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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_4586_Библиотеки_им_академика_М_И_Перельмана
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25 Maxillomandibular Advancement
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patients showed baseline anteroposterior epiglottis collapse (complete collapse:
n=2; partial collapse: n=2). After MMA, this collapse pattern persisted in two
patients (partial collapse: n=1; complete collapse: n=1). Two out of 20 patients
had complete lateral epiglottis collapse preoperatively, and one patient had partial
lateral epiglottis collapse postoperatively. Due to the small numbers of events for
epiglottis collapse, their study cannot be an indicative of the role of MMA on epiglottis collapse.
The upper airway collapse patterns during DISE before and after MMA
were also evaluated by Kastoer etal. in 2020 [36]. Eight out of 14 patients
had anteroposterior epiglottis collapse at baseline (partial collapse: n =5;
complete collapse: n=3). Residual epiglottis collapse after MMA was present in six patients (partial collapse: n=3; complete collapse: n=3), two of
which exhibited a floppy epiglottis. No significant difference was found in
distribution of epiglottis collapse before and after MMA.They assumed that
MMA surgery may not be an effective therapeutic option for epiglottis collapse. However, due to the small number of patients, conclusions must be
taken with care.
In our previous study consisting of 64 OSA patients who underwent baseline
DISE followed by MMA, the association between airway collapse patterns in DISE
ndings and MMA surgery outcome was investigated [10]. It was found that complete anteroposterior epiglottis collapse was independently related to non-response
to MMA after correction for confounders (i.e., age, gender, BMI, baseline AHI,
degree of maxillary advancement, and degree of mandibular advancement). This
nding is supported by the study did by Kastoer etal. [36].
Of note, several mechanisms have been proposed to explain the epiglottis collapse: (1) secondary to an anteroposterior collapse of the tongue base that pushes
the epiglottis backwards; (2) a complete isolated anteroposterior epiglottis collapse,
also known as oppy epiglottis or trapdoor phenomenon; and (3) lateral epiglottis
collapse due to underdevelopment of the epiglottis [37]. The role of MMA for different types of epiglottis collapse may be different. The lack of studies on this topic
should be addressed in the future.
321
25.8 Conclusions
According to the current evidence, MMA could be less effective in addressing epiglottis collapse, especially complete anteroposterior epiglottis collapse. For OSA
patients with epiglottis collapse, subsequent therapy may be needed to treat this
collapse when MMA surgery fails and residual epiglottis collapse is present. Given
the limited availability of data, further investigation is essential to fully understand
the role of MMA for epiglottis collapse, and in which the type of epiglottis collapse
it is indicated.

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N. Zhou et al.
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Anesthesia Management inOSA Patient
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26
AbdulrahmanDardeer, MuhammadFirasAlhammad,
andNabilA.Shallik
26.1 Introduction
Obstructive sleep apnea (OSA) is a disorder involving frequent breathing pauses during sleep. According to the International Classication of Sleep Disorders (ICSD-3)
in adults without associated symptoms or comorbidities, it is classied according to
Apnea Hypopnea Index (AHI) into mild OSA (5–15 AHI), moderate OSA (15–30
AHI), and sever OSA (> 30 AHI). In a patient with associated medical or psychiatric
disorders, the clinical signs and symptoms will be more exaggerated. Common signs
and symptoms of OSA include snoring (frequently noted by other family members
rather than the patient himself) and sleepiness or feeling tired during the daytime [1].
The estimated OSA prevalence rate in recent studies was around 14% in men and 5%
in women aged 30 to 70years, and it may increase to 20–30% in elderly or obese
population [2]. The risk factors for OSA include obesity [3, 4], family history of
sleep apnea [5], and allergy [6, 7]. Some studies suggested that occupational stress
could be a possible risk factor for OSA [8, 9]. The focus of this chapter is on perioperative management of OSA patients, with special attention to OSA caused by the
epiglottis. Those patients are a small in number but challenging group. A more
detailed overview of OSA will be discussed in other chapters of this book.
A. Dardeer · M. F. Alhammad
Department of Anaesthesia, ICU and Perioperative Medicine, Hamad Medical Corporation,
Doha, Qatar
N. A. Shallik (*)
Department of Anaesthesia, ICU and Perioperative Medicine, Hamad Medical Corporation,
Doha, Qatar
Department of Clinical Anesthesiology, Weill Cornell Medical College in Qatar,
Al Rayyan, Qatar
Department of Clinical Anesthesiology, Qatar University, Doha, Qatar
e-mail: nshallik@hamad.qa
© The Author(s), under exclusive license to Springer Nature
Switzerland AG 2023
M. Delakorda, N. de Vries (eds.), The Role of Epiglottis in Obstructive Sleep
Apnea, https://doi.org/10.1007/978-3-031-34992-8_26
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Epiglottis pathology is an uncommon cause of OSA and may be very challenging to both anesthetists and surgeons in terms of diagnosis and management and is
usually overlooked and ignored [10]. Epiglottis prolapse during inspiration is an
unusual cause of airway obstruction and a rare cause of OSA [11]. Closing door
epiglottis or oppy epiglottis (Fig.26.1) is a collapsible epiglottis that blocks the
airway and is one of the most challenging situations that a sleep surgeon can encounter. Omega-shaped epiglottis (or pipe-line epiglottis) which is another anatomic
variation that can cause dynamic obstruction of the airway (Fig.26.2). Epiglottic
collapse should be identied as it may cause treatment failure, either by CPAP or
surgically. Misidentication of the condition may even lead to worsening of OSA
symptoms with CPAP, or may lead to non-compliance by patients as the treatment
becomes suboptimal [11–14]. Schwannoma of the epiglottis is a rare condition [15]
and usually a solitary incident rather than being part of a more systemic condition,
like neurobromatosis, either type 1 or 2 [16]. While these conditions are more
Fig. 26.1 Closing door
epiglottis
Fig. 26.2 Pipe-line
epiglottis

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chronic in nature, some acute conditions related to epiglottis can also cause airway
obstruction, with more devastating outcomes if improperly managed. Acute epiglottitis and epiglottic abscess are life-threatening situations with serious implications
because of the potential for laryngospasm and irrevocable loss of the airway. There
is inammatory edema of the arytenoids, aryepiglottic folds, and epiglottis. The
term supraglottitis may be used instead of or preferred to the term acute epiglottitis
[17]. In children, epiglottitis is more challenging as the apprehensive child might
make it difcult for the anesthetists to manage his airway. There is always a risk of
impending airway obstruction and difcult bag-mask ventilation and of course, difcult intubation (DI). It is crucial not to upset the child or manipulate the airway to
keep it patent. The anesthesia considerations in such patients are increased risk of
aspiration, little or almost no time to airway stabilization, and associated sepsis, in
addition to other usual pediatric considerations (e.g., difcult cannulation, apprehensive parents, etc.).
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26.2 Preoperative Assessment andOptimization
Preoperative evaluation is a powerful tool that denes the safe practice of anesthesia
from unsafe, especially in patients with OSA.It helps formulate a sound perioperative plan that ensure maximum safety and the least risk possible to the patient. A
proper preoperative assessment should ensure sufcient time for any possible optimization of the patient’s condition to decrease his perioperative risk. Every preoperative evaluation should include the following:
1. The detailed history of all medical conditions and prior surgical procedures and
anesthesia received before, and if the patient had any reaction or difculty during
the conduct of previous anesthetics. The history should include the STOP-BANG
survey or Berlin Questionnaire. Patients should be referred for Sleep study if
they score high to categorize the severity of OSA.
2. American Society of Anesthesiologists (ASA) physical status score.
3. Routine investigations, and additionally any further investigations indicated by
patient’s condition (e.g., Pulmonary Function Test, Arterial Blood Gases, etc.).
4. Anesthesia plan (e.g., General Anesthesia, Monitored Anesthesia Care, Regional
Anesthesia [RA]). It is advisable to plan for RA if feasible, especially if OSA
is severe.
5. Airway management strategy (awake beroptic intubation [AFOI], video laryn-
goscopy [VL], direct laryngoscopy [DL], tracheostomy, etc.).
6. Indication for special monitoring (e.g., arterial catheter, central line, advance
cardiac output monitoring, etc.).
7. Probability for the need of blood and blood derived products substituting.
8. Patient disposition postoperatively.

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9. Airway evaluation in more detail in Difcult Airway Clinic (DAC) to include the
following, if possible:
(a) Routine airway assessment.
(b) Naso-endoscopy or naso-laryngoscopy: this proved to be the most important
ofce-based diagnostic tool of upper airway pathologies and would recognize epiglottis pathologies and guide further investigations or manage-
ment plan.
(c) Ultrasound (US) assessment of the upper airway.
(d) Dynamic documentation in electronic health system.
(e) Difcult Airway Alert Card (DAAC).
(f) Virtual Endoscopy (VE) and 3D-CT reconstruction of the upper airway.
A. Dardeer et al.
26.2.1 The Role of3D Reconstruction andVirtual Endoscopy (VE)
Studies have demonstrated that inadequate assessment and planning contribute to airway complications and that current airway assessment strategies have
poor diagnostic accuracy in predicting DI in the general population [18].
Virtual endoscopy (VE) can simulate endoscopic intraluminal views like those
obtained by the conventional fiberoptic bronchoscopy (FOB). It is non-invasive and easily obtained by postprocessing a routinely acquired high-resolution computed tomography (CT) data set using simple computer software.
Multi-plane CT scanning is often performed for patients with head and neck
disease [18, 19]. Compared with FOB, which is limited for the evaluation of
intraluminal pathologies, VE in a single examination which can depict intraluminal manifestations of different diseases, along with a bird-eye-like demonstration of surrounding anatomy, giving a more holistic view of the airway.
Preprocedural VE information with precise mapping of location and extent of
airway pathologies helps in proper planning of anesthesia [20]. Evidence indicates that multi-slice detector CT imaging with a 3D reconstruction of the
images can significantly increase the diagnostic accuracy of the procedure up
to 94–100% [21]. VE can be very helpful in detecting epiglottis pathologies.
Though not able to detect dynamic pathologies, it can detect other pathologies
like morphological anomalies or misplaced epiglottis. This would save the
patient discomfort of naso-endoscopy in some instances. For example, one can
find the epiglottitis in adult patient with VE after CT-3D reconstruction
(Fig.26.3a) and with the bronchoscopic exam in the same patient (Fig.26.3b).
There are now some trials to get 3D images from MRI scans to better visualize
the soft tissue [22, 23].

ab
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Fig. 26.3 (a) VE of epiglottitis and (b) bronchoscopic view of epiglottitis
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26.3 Airway Management
Difcult airway, either difcult mask ventilation (DMV) or DI, may be common in
OSA patients [24, 25]. According to the most recent ASA practice guidelines, a difcult airway includes the clinical situation in which anticipated or unanticipated
difculty or failure is experienced by a physician trained in anesthesia care, including but not limited to one or more of the following: face-mask ventilation, laryngoscopy, ventilation using a supraglottic airway, tracheal intubation, extubation, or
invasive airway [26].
26.3.1 Optimizing Preoxygenation, Positioning (Safety Apnea
Rescue Time)
It cannot be stressed enough how the bed position, such a simple maneuver, can
inuence the patient’s outcome. It has been shown that a head-up position with a
25° inclination (reverse Trendelenburg) increases the duration of apnea without
arterial desaturation, increasing the window for tracheal intubation. Another useful
technique is the “ramped” position, aiming at the horizontal alignment of the sternal
notch with the external auditory meatus using folded blankets or commercially
available pillows (Oxford or Troop pillow) under the upper body, shoulders, and
head- Head Elevated Laryngoscopy Position [HELP] [27, 28]. This would facilitate
DL [29] (Fig. 26.4). Pre-oxygenation or “de-nitrogenization” is not simply

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Fig. 26.4 (a) Normal pillow. (b) Oxford pillow
A. Dardeer et al.
providing “extra oxygen” to the patient, but is a crucial step, especially in patients
with suspected DI, that will allow enough time (3–5minutes) needed to introduce
the tracheal tube (Safety Apnea Rescue Time). It must be conducted correctly to
ensure maximum benet. In the absence of respiratory failure, preoxygenation
using a tight-tting face-mask, with 10 to 15L per minute of 100% oxygen for
3min would be sufcient. Adequate preoxygenation is preferably measured using
end-tidal oxygen concentration (>85%) [30]. Obese patients, especially if suffering
from OSA, benet of positive airway pressure, supplemental nasopharyngeal oxygen insufation, and noninvasive ventilation (NIV) before anesthesia induction.
High-ow oxygenation by nasal cannula (HFNC) has been studied in intensive care
units (ICUs) and in the operating room as a pre-oxygenation device and has shown
the ability to extend safe apnea time during DI, and to be held during beroptic
bronchoscopic intubation (FOI) to provide sort of “relaxed atmosphere” to the anesthetist to conduct FOI.This device can deliver up to 80L/min with an inspired fraction of oxygen of up to 100% and generate a moderate positive supraglottic
end- expiratory pressure. Moreover, in toothless or bearded patients, signicant
leaks around the mask can alter oxygenation, which is not a problem for
HFNC. HFNC allows inserting the berscope in the patient’s nostril to perform
intubation while continuing the oxygenation and may be better tolerated [31].
However, HFNC cannot be used in all patients. Contraindications include nasal
surgery, nasal bleeding, complete nasal obstruction, nasal infection, severe facial
trauma, or suspected skull base fractures [32].
26.3.2 Airway Management Plans: Risk Assessment
andPatient Categorization
Some experts argue that there is really no difcult airway but rather unplanned conduct of anesthesia. Evaluation and planning of anesthesia during preoperative
assessment, with a strategy that includes multiple exit routes if needed, for patients
with OSA, ensures a safe anesthesia with minimum unnecessary risks. El-Ganzouri
etal. [33] developed a multivariate risk index, El-Ganzouri Risk Index (EGRI), that

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331
Table 26.1 El-Ganzouri
Risk Index (EGRI).
Interpretation: ≥ 4- high risk
of difcult airway (93.8%
specicity), < 4- low risk of
difcult airway
Variable Points
Mouth opening
≥ 4cm
< 4cm 1
Thyromental distance
> 6.5cm 0
6.0–6.5cm 1
< 6.0cm 2
Modied Mallampati classication
I (soft palate, fauces, uvula, and pillars seen) 0
II (soft palate, fauces, and uvula seen) 1
III (soft palate and base of uvula seen) 2
IV (soft palate not visible) 2
Neck movement
>90° 0
80–90° 1
<80° 2
Ability to prognath (advance lower jaw forward)
Yes 0
No 1
Weight
< 90kg (198.4 lbs) 0
90–110kg (198.4–242.5 lbs) 1
> 110kg (242.5 lbs) 2
History of difcult intubation
None 0
Questionable 1
Denite 2
0
involves the analysis of six parameters commonly performed during the preoperative evaluation. Each variable is assigned a score (0 or 1). A score≥4 has a high
sensitivity for predicting DI (Table26.1). In a study by Corso etal. [34], EGRI has
proven to predict DI and DMV.This would enable the operator to identify difcult
cases with a single bedside test to formulate a tailored airway management plan that
mitigates the potential risks. Cortellazzi etal. [35] showed that predicted difcult
airway by EGRI; using video laryngoscopy (VL) had better outcomes compared to
those who were managed with DL.A protocol for patients undergoing general anesthesia and scored 7in EGRI was developed by Cortellazzi etal., and they advocated
routine intubation with GlideScope® video laryngoscope (Verathon Inc., WA, USA).
For patients scoring eight or more, awake FOI (AFOI) is advised with a backup
Supraglottic Airway Device (SAD). In case of a score, less than seven but more than
four, both DL and VL, can be implemented based on operator preference and experience, with a backup SAD.Awake intubation is frequently described in the literature as the preferred method for securing the airway in adult patients with epiglottitis,
whereas children are usually intubated following an inhalational induction.
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