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M. Delakorda and B. Maver
of the epiglottis was a signicant factor in predicting AHI>30 even after adjustment for BMI [109]. In a study from 2019, Bolzer etal. described some anatomical
characteristics of the epiglottis (shape, position, shape of the retroepiglottic airway)
by which OSA patients could be distinguished from others, and found a correlation
between the presence of a mega-epiglottis—i.e., large epiglottis obstructing the
view of the glottis—and severity of OSA [110].
A widely accepted grading system is still lacking for classifying OSA-relevant
ndings determined in the awake state at the level of the larynx. Additionally, in
many OSA texts, the epiglottic obstructions are often described as part of the hypopharynx [111]. This makes reproducible and clinically relevant communication of
the laryngeal status difcult. In 2018, Torre etal. conducted a study to assess the
utility of adopting the existing Cormack–Lehane grading systems for vocal cord
visualization during direct laryngoscopy in awake beroptic examination. They
proposed the use of a 5-grade system to describe the hypopharyngeal airway in a
reliable and reproducible fashion [9]. In 2002, Moore etal. proposed a modication
of the Fujita clinical classication system to evaluate narrowing at the tongue base
level in OSA patients. Using awake beroptic nasopharyngoscopy with Mueller’s
maneuver in both upright and supine positions, they described different types of
obstructions based on the involvement of the tongue base and/or epiglottis. No statistical correlation was found between the obstruction pattern and severity of OSA,
age, or facial skeletal pattern, but males had a higher percentage of type C pattern—
isolated retro-epiglottic narrowing [112].
It would be very practical for every sleep surgeon to be able to anticipate possible
sites of obstruction based on anatomical features in wakefulness. Unfortunately,
examination in the awake state often underestimates the degree of laryngeal obstruction [59, 60]. Nevertheless, some anatomical features of OSA patients with obstruction at the epiglottis level have been presented in recent years. When examining the
larynx, one should try to get an impression of the laryngeal position (high vs. low).
It is important to assess the epiglottis position relative to the tongue base, its angle,
consistency, and airspace behind it. Describing its shape (regular, at, or omegashaped) is needed since it affects the conguration of obstruction at this level.
Surgical approach to lateral epiglottis obstructions that occur in patients with a
closed, omega-shaped epiglottis, differs from the “trap door” type. Laryngeal motility should be evaluated and described. The assessment of aryepiglottic folds, subglottic area, and initial part of trachea is also important. We must pay attention to
possible cysts, vascular formations, or other hyperplastic mucosal changes that can
cause additional resistance to airow (Fig.6.5).
For a long time, it was considered that patients with obstruction at the level of the
larynx cannot be distinguished from other OSA patients with awake clinical assessment. In a study by Woodson and Wooten, clinical examination results were compared
to endoscopic and manometry ndings. The absence of obstructing oropharyngeal
features was the most characteristic feature of patients with collapse at the tongue
base and epiglottis [59]. More recently, some studies have shown that certain epiglottis characteristics observed during awake examination could be used in clinical practice for a preliminary assessment of laryngeal obstructions. The omega-shaped

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Fig. 6.5 Epiglottic
retention cyst
99
abc d
Fig. 6.6 Different shapes of epiglottis. Type 1—omega-shaped epiglottis (a); type 2—normal
concave epiglottis shape (b); and type 3—at epiglottis (c), graphic scheme (d)
epiglottis is present in about 30–50% of infants, but is much less common in adults,
as it becomes atter during growth [113, 114]. In a study by Li etal., it was established that spacing between the tongue base and epiglottis as assessed in the awake
state in the supine position could predict glossopharyngeal obstructions detected with
PSG and the nasopharyngeal tube inserted. The nding of obscured valleculae correlated well with some polysomnographic ndings (AHI, lowest saturation). However,
their method did not allow for distinction between obstructions at the base of tongue
and isolated epiglottis obstructions [115]. In a recently published study, the authors
described how epiglottis shape correlates to obstructions at the level of the tongue
base and epiglottis as assessed during the DISE.They have also proposed a classication system based on epiglottis concavity as seen during the awake examination
(Fig.6.6). In the group of patients with at epiglottises (type 3), obstructions at the
level of the epiglottis and/or base of tongue—primary and secondary epiglottis collapse—occurred in most cases (94%) [116]. Another study analyzing the clinical
characteristics of patients with isolated epiglottis collapse found a relation between
such collapse and a shorter distance between mandible plane and hyoid, relative to the
control group. However, no differences were observed between the two groups in
terms of epiglottis shape or curvature, and the authors concluded that isolated epiglottic collapse could not be determined during awake endoscopy [30].

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M. Delakorda and B. Maver
6.8 Conclusion
Although obstructions at the epiglottic level are present in a signicant number of
OSA patients, there are still many unresolved issues related to the role of this structure. Predicting the level of obstructions solely by clinical assessment is not yet
adequately reliable. A widely accepted system for describing this part of the UA
during awake laryngoscopy is currently lacking, and this makes communication difcult. The current body of evidence indicates some unique laryngeal characteristics
by which OSA patients differ from others. Moreover, the connection between some
clinical features and epiglottic collapse has been established. While the laryngeal
position and some other cephalometric features are a known risk factor for epiglottic collapse, male gender, lower BMI, and OSA severity also seem to coincide with
obstructions at this level. In cases of suspected epiglottic collapse, it is sensible to
supplement the data obtained during clinical examination with other investigations,
particularly DISE—although its results should be carefully interpreted. Further
larger studies using uniform classication systems could shed more light on the role
of clinical assessment in patients with epiglottic collapse.
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M. Delakorda and B. Maver

Sleep Studies
https://t.me/medicina_free
JohanVerbraecken
7.1 Introduction
The term “polysomnography” (PSG) was rst proposed by Holland, Dement, and
Raynal in 1974 [1], and describes the recording, analysis, and interpretation of multiple, simultaneous, physiological parameters that are used in the diagnosis of sleep
disorders. Nocturnal PSG can be considered as the gold standard lab technique in
the management of sleep-wake disturbances. Respiratory phenomena have to be
linked with other sleep features, like sleep stage and leg movements. The following
parameters are assessed during sleep by means of PSG:
1. The electroencephalogram (EEG) with different congurations but most often at
least C4-M1 and C3-M2. This technique records the electrical activity of the
brain from surface electrodes and is mandatory for the identication of sleep and
wake. By convention, the EEG electrodes are placed according to the 10–20
electrode placement system [2].
2. The detection of eye movements or electrooculogram (EOG), muscle tone or
electromyogram (EMG) of the chin and the lower extremities [3]. The EOG and
chin EMG allow the detection of REM sleep, which is characterized by the presence of rapid eye movements and reduced skeletal muscle tone. The EOG electrodes are placed at the right and left outer orbital canthus, one slightly below
and the other one slightly above the horizontal axis of the eyes and are refer-
7
J. Verbraecken (*)
Department of Pulmonary Medicine and Multidisciplinary Sleep Disorders Center, Antwerp
University Hospital, Edegem, Belgium
University of Antwerp, Antwerp, Belgium
e-mail: johan.verbraecken@uza.be
© The Author(s), under exclusive license to Springer Nature
Switzerland AG 2023
M. Delakorda, N. de Vries (eds.), The Role of Epiglottis in Obstructive Sleep
Apnea, https://doi.org/10.1007/978-3-031-34992-8_7
107
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