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25 Maxillomandibular Advancement
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patients showed baseline anteroposterior epiglottis collapse (complete collapse: n=2; partial collapse: n=2). After MMA, this collapse pattern persisted in two patients (partial collapse: n=1; complete collapse: n=1). Two out of 20 patients had complete lateral epiglottis collapse preoperatively, and one patient had partial lateral epiglottis collapse postoperatively. Due to the small numbers of events for epiglottis collapse, their study cannot be an indicative of the role of MMA on epi­glottis collapse.
The upper airway collapse patterns during DISE before and after MMA were also evaluated by Kastoer etal. in 2020 [36]. Eight out of 14 patients had anteroposterior epiglottis collapse at baseline (partial collapse: n =5; complete collapse: n=3). Residual epiglottis collapse after MMA was pres­ent in six patients (partial collapse: n=3; complete collapse: n=3), two of which exhibited a floppy epiglottis. No significant difference was found in distribution of epiglottis collapse before and after MMA.They assumed that MMA surgery may not be an effective therapeutic option for epiglottis col­lapse. However, due to the small number of patients, conclusions must be taken with care.
In our previous study consisting of 64 OSA patients who underwent baseline DISE followed by MMA, the association between airway collapse patterns in DISE ndings and MMA surgery outcome was investigated [10]. It was found that com­plete anteroposterior epiglottis collapse was independently related to non-response to MMA after correction for confounders (i.e., age, gender, BMI, baseline AHI, degree of maxillary advancement, and degree of mandibular advancement). This nding is supported by the study did by Kastoer etal. [36].
Of note, several mechanisms have been proposed to explain the epiglottis col­lapse: (1) secondary to an anteroposterior collapse of the tongue base that pushes the epiglottis backwards; (2) a complete isolated anteroposterior epiglottis collapse, also known as oppy epiglottis or trapdoor phenomenon; and (3) lateral epiglottis collapse due to underdevelopment of the epiglottis [37]. The role of MMA for dif­ferent types of epiglottis collapse may be different. The lack of studies on this topic should be addressed in the future.
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25.8 Conclusions
According to the current evidence, MMA could be less effective in addressing epi­glottis collapse, especially complete anteroposterior epiglottis collapse. For OSA patients with epiglottis collapse, subsequent therapy may be needed to treat this collapse when MMA surgery fails and residual epiglottis collapse is present. Given the limited availability of data, further investigation is essential to fully understand the role of MMA for epiglottis collapse, and in which the type of epiglottis collapse it is indicated.
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37. Vonk PE, Ravesloot MJL, Kasius KM, van Maanen JP, de Vries N.Floppy epiglottis during drug-induced sleep endoscopy: an almost complete resolution by adopting the lateral posture. Sleep Breath. 2020;24(1):103–9.
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26
AbdulrahmanDardeer, MuhammadFirasAlhammad, andNabilA.Shallik
26.1 Introduction
Obstructive sleep apnea (OSA) is a disorder involving frequent breathing pauses dur­ing sleep. According to the International Classication of Sleep Disorders (ICSD-3) in adults without associated symptoms or comorbidities, it is classied according to Apnea Hypopnea Index (AHI) into mild OSA (5–15 AHI), moderate OSA (15–30 AHI), and sever OSA (> 30 AHI). In a patient with associated medical or psychiatric disorders, the clinical signs and symptoms will be more exaggerated. Common signs and symptoms of OSA include snoring (frequently noted by other family members rather than the patient himself) and sleepiness or feeling tired during the daytime [1]. The estimated OSA prevalence rate in recent studies was around 14% in men and 5% in women aged 30 to 70years, and it may increase to 20–30% in elderly or obese population [2]. The risk factors for OSA include obesity [3, 4], family history of sleep apnea [5], and allergy [6, 7]. Some studies suggested that occupational stress could be a possible risk factor for OSA [8, 9]. The focus of this chapter is on periop­erative management of OSA patients, with special attention to OSA caused by the epiglottis. Those patients are a small in number but challenging group. A more detailed overview of OSA will be discussed in other chapters of this book.
A. Dardeer · M. F. Alhammad Department of Anaesthesia, ICU and Perioperative Medicine, Hamad Medical Corporation, Doha, Qatar
N. A. Shallik (*) Department of Anaesthesia, ICU and Perioperative Medicine, Hamad Medical Corporation, Doha, Qatar
Department of Clinical Anesthesiology, Weill Cornell Medical College in Qatar, Al Rayyan, Qatar
Department of Clinical Anesthesiology, Qatar University, Doha, Qatar e-mail: nshallik@hamad.qa
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2023 M. Delakorda, N. de Vries (eds.), The Role of Epiglottis in Obstructive Sleep Apnea, https://doi.org/10.1007/978-3-031-34992-8_26
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Epiglottis pathology is an uncommon cause of OSA and may be very challeng­ing to both anesthetists and surgeons in terms of diagnosis and management and is usually overlooked and ignored [10]. Epiglottis prolapse during inspiration is an unusual cause of airway obstruction and a rare cause of OSA [11]. Closing door epiglottis or oppy epiglottis (Fig.26.1) is a collapsible epiglottis that blocks the airway and is one of the most challenging situations that a sleep surgeon can encoun­ter. Omega-shaped epiglottis (or pipe-line epiglottis) which is another anatomic variation that can cause dynamic obstruction of the airway (Fig.26.2). Epiglottic collapse should be identied as it may cause treatment failure, either by CPAP or surgically. Misidentication of the condition may even lead to worsening of OSA symptoms with CPAP, or may lead to non-compliance by patients as the treatment becomes suboptimal [1114]. Schwannoma of the epiglottis is a rare condition [15] and usually a solitary incident rather than being part of a more systemic condition, like neurobromatosis, either type 1 or 2 [16]. While these conditions are more
Fig. 26.1 Closing door epiglottis
Fig. 26.2 Pipe-line epiglottis
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chronic in nature, some acute conditions related to epiglottis can also cause airway obstruction, with more devastating outcomes if improperly managed. Acute epiglot­titis and epiglottic abscess are life-threatening situations with serious implications because of the potential for laryngospasm and irrevocable loss of the airway. There is inammatory edema of the arytenoids, aryepiglottic folds, and epiglottis. The term supraglottitis may be used instead of or preferred to the term acute epiglottitis [17]. In children, epiglottitis is more challenging as the apprehensive child might make it difcult for the anesthetists to manage his airway. There is always a risk of impending airway obstruction and difcult bag-mask ventilation and of course, dif­cult intubation (DI). It is crucial not to upset the child or manipulate the airway to keep it patent. The anesthesia considerations in such patients are increased risk of aspiration, little or almost no time to airway stabilization, and associated sepsis, in addition to other usual pediatric considerations (e.g., difcult cannulation, appre­hensive parents, etc.).
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26.2 Preoperative Assessment andOptimization
Preoperative evaluation is a powerful tool that denes the safe practice of anesthesia from unsafe, especially in patients with OSA.It helps formulate a sound periopera­tive plan that ensure maximum safety and the least risk possible to the patient. A proper preoperative assessment should ensure sufcient time for any possible opti­mization of the patient’s condition to decrease his perioperative risk. Every preop­erative evaluation should include the following:
1. The detailed history of all medical conditions and prior surgical procedures and
anesthesia received before, and if the patient had any reaction or difculty during the conduct of previous anesthetics. The history should include the STOP-BANG survey or Berlin Questionnaire. Patients should be referred for Sleep study if they score high to categorize the severity of OSA.
2. American Society of Anesthesiologists (ASA) physical status score.
3. Routine investigations, and additionally any further investigations indicated by
patient’s condition (e.g., Pulmonary Function Test, Arterial Blood Gases, etc.).
4. Anesthesia plan (e.g., General Anesthesia, Monitored Anesthesia Care, Regional
Anesthesia [RA]). It is advisable to plan for RA if feasible, especially if OSA is severe.
5. Airway management strategy (awake beroptic intubation [AFOI], video laryn-
goscopy [VL], direct laryngoscopy [DL], tracheostomy, etc.).
6. Indication for special monitoring (e.g., arterial catheter, central line, advance
cardiac output monitoring, etc.).
7. Probability for the need of blood and blood derived products substituting.
8. Patient disposition postoperatively.
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9. Airway evaluation in more detail in Difcult Airway Clinic (DAC) to include the
following, if possible: (a) Routine airway assessment. (b) Naso-endoscopy or naso-laryngoscopy: this proved to be the most important
ofce-based diagnostic tool of upper airway pathologies and would recog­nize epiglottis pathologies and guide further investigations or manage-
ment plan. (c) Ultrasound (US) assessment of the upper airway. (d) Dynamic documentation in electronic health system. (e) Difcult Airway Alert Card (DAAC). (f) Virtual Endoscopy (VE) and 3D-CT reconstruction of the upper airway.
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26.2.1 The Role of3D Reconstruction andVirtual Endoscopy (VE)
Studies have demonstrated that inadequate assessment and planning contrib­ute to airway complications and that current airway assessment strategies have poor diagnostic accuracy in predicting DI in the general population [18]. Virtual endoscopy (VE) can simulate endoscopic intraluminal views like those obtained by the conventional fiberoptic bronchoscopy (FOB). It is non-inva­sive and easily obtained by postprocessing a routinely acquired high-resolu­tion computed tomography (CT) data set using simple computer software. Multi-plane CT scanning is often performed for patients with head and neck disease [18, 19]. Compared with FOB, which is limited for the evaluation of intraluminal pathologies, VE in a single examination which can depict intra­luminal manifestations of different diseases, along with a bird-eye-like dem­onstration of surrounding anatomy, giving a more holistic view of the airway. Preprocedural VE information with precise mapping of location and extent of airway pathologies helps in proper planning of anesthesia [20]. Evidence indi­cates that multi-slice detector CT imaging with a 3D reconstruction of the images can significantly increase the diagnostic accuracy of the procedure up to 94–100% [21]. VE can be very helpful in detecting epiglottis pathologies. Though not able to detect dynamic pathologies, it can detect other pathologies like morphological anomalies or misplaced epiglottis. This would save the patient discomfort of naso-endoscopy in some instances. For example, one can find the epiglottitis in adult patient with VE after CT-3D reconstruction (Fig.26.3a) and with the bronchoscopic exam in the same patient (Fig.26.3b). There are now some trials to get 3D images from MRI scans to better visualize the soft tissue [22, 23].
ab
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Fig. 26.3 (a) VE of epiglottitis and (b) bronchoscopic view of epiglottitis
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26.3 Airway Management
Difcult airway, either difcult mask ventilation (DMV) or DI, may be common in OSA patients [24, 25]. According to the most recent ASA practice guidelines, a dif­cult airway includes the clinical situation in which anticipated or unanticipated difculty or failure is experienced by a physician trained in anesthesia care, includ­ing but not limited to one or more of the following: face-mask ventilation, laryngos­copy, ventilation using a supraglottic airway, tracheal intubation, extubation, or invasive airway [26].
26.3.1 Optimizing Preoxygenation, Positioning (Safety Apnea
Rescue Time)
It cannot be stressed enough how the bed position, such a simple maneuver, can inuence the patient’s outcome. It has been shown that a head-up position with a 25° inclination (reverse Trendelenburg) increases the duration of apnea without arterial desaturation, increasing the window for tracheal intubation. Another useful technique is the “ramped” position, aiming at the horizontal alignment of the sternal notch with the external auditory meatus using folded blankets or commercially available pillows (Oxford or Troop pillow) under the upper body, shoulders, and head- Head Elevated Laryngoscopy Position [HELP] [27, 28]. This would facilitate DL [29] (Fig. 26.4). Pre-oxygenation or “de-nitrogenization” is not simply
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Fig. 26.4 (a) Normal pillow. (b) Oxford pillow
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providing “extra oxygen” to the patient, but is a crucial step, especially in patients with suspected DI, that will allow enough time (3–5minutes) needed to introduce the tracheal tube (Safety Apnea Rescue Time). It must be conducted correctly to ensure maximum benet. In the absence of respiratory failure, preoxygenation using a tight-tting face-mask, with 10 to 15L per minute of 100% oxygen for 3min would be sufcient. Adequate preoxygenation is preferably measured using end-tidal oxygen concentration (>85%) [30]. Obese patients, especially if suffering from OSA, benet of positive airway pressure, supplemental nasopharyngeal oxy­gen insufation, and noninvasive ventilation (NIV) before anesthesia induction. High-ow oxygenation by nasal cannula (HFNC) has been studied in intensive care units (ICUs) and in the operating room as a pre-oxygenation device and has shown the ability to extend safe apnea time during DI, and to be held during beroptic bronchoscopic intubation (FOI) to provide sort of “relaxed atmosphere” to the anes­thetist to conduct FOI.This device can deliver up to 80L/min with an inspired frac­tion of oxygen of up to 100% and generate a moderate positive supraglottic end- expiratory pressure. Moreover, in toothless or bearded patients, signicant leaks around the mask can alter oxygenation, which is not a problem for HFNC. HFNC allows inserting the berscope in the patient’s nostril to perform intubation while continuing the oxygenation and may be better tolerated [31]. However, HFNC cannot be used in all patients. Contraindications include nasal surgery, nasal bleeding, complete nasal obstruction, nasal infection, severe facial trauma, or suspected skull base fractures [32].
26.3.2 Airway Management Plans: Risk Assessment
andPatient Categorization
Some experts argue that there is really no difcult airway but rather unplanned con­duct of anesthesia. Evaluation and planning of anesthesia during preoperative assessment, with a strategy that includes multiple exit routes if needed, for patients with OSA, ensures a safe anesthesia with minimum unnecessary risks. El-Ganzouri etal. [33] developed a multivariate risk index, El-Ganzouri Risk Index (EGRI), that
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Table 26.1 El-Ganzouri Risk Index (EGRI). Interpretation: 4- high risk of difcult airway (93.8% specicity), < 4- low risk of difcult airway
Variable Points Mouth opening
4cm < 4cm 1 Thyromental distance > 6.5cm 0
6.0–6.5cm 1 < 6.0cm 2 Modied Mallampati classication I (soft palate, fauces, uvula, and pillars seen) 0 II (soft palate, fauces, and uvula seen) 1 III (soft palate and base of uvula seen) 2 IV (soft palate not visible) 2 Neck movement >90° 0 80–90° 1 <80° 2 Ability to prognath (advance lower jaw forward) Yes 0 No 1 Weight < 90kg (198.4 lbs) 0 90–110kg (198.4–242.5 lbs) 1 > 110kg (242.5 lbs) 2 History of difcult intubation None 0 Questionable 1 Denite 2
0
involves the analysis of six parameters commonly performed during the preopera­tive evaluation. Each variable is assigned a score (0 or 1). A score4 has a high sensitivity for predicting DI (Table26.1). In a study by Corso etal. [34], EGRI has proven to predict DI and DMV.This would enable the operator to identify difcult cases with a single bedside test to formulate a tailored airway management plan that mitigates the potential risks. Cortellazzi etal. [35] showed that predicted difcult airway by EGRI; using video laryngoscopy (VL) had better outcomes compared to those who were managed with DL.A protocol for patients undergoing general anes­thesia and scored 7in EGRI was developed by Cortellazzi etal., and they advocated routine intubation with GlideScope® video laryngoscope (Verathon Inc., WA, USA). For patients scoring eight or more, awake FOI (AFOI) is advised with a backup Supraglottic Airway Device (SAD). In case of a score, less than seven but more than four, both DL and VL, can be implemented based on operator preference and expe­rience, with a backup SAD.Awake intubation is frequently described in the litera­ture as the preferred method for securing the airway in adult patients with epiglottitis, whereas children are usually intubated following an inhalational induction.