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- •Preface
- •Contents
- •Contributors
- •Extrinsic Factors
- •Intrinsic Factors
- •References
- •Indications
- •Surgical Technique
- •References
- •Background
- •Preoperative Considerations
- •Other Operative Points
- •Surgical Indications
- •Surgical Technique (Video 3.1)
- •Reported Outcomes
- •Potential Complications
- •References
- •4: Endoscopic Denker’s Approach
- •Background
- •Surgical Technique
- •Reported Outcomes
- •References
- •Background
- •Reported Outcomes
- •References
- •Background
- •Surgical Indications
- •Surgical Technique
- •Reported Outcomes
- •References
- •Background
- •Technical Factors
- •Patient Factors
- •Anatomic Factors
- •Imaging Review
- •Surgical Technique
- •Draf IIA
- •Draf IIB (Video 7.2)
- •References
- •Background
- •Surgical Techniques
- •Standard Frontal Sinus Approaches
- •Modified Hemi-Lothrop Procedure (Eloy IIC)
- •Modified Mini-Lothrop Procedure (Eloy IID)
- •Modified Subtotal-Lothrop Procedure (Eloy IIE)
- •Modified Central-Lothrop Procedure (Eloy IIF)
- •References
- •Background
- •Surgical Techniques
- •Modifications
- •Reported Outcomes
- •References
- •Background
- •Surgical Technique
- •References
- •11: The Outside-in Draf III Procedure
- •Background
- •Surgical Technique
- •Surgical Steps
- •Post-Operative Management
- •Reported Outcomes
- •Patient Reporting Outcome Measures
- •Operative Time
- •Complications
- •References
- •12: Balloon Sinuplasty
- •Background
- •Reported Outcomes
- •Surgical Technique
- •Local Anesthesia Protocol
- •Procedure: Maxillary Sinus Balloon Dilation
- •Procedure: Frontal Sinus Balloon Dilation
- •Procedure: Sphenoid Sinus Balloon Dilation
- •References
- •Background
- •Surgical Technique
- •Nasal Polypectomy
- •Maxillary Sinus Disease
- •Ethmoid Sinus Disease
- •Frontal Sinus Disease
- •Sphenoid Sinus Disease
- •Mucocele Drainage
- •Balloon Sinus Dilation
- •Outcomes
- •References
- •Background
- •Patient Selection
- •Room Setup/Equipment
- •Navigation Systems
- •Monitoring
- •Patient Comfort
- •Staff Training
- •Reported Outcomes/Evolving Practice Patterns
- •References
- •16: Steroid Eluting-Implants
- •Background
- •Indications
- •Background
- •Surgical Technique (Video 15.1)
- •In-Office Polypectomy
- •Reported Outcomes
- •References
- •Surgical Technique
- •Reported Outcomes
- •References
- •Background
- •Cryotherapy
- •Radiofrequency Ablation
- •Surgical Technique
- •Reported Outcomes
- •References
- •18: Inferior Turbinate Reduction
- •Background
- •Extramucosal Surgical Techniques
- •Complete Turbinectomy
- •Laser Cautery
- •Electrocautery
- •Cryotherapy
- •Turbinate Lateralization
- •Submucosal Techniques
- •Microdebrider Turbinoplasty (Video 18.1)
- •Coblation (Video 18.2)
- •Radiofrequency Ablation (Video 18.3)
- •Ultrasound Turbinoplasty
- •References
- •Background
- •Surgical Technique
- •Bioabsorbable Nasal Sidewall Implant (LATERA)
- •Patient Selection
- •Local Anesthesia
- •Surgical Technique
- •Patient Selection
- •Local Anesthesia
- •Surgical Technique
- •References
- •Background
- •Topical Antibacterial Therapy
- •Topical Antifungal Therapy
- •Senior Author’s Practice
- •Conclusions
- •References
- •21: Intravenous Antimicrobial Therapy
- •Background
- •When Is Recalcitrant Chronic Rhinosinusitis Infectious?
- •Anatomically Complicated Infections
- •Empiric Oral Antimicrobial Therapy
- •Oral Versus Intravenous Therapy
- •Staphylococcus
- •Streptococcus
- •Enterococcus
- •Enterobacterales
- •Pseudomonas
- •Other Gram-Negative Organisms
- •Anaerobes
- •Multidrug-Resistant Organisms
- •Antimicrobial Stewardship
- •References
- •Background
- •Chronic Rhinosinusitis
- •Glucocorticoids
- •Intranasal Steroid Irrigations
- •Rationale
- •Evidence
- •The Exhalation Delivery System
- •Rationale
- •Evidence
- •Steroid-Eluting Sinus Stents
- •Rationale
- •Rationale
- •Glucocorticoid Insensitivity
- •Conclusions
- •References
- •Background
- •Pathophysiology
- •Diagnosis
- •Aspirin Challenge
- •Aspirin Challenge Procedure
- •Aspirin Desensitization
- •Preparation
- •Logistics
- •Monitoring
- •Protocols
- •Aspirin-Induced Reactions
- •Maintenance Aspirin Therapy after Desensitization
- •Silent Desensitization
- •References
- •Background
- •Conclusions
- •References
- •Background
- •Patient Selection
- •Dupilumab
- •Omalizumab
- •Mepolizumab
- •Summary
- •References
- •Background
- •Povidone-Iodine (PVP-I) Rinses
- •Manuka Honey Rinses
- •Colloidal Silver
- •Topical Antibiotics
- •Photodynamic Therapy
- •Phage Therapy
- •Sinonasal Microbiota Transfer (SNMT)
- •Conclusion
- •References
- •Index

148
N. W. Perkins
These technological advancements have also allowed surgeons to expand the
breadth of their ofce-based surgical repertoire. There are numerous studies and
reports of safety and feasibility for a diverse scope of sinus procedures in the ofce,
including balloon sinus dilation, turbinate reduction, mucocele drainage and marsupialization, polypectomy, septoplasty, and traditional endoscopic sinus procedures
(maxillary antrostomy, ethmoidectomy, etc.) [4, 5, 7–13].
As access to these technological advancements has expanded beyond the operating room, surgeons are able to perform ofce-based primary sinus procedures in
patients with medically recalcitrant chronic rhinosinusitis, with or without nasal
polyps, about 30–55% of who require some type of surgical treatment, and ofcebased revision surgical procedures in those patients with surgically recalcitrant
chronic rhinosinusitis, who constitute about 4–20% of those patients who previously underwent primary surgery for CRS [2, 6]. With these tools at their disposal,
surgeons may now reframe their surgical discussions with patients to include the
ofce as a potential site of service and further challenge their own historical bias to
ask themselves, “is there a reason this case cannot be done in the ofce setting?”
History ofSinus Navigation
Since its inception, developments in CT imaging, including patient access, speed of
the study and higher resolution images, have allowed surgeons the ability to easily
and effectively evaluate patient sinus anatomy and disease [1]. CT scanners are
readily available in the community and often offered in the surgeon’s own ofce,
allowing for immediate imaging and interpretation in appropriately selected
patients. These high-resolution images can easily be transferred into the navigation
systems for all scheduled surgical patients and used if needed at the surgeon’s choice.
Improvements in image-guidance systems, such as improvements in accuracy,
ease of registration and setup, have contributed to the transition of navigation systems into the ofce-setting [1, 2, 7, 10]. Navigation systems can now be housed on
the same tower as the video system, monitor and powered shaver, eliminating spatial barriers in the ofce setting. Although use of navigation in sinus procedures is
not necessarily the industry standard, the American Academy of Otolaryngology—
Head and Neck Surgery offered a position statement supporting the use of navigation in appropriate cases, which are determined at the discretion of the surgeon [14].
A 2016 survey of the American Rhinologic Society members shows that 10% of
respondents were using ofce-based navigation systems at that time, with 63% noting that they were performing more ofce-based procedures over the prior 5-year
period [9]. Extrapolating from that trend, it is likely that the number of surgeons
using ofce-based navigation systems is higher now, nine years after that survey,
and will continue to rise. While there has not been conclusive data that supports the
use of navigation in reducing complications, some propose that it may assist in
reducing the surgeons perceived surgical workload, improve speed and efciency of
cases, and provide surgeons the tools to complete a more thorough surgical dissection [1].

14 In-Oce Navigation forRecalcitrant Chronic Rhinosinusitis
149
Techniques andConsiderations
Patient Selection
Patient selection and in-ofce techniques are thoroughly described in Chap. 13 of
this text. In brief, when selecting patients for in-ofce sinus procedures, there are
many factors which should be considered. Firstly, surgeons should recognize that
they themselves may have a bias toward choosing the operating room as the site of
service. Most surgeons are most familiar and comfortable with the operating room
and patients being under general anesthesia. That bias will impact the surgeon’s
recommendation to patients when considering the ofce as a potential site of
service.
Patients themselves may have strong preferences about avoiding general anesthesia and prefer to have their sinus procedure performed in the ofce setting.
Conversely, others may express signicant anxiety about pain or awareness during
an ofce-based procedure and request “to be knocked out.” Those who self-report
difculty tolerating dental procedures or who have not had success with local anesthetic in the past may be poor candidates for in-ofce procedures. However, patients
who express concern about anxiety or pain during the procedure can be reassured
that the procedural pre-medication regimen adequately addresses anxiety concerns
and the local anesthetic protocol will assure that they will have minimal pain or
discomfort during the procedure. Some patients may express that they “want to be
knocked out” for their procedure. It is reasonable to clarify that desire with the
patient, as they typically are not requesting general anesthesia, but instead are
expressing their wish to manage pain and anxiety during their procedure. Setting
appropriate and realistic expectations with patients prior to the procedure is critical.
Patients should be counseled that they will feel pressure, even when local anesthesia
is working well to eliminate pain, and they will also hear portions of the procedure,
like lateral out-fracturing of the inferior turbinate or medialization of the middle
turbinate. In order to assure a predictable patient experience, surgeons should follow a standard anesthetic protocol, both with regard to anxiolytic and analgesic
pre-procedure medication regimen and local anesthesia protocol. This is particularly important as a surgeon is beginning to transition procedures from the operating
room to the ofce. Following a standard protocol will increase the likelihood of
success, as the variables related to patient anxiety and comfort will be better managed, allowing the surgeon to focus on the procedure itself. Tables 14.1 and 14.2
detail the author’s preferred anesthesia protocol and local anesthetic administration
protocol, respectively.
Lastly, patients with medical comorbidities that increase risks related to general
anesthesia, or those who are unable to stop anticoagulation medications, may be
better candidates for local anesthesia with or without minimal anxiolysis in the
ofce-setting [15–17].

150
Table 14.1 Anesthesia protocol for preceding and during in-ofce procedure
Anesthesia Protocol
Pre-medications—although these are optional, particularly for very minor, brief procedures
where the surgeon can expect local anesthesia to be very effective (cryoablation, nasal airway
obstruction procedures, placement of drug-eluding stents), I nd this regimen to be very
effective for the majority of my patients. This regimen helps assure that you will have a
predictable patient, which allows the surgeon to perform the procedure in their customary
fashion, with fewer unpredictable patient factors. This regimen also helps address patient
concerns regarding anxiety during the procedure, which can impact their surgical site choice
(OR vs. ofce). Assuring them that they will have a medication regimen to address anxiety and
pain, and a local anesthesia protocol that will limit pain or discomfort can help appropriate
patients feel more comfortable in choosing an ofce procedure and avoiding general
anesthesia
Pre-Procedure Day 1—start Medrol Dose pack (only if inammatory/polyp disease
present)
If signicant inammation, polyp disease is present, earlier pre-treatment with oral
steroid may be benecial
Procedure Day (*consents signed prior to procedure day*)
Eat light breakfast or lunch (do not need to be NPO)
2Hours prior to procedure
Oxymetazoline 2 sprays each side of nose every 30min (2–3 doses)
60minutes prior to procedure
Promethazine 25mg
Triazolam 0.125mg
Tramadol 50mg (optional, may not be necessary for minor procedures)
MD Evaluation
If patient remains anxious, can take additional 1–2 Triazolam 0.125mg
Post-Procedure Day 1
Start saline irrigations (+/− topical steroid)
Antibiotic if indicated
Oral steroid if indicated
N. W. Perkins
Room Setup/Equipment
In-ofce sinus procedures can be performed in any ENT ofce exam room. The
most basic room requirements include an ENT chair that will convert into the supine
position, a video system and monitor to attach to sinus endoscopes, suction and the
necessary equipment for the particular procedure. As the surgeon is expanding their
breadth of in-ofce sinus procedures, a more extensive room setup may develop
(Fig.14.1). An advanced ofce-based procedure room will include a comfortable
ENT chair that will go into the supine position and raise/lower for surgeon comfort,
a video/monitor system to allow for endoscopic visualization, various 3 or 4mm
endoscopes (0, 30, 45, 70 degrees), a microdebrider or shaver system, an imageguidance navigation system, secondary suction, traditional FESS instruments
(through cutting forceps, back biting forceps, mushroom punch, Kerrison forceps),
balloon sinus dilation devices, irrigation devices, drug-eluting sinus implants,
hemostatic agents, and cautery [10]. Staff may nd benet from having an additional instrument cart that is easily accessible during procedures (Fig.14.2). This

14 In-Oce Navigation forRecalcitrant Chronic Rhinosinusitis
151
Table 14.2
Local Anesthesia
2Hours prior to procedure
Oxymetazoline 2 sprays each side of nose every 30min (2–3 doses)
In ofce
Topical 4% lidocaine and Afrin (1:1) cotton pledgets—squeezed out to avoid dripping down
Leave in place for 7–10minutes
Topical 4% Lidocaine and 1:1000 Adrenaline (1:1)
Small pledgets placed along middle turbinate root, anterior face of the middle turbinate,
Long cotton pledgets along oor of the nose between inferior turbinate and septum
Squeeze out excess liquid to avoid dripping anesthetic into pharynx
Leave in placed for 7–10min
1% or 2% Lidocaine with 1:200,000 epinephrine
Injection sites (27g needle)
Inferior turbinate
Septum (particularly if spur or deviation present or anteriorly if instruments will be
Root of the middle turbinate, anterior face of the middle turbinate
Septum medial to middle turbinate (optional)
Injection sites (Spinal Needle or Reinforced Anesthesia Needle (Stryker ENT, Plymouth,
Sphenoid rostrum (if surgical plan includes sphenoid)
Sphenopalatine (infero/lateral attachment of middle turbinate)
Polyp tissue
Local anesthesia protocol for in-ofce procedures
the pharynx—placed along the oor of the nose between the septum and inferior turbinate
in middle meatus (if adequate spacing), medial to middle turbinate against septum
abutting septum)
MN)
Fig. 14.1 Ofce-based
procedure room setup—
tower holds navigation
system, microdebrider, and
video monitor. The surgeon
can stand or sit to the
patient’s right, with a chair
in their preferred position.
Staff can stand to the
patient’s left and assist in
typical surgical fashion

152
Fig. 14.2 Instrument
cart—procedure pack and
individually wrapped
instruments, easily
accessible to staff
throughout the procedure
N. W. Perkins
can reduce confusion during a procedure when an unanticipated instrument is
needed and allows the surgeon to feel condent that all instruments are available if
intra-operative treatment changes.
Navigation Systems
The utilization of navigation during sinus procedures in the ofce is increasing and
will likely continue to rise as residents are increasingly trained with navigation systems in the OR for a variety of reasons; such as to facilitate teaching, improve
supervising surgeon comfort/guidance and the perception of improved safety and
completeness of surgery [2, 9]. Historically, navigation may have only been used in
rare cases, like skull base or neoplastic surgeries, but as the devices became less
cumbersome, easier for staff to set up and surgeons to use, and accuracy improved,
navigation may now be used even for routine cases [1, 2]. Additionally, the smaller
footprint of the navigation systems allowed for a natural transition of the technology
into the ofce setting. These advances, coupled with surgeon, patient, and overall
healthcare system preferences for in-ofce procedures, have complemented one
another and allowed for an increasing number and complexity of cases to be performed in the ofce setting.

14 In-Oce Navigation forRecalcitrant Chronic Rhinosinusitis
153
The current ofce-based sinus navigation system market includes the Acclarent
TruDi Navigation System (Acclarent, Irvine, CA), the Karl Storz NAV1 Navigation
System (Karl Storz, El Segundo, CA), the Medtronic StealthStation FlexENT
Navigation System (Medtronic, Minneapolis, MN), and the Stryker Scopis ENT
Navigation System (Stryker ENT, Plymouth, MN). Surgeon preference may dictate
the system used; however, economic factors, trackable device options, and availability (what the surgeon has access to in their facility) may also be considered
when choosing an in-ofce navigation system. These systems utilize either electromagnetic or hybrid, electromagnetic and optical, tracking technologies. They can be
housed in a single unit with the monitor, video system, and other devices, like a
powered shaver/microdebrider, and secondary suction.
Depending on the navigation system, there may be no cost associated with registering patients, so staff can be trained to upload CT images and register all scheduled patients, with cost only being incurred if the surgeon chooses to use navigation
during the procedure. The navigation systems have various capabilities that allow
the surgeon to pre-mark surgical targets, critical structures to be avoided and plan
pathways into the targeted sinuses. These pre-planning software features allow the
surgeon to map their surgical plan and can be particularly useful in the teaching setting. The Stryker Scopis system (Stryker, Plymouth, MN) features an augmented
reality option, where the surgeon can pre-plan the surgical pathway and then utilize
the hybrid optical and electromagnetic properties to follow the pre-planned surgical
pathway to the targeted sinus. Other systems, like the Acclarent TruDi (Acclarent,
Irvine, CA), have software that uses articial intelligence to identify known structures and calculate likely surgical pathways.
Although specic trackable devices vary by manufacturer, devices such as suction, pointers, powered shavers/microdebriders, sinus balloons, and traditional sinus
instruments can all be tracked. These capabilities have allowed surgeons to treat
cases that may not have historically been considered for ofce-based surgery, such
as revision sinus cases, synechiae and stenosis, drainage and marsupialization of
mucoceles, polypectomy, and ethmoidectomy. Excision of limited neoplasms, like
inverting papilloma, can also be considered with the assistance of navigation in the
ofce setting. Video 14.1 shows a revision frontal sinus polypectomy using in-ofce
navigation. A navigatable frontal sinus seeker is used to conrm the location of the
frontal sinus ostium. A curved microdebrider is used to remove polyps within the
frontal sinus. A steroid-eluting implant is then placed into the frontal sinus at the
end of the procedure.
Monitoring
Patient monitoring is dependent on type of anesthesia (local, oral sedation, IV sedation) and varies by state. Surgeons should conrm their state monitoring requirements, as well as any state specic accreditation requirements. In our practice, we
do not utilize IV sedation, and our sedation goal, according to the American Society
of Anesthesiologists Continuum of Depth of Sedation, is Minimal Sedation

154
N. W. Perkins
Anxiolysis, dened as “a drug-induced state during which patients respond normally to verbal commands. Although cognitive function and physical coordination
may be impaired, airway reexes, and ventilatory and cardiovascular functions are
unaffected [18].” We routinely record pre and post procedure vital signs and monitor
pulse oximetry throughout the procedures. Depending on patient comorbidities,
state requirements, type of anesthesia, and surgeon preference, some surgeons may
choose or be required to monitor blood pressure and EKG throughout their procedures [15, 17]. Surgeons should be prepared for potential complications related to
anesthesia, including allergic reaction and medication toxicity, and be prepared to
manage immediate complications.
Patient Comfort
To create a comfortable experience for patients, the surgeon and staff should consider playing relaxing music, or music of the patients choosing, and covering the
eyes to limit irritation from bright endoscopic lights and anxiety caused by seeing
surgical instruments. Instruct patients to wear comfortable clothing, and place them
in a comfortable position, with a pillow or other support under the lower legs and a
gel pillow under their head. If the room is small, and becomes warm due to equipment and staff, having a fan to keep the patient comfortable can also be helpful.
Although ultimately patient position is the surgeon’s preference, placing patients in
a supine position may limit drainage into the oropharynx, as secretions will pool in
the nasopharynx and can be easily suctioned.
Staff Training
In order to successfully perform ofce-based rhinology procedures and particularly ofce-based image guidance, it is imperative to train nursing and medical
staff on the surgical equipment, navigation systems, typical order of surgical procedures and surgeon preferences. It is also important to remind staff that the
patients are awake throughout the procedure, so using gentle terms to describe
surgical instruments (asking for the local anesthetic, not the needle or injection)
can alleviate patient anxiety. Also, if a complication or unforeseen event occurs, it
is critical for staff to avoid comments that may increase patient anxiety. Although
many surgeons may prefer a dedicated staff member, or champion, to assist in their
cases, cross-training throughout many staff can help reduce challenges related to
illness, vacation or staff changes. Regular staff training and retraining, as well as
“mock” cases and navigation system troubleshooting guides can improve staff condence and comfort during procedures. The author’s preferred procedure protocol
is detailed in Table14.3.

14 In-Oce Navigation forRecalcitrant Chronic Rhinosinusitis
Table 14.3 Surgical technique, room set-up, and required prerequisite skills to perform in-ofce
procedures
Surgical Technique/How I Do It:
Room setup/Equipment
Dark room, Relaxing music, eye covering, comfortable clothing, supine position with gel
donut under head and pillow under knees, fan, blankets
Patient positioning
Surgeon preference
Supine
Traditional operating position for Surgeon
Potentially less drainage into nasopharynx/oropharynx (secretions pool in
nasopharynx—can be suctioned)
May need to add leg/knee support/pillow for low back comfort
Semi-recumbant
Non-standard operating position for Surgeon
Potentially more drainage into nasopharynx/oropharynx
Seated
Potentially less drainage into nasopharynx/oropharynx
Non-standard operating position for Surgeon
Surgeon position—standing or sitting
Staff training
Staff should become “super-users” with navigation systems—able to troubleshoot problems,
upload images, set up for surgeon preferences
Perform mock cases with all staff—familiarity with instruments, familiarity with
progression/ow of common procedures, ability to setup/access instrumentation during
procedure
Staff champion—able to lead new trainees/staff in cross-training, the “go-to” person for
questions
Nursing –
Call patient about 7–14days prior to procedure. Review their medications (current), as
well as prescriptions for pre-medications that will be sent to pharmacy (triazolam,
promethazine, +/− tramadol, methylprednisolone).—procedure protocols—similar to OR
(stopping NSAIDs, ASA), review timing of pre-medication regimen, expected length of
procedure/visit, conrm transportation/responsible person (mandatory if taking premedication, option if local anesthetic only)
Post-procedure protocols—POD #1 telephone call
155
Reported Outcomes/Evolving Practice Patterns
Lee etal. reported 2016 survey results from the American Rhinological Society in
2019 and found an increasing trend toward in-ofce rhinologic procedures, both for
academic and private practice physicians [5]. At that time, about 10% of surveyed
physicians were using navigation in the ofce setting, but 77% were performing
polypectomy in the ofce, 56% were performing balloon ostial dilations in the
ofce, and about 1/3 of respondents performed more traditional FESS procedures
(maxillary antrostomy, ethmoidectomy. Sphenoidotomy, frontal sinusotomy) in the
ofce setting [5]. There are numerous feasibility, safety, and outcome durability
studies supporting the success of balloon ostial dilation, steroid eluting implant
placement, management of mucoceles, correction of recirculation, and recalcitrant
frontal sinus disease in the ofce setting [8, 9, 11–13, 19–21].

156
N. W. Perkins
With the vast technological advances available to surgeons in the ofce setting,
the reduced healthcare costs, and the encouraging safety and feasibility reports,
there is likely to be a continued shift away from the operating room and toward the
ofce as the primary choice for site of service.
Tips and Pearls
• Set realistic patient expectations regarding anxiety, pain/discomfort.
• Set up the room optimally for your procedure prior to patient arrival.
• Modern navigation systems have a small footprint, but ensure that you have ade-
quate space for monitors and navigation systems and that they are set up appro-
priately for visualization during the entirety of the procedure.
• Try to limit case times to less than 1h from start to nish, longer cases can lead
to increased discomfort with prolonged patient immobility. This should, when
able, include set-up time.
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