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T. R. McCarty and C. C. Thompson488
CRE balloon dilation or pneumatic dilation, remains a first-line strategy based upon stricture length and location, it is critical to individualize treatment based on timing of stenosis formation, mechanism of stricture formation, patient reported symptoms, and ability to achieve successful dilation.

References

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obesity in 195 countries over 25 years. N Engl J Med. 2017;377:13–27.
2. Obesity and Overweight. World Health Organization. Available from: https://www.who.int/
news-room/fact-sheets/detail/obesity-and-overweight. Accessed: 16 April 2020.
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4. Bariatric Surgery Procedures. American Society for Metabolic and Bariatric Surgery
(ASMBS). Available at: https://asmbs.org/patients/bariatric-surgery-procedures. Accessed 3 May 2020.
5. Gagner M, Hutchinson C, Rosenthal R. Fifth international consensus conference: current sta-
tus of sleeve gastrectomy. Surg Obes Relat Dis. 2016;12:750–6.
6. Varela JE, Nguyen NT. Laparoscopic sleeve gastrectomy leads the U.S. utilization of bariat-
ric surgery at academic medical centers. Surg Obes Relat Dis. 2015;11:987–90.
7. Estimate of Bariatric Surgery Numbers. American Society for Metabolic and Bariatric
Surgery (ASMBS). https://asmbs.org/resources/estimate-of-bariatric-surgery-numbers. Accessed 19 April 2020.
8. Zundel N, Hernandez JD, Galvao Neto M, Campos J. Strictures after laparoscopic sleeve
gastrectomy. Surg Laparosc Endosc Percutan Tech. 2010;20:154–8.
9. Schulman AR, Thompson CC. Endoscopic evaluation/management of bariatric surgery com-
plications. Curr Treat Options Gastroenterol. 2017a;15:701–16.
10. Schulman AR, Thompson CC. Complications of bariatric surgery: what you can expect to
see in your GI practice. Am J Gastroenterol. 2017b;112:1640–55.
11. Rebibo L, Hakim S, Dhahri A, Yzet T, Delcenserie R, Regimbeau JM. Gastric stenosis after
laparoscopic sleeve gastrectomy: diagnosis and management. Obes Surg. 2016;26:995–1001.
12. de Moura DTH, Jirapinyo P, Aihara H, Thompson CC. Endoscopic tunneled stricturotomy in
the treatment of stenosis after sleeve gastrectomy. VideoGIE. 2019;4:68–71.
13. Frezza EE, Reddy S, Gee LL, Wachtel MS. Complications after sleeve gastrectomy for mor-
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14. Javanainen M, Penttila A, Mustonen H, Juuti A, Scheinin T, Leivonen M. A retrospective
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15. Brethauer SA, Hammel JP, Schauer PR. Systematic review of sleeve gastrectomy as staging
and primary bariatric procedure. Surg Obes Relat Dis. 2009;5:469–75.
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nique, indications and clinical results. Obes Surg. 2007;17:1442–50.
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19. Chang SH, Popov VB, Thompson CC. Endoscopic balloon dilation for treatment of
sleeve gastrectomy stenosis: a systematic review and meta-analysis. Gastrointest Endosc. 2020;91(989–1002):e4.
How to Manage Sleeve Complications Through Endoscopy …
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gastrectomy with or without duodenal switch. Obes Surg. 2009;19:495–9.
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489

Sleeve Gastrectomy Stenosis: Surgical Treatment

Jacques M. Himpens

1 Introduction

According to the latest literature data, laparoscopic sleeve gastrectomy (LSG) has become the most popular bariatric-metabolic procedure across the world [1]. One of the obvious explanations for this rather unexpected situation is the relative tech­nical ease of the laparoscopic sleeve gastrectomy operation, but also the fact that, according to most publications, LSG appears to cause fewer short- and mid-term complications than Roux-en-Y gastric bypass (RYGB) procedure, which was con­sidered the “champion” bariatric-metabolic technique up until recently. In addi­tion, the metabolic activity of LSG appears to closely match the clinical outcomes of RYGB [2].
In terms of mid- to long-term LSG-linked complications, the most frequently reported is stenosis. This condition is usually described either at the mid-gastric body level (incisura angularis) or, less frequently, at the level of the cardia [3].

2 Diagnosis

Until recently, the diagnosis of sleeve stenosis typically was achieved by conven­tional radiology (contrast swallow) but this approach has been widely abandoned to the benefit of upper gastro-intestinal endoscopy [4]. Conversely, however,
J. M. Himpens (*) Delta CHIREC Hospitals, Brussels, Belgium e-mail: jacques_himpens@hotmail.com
J. M. Himpens St Pierre University Hospital, Brussels, Belgium
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021 S. Al-Sabah et al. (eds.), Laparoscopic Sleeve Gastrectomy,
https://doi.org/10.1007/978-3-030-57373-7_46
491
J. M. Himpens492
endoscopy may generate a false negative diagnosis because often stenosis are functional and allow passage of the endoscope [5], which is the criterion usually used by endoscopists for ruling out stenosis. Nowadays the most accurate diagno­sis relies in three-dimensional CT reconstruction of the sleeved stomach [6].
Three-dimensional CT- reconstructions allow to accurately locate the possible stricture (i.e. actual significant diameter reduction of the stomach), but at the same time to detect axial aberrations such as torsions (the so-called corkscrew deform­ity) and kinks, that are significant contributors to functional stenosis [7].

3 Incidence

Stenosis after LSG, is quite rare a condition (occurring in between 0.1 and 4% of the cases according to a recent meta-analysis [8]. Post-LSG stenosis symptoms usually include gastro-esophageal reflux (GERD), sometimes accompanied by sig­nificant dysphagia, regurgitation and vomiting of thick, white slime. Most steno­sis, located at the level of the angulus, are due either to technical factors (such as overstretching the tissues causing the stapler to staple closer to the endoluminal bougie), or oversewing the staple line, or to scarring issues [9].

4 Prevention

Post-sleeve stenosis may be avoided by the judicious use of peroperative endos­copy. Nimeri et al. [10] demonstrated that with this strategy the incidence of stenosis may drop from 3.2 to 0%. Possible mechanisms resulting in better out­comes—as mentioned by the authors—included the ability to detect and remove ill placed sutures covering the staple line, or to address stapling errors such as staples placed too close to the incisura, Of note, Nimeri et al. mentioned that short steno­sis created by stapling flaws may be addressed by an immediate short seromyot­omy, a technique that will be described later. In one Italian study, it appeared that oversewing the staple line was accompanied by a significant increase of stenosis rate, while it did not improve bleeding and fistula prevalence [10]. This experience has recently been duplicated [9].
Along the same lines, smaller bougie sizes may negatively affect the steno­sis rate after sleeve gastrectomy, as concluded during the fifth consensus confer­ence on sleeve gastrectomy [11]. More recent data, however, do not confirm this assumption [12].

5 Treatment

First line treatment of sleeve stenosis nowadays is undoubtedly endoscopic, and consists of balloon dilation, preferably with high pressure balloons dilations, kept dilated for a substantial length of time [8, 13]. The balloon treatment may
Sleeve Gastrectomy Stenosis: Surgical Treatment
493
be complemented by placement of self-expandable fully or partly covered metallic stents. Of note, the endoscopic insertion of fully covered self-expanding metallic stents, usually requires endoscopic fastening to avoid migration [14].
The surgical options usually are kept for the failure cases of repeated balloon dilation treatment. Nath et al. [5] found that, while close to 10% of the individuals submitted to sleeve gastrectomy had developed stenosis or symptomatic angula­tion, 69% of those were successfully treated by one or more sessions of balloon dilation. Chang et al. [15] reported a success rate of the endoscopic approach of 37%, but 50% of the patients still required conversion to Roux-en-Y gas­tric bypass. Burgos et al. [16] reported a success rate of 80% in a small group of patients, the remaining failures being addressed by conversion to Roux-en-Y gas­tric bypass.
A recently described “minimally invasive” technique consists of endoscopic tunneled stricturotomy, but the numbers are small [17].
Considering the abundance of endoscopic techniques, nowadays, surgery is mostly saved for recalcitrant post-sleeve stenosis. There are still several surgical options to address the stenosis of the gastric body after sleeve gastrectomy. The theoretically most appealing technique (briefly mentioned above to address perop­eratively diagnosed stenosis induced by ill stapling) is probably laparoscopic sero­myotomy [18] (Fig. 1). The laparoscopic technique is quite similar to proximal gastric seromyotomy used in achalasia (Heller’s procedure). In brief, in gasric sero­myotomy, the serosal and muscular layers of the anterior stomach are incised by cautery or harmonic scissors, leaving the mucosa intact. Burning lesions must be avoided at all cost and simple mechanical disruption of the deepest layers may be a good and safe technique to this regard. It is essential to extend the incision far
Fig. 1 Artist impression of seromyotomy in sleeve stenosis. The magnified view provided by the laparoscopy facilitates the identification of the different layers of the gastric wall, authorizing the safe severance of the muscular fibers, and the preservation of the mucosa
J. M. Himpens494
beyond the stenosis, both proximally and distally to tackle the entire stenotic area. However, the drawbacks of this approach appeared to be many and included a high leak rate, a substantial stenosis recurrence rate, and weight regain [18]. This is the reason why many teams have looked for surgical alternatives. Our group reported on a small group of patients who had their stenotic sleeve gastrectomy treated by resecting the stenotic area, followed by an end to end manual reanastomosis [19] (Fig. 2). A similar approach was described by Kalaseilvan et al. [20]. Unfortunately, attempts at resecting the stenosis appeared to be unsatisfactory because of the recur­rence of the condition, as reported both by our team and by the team of Kalaseilvan who experienced a stenosis recurrence in one of their two patients.
Another theoretical option to deal with gastric stenosis after LSG consists of stricturoplasty, in analogy with the technique used in small bowel strictures linked with Crohn’s disease [21]. Despite the elegance of this approach we could find only one report on this technique [22].
Because of the drawbacks and possible complications of the “direct” treatment technique of post-LSG stenosis, conversion to Roux-en-Y gastric bypass (RYGB) (Fig. 3) remains the most frequently described strategy in addressing the side­effects of an ill-fated sleeve gastrectomy, ranging from chronic leaks to highly symptomatic stenosis, recurrence of the condition despite other treatment modes, and, quite frequently, invalidating gastro-esophageal reflux (GERD).
Laparoscopic conversion of the stenotic sleeve to RYGB must comprise tran­section of the stomach proximal to the stenosis in order to avoid possible recur­rence of stenosis symptoms [23]. Of note, whereas conversion from sleeve
Fig. 2 Artist impression of the “wedge” or “segmental resection” dealing with the “corkscrew deformity” of a stenotic sleeve. The redundant part is being resected and the continuity restored by a manual end-to-end anastomosis
Sleeve Gastrectomy Stenosis: Surgical Treatment
Fig. 3 Conversion of sleeve gastrectomy to Roux-en-Y Gastric Bypass for sleeve stenosis. The small gastric pouch is constructed well proximal to the stenotic area
495
to RYGB does not appear to offer a sound solution in case of associated insuf­ficient weight loss or weight recovery after initial acceptable weight loss the consequences of gastric corpus stenosis appear to be adequately addressed [24]. Consequently, some consensus exists as to the efficacy of converting sleeve gas­trectomy stenosis to RYGB, with reported good clinical outcomes, but at the cost of more complications than primary RYGB [25, 26].
A more recently reported solution for sleeve gastrectomy stenosis is conversion to One Anastomosis (or mini-) Gastric Bypass [27] (OAGB) (Fig. 4). This tech- nique that involves just one anastomosis is obviously simpler than conversion to RYGB and is accompanied by fewer complications.
In our department we are however reluctant to use this solution because con­structing a correct OAGB implies a long pouch that extends beyond the crow’s foot, hence more often than not the stenotic area will not be excluded. In addition, theoretical long-term side effects such as bile reflux must still be assessed.

6 Conclusion

The treatment of post-LSG stenosis is endoscopic in the majority of cases. In case of failure of endoscopic treatment, surgical options are available, including sero­myotomy, segmental resection and, theoretically, stricturoplasty. The high inci­dence of complications after seromyotomy and other “targeted treatment mode” make these technique less desirable for the indication of (late) post-sleeve steno­sis. Consequently, the preferred solution remains conversion to Roux-en-Y gastric bypass. Conversions to single anastomosis gastric bypass are at risk of leaving the stenosis in place.
J. M. Himpens496
Fig. 4 Conversion of sleeve gastrectomy to One Anastomosis Gastric Bypass. Because the gas­tric pouch must be quite long it is often difficult to avoid the stenotic part of the sleeve while constructing the pouch
Treatment Algorithm
Sleeve Gastrectomy Stenosis: Surgical Treatment
497

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