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The Role of Epiglottis in
Obstructive Sleep Apnea
Matej Delakorda
Nico de Vries
Editors
123

The Role of Epiglottis in Obstructive Sleep
Apnea


Matej Delakorda • Nico deVries
Editors
The Role of Epiglottis in
Obstructive Sleep Apnea

Editors
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Matej Delakorda
General Hospital Celje
Celje, Slovenia
Nico deVries
Jan Tooropstraat
Onze Lieve Vrouwe Gasthuis
Amsterdam, The Netherlands
ISBN 978-3-031-34991-1 ISBN 978-3-031-34992-8 (eBook)
https://doi.org/10.1007/978-3-031-34992-8
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature
Switzerland AG 2023
This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether
the whole or part of the material is concerned, specically the rights of translation, reprinting, reuse of
illustrations, recitation, broadcasting, reproduction on microlms or in any other physical way, and
transmission or information storage and retrieval, electronic adaptation, computer software, or by similar
or dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication
does not imply, even in the absence of a specic statement, that such names are exempt from the relevant
protective laws and regulations and therefore free for general use.
The publisher, the authors, and the editors are safe to assume that the advice and information in this book
are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the
editors give a warranty, expressed or implied, with respect to the material contained herein or for any
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claims in published maps and institutional afliations.
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The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Paper in this product is recyclable.

To my parents for teaching me how
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To my wife for showing me why
To my children for making it worth it
—Matej Delakorda, Celje
This book is dedicated to my wife Judith and
our wonderful kids David, Lisa, and Maurits.
—Nico de Vries, Amsterdam

Foreword
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Dear Colleague,
Thanks for choosing this book and for reading this foreword. I’ll try to explain
why in my opinion you have made a good decision to study this book. As an expert
in sleep medicine and sleep surgery you are aware that the epiglottis has become an
area of interest in this eld. Many years ago, we used to focus in particular on the
nose, the palate, the tongue, and the facial bone framework, while the epiglottis as a
source of obstruction was mostly neglected. There might be several reasons for this:
in the rst place, the epiglottis is not visualized by standard physical examination,
as performed by pulmonologists and neurologists; it is mostly diagnosed by druginduced sleep endoscopy. Secondly, it was until recently regarded as a rare phenomenon. In the last place, most OSA care givers would reason that epiglottis collapse,
if present anyhow, would be effectively treated by CPAP.This probably explains
both the apathy in the sleep community regarding the epiglottis and the relatively
low number of papers on this topic in the sleep surgery literature. This book however indicates that epiglottis collapse is not rare at all, it discusses different ways to
diagnose it, and that epiglottis collapse in fact might be a reason for CPAP failure.
The increasing amount of worldwide clinical data seems to disclose an underevaluated problem, and epiglottis collapse might very well be much more prevalent than
we used to think. Moreover, the pathophysiology of epiglottis instability and collapse, primary or secondary, may explain many challenging and not well- understood
situations (e.g., unexpected and unexplained CPAP failures, residual OSA after
upper airway surgery, etc.) in the daily practice. This book is intended as another
contribution in helping you to build a better understanding of the role of the epiglottis in upper airway collapse during sleep. Most of the available basic and advanced
data is organized in a logical sequence, giving you the possibility to get into the
problem in a very smooth and comprehensive way. After a general introductory
overview of the problem about denition, epidemiology, pathogenesis, and outcome
denitions, several main sections are expanded. A rst section is devoted to the
proper identication of epiglottis dysfunction during sleep. Clinical and endoscopical information is discussed within a wide range of additional options (sleep studies,
DISE, imaging and manometry) in order to build up a sound diagnostic approach
workup. Some situations that deserve special attention are described in detail for
their relative more complex prole: epiglottis collapse in childhood (laryngomalacia), the role of obesity in epiglottis collapse, and the role of the nose as related to
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Foreword
hypopharyngeal obstructions. The last couple of chapters are intended to highlight
the great variety of treatment options, conservative and surgical, in a comprehensive, detailed and critical way. CPAP therapy, myofunctional therapy, oral appliances, and positional therapy are described in the nonsurgical section. All the
state-of-the-art updated surgical techniques are a matter of discussion in a special
section. Last but not least, the long experience and competence of all authors in the
eld of sleep disorders makes this book a real treasure of knowledge and an useful
compass in the still dark sea of epiglottis collapse in OSA.Enjoy the lecture.
Department of Otolaryngology and Head-Neck Surgery ClaudioVicini
Morgagni-Pierantoni Hospital,
Forlì, Italy

Contents
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Part I Introduction to OSA
1 OSA Epidemiology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Hsin-Ching Lin, Russell Chung-Wei Lin, and Michael Friedman
2 OSA Pathogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13
A. Simon Carney, Peter G. Catcheside, and Danny J. Eckert
3 Current Diagnostics and Therapy Concept and Limitations . . . . . . . . 23
Simon D. Herkenrath and Winfried J. Randerath
4 Redefining Outcome Measures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45
Madeline J. L. Ravesloot
Part II Diagnosis of Epiglottis Collapse
5 Relevant Anatomy and Physiology of the Epiglottis . . . . . . . . . . . . . . . 61
Matej Delakorda
6 Clinical Assessment of OSA Patients . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87
Matej Delakorda and Blaz Maver
7 Sleep Studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107
Johan Verbraecken
8 Diagnostic Workup by DISE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 127
Mickey Leentjens, Patty E. Vonk, and Nico de Vries
9 Manometry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139
Markus Wirth
10 Acoustic Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147
Zhengfei Huang, Frank Lobbezoo, Ghizlane Aarab, Nico de Vries,
and Antonius A. J. Hilgevoord
Part III Special Section
11 The Role of the Epiglottis in Pediatric OSA . . . . . . . . . . . . . . . . . . . . . . 161
Ashley L. Soaper, Cynthia S. Wang, and Stacey L. Ishman
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Contents
12 The Role of Obesity in Epiglottis Collapse . . . . . . . . . . . . . . . . . . . . . . . 175
Christel A. L. de Raaff
13 The Role of the Nose in Pharyngeal Obstructions . . . . . . . . . . . . . . . . . 181
Thomas Verse
Part IV Conservative Treatment of Epiglottis Collapse
14 Therapy Decision-Making in Epiglottis Collapse . . . . . . . . . . . . . . . . . 197
Matej Delakorda and Nico de Vries
15 Treatment with CPAP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205
Marina Carrasco-Llatas and Joana Vaz de Castro
16 Orofacial Myofunctional Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 221
Carlos O’Connor-Reina and Marina Carrasco-Llatas
17 Oral Appliance Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 239
Eli Van de Perck, Peter A. Cistulli, and Olivier M. Vanderveken
18 Treatment of Epiglottic Collapse with Positional Therapy . . . . . . . . . . 247
Mickey Leentjens, Patty E. Vonk, and Nico de Vries
Part V Surgical Treatment of Epiglottis Collapse
19 Epiglottectomy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 257
Bhik T. Kotecha
20 Epiglottis Stiffening Operation (ESO) . . . . . . . . . . . . . . . . . . . . . . . . . . 265
Fabrizio Salamanca and Federico Leone
21 Glossoepiglottopexy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 271
Marco Barbieri, Marco Fragale, and Davide Mocellin
22 Upper Airway Stimulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 281
Clemens Heiser
23 Tongue Base Surgery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289
Vikas Agrawal, Vijaya Krishnan, and Srinivas Kishore
24 Transoral Robotic Surgery (TORS) . . . . . . . . . . . . . . . . . . . . . . . . . . . . 299
Filippo Montevecchi and Claudio Vicini
25 Maxillomandibular Advancement . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 311
Ning Zhou, Jean-Pierre T.F. Ho, and Jan de Lange
26 Anesthesia Management in OSA Patient . . . . . . . . . . . . . . . . . . . . . . . . 325
Abdulrahman Dardeer, Muhammad Firas Alhammad,
and Nabil A. Shallik
27 Future Directions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 349
Mohamed Abdelwahab, Rakha Abdelwahab, and Robson Capasso
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