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M. Delakorda and B. Maver
of the epiglottis was a signicant factor in predicting AHI>30 even after adjust­ment for BMI [109]. In a study from 2019, Bolzer etal. described some anatomical characteristics of the epiglottis (shape, position, shape of the retroepiglottic airway) by which OSA patients could be distinguished from others, and found a correlation between the presence of a mega-epiglottis—i.e., large epiglottis obstructing the view of the glottis—and severity of OSA [110].
A widely accepted grading system is still lacking for classifying OSA-relevant ndings determined in the awake state at the level of the larynx. Additionally, in many OSA texts, the epiglottic obstructions are often described as part of the hypo­pharynx [111]. This makes reproducible and clinically relevant communication of the laryngeal status difcult. In 2018, Torre etal. conducted a study to assess the utility of adopting the existing Cormack–Lehane grading systems for vocal cord visualization during direct laryngoscopy in awake beroptic examination. They proposed the use of a 5-grade system to describe the hypopharyngeal airway in a reliable and reproducible fashion [9]. In 2002, Moore etal. proposed a modication of the Fujita clinical classication system to evaluate narrowing at the tongue base level in OSA patients. Using awake beroptic nasopharyngoscopy with Mueller’s maneuver in both upright and supine positions, they described different types of obstructions based on the involvement of the tongue base and/or epiglottis. No sta­tistical correlation was found between the obstruction pattern and severity of OSA, age, or facial skeletal pattern, but males had a higher percentage of type C pattern— isolated retro-epiglottic narrowing [112].
It would be very practical for every sleep surgeon to be able to anticipate possible sites of obstruction based on anatomical features in wakefulness. Unfortunately, examination in the awake state often underestimates the degree of laryngeal obstruc­tion [59, 60]. Nevertheless, some anatomical features of OSA patients with obstruc­tion at the epiglottis level have been presented in recent years. When examining the larynx, one should try to get an impression of the laryngeal position (high vs. low). It is important to assess the epiglottis position relative to the tongue base, its angle, consistency, and airspace behind it. Describing its shape (regular, at, or omega­shaped) is needed since it affects the conguration of obstruction at this level. Surgical approach to lateral epiglottis obstructions that occur in patients with a closed, omega-shaped epiglottis, differs from the “trap door” type. Laryngeal motil­ity should be evaluated and described. The assessment of aryepiglottic folds, sub­glottic area, and initial part of trachea is also important. We must pay attention to possible cysts, vascular formations, or other hyperplastic mucosal changes that can cause additional resistance to airow (Fig.6.5).
For a long time, it was considered that patients with obstruction at the level of the larynx cannot be distinguished from other OSA patients with awake clinical assess­ment. In a study by Woodson and Wooten, clinical examination results were compared to endoscopic and manometry ndings. The absence of obstructing oropharyngeal features was the most characteristic feature of patients with collapse at the tongue base and epiglottis [59]. More recently, some studies have shown that certain epiglot­tis characteristics observed during awake examination could be used in clinical prac­tice for a preliminary assessment of laryngeal obstructions. The omega-shaped
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Fig. 6.5 Epiglottic retention cyst
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abc d
Fig. 6.6 Different shapes of epiglottis. Type 1—omega-shaped epiglottis (a); type 2—normal concave epiglottis shape (b); and type 3—at epiglottis (c), graphic scheme (d)
epiglottis is present in about 30–50% of infants, but is much less common in adults, as it becomes atter during growth [113, 114]. In a study by Li etal., it was estab­lished that spacing between the tongue base and epiglottis as assessed in the awake state in the supine position could predict glossopharyngeal obstructions detected with PSG and the nasopharyngeal tube inserted. The nding of obscured valleculae corre­lated well with some polysomnographic ndings (AHI, lowest saturation). However, their method did not allow for distinction between obstructions at the base of tongue and isolated epiglottis obstructions [115]. In a recently published study, the authors described how epiglottis shape correlates to obstructions at the level of the tongue base and epiglottis as assessed during the DISE.They have also proposed a classica­tion system based on epiglottis concavity as seen during the awake examination (Fig.6.6). In the group of patients with at epiglottises (type 3), obstructions at the level of the epiglottis and/or base of tongue—primary and secondary epiglottis col­lapse—occurred in most cases (94%) [116]. Another study analyzing the clinical characteristics of patients with isolated epiglottis collapse found a relation between such collapse and a shorter distance between mandible plane and hyoid, relative to the control group. However, no differences were observed between the two groups in terms of epiglottis shape or curvature, and the authors concluded that isolated epiglot­tic collapse could not be determined during awake endoscopy [30].
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6.8 Conclusion
Although obstructions at the epiglottic level are present in a signicant number of OSA patients, there are still many unresolved issues related to the role of this struc­ture. Predicting the level of obstructions solely by clinical assessment is not yet adequately reliable. A widely accepted system for describing this part of the UA during awake laryngoscopy is currently lacking, and this makes communication dif­cult. The current body of evidence indicates some unique laryngeal characteristics by which OSA patients differ from others. Moreover, the connection between some clinical features and epiglottic collapse has been established. While the laryngeal position and some other cephalometric features are a known risk factor for epiglot­tic collapse, male gender, lower BMI, and OSA severity also seem to coincide with obstructions at this level. In cases of suspected epiglottic collapse, it is sensible to supplement the data obtained during clinical examination with other investigations, particularly DISE—although its results should be carefully interpreted. Further larger studies using uniform classication systems could shed more light on the role of clinical assessment in patients with epiglottic collapse.
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M. Delakorda and B. Maver
Sleep Studies
https://t.me/medicina_free
JohanVerbraecken
7.1 Introduction
The term “polysomnography” (PSG) was rst proposed by Holland, Dement, and Raynal in 1974 [1], and describes the recording, analysis, and interpretation of mul­tiple, simultaneous, physiological parameters that are used in the diagnosis of sleep disorders. Nocturnal PSG can be considered as the gold standard lab technique in the management of sleep-wake disturbances. Respiratory phenomena have to be linked with other sleep features, like sleep stage and leg movements. The following parameters are assessed during sleep by means of PSG:
1. The electroencephalogram (EEG) with different congurations but most often at
least C4-M1 and C3-M2. This technique records the electrical activity of the brain from surface electrodes and is mandatory for the identication of sleep and wake. By convention, the EEG electrodes are placed according to the 10–20 electrode placement system [2].
2. The detection of eye movements or electrooculogram (EOG), muscle tone or
electromyogram (EMG) of the chin and the lower extremities [3]. The EOG and chin EMG allow the detection of REM sleep, which is characterized by the pres­ence of rapid eye movements and reduced skeletal muscle tone. The EOG elec­trodes are placed at the right and left outer orbital canthus, one slightly below and the other one slightly above the horizontal axis of the eyes and are refer-
7
J. Verbraecken (*) Department of Pulmonary Medicine and Multidisciplinary Sleep Disorders Center, Antwerp University Hospital, Edegem, Belgium
University of Antwerp, Antwerp, Belgium e-mail: johan.verbraecken@uza.be
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2023 M. Delakorda, N. de Vries (eds.), The Role of Epiglottis in Obstructive Sleep Apnea, https://doi.org/10.1007/978-3-031-34992-8_7
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