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20 Otalgia inChildren
Table 20.1 Symptoms and examination ndings consistent with the clinical diagnosis causing otalgia in children
Symptoms and examination ndings/clinical diagnosis
Primary otalgia
Auricle
Infection (perichondritis, cellulitis, H. zoster)
Trauma x/xx/
Allergic angioedema x/xx Thermal damage x/xx/
External auditory canal
Otitis externa x/xx
Malignant Otitis externa xxx Eczematous dermatitis x/xx Furunculosis x/xx Foreign body x/xx Cerumen impaction x Tumors xx/xxx
Middle ear
Acute otitis media xx/xxx +
Otitis media with effusion Eustachian tube dysfunction x Cholesteatoma x/xx Trauma x/xx/
Secondary otalgia
Oropharyngeal infections x/xx + Dental causes x/xx Auricular lymphadenitis x Neck abscess x/xx + Parotitis x/xx Temporomandibular joint
dysfunction
Sinusitis x
Otalgia severity x:mild, xx:moderate, xxx:severe; + presence; absence
Otalgia Fever Otorrhea
xx
xxx
xxx
x/
xxx
x
+/
+
+/
+ +
+/
+/ +/
+/
+
+/ +/
+/
+/
+/ +/
+/ +/
+/
+/
Hearing Loss
+/
+
+
Other symptoms and ndings
Itching
Bleeding
Itching, tragal tenderness
Itching
Restlessness, vomiting, headache
Tinnitus
Rhinorrea, vertigo, tinnitus
Dysphagy, sore throat Toothache
Swelling, hyperemia
Difculty chewing, clicking sound, malocclusion
Nasal congestion, cough, nasal discharge
273
274
Table 20.2 Presence of examination, laboratory, and radiological ndings consistent with the clinical diagnosis causing otalgia in children
Otoscopic Examination ndings/ clinical diagnosis
Primary otalgia
Auricle
Infection (perichondritis, cellulitis, H. zoster)
Trauma + Allergic angioedema + Thermal damage +
External auditory canal
Otitis externa Malignant Otitis externa Eczematous dermatitis + + Furunculosis + + Foreign body Cerumen impaction Tumors
Middle ear
Acute otitis media Otitis media with
effusion Eustachian tube
dysfunction Cholesteatoma Trauma + +
Secondary otalgia
Oropharyngeal infections + Dental causes Auricular lymphadenitis + Neck abscess + Parotitis + Temporomandibular joint
dysfunction Sinusitis
Inspection ndings
+
+/ +/
+/
+/
+/ +/
+/ +/
+/ +/
examination
ndings
+/ +/
+/ +/
+/
+
+ + +
+
+
+
+ +
+
+
+
+/
+/
Laboratory ndings
+/
+/
+/
+
+ +
Y. Yüksel et al.
Radiological ndings (CT/ MR)
+
+/
+ +
+

References

1. Earwood JS, Rogers TS, Rathjen NA.Ear pain: diagnosing common and uncommon cause. Am Fam Physician. 2018;97(1):20–7.
2. Harrison E, Cronin M.Otalgia. Aust Fam Physician. 2016;45(7):493–7.
3. Majumdar S, Wu K, Bateman ND, Ray J.Diagnosis and management of otalgia in children. Arch Dis Child Educ Pract Ed. 2009;94:33–6.
4. Greenes D, Neuman MI, Wiley JF.Evaluation of earache in children. 2023. www.uptodate.com.
5. Kansu L, Yılmaz I.Herpes zoster oticus (Ramsay Hunt syndrome) in children: case report and literature review. Int J Pediatr Otorhinolaryngol. 2012;76:772.
20 Otalgia inChildren
6. Leung AKC, Fong JHS, Leong AG.Otalgia in children. U Natl Med Assoc. 2000;92:254–60.
7. Rosenfeld RM, Schwartz SR, Cannon CR, et al. Clinical practice guideline: acute otitis externa. Otolaryngol Head Neck Surg. 2014;150:S1–S24.
8. Neilan RE, Roland PS.Otalgia. Med Clin North Am. 2010;94(5):961–71.
9. Jamal A, Alsabea A, Tarakmeh M, Safar A.Etiology, diagnosis, complications, and manage­ment of acute otitis media in children. Cureus. 2022;14(8):e28019.
10. Büyükcam A, Kara A, Bedir T, Gülhan B, Özdemir H, Sütçü M, etal. Pediatricians’ attitudes in management of acute otitis media and ear pain in Turkey. Int J Pediatr Otorhinolaryngol. 2018;107:14–20.
11. Lieberthal AS, Carroll AE, Chonmaitree T, etal. The diagnosis and management of acute otitis media. Pediatrics. 2013;131:e964.
12. Makuszewska M.Classication, diagnosis and treatment of Eustachian tube dysfunction–lit­erature review. Polish Otorhinolaryngol Rev. 2021;10(4):22–8.
13. Levenson MJ, Parisier SC, Chute P, Wenig S, Juarbe C.A review of twenty congenital cho­lesteatomas of the middle ear in children. Otolaryngol Head Neck Surg. 1986;94(5):560–7.
14. Fontes Lima A, Carvalho Moreira F, Sousa Menezes A, Esteves Costa I, Azevedo C, Sá Breda M, Dias L.Is pediatric cholesteatoma more aggressive in children than in adults? A comparative study using the EAONO/JOS classication. Int J Pediatr Otorhinolaryngol. 2020;138:110170.
15. Hurtado TR, Zeger WG.Hemotympanums secondary to spontaneous epistaxis in a 7-year-old. J Emerg Med. 2004;26:61.
16. Conover K.Earache. Emerg Med Clin North Am. 2013;31:413.
17. Vicedomini D, Lalinga G, Lugli N, D’Avino A.Diagnosis and management of acute pharyngo­tonsillitis in the primary care pediatrician’s ofce. Minerva Pediatr. 2014;66(1):69–76.
18. Ely JW, Hansen MR, Clark EC.Diagnosis of ear pain. Am Fam Physician. 2008;77(5):621–8.
19. Erbaş İC, Özlü C, Asrak HK, Güzin AÇ, Belet N.Deep neck infections in childhood. J Pediatr Inf. 2021;15(1):38–43.
20. Battle S, Laudenbach J, Maguire JH.Inuenza parotitis: a case from the 2004 to 2005 vaccine shortage. Am J Med Sci. 2007;333:215.
21. Francis CL, Larsen CG.Pediatric sialadenitis. Otolaryngol Clin N Am. 2014;47:763.
22. Stong BC, Sipp JA, Sobol SE.Pediatric parotitis: a 5-year review at a tertiary care pediatric institution. Int J Pediatr Otorhinolaryngol. 2006;70:541.
275
Otorrhea inChildren
21
YavuzSultanSelimYıldırım, NurayBayar Muluk, andChae-SeoRhee

21.1 Introduction

Otorrhea refers to the discharge of uid from the ear. It can occur due to issues in the external ear canal or middle ear problems involving a perforation in the tym­panic membrane (TM). To discern the primary reasons behind otorrhea in children, a thorough examination and medical history are essential. The majority of children experiencing otorrhea are typically diagnosed with bacterial otitis externa or acute otitis media (AOM) featuring a perforated tympanic membrane. Also, button batter­ies require emergent removal because pressure necrosis and/or severe burns from residual electric current or leakage of caustic contents may rapidly lead to extensive damage to adjacent structures [1]. Patients who appear unwell or exhibit otorrhea following head trauma necessitate immediate and thorough efforts to diagnose and address potential life-threatening factors contributing to otorrhea, such as basilar skull fractures, necrotizing otitis externa, or infectious complications associated with acute otitis media.
Otorrhea presents a common challenge for otolaryngologists, with its causes ranging from relatively harmless to severe and life-threatening conditions. Consequently, an accurate determination of the underlying cause becomes para­mount in establishing an effective treatment plan. In this discussion, we will focus
Y. S. S. Yıldırım Clinic of Otorhinolaryngology, Elazig Fethi Sekin City Hospital, Elazig, Turkey
N. Bayar Muluk (*) Department of Otorhinolaryngology, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkey
C.-S. Rhee Department of Otorhinolaryngology, Head and Neck Surgery, College of Medicine, Seoul National University, Seoul, South Korea e-mail: csrhee@snu.ac.kr
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2024 H. Yüksel et al. (eds.), Pediatric Airway Diseases, Comprehensive ENT,
https://doi.org/10.1007/978-3-031-74853-0_21
277
278
on the most prevalent causes of otorrhea in children and provide guidance on deci­sion-making for management based on a precise diagnosis.
Y. S. S. Yıldırım et al.

21.2 Bacterial Otitis Externa

Acute otitis externa is a common condition characterized by inammation of the ear canal. Bacterial infection, primarily driven by Pseudomonas aeruginosa and Staphylococcus aureus, is the main cause of the acute form. It manifests with the sudden onset of inammation in the ear canal, leading to symptoms like ear pain, itching, swelling of the canal, redness, and discharge. Often, this condition arises after activities like swimming or minor injuries resulting from improper cleaning. A characteristic sign is tenderness when moving the tragus or pinna.
Upon examination, you will observe an ear canal that appears red, swollen, and contains cellular debris. Importantly, external otitis does not necessarily involve the middle ear, so there may not be any middle ear uid buildup or a purulent middle ear infection. When visible, the eardrum (tympanic membrane or TM) typically exhibits redness or debris. In some cases, the swollen canal can make it challenging to see the eardrum clearly. The discharge is usually purulent, ranging from white to yellow and may dry to form a crust.
For uncomplicated cases, the preferred treatment options include topical antimicrobials or antibiotics like acetic acid, aminoglycosides, polymyxin B, and quinolones. These medications are available in formulations with or without topical corticosteroids, and the addition of corticosteroids can help expedite symptom relief. Oral antibiotics are reserved for situations where the infection has spread beyond the ear canal or in patients at risk of a rapidly worsening infection [2, 3].

21.3 Acute Otitis Media

Acute Otitis Media (AOM) is an infection of the middle ear, which can be caused by viruses and/or bacteria. It stands as the most common childhood infection for which antibiotics are prescribed in the United States. On occasion, during an episode of acute otitis media, the eardrum may rupture. This is often accompanied by ear pain and a relatively short-lived fever, followed by relief from pain coinciding with the onset of ear discharge. The drainage typically appears clear or white. The perfora­tion may have healed by the time the patient seeks medical attention, but the dis­charge may persist for some time, especially if external otitis has developed.
Frequently, the perforation itself may not be visible during ear examination (otoscopy) due to the ear discharge obstructing the view of the tympanic membrane (TM). Alternatively, the perforation may have healed rapidly, as shown in Fig.21.1. When it is visible, the TM typically exhibits an abnormal appearance and lacks mobility when assessed with pneumatic otoscopy. If the perforation is of recent origin, it generally heals spontaneously once the infection resolves [4, 5].
21 Otorrhea inChildren
Fig. 21.1 Endoscopic view of suppurated acute otitis media

21.4 Chronic Suppurative Otitis Media

279
Chronic suppurative otitis media (CSOM), or mastoiditis, is an eardrum perforation with chronic drainage from the middle ear cleft [5]. This condition is more fre­quently seen in children who lack access to health care and, thus, do not have timely diagnosis and treatment of acute otitis media. It should not be confused with long­standing otitis media with effusion (OME, or “serous” otitis media) or persistent acute otitis media, which involve an intact tympanic membrane and no drainage.
CSOM is often painless. On examination, a debris-lled canal is noted. The dis­charge is often white to yellow and mixed with soft cerumen. Pseudomonas aerugi­nosa and Staphylococcus aureus are common pathogens. Treatment typically consists of topical antibiotic ear drops, with topical quinolones being the best­studied treatment choice. Parenteral antibiotic administration guided by culture of the ear discharge and/or tympanomastoidectomy may be necessary in refractory cases, though the evidence for the superiority of systemic antibiotics over topical quinolone antibiotics is mixed and not convincing [5, 6].

21.5 Foreign Body

The primary foreign objects encountered in cases are usually food, plastic toys, and small household objects. Identifying these cases can be challenging due to the often unnoticed nature of the incident, non-specic symptoms, and frequent initial misdi­agnosis. In the majority of instances involving foreign objects lodged in the ear or
280
Y. S. S. Yıldırım et al.
nose, a trained physician can safely extract them within an ofce setting with mini­mal risk of complications. Typical removal techniques comprise the use of forceps, water irrigation, and suction catheters. Typical foreign bodies include:
• Toys or small objects placed in the ear by toddlers or placed into younger sib-
ling’s ears
• Insects, although they are often so irritating that removal occurs before otorrhea
develops
• Food material, especially nuts with irritating oils that can cause a signicant
reaction
• Button batteries (often used in small electronic devices such as hearing aids)
• Expelled tympanostomy tube with granulation tissue and bloody otorrhea
Button batteries require emergent removal because pressure necrosis and/or severe burns from residual electric current or leakage of caustic contents may rap­idly lead to extensive damage to adjacent structures [1].
Otoscopy serves as a diagnostic tool. However, the presence of either cerumen buildup or otorrhea may obstruct the visibility of the foreign body, necessitating cleaning before the object becomes visible (as depicted in Fig.21.2). In cases where ear foreign bodies are present and do not lead to otorrhea, straightforward tech­niques can typically be employed for removal within an outpatient environment. However, if removal in the outpatient setting is not feasible, the foreign body should be extracted in an operating room while the patient is under sedation or general anesthesia. The initial attempt at removal is of paramount importance since the suc­cess rates signicantly decrease after the rst unsuccessful attempt. Consequently,
Fig. 21.2 Endoscopic view of foreign body in external ear canal
21 Otorrhea inChildren
281
complications are more likely to arise as the number of failed removal attempts increases. These removal attempts can often be painful, lead to bleeding that limits visibility, and potentially push the foreign body further into the ear canal.
21.5.1 Cerumen
Annoying to many parents but generally harmless, some children have thin cerumen that can present as ear drainage. In general, cerumen is only a problem if it is impacted or precludes eardrum examination. Removal may be necessary in such cases, but precautions should be taken when instrumenting the ear canal [7].
21.5.2 Tympanostomy Tube Drainage
About 10–30% of children with tympanostomy tubes will have at least one episode of acute otorrhea while their tympanostomy tubes are in place immediately postop­eratively or during an episode of acute otitis media (Fig.21.3). The drainage is usu­ally foul-smelling, mucoid, and may be mixed with blood. It is generally treated with antibiotic drops. Suction cleaning of the ear canal may be needed for slides to be effective. Rarely, systemic antibiotics or even mastoid surgery is required if the drainage is persistent.
In a patient with a history of trauma or compromised immune system, the pres­ence of otorrhea can be a sign of a critical and potentially life-threatening condition.
Fig. 21.3 Endoscopic view of infected ventilation tube with mucoid discharge
282
Y. S. S. Yıldırım et al.
21.5.3 Traumatic Cerebrospinal Fluid Otorrhea
Trauma to the temporal bone can lead to immediate leaks through the fracture line or delayed leaks caused by obstructions in the cochlear aqueduct, typically due to soft tissue or bone. The presence of cerebrospinal uid (CSF) otorrhea is a signi­cant concern following head trauma. If there is any discharge from the ear noticed after a severe head injury, especially if it is clear or contains blood, it is essential to evaluate the patient for CSF otorrhea, which can originate from a basilar temporal skull fracture. Additionally, hemorrhagic otorrhea may result from middle ear trauma caused by a direct ear impact, auditory barotrauma, or the insertion of a foreign object into the external ear canal [8].
To assess the potential CSF leakage, a quick bedside test can be performed by placing a drop of ear drainage on absorbent material like a coffee lter or paper towel. A rapidly spreading “halo” or a ring of clear uid around the area stained with red blood indicates a positive result. However, it is crucial to note that the halo test does not differentiate between CSF, saline, saliva, or other clear uids and has not undergone formal clinical validation.
As an alternative, healthcare professionals may analyze the uid coming from the ear or nose for the presence of beta2 transferrin, a variant of the transferrin pro­tein primarily found in cerebrospinal uid.
21.5.4 Complications ofAcute Otitis Media
The mastoid air cells are linked to the far end of the middle ear through a narrow canal or antrum. Consequently, most instances of Acute Otitis Media (AOM) involve some degree of inammation in the mastoid. In exceptional cases, the mastoid infection does not resolve, leading to the development of acute mastoid­itis, characterized by the accumulation of pus within the mastoid air cells. The child with mastoiditis will have painful swelling behind the ear that typically pushes the pinna forward.
Other infratemporal complications that occur by contiguous spread of infec­tion include petrositis (Gradenigo syndrome with sixth nerve palsy) and labyrinthitis.
Intracranial complications arising from Acute Otitis Media (AOM) are of special concern when dealing with children who exhibit signs of illness. These complications can encompass conditions such as “meningitis, epidural abscess, brain abscess, lateral sinus thrombosis, cavernous sinus thrombosis, subdural empyema, and carotid artery thrombosis” [9, 10]. Patients experiencing these complications typically present with fever and gradually develop a toxic appear­ance. Some may also display cranial nerve decits, with cranial nerve VII (facial nerve) being the most commonly affected, and less frequently, cranial nerve VI [9, 10].
21 Otorrhea inChildren
283
21.5.5 Necrotizing Otitis Externa (Malignant External Otitis)
Malignant external otitis is a condition primarily affecting children who have chronic illnesses or are immunosuppressed. Clinicians should be on the lookout for signs such as severe and persistent ear pain, ear discharge containing Pseudomonas aeruginosa, a signicantly elevated erythrocyte sedimentation rate, and evidence of bone damage on a computed tomography scan, especially when dealing with these vulnerable populations. The infection typically starts with a skin infection and can progress to involve deeper structures like cartilage, tissue, and bone. As the infec­tion advances, it can lead to complications such as osteomyelitis at the base of the skull, osteomyelitis of the temporomandibular joint, the formation of brain abscesses, and the development of generalized bacterial sepsis. Culture of the exter­nal ear canal in otorrhea is rarely helpful, as Pseudomonas species are commonly identied with or without local infection. It is also quite difcult to obtain samples from the middle ear that are not contaminated by external canal ora. In addition, culture rarely changes management decisions in children with otorrhea.
Indications for culture of ear drainage include:
• Suspected necrotizing otitis externa
• Otitis media with chronic drainage, where previous treatment has failed
Patients with malignant external otitis classically present with otorrhea and exquisite otalgia which are not responsive to topical measures used to treat simple external otitis. The pain is generally more severe than that found in simple external otitis, although the two may be difcult to distinguish in their early stages. The pain in malignant external otitis tends to extend into the temporomandibular joint, result­ing in pain with chewing [11].
On physical examination, purulent otorrhea is seen in more than half of cases, and ipsilateral lower motor neuron facial nerve palsy can also be present. Granulation tissue may be visible in the inferior portion of the external auditory canal at the bone–cartilage junction (at the site of Santorini’s ssures). This nding may be absent in atypical patients (e.g., HIV-infected patients and children). Early empiric antibiotic therapy and, if needed, surgery are essential to good outcomes [12].
21.5.6 Neoplasms
Cancer is an uncommon source of otorrhea in childhood; however, it should be taken into consideration in cases where there is abnormal tissue growth in the ear canal or when extended treatment for external otitis does not yield the expected results.
Ear canal cancer is a less frequent occurrence compared to cancer in the outer ear (auricular cancer), but it tends to present with more aggressive characteristics. During the initial stages, it may be challenging to distinguish it from external otitis.