaging techniques such as magnetic resonance imaging (MRI) and computed tomography (CT) scan have been described to detect anatomic and func­tional impairments of the upper airway in OSA patients during wakefulness [29]. However, these techniques are not suitable for clinical practice due to cost and the challenge of having adequate imaging during natural sleep. While it has some limi­tations, DISE is the most commonly used tool for detecting the level(s), severity, and patterns of airway collapse [25]. This can guide the surgical intervention, towards either the palate, the pharynx, or the larynx.
In our practice at Stanford, we rely on manual-controlled propofol infusions. Preoperatively, the patient is given nasal decongestant (oxymetazoline). As sedation is started and before the patient is sleepy, the surgeon places the distal chip-on-tip exible scope into the nares on the side with least obstruction. The scope is prefer­ably passed through the middle meatus, on top of the inferior turbinate, and inferior to the middle turbinate, and advanced posteriorly until the posterior wall of the