Книга_5221_Библиотеки_им_академика_М_И_Перельмана

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<<< < Предыдущая 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 4950 / 5050

 Index

mania

AIDS 81, 82 HIV 81, 82– 83 human African trypanosomiasis 234 Lyme disease 339 neurocysticercosis 271 neurosyphilis 309, 338– 39

see also bipolar disorder measles 2, 317– 18 memory

cerebral malaria 186

biomarkers of severity 197– 98 computerized cognitive rehabilitation

therapy 186, 187– 89

neurological sequelae 189– 90

Covid- 19 1, 53, 55– 56

long Covid 389t encephalitis lethargica 1, 11– 12 bromyalgia 369– 79, 370t, 381t Helicobacter pylori 143– 45, 146– 47 HIV 80– 81 HIV- associated neurocognitive disorder 308 HTLV- 1 88 microbiome 422, 423– 24, 428– 29, 430 myalgic encephalitis/ chronic fatigue

syndrome 382t, 387 neurocysticercosis 268– 69, 271– 72 neuroEbola 42– 43, 44– 45 neurosyphilis 309 post- treatment Lyme disease 121– 22, 123,

124– 25, 128– 29

neuroradiological ndings 126

research limitations 127 schizophrenia 423– 24 toxocariasis 250, 257

mouse models 253– 54 toxoplasmosis 217– 18, 334 tuberculous meningitis 164, 165, 168– 69,

172, 175– 76

Whipple’s disease

case studies 133– 34, 135– 37

pathomechanisms 137– 38, 138b see also dementia

meningitis 2, 4

cognitive function 393t Covid- 19 51– 52 dementia risk 306 dierential diagnosis 288 herpes simplex viruses 317– 18 Lyme disease 339 neurocysticercosis 267– 68 neuroEbola 42– 43 neurosyphilis 102– 4, 309 oligoclonal bands 317– 18

post- treatment Lyme disease 125 toxocariasis 246– 47 tuberculous (TBM) 163– 64, 176

meningoencephalitis

Baggio– Yoshinari syndrome 38 child development 447 neuroEbola 42– 43 parvovirus B19 447

Whipple’s disease 135 meningovascular neurosyphilis 102– 4, 109 mental exhaustion 10 men who have sex with men (MSM) 101, 112 mice

depression 424, 450

human African trypanosomiasis

models 239– 40

microbiome 421, 422, 427– 29, 430

Alzheimer’s disease 425 anxiety 427– 28 depression 424 Parkinson’s disease 424– 25

stress 428 mouse hepatitis virus (MHV) 319 multiple sclerosis models 319, 325 murine typhus 393t eiler’s murine encephalomyelitis

virus 319

toxocariasis

behavioral alterations 251– 54, 252t, 258

cerebral immunity and brain injury

biomarkers 254– 57, 255t, 258

larval accumulation 250– 51, 258 toxoplasmosis 209f, 218– 19, 219f

microbiome

brain 3 gut, see gut microbiome

microcephaly 445t, 447 microglia

Covid- 19 53, 57 dementia risk 305 HIV 337 microbiome 429– 30 tuberculous meningitis 170– 71

Middle East respiratory syndrome coronavirus

(MERS- CoV) 50– 51, 53– 54, 56 migraine 370t mild cognitive impairment, see cognitive

function monoplegia 286 mood disorders

herpes simplex virus 29 HIV 77– 78, 82 HTLV- 1 90– 91 misdiagnosis 104

Index 479

post- treatment Lyme disease 124– 25, 126– 27,

128, 129

see also anxiety; depression mosquitoes 4, 444, 463 mouse hepatitis virus (MHV) 319 multiple sclerosis (MS) 316– 17, 462, 463– 64

animal models 318– 20

Epstein– Barr virus 317, 320, 321, 324, 325,

359– 60, 462 fertile eld hypothesis 319 future directions 324– 25 HAM/ TSP similarities 87 Helicobacter pylori 142– 43, 145– 46, 147, 151–

52, 154 herpesviruses association 320– 21 incorporation hypothesis 321– 23

autoimmunity consequences 323– 24 microbiome 462 molecular mimicry hypothesis 320– 21 viral infections 317– 18

treatments indirectly targeting 324

murine typhus 393t myalgia 51– 52 myalgic encephalomyelitis/ chronic fatigue

syndrome (ME/ CFS) 348– 49, 388– 92, 395– 96

chronological summary of case

denitions 397– 404 cognitive function 38, 368, 380– 88, 382t, 387f infection 349– 61, 350f, 351t, 359f

myasthenia gravis 51– 52 Mycobacterium tuberculosis 170– 71

myalgic encephalitis/ chronic fatigue

syndrome 351t, 361

Mycoplasma spp.

bromyalgia 363t myalgic encephalitis/ chronic fatigue

syndrome 351t, 361

myelitis 51– 52 myoclonus 137

Naville, François 14 Necator americanus 394 neglected tropical diseases 453

Neisseria spp.

N. gonorrhoeae 285– 86 N. meningitides 306

neonates

cytomegalovirus 66 herpes simplex virus 27

neural larva migrans, see cerebral toxocariasis neuregulin- 1 199– 202 neuroborreliosis, see Lyme dise ase neurocysticercosis 2, 263– 65, 272– 73

bipolar disorder 271 cognitive function 271– 72 dementia risk 303– 4 depression 269– 70 epilepsy 265– 66 focal neurological decits 267 headache 266 hydrocephalus 267– 68 movement disorders 267 parkinsonism 267 psychosis 268– 69

neuroEbola 41– 44

cognitive function 393t future perspectives 46– 47 multifaceted nature 44– 45 pathogenesis 45– 46 treatment 46

neurosyphilis (NS) 1– 2, 99

bipolar disorder 338– 39 clinical ndings 101– 2

early 102– 4

late 104– 5 cognitive function 393t dementia risk 309 diagnosis 105

blood serologies 105– 6

CSF testing 106– 7, 107t epidemiology 101 natural history 100f, 102f neurocognitive function 109, 110t

mechanisms 111

mitigation 111– 12 treatment 107

asymptomatic NS 108– 9

neurotoxocariasis, see cerebral toxocariasis nocturnal excitation crises 10– 11 noradrenaline (norepinephrine) 419– 20 nutrition, see diet and nutrition nutritional decits, older people 300– 1

obsessive– compulsive disorder (OCD) 331– 32,

339– 40, 341 bradyphrenia comparison 15 Covid- 19 53– 54, 463– 64 etiology 462 immunological subtype 463– 64 PANDAS 461– 62 post- treatment Lyme disease 126– 27 Streptococcus 340– 41 toxoplasmosis 2, 223, 340, 453– 54

ocular motor decits 45 oculogyric crises 16– 17, 19– 20 older people

climate change 444

 Index

older people (cont.)

cognitive decline 368 dementia risk 300 Helicobacter pylori 148– 50 microbiome 424, 428 neuroEbola 43 nutritional decits 300– 1 toxocariasis 250, 453– 54 toxoplasmosis 208– 9 tuberculous meningitis 172

olfactory impairment

Covid- 19/ long Covid 380

bromyalgia 370t, 379– 80, 381t olfactory nerve 52– 53 oligoadenylate synthetase 1 gene

Alzheimer’s disease 3, 464

Covid- 19 3 omega- 3 429 ophthalmoplegia 44– 45 oppositional deant disorder (ODD) 191– 92 optic atrophy 44– 45 optic nerve 44– 45, 46 organ transplantation 64– 65 Oscillospira spp. 424– 25 osteoarthritis 370t osteomyelitis 363t, 368

Paenibacillus macerans 423 pain, and bromyalgia 370t panic, and Whipple’s disease 134 Parabacteroides goldsteinii 425 paranoia

neurocysticercosis 268

Whipple’s disease 134 paresis, general 104, 106, 109 parkinsonism

encephalitis lethargica 9, 12, 13, 14, 15, 16–

17, 19– 20 HIV 308 neurocysticercosis 267 Whipple’s disease 136, 137, 138b, 139

Parkinson’s disease (PD)

Desulfovibrio bacteria 461 encephalitis lethargica 1 Helicobacter pylori 142– 43, 145, 146– 47, 150–

51, 154, 303– 4 microbiome 424– 25, 430 progressive nature 267 toxoplasmosis 217

parvovirus

child development 447 bromyalgia 362– 68, 363t myalgic encephalitis/ chronic fatigue

syndrome 351t, 360– 61

p- cresol 429 pediatric acute neuropsychiatric syndrome

(PANS) 461– 62

pediatric autoimmune neuropsychiatric disorder

associated with streptococcal infection (PANDAS) 461– 62

obsessive– compulsive disorder 340, 341 pediatrics, see children pelvic inammatory disease 450– 51 peptic ulcer disease 153– 54 peruoroalkyl 444 periodontitis 363t, 368 personality change

encephalitis lethargica 11, 14, 18, 19– 20

neurosyphilis 104, 309

toxoplasmosis 209– 11, 215– 16 pigs 263, 264– 65, 272– 73, 453– 54

Plasmodium spp.

P. berghei 201

P. falciparum 192, 200

pneumonia 303– 4 Pollnow, Hans 13– 14 pollutants 444 polyuoroalkyl 444 post- active phase of infection syndromes

(PAPIS) 394, 395– 96

post- Covid- 19 syndrome 53– 54

see also long Covid post- Ebola syndrome, see neuroEbola post- encephalitic behavioral syndrome 11– 14 post- traumatic stress disorder (PTSD)

Covid- 19 53– 54

neuroEbola 43, 44– 45 post- treatment Lyme disease (PTLD) 119–

20, 128– 29 neuropsychiatric functioning 126– 27 neuropsychological functioning 120

attention and executive functioning 123– 24 language 123 memory 121– 22 mood and fatigue associations 124– 25 processing speed 122

severity of decits 124 neuroradiological ndings 125– 26 research limitations 127– 28

poverty 4

cerebral malaria 185 child development 443– 45, 452– 54, 455– 56 climate change 4, 463 toxocariasis 244, 249– 50, 258 see also socioeconomic status

prebiotics

autism spectrum disorders 423 depression 424

Index 481

prematurity 427 Prevotella spp. 420– 21, 429 prion diseases 310 probiotics 422

depression 424

processing speed

cerebral malaria 190 bromyalgia 370t, 380, 381t long Covid 389t myalgic encephalitis/ chronic fatigue

syndrome 382t, 387

post- treatment Lyme disease 122, 124,

127, 128– 29 toxoplasmosis 213– 16 tuberculous meningitis 165, 175– 76 Whipple’s disease 134, 135

progressive multifocal

leukoencephalopathy (PML) dementia risk 306– 7 John Cunningham virus 318

progressive supranuclear palsy

subcortical dementia 15 Whipple’s disease 133, 137– 38, 138b

Propionibacterium spp. 420– 21 prosopagnosia 135, 138b, 138 Protein Atlas 324– 25 Proteobacteria 428 Pseudomonas spp. 429 pseudo- neurasthenia 9, 10 psychosis

child development 445t, 449– 51, 455 Covid- 19 52 encephalitis lethargica 1, 18– 20 HIV 82– 83 neurocysticercosis 268– 69, 271, 272– 73 neurosyphilis 1– 2 toxoplasmosis 220– 21

ptosis 44– 45 public health 462– 63, 464

child development 443, 454– 56

rabies 368 race and ethnicity

cytomegalovirus 70– 71 Helicobacter pylori 152 myalgic encephalitis/ chronic fatigue

syndrome 360 toxocariasis 244, 249– 50

rats

microbiome 428 toxoplasmosis 220, 334

repetitive behaviors 134 retinal scarring 44– 45, 46 retinopathy 191– 92

rhesus blood group (Rh) 212, 213– 14, 215 rhesus monkeys 446– 47 rhinosinusitis 363t, 368 Rhodesian African trypanosomiasis, see

east African (Rhodesian African)

trypanosomiasis rhombencephalitis 137– 38, 138b, 139 rodents

toxoplasmosis 209, 213, 218– 19, 221– 23 trypanosomiasis 239

see also mice; rats rubella 445t, 446– 47, 450– 51 Ruminococcus spp. 429

Alzheimer’s disease 425

Sacks, Oliver 16, 18– 19 Salmonella spp. 423– 24 SARS- CoV- 2, see Covid- 19 schizophrenia

child development 445t, 448, 449, 450– 51,

452– 53, 455 cytomegalovirus 67– 68, 71, 73 encephalitis lethargica comparison 18, 19 etiology 462 genetics 337– 38 herpes simplex virus 31 maternal vaccination 454– 55 microbiome 420, 423– 24 misdiagnosis 104 toxoplasmosis 2, 214, 215– 16, 217, 218– 19,

220, 223, 453– 54

seizures

acute necrotizing encephalopathy of

childhood 281, 284– 85, 286, 288 cerebral malaria 189– 90, 197 child development 445t, 447 Covid- 19 52– 53 HIV 78 human African trypanosomiasis 234 neurocysticercosis 264, 265– 66, 268 neuroEbola 42, 46 toxocariasis 247, 256– 57 tuberculous meningitis 164 Whipple’s disease 133– 34, 139 see also epilepsy

self- mutilation 12 sensorineural hearing loss (SNHL) 67 severe acute respiratory syndrome

(SARS) 53– 54 fatigue 56

severe acute respiratory syndrome coronavirus

(SARS- CoV) 50– 51

severe acute respiratory syndrome coronavirus 2,

see Covid- 19

 Index

severe malaria anemia (SMA) 186

biomarkers of severity 198 computerized cognitive rehabilitation

therapy 188– 89 EEG evaluation 194 machine learning modeling of

neurodevelopmental outcomes 199 neurological sequelae 189– 90 neuropsychological rehabilitation and school

performance 190– 91 protective role of neuregulin- 1 199– 200

sexual behavior

encephalitis lethargica 12– 13 human African trypanosomiasis 234 toxoplasmosis 212– 13, 220 Whipple’s disease 135– 36

sex workers 101 short- chain fatty acids (SCFAs) 429 short- term memory, see memory sleep disturbances

Covid- 19 53– 54 bromyalgia 370t human African trypanosomiasis 233– 34,

235f, 239 Lyme disease 339 major depressive disorder 332, 333 myalgic encephalitis/ chronic fatigue

syndrome 382t neuroEbola 42 Parkinson’s disease 150 toxocariasis 256– 57 Whipple’s disease 136, 139

sleeping sickness, see human African

trypanosomiasis

Sneathia spp. 420– 21 socioeconomic status

cerebral malaria 190– 91 child development 443, 452 Helicobacter pylori 142– 43, 148– 49, 152 HIV 81 HTLV- 1 86, 89, 90– 91, 93 neurocysticercosis 263

toxoplasmosis 214, 215 see also poverty

somatization 126– 27 spatial ability 271– 72 speech impairment, see language spongiform encephalopathies 310 Staphylococcus spp.

bromyalgia 363t microbiome 420– 21

status epilepticus 189 Steck, Hans 14 Streptococcus spp.

group A 340– 41

group B 445t microbiome 429 ADHD 423 OCD 340– 41

S. pneumoniae

acute necrotizing encephalopathy of

childhood 285– 86

dementia risk 306

S. pyogenes 461– 62

stress

child development 452– 53 cytomegalovirus 71, 72 bromyalgia 370t HIV 78– 79 microbiome 419– 20, 421– 22, 428, 430– 31

autism spectrum disorders 423

schizophrenia 423– 24 post- treatment Lyme disease 128 toxoplasmosis 210

stroke

Covid- 19 51– 53, 54– 55 Helicobacter pylori 142– 43 microbiome 428 neurocysticercosis 267 neurosyphilis 103– 4 Whipple’s disease 139

subacute sclerosing panencephalitis 317– 18 subcortical dementia 15 substance- use disorder

bipolar disorder 337 Lyme disease 339 microbiome 420 OCD 339

suicidality

child development 449– 50 cytomegalovirus 73 encephalitis lethargica 16 major depressive disorder 332, 333– 34 neuroEbola 43 post- treatment Lyme disease 127 toxoplasmosis 215– 16, 334, 453– 54, 462

syphilis 99, 112

biology 99– 100 bipolar disorder 338– 39 child development 445t, 450– 51 cognitive function 368 dementia risk 308, 309 epidemiology 101 natural history 100f transmission 99 see also neurosyphilis

tabes dorsalis

dementia risk 309 neurosyphilis 104– 5, 106

Index 483

epilepsy 265– 66 headache 266 poverty 453– 54 psychosis 268, 269

TAR DNA- binding protein 43

(TDP- 43) 54– 55 testosterone 218, 220 eiler’s murine encephalomyelitis virus

(TMEV) 319 tic disorders 339 tick- borne diseases

cognitive function 393– 94, 395 see also Lyme disease; post- treatment Lyme

disease TORCH infections 446– 47 Tourette syndrome 339

Toxascaris leonine 245 To xo c ar a spp. 244, 245– 46, 258

animal models 250– 54 cerebral immunity and biomarkers of brain

injury 254– 57

cerebral toxocariasis 246– 48 Human Development Index 4 neurocognitive function 248– 50 pollutants 444 T. ca ni s 245, 246– 47, 250– 56, 252t, 257, 258

poverty 453– 54

T. ca ti 245, 252t, 253– 54, 257, 258

poverty 453– 54

toxocariasis 244– 46, 258

cerebral, see cerebral toxocariasis child development 445t covert 246 disease syndromes 246 mice

behavioral alterations 251– 54, 252t, 258 cerebral immunity and biomarkers of brain

injury 254– 57, 255t

larval accumulation 250– 51 neurocognitive function 248– 54 ocular 246, 250 poverty 453– 54 seroprevalence 246

Toxoplasma gondii 2, 208– 23, 209f, 219f

child development 445t, 446– 47, 449–

51, 455 dementia risk 310– 11 major depressive disorder 334– 35 OCD 340 pediatric acute neuropsychiatric

syndrome 461– 62 pollutants 444 poverty 453– 54 prevention 454– 55 suicides and trac accidents 215– 16, 334,

453– 54, 462

toxoplasmosis 208– 10, 221– 23

acute 208– 9, 216– 17 behavior 211– 13, 218– 20, 221 bipolar disorder 338 child development 447 congenital 208– 9, 447 dementia risk 310– 11 intelligence 216– 17 major depressive disorder 334– 35 manipulation vs side eects of disease 220–

21, 222f memory 217– 18 OCD 340 personality 210– 11, 221 poverty 453– 54 processing speed 213– 16

transverse myelitis 306– 7 tremor

human African trypanosomiasis 234 neurocysticercosis 267 neuroEbola 42

Treponema pallidum 99– 100, 101– 2, 103– 4

bipolar disorder 338– 39 blood serologies 105– 6 child development 445t, 447 dementia 309

Alzheimer’s disease 394 neurocognitive function 109, 111– 12 treatment 108

see also neurosyphilis; syphilis

Trichuris trichiura 394 Tropheryma whipplei 133, 136, 137, 138, 139

morphology 134f

tropical spastic paresis (TSP) 87– 88 Trypanosoma brucei 229, 230– 31

biological models 239 sleep disturbances 234 T.b. gambiense 2, 229, 230, 237– 38

biological models 239, 240

clinical manifestations 231, 232t, 232,

233, 238

diagnosis 236 T.b. rhodesiense 2, 229, 230, 237– 38

biological models 239

clinical manifestations 231, 232t,

232, 233

trypanosomiasis, see Chagas disease; human

African trypanosomiasis Trypanosomiasis cruzi 229, 453– 54 tryptophan

microbiome 429 toxoplasmosis 218, 220

major depressive disorder 335

tsetse y 229, 230– 31, 232

preventive measures 238, 238t

 Index

tuberculous meningitis (TBM) 163– 64, 176

clinical features and cognitive

abnormalities 164– 65, 166f– 67f attention 167– 68 executive function 169 memory 168– 69 verbal skills 169– 70

management 175– 76 neurocognitive testing 171– 72, 173t pathogenesis of neurocognitive

functions 170– 71

tuberous sclerosis

child development 449 cytomegalovirus 453– 54

tumor necrosis factor alpha 52– 53

ulcerative colitis 332– 33 United States Centers for Disease Control and

Prevention

human African trypanosomiasis 238t

urbanization

child development 443

urinary tract infections 448– 50 uveitis 45

vagal nerve

microbiome 424, 427 myalgic encephalitis/ chronic fatigue

syndrome 351t

vaginal birth, and microbiome 420– 21 vaginitis 450– 51 varicella zoster virus (VZV) 2

cognitive function 393t dementia 301

Alzheimer’s disease 394

myalgic encephalitis/ chronic fatigue

syndrome 351t, 361

vascular dementia

cytomegalovirus 70, 71 Helicobacter pylori 148 HTLV- 1 90

verbal skills, see language Verrucomicrobiaceae 428

Parkinson’s disease 424– 25 vesicular stomatitis virus 322 violence 12 viral infection theory 305 visceral larva migrans 246 visual problems

acute necrotizing encephalopathy of

childhood 286– 87

neurocysticercosis 271– 72 vitamins

B12 220

Helicobacter pylori 143– 45, 144f volition decit 14, 15– 16, 19– 20 von Economo, Constantin 9, 19– 20

water quality, and climate change 444 Wernicke– Korsako syndrome 139 west African (Gambian)

trypanosomiasis 229, 235

see also Trypanosoma brucei: T.b. gambiense West Nile virus 2 Whipple’s disease (WD) 133, 140

case studies 133– 37

pathomechanisms 137– 39, 139f

phenomenology 138b word- nding diculties, see language working memory, see memory World Health Assembly 237– 38 World Health Organization (WHO)

human African trypanosomiasis 236– 38,

238t, 240, 241

myalgic encephalitis/ chronic fatigue

syndrome 349– 50

xenotropic murine leukemia virus

(XMRV) 351t

Zika virus

child development 445t, 447

climate change 4, 444, 463 cognitive function 393t

<<< < Предыдущая 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 4950 / 5050

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