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thestomachisnexttotherightpillarofthecrus.
■
Thesecondrowofsuturesontherightsideoftheesophagusconsistsofthree
stitchesbetweenthefundusandtherightpillarofthecrus.
■
Finally,twoadditionalstitchesareplacedbetweenthefundusandtherimof
theesophagealhiatustoeliminateanytensionfromthefundoplication.
PEARLSANDPITFALLS
Indications ■Acarefulevaluation,includingmanometry,24-hour
pHmonitoring,upperendoscopy,andbarium
swallowmustbedone.
Placementofports ■Extremecaremustbetakenwhenpositioningport1,
becausethesiteofinsertionisjustabovetheaorta.
■Werecommendusinganopticaltrocarwitha0-
degreescopetoobtainaccess.
■Ifport3istoolow,theleftlateralsegmentofthe
liverwillnotbeproperlyretracted,resultingin
inadequateexposureoftheesophagogastric
junction.
■Ifport2istoolow,theesophagogastricjunctionor
theuppershortgastricvesselswillbedifficultto
reach.
■Ifports4and5aretoolow,thedissectionatthe
beginningoftheprocedureandthesuturingatthe
endwillbechallenging.
■Ifport3istoomedial,theliverretractormay
interferewiththeinstrumentusedthroughport4.
Dissection ■Anaccessorylefthepaticarteryoriginatingfromthe
leftgastricarteryisfrequentlypresentinthe
gastrohepaticligament.Ifthisvessellimitsthe
exposure,itmaybesafelydivided.

■Theelectrocauteryshouldbeusedwithextreme
caution.Becauseofthelateralspreadofthe
monopolarcurrent,vagusnervesmaybedamaged
evenwithoutdirectcontact.Abipolarinstrument
representsasaferalternative.
Shortgastricvessels
division
■Bleeding,eitherfromtheshortgastricvesselsor
fromthespleen,anddamagetothegastricwallare
possiblecomplications.
■Excessivetractionanddivisionofavesselnot
completelycoagulatedareusuallythemaincauses
ofbleeding.
■Aburncausedduringdissectionoftheshortgastric
vesselsortractionappliedwiththegraspersorthe
Babcockclamparethemostcommonmechanisms
ofdamagetothegastricwall.
Creationofawindow
andplacementofa
Penrosedrainaround
theesophagus
■Leftpneumothoraxandperforationofthegastric
fundusaretwomaincomplicationsthatcanoccur
duringthisstepoftheprocedure.
■Leftpneumothoraxisusuallycreatedwhenthe
dissectionisperformedinthemediastinumabove
theleftpillarofthecrusratherthanbetweenthe
crusandthegastricfundus.
■Properidentificationanddissectionoftheleftpillar
ofthecrusarecrucial.
■Perforationofthegastricfundusisusuallycausedby
pushingabluntinstrumentundertheesophagusor
byusingmonopolarelectrocauteryfordissection.
Closureofthecrura ■Thebougieisnotplacedinsidetheesophagusduring
thisstepoftheprocedureinordertohaveaproper
exposureforsuturing.
Insertionofthebougie
intoesophagusand
throughesophageal
junction
■Themostseriouscomplicationduringthisstepisan
esophagealperforation.
■Lubricationofthebougieandinstructiontothe
anesthesiologisttoadvancethebougieslowlyand

tostopifanyresistanceisencounteredhelpto
preventthiscomplication.
■Allinstrumentsmustberemovedfromthe
esophagogastricjunctionandthePenrosedrain
mustbeopened.Inthisway,thecreationofan
anglebetweenthestomachandtheesophagus,
whichincreasestheriskofperforation,is
prevented.
Partialfundoplication ■Atraumaticgraspersmustbeusedtoreducetherisk
ofinjurytothegastricwall.
POSTOPERATIVECARE
■
Patientsareusuallydischargedafter23to48hours.
■
Patientsstartclearliquidsandthenasoftdietthemorningaftersurgery.
■
Theyareinstructedtoavoidmeat,bread,andcarbonatedbeveragesforthe
following2weeks.
■
Thetimetofullrecoveryrangesbetween2and3weeks.
OUTCOMES
■
Long-termstudiesconductedinUnitedStateshavereportedalesseffective
controlofGERDwithapartialfundoplicationratherthanatotal
fundoplication.
10–12
■
At5-yearfollow-up,recurrenceofGERDconfirmedbypHmonitoringis
reportedinmorethan50%ofpatientsafterpartialfundoplication.
10

COMPLICATIONS
■
Esophagealorgastricperforationcanbecausedeitherbytractionorbyan
inadvertentelectrocauteryburnduringanystepofthedissection.
■
Aleakusuallymanifestsitselfduringthefirst48hours.
■
Peritonealsignswillbepresentifthespillageislimitedtotheabdomen;
shortnessofbreathandapleuraleffusionwillbenotedifspillagealsooccurs
inthechest.
■
Thesiteoftheleakmustalwaysbeconfirmedbyacontraststudyusingawater-
solublecontrastagent.
■
Optimalmanagementconsistsofareoperationanddirectrepair.An
esophagectomymaybeindicatedincaseofatooextensivedamageorwhen
theextentoftheinflammatoryreactionmakesthedirectrepairimpossible.
Widedrainage,feedingjejunostomytube,anduseofacoveredesophageal
stentmayalsoassistinhealingtheinjurywhenitcannotbedirectlyrepaired.
■
Gastroesophagealjunctionandwrapslippageintothechestrarelyoccurswhen
coronalsutureisplacedandthecruraareclosed.8Themainsymptomsof
recurrencearedysphagiaandregurgitation.Abariumswallowconfirmsthe
diagnosis.
■
Theincidenceofparaesophagealherniamaybeincreasediftheclosureofthe
cruraisnotperformedorifitistooloose.
8
REFERENCES
1.Moraes-FilhoJ,CecconelloI,Gama-RodriguesJ,etal.Brazilianconsensusongastroesophageal
refluxdisease:proposalsforassessment,classification,andmanagement.AmJGastroenterol.
2002;97:241–248.
2.VakilN,vanZantenSV,KahrilasP,etal.TheMontrealdefinitionandclassificationof

gastroesophagealrefluxdisease:aglobalevidence-basedconsensus.AmJGatreoenterol.
2006;101:1900–1920.
3.PattiMG,DienerU,TamburiniA,etal.Roleofesophagealfunctiontestsinthediagnosisof
gastroesophagealrefluxdisease.DigDisSci.2001;46:597–602.
4.AmanoY,IshimuraN,FurutaK,etal.Interobserveragreementonclassifyingendoscopic
diagnosesofnonerosiveesophagitis.Endoscopy.2006;38:1032–1035.
5.PattiMG,ArceritoM,TamburiniA,etal.Effectoflaparoscopicfundoplicationon
gastroesophagealrefluxdisease-inducedrespiratorysymptoms.JGastrointestSurg.2000;4:143–149.
6.CamposGM,PetersJH,DeMeesterTR,etal.Multivariateanalysisoffactorspredictingoutcome
afterlaparoscopicNissenfundoplication.JGastrointestSurg.1999;3:292–300.
7.GalvaniC,FisichellaPM,GorodnerMV,etal.Symptomsareapoorindicatorofrefluxstatus
afterfundoplicationforgastroesophagealrefluxdisease:roleofesophagealfunctiontests.ArchSurg.
2003;138:514–518.
8.PattiMG,ArceritoM,FeoCV,etal.Ananalysisofoperationsforgastroesophagealreflux
disease.Identifyingtheimportanttechnicalelements.ArchSurg.1998;133:600–606.
9.PattersonEJ,HerronDM,HansenPD,etal.Effectofanesophagealbougieontheincidenceof
dysphagiafollowingNissenfundoplication:aprospective,blinded,randomizedclinicaltrial.Arch
Surg.2000;135:1055–1061.
10.HorvathKD,JobeBA,HerronDM,etal.LaparoscopicToupetfundoplicationisaninadequate
procedureforpatientswithsevererefluxdisease.JGastrointestSurg.1999;3:583–591.
11.OleynikovD,EubanksTR,OelschlagerBK,etal.Totalfundoplicationistheoperationof
choiceforpatientswithgastroesophagealrefluxanddefectiveperistalsis.SurgEndosc.2002;16:909–
913.
12.PattiMG,RobinsonT,GalvaniC,etal.Totalfundoplicationissuperiortopartial
fundoplicationevenwhenesophagealperistalsisisweak.JAmCollSurg.2004;198:863–869.

Chapter8
TheMinimallyInvasive
SurgicalApproachto
GastroesophagealReflux
Disease
W.ScottMelvinLukeM.Funk
DEFINITION
■
Endoscopictherapiesforgastroesophagealrefluxdisease(GERD)include
transoralincisionlessfundoplication(TIF)andtheapplicationof
radiofrequencyenergytotheloweresophagealsphincter(LES).Minimally
invasiveLESaugmentationsurgeryinvolvestheplacementofamagnetic
bandacrosstheLES.AllthreetherapiesaredesignedtoreduceGERD
symptomsbyminimizingtherefluxofgastriccontentsintotheesophagusand
arealternativestotraditionalsurgicalfundoplicationtechniques.
DIFFERENTIALDIAGNOSIS
■
TypicalGERDsymptoms
■
Achalasia
■
Biliarycolic/cholecystitis
■
Delayedgastricemptying
■

Esophagealcancer,esophagitis,esophagealmotilitydisorders
■
Gastritis
■
Hiatalhernia
■
Helicobacterpyloriinfection
■
Irritablebowelsyndrome
■
AtypicalGERDsymptoms
■
Coronaryarterydisease
■
Asthma
■
Bronchogeniccarcinoma
PATIENTHISTORYANDPHYSICALFINDINGS
■
Historytakingshouldfocusonidentifyingbothtypicalandatypicalsymptoms
associatedwithGERD.
■
Typicalsymptomsincludeheartburn,regurgitation,waterbrash(saltytaste
relatedtosalivarysecretion),anddysphagia.
■
Atypicalsymptomsincludedyspnea,cough,wheezing,chestpain,recurrent
pneumonias,hoarseness,anddentalerosions.
■
Responsetoantirefluxmedications,suchasprotonpumpinhibitorsandH
2
blockersisimportanttoillicit,asthemajorityofpatientswithtypicalGERD
symptomswillrespondtothesemedications.Failuretorespondtothese
medicationsshouldheightenthesurgeon’sconcernthatthepatient’s

symptomsmaybeunrelatedtoGERD.
■
OncethediagnosisofGERDisconfirmedwithobjectivetesting,severalkey
pointsshouldbediscussedwiththepatient:
■
Medicaltherapy,includinglifestylemodifications(i.e.,dietmodification,
weightloss,smokingcessation)andantirefluxmedications,shouldcontrol
typicalGERDsymptomsformostpatients.Surgicalinterventionis
indicatedforGERDpatientswho(1)cannottakeantirefluxmedications
duetosideeffects,(2)wouldprefernottotakeantirefluxmedicationsdue
tocostorlifestyleimpact,or(3)continuetoexperiencesymptomsdespite
antirefluxmedications.
■
Laparoscopicgastricfundoplication(i.e.,Nissenfundoplication)isconsidered
tobethegoldstandardsurgicaltherapyforthetreatmentofGERD.
EndoscopictherapiesandlaparoscopicLESaugmentationsurgeryshould
probablybereservedforGERDpatientswhoarecandidatesforsurgical
interventionand(1)wouldpreferalessinvasiveoptionthanlaparoscopic
fundoplicationsurgeryor(2)wouldbeconsideredtoohighriskfor
laparoscopicfundoplicationduetocomorbiditiesorpreviousabdominal
surgery,includingpriorlaparoscopicfundoplication.
■
Ofthethreeproceduresdiscussedinthischapter,laparoscopicLES
augmentationsurgeryistheonlyonethatrequiresgeneralanesthesia,
althoughTIFalsoinvolvesgeneralanesthesiainthevastmajorityofcases.
Conscioussedationisusuallyadequateforradiofrequencytherapy.Thus,poor
candidatesforgeneralanesthesia(i.e.,thosewithcardiopulmonaryconditions
suchasseverechronicobstructivepulmonarydisease[COPD]orcongestive
heartfailure[CHF])maybebettercandidatesforradiofrequencytherapy.The
presenceofthesecomorbidconditionsshouldbesoughtoutinthehistory.
AdditionalcontraindicationsfortheseproceduresarelistedinTable1.

■
BecausetherearefewphysicalexamfindingsassociatedwithGERD,the
physicalexamshouldfocusonconditionsthatmightsuggestanalternative
explanationforthepatient’ssymptoms.Theseincluderecentweightlossor
progressiveinabilitytotoleratesolidsandliquids(malignancy),atypical
symptomsassociatedwithexertion(coronaryarterydiseaseorasthma),or
diarrhea(irritablebowelsyndrome).
■
Thepresenceofabdominalsurgicalscarsorabdominalwallherniasisimportant
toidentifyiflaparoscopicLESaugmentationsurgeryisbeingconsideredas
theymaymakeaccesstotheperitonealcavityandthegastroesophageal(GE)
junctionchallenging.
■
LaparoscopicLESaugmentationsurgery,whichinvolvesplacementofa
magneticdevicearoundtheGEjunction,isconsiderednotsafeformagnetic
resonanceimaging(MRI).Patientsshouldbeawareofthiscontraindication
priortosurgery.
IMAGINGANDOTHERDIAGNOSTICSTUDIES
■
EstablishingGERDastheetiologyofthepatient’ssymptomsiscriticalbefore
proceedingwithanyintervention.Patientsmayhavesubjectivecomplaintsof
heartburnordysphagiathatareunrelatedtotheirrefluxdisease.Thefour

diagnosticteststhataremostcommonlyusedtoestablishadiagnosisare
upperendoscopy,bariumesophagram,pHtesting,andmanometry.
■
Upperendoscopy(esophagogastroduodenoscopy[EGD])
■
AllpatientsundergoinganantirefluxprocedureshouldhaveanEGD.
■
EGDscanidentifythepresenceofhiatalherniasandruleoutotherpathology,
whichmaybecontributingtothepatient’ssymptoms,suchaspepticulcer
diseaseormalignancy.
■
GERD-relatedcomplicationssuchasesophagitis,Barrett’sesophagus,and
esophagealstricturescanalsobeidentified(FIG1).
■
AmbulatorypHtesting
■
Thisisconsideredtobethegoldstandardtestfordiagnosingthepresenceof
symptomaticGERD.
■
Patientsshouldtypicallynotbetakingtheirantirefluxmedicationswhenthe
studyisperformed.
■
pHtestingcanbeperformedviacatheter-basedsystems(i.e.,24-hourpH
probetesting)orwirelesssystems(i.e.,48-hourBravotesting).
■
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