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Comprehensive ENT
HasanYüksel OzgeYilmaz NurayBayarMuluk CharlesM.MyerEditors
Pediatric Airway Diseases
Comprehensive ENT
Series Editor
CemalCingi, Department of Otorhinolaryngology, Medical Faculty, Eskişehir Osmangazi University, Eskisehir,Türkiye
As technology progresses, there are continuous advances in every medical subspeciality, and otorhinolaryngology/ENT is a particularly outstanding example of this. ENT lends itself well to the development of innovative and sophisticated solutions, including those affecting the vital area of airway management. Rhinoplasty and related cosmetic procedures are now a well-established part of ENT practice, and make major contributions to patient well-being, quality of life and social function. The series also covers the key principles involved in the use of social media for advertising and sharing cosmetic outcomes, from minor procedures to full-scale surgical operations. The series gathers ENT and related sub-specialty experts from across the globe and translates their knowledge into easily accessible, well-structured summaries of the current state of knowledge, with accompanying illustrations, diagrams and summary tables. Each volume is under the leadership of editors who are thoroughly familiar with the area covered and understands exactly which information is of most relevance and interest to those entering the eld for the rst time or seeking to update their existing knowledge. The series both outlines precisely the current state of the art in each area of ENT practice and shows where the future of the feld may lie. The fundamental scientifc basis of various disorders is covered, including molecular and cellular aspects, as well as diagnostic practice and the appropriate use of investigations. Historical aspects will be covered where they cast light on the general direction of the specialty. The latest developments in clinical management, disease prevention and public health aspects are described. The series shows how these multiple scientifc and clinical aspects can be best understood in supporting an individual, personalized approach to patient care that fts the patient-centered ethos of twenty-frst century ENT healthcare.
Hasan Yüksel • Ozge Yilmaz Nuray BayarMuluk • Charles M. Myer
Editors
Pediatric Airway Diseases
Editors
Hasan Yüksel Department of Pediatric Pulmonology and Department of Pediatric Allergy and Immunology Celal Bayar University, School of Medicine Manisa, Türkiye
Nuray BayarMuluk Department of Otorhinolaryngology Kırıkkale University Kırıkkale, Türkiye
Ozge Yilmaz Department of Pediatric Allergy and Immunology Celal Bayar University, School of Medicine Manisa, Türkiye
Charles M. Myer Academic Health Center University of Cincinnati Cincinnati, OH, USA
ISSN 2731-6742 ISSN 2731-6750 (electronic) Comprehensive ENT ISBN 978-3-031-74852-3 ISBN 978-3-031-74853-0 (eBook)
https://doi.org/10.1007/978-3-031-74853-0
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2024 This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether the whole or part of the material is concerned, specically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microlms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specic statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional afliations.
This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
If disposing of this product, please recycle the paper.

Contents

Part I General Concepts of Upper Respiratory Tract for Pediatric
Pulmonology
1 Embryological Origins of the Upper and Lower Respiratory Tract . . . . 3
Şeyda Demir Yüksel, Georgina Siordia, and H. Alper Bağrıyanık
2 Histological Characteristics of the Upper Respiratory Tract:
Continuum with Lower Respiratory Tract . . . . . . . . . . . . . . . . . . . . . . . . 17
Elgin Turkoz Uluer, Muhammed Yusuf Pekmezci, Ralph Epaud, and Mahmud Kemal Ozbilgin
3 Structural and Physiological Basis of the Upper
Respiratory Tract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33
Oğuzhan Oğuz, Nuray Bayar Muluk, and Felicia Manole
4 Congenital Anomalies of the Upper Respiratory Tract . . . . . . . . . . . . . . 49
Emine Körkuyu Yardımcı, Cemal Cingi, Emmanuel P. Prokopakis, and Nuray Bayar Muluk
5 Immunological Defense Mechanisms of the Respiratory System . . . . . . 69
Neslihan Edeer Karaca, Ayse Aygun, and Tsvetelina Velikova
6 Innate and Adaptive Immunity of the Respiratory System . . . . . . . . . . 77
Esra Hazar, Mehmet Ali Karaselek, and Sevgi Keles
7 Immune Responses to Respiratory Infections . . . . . . . . . . . . . . . . . . . . . 89
Ezgi Topyildiz, Francesco Cinetto, and Guzide Aksu
8 Respiratory Microbiome . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97
Ülkü Rabia Korkmaz, Omer Faruk Cetiner, Asha Rani, Ravi Ranjan, and Ayşe Bilge Öztürk
9 Communication with Sick Children . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113
Burak Çakir, Alberto Adalid, and Öznur Bilaç
10 Communication with Sick Child’s Parents . . . . . . . . . . . . . . . . . . . . . . . 119
Can Cemal Cingi
v
vi
Contents
Part II Diagnostic Testing
11 Radiologic Evaluation of Upper Respiratory System . . . . . . . . . . . . . . 129
Gonca Koc, Aloisia Paloma Hernandez Morales, and Huseyin Hudaver Alper
12 Radiologic Evaluation of Lower Respiratory System . . . . . . . . . . . . . . 151
Sevinç Taşar and Recep Savaş
13 Fundamentals of Upper Respiratory Tract Endoscopy . . . . . . . . . . . . . 177
Semih Ak, Nuray Bayar Muluk, and Sheng-Po Hao
14 Upper Airway Evaluatıon: Dıagnostıc Clues from Upper
Respıratory Tract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 189
Sedef Narin Tongal, Adaeze Ayuk, and Hasan Yüksel
15 Preschool Lung Functıon Testıng and the Upper
Respıratory Tract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 199
Seda Tunca, Özge Yilmaz, and Enrico Lombardi
16 Spirometry and Upper Respiratory Tract . . . . . . . . . . . . . . . . . . . . . . . 205
Václav Koucký and Nazan Cobanoglu
17 Allergen Testing: Purpose, Procedure, Interpretation . . . . . . . . . . . . . 215
Cansu Özdemiral and Ümit Murat Şahiner
18 Smell Testing: Purpose, Procedure, Interpretation . . . . . . . . . . . . . . . . 237
Ali Türkcan, Nuray Bayar Muluk, and Philippe Rombaux
19 Taste Testing: Purpose, Procedure, Interpretation . . . . . . . . . . . . . . . . 247
Ramazan Öcal, Nuray Bayar Muluk, and Desiderio Passali
Part III Symptoms and Signs Related with Upper
and Lower Respiratory Tract Diseases
20 Otalgia in Children . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 263
Yeşim Yüksel, Erdem Atalay Çetinkaya, and Codrut Sarafoleanu
21 Otorrhea in Children . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277
Yavuz Sultan Selim Yıldırım, Nuray Bayar Muluk, and Chae-Seo Rhee
22 Nasal Congestion in Children . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 287
Murat Gümüşsoy and İbrahim Çukurova
23 Nasal Itching and Sneezing in Children . . . . . . . . . . . . . . . . . . . . . . . . . 313
Nurullah Türe and Fatih Oğhan
24 Rhinorrhea: Pathogenesis, Diagnosis, and Treatment . . . . . . . . . . . . . . 327
İlker Burak Arslan and İbrahim Çukurova
Contents
vii
25 Tonsillary Hypertrophy in Children . . . . . . . . . . . . . . . . . . . . . . . . . . . . 337
Abdullah Kınar, Cemal Cingi, and Tania Sih
26 Halitosis Due to Pediatric Ear, Nose, and Throat Field Infections . . . . 345
İlyas Dişikırık and Mahmut Alper Kanmaz
27 Dysphonia in Children . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 363
İbrahim Çukurova and İlter Denizoğlu
28 Dysphagia in Children . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 371
Dogan Barut, Grazia Fenu, and Funda Cetin
29 Cervical Lymphadenopathy in Children . . . . . . . . . . . . . . . . . . . . . . . . 385
Mehmet Kantar and Eda Ataseven
30 Chronic Cough in Children: Upper Respiratory Tract Related
Etiologies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 391
Tugba Ramasli Gursoy and Laura Gochicoa-Rangel
31 Upper Respiratory Tract Comorbidities in Children
with Wheezing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 403
Şule Büyük Yaytokgil and Ersoy Civelek
32 Hemoptysis in Children: ENT-Related Etiologies . . . . . . . . . . . . . . . . . 417
Muge Ozcelik Korkmaz, Cemal Cingi, and Kamil Janeczek
Part IV Pediatric Pulmonology Disease Specic Upper Respiratory
Tract Involvement
33 Airway Inflammation: United Airway in Children . . . . . . . . . . . . . . . . 429
Mahir Serbes, Renato Cutrera, and Derya Altıntaş
34 Pediatric Allergic Rhinitis: Otolaryngology Perspective . . . . . . . . . . . . 437
Mert Cemal Gökgöz, Cemal Cingi, and Gabriela Kopacheva-Barsova
35 Allergic Rhinitis: Pediatric Pulmonologist Perspective . . . . . . . . . . . . . 455
Ahmet Turkeli and Batuhan Berk Demir
36 Allergic Rhinitis: Clinical and Therapeutic Aspects in Asthma . . . . . . 467
Adem Yaşar, Erol A. Gaillard, and Ozge Yilmaz
37 Meeting Organ for ENT and Pediatric Pulmonology: Adenoids . . . . . 475
Çiğdem Firat Koca, Cemal Cingi, and Sergei Karpischenko
38 Meeting Organ for ENT and Pediatric Pulmonology: Tonsils . . . . . . . 491
Duygu Demirbaş Keskin, Ayşe Seçil Kayalı Dinç, and Andrew A. Winkler
viii
Contents
39 Overview of Pediatric Rhinosinusitis . . . . . . . . . . . . . . . . . . . . . . . . . . . 517
Oben Yıldırım and Yusuf Dundar
40 Pediatric Rhinosinusitis and Comorbid Asthma . . . . . . . . . . . . . . . . . . 531
Beste Ozsezen and Hossein Sadeghi
41 Pediatric Otitis Media and Comorbid Asthma. . . . . . . . . . . . . . . . . . . . 541
Dilber Ademhan Tural, Şule Selin Akyan Soydaş, and Reloe Masekela
42 Pneumonia in Children and Comorbid Rhinosinusitis . . . . . . . . . . . . . 557
Gökçen Kartal Öztürk, Zorika Zivkovic, and Demet Can
43 Sleep-Related Breathing Disorder: Upper Respiratory
Tract-Related Etiologies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 575
Birce Sunman and Uğur Özçelik
44 Upper Respiratory Tract Involvement in Cystic Fibrosis:
Genetics and Developmental Basis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 583
Azer Kilic Baskan, Ayse Ayzit Kilinc Sakallı, and Bruce K. Rubin
45 Upper Respiratory Tract Involvement in Cystic Fibrosis:
Clinics and Diagnosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 593
Pelin Asfuroğlu and Larry C. Lands
46 Upper Respiratory Tract Involvement in Cystic Fibrosis . . . . . . . . . . . 601
Raziye Atan and Deniz Doğru Ersöz
47 Upper Respiratory Tract Involvement in Primary
Ciliary Dyskinesia: Genetics and Developmental Abnormalities . . . . . 605
Meltem Akgül Erdal, Nagehan Emiralioğlu Ordukaya, and Samya Nasr
48 Upper Respiratory Tract Involvement in Primary
Ciliary Dyskinesia: Clinics and Diagnosis . . . . . . . . . . . . . . . . . . . . . . . 611
Pelin Asfuroglu, Ophir Bar-On, and Tugba Sismanlar Eyuboglu
49 Upper Respiratory Tract Involvement in Primary
Ciliary Dyskinesia: Therapeutic Continuity . . . . . . . . . . . . . . . . . . . . . . 619
Handan Kekeç, Lina Jankauskaite, and Ayşe Tana Aslan
50 Primary Immunodeficiencies: Upper Respiratory
Tract Consequences . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 629
Zeynep Meric, Zita Chovancova, and Ayca Kiykim
51 Foreign Bodies in Children as A Cause of Upper
and Lower Airways Infection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 655
Melih Hangul, Mehmet Kose, and Hannah Blau
Contents
Part V Infectious Diseases of the Pediatric Airway
52 Rhinosinusitis in Children . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 663
Bünyamin Kutlu, Cemal Cingi, and Glenis Scadding
53 Adenoiditis in Children . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 677
Samet Aydemir, Cemal Cingi, and Luisa Maria Bellussi
54 Tonsillitis in Children . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 687
Saltuk Bugra Kilinc, Cemal Cingi, and Ljiljana Jovancevic
55 Epiglottitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 695
Ali Budak, Cemal Cingi, and Yusuf Dundar
56 Laryngitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 705
Berat Baturay Demirkiran, Nuray Bayar Muluk, and Stephan Lang
57 Tracheitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 717
Cem Bulut, Nuray Bayar Muluk, and Dennis Chua
58 Peritonsillar Abscess . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 727
Berzan Haznedar, Nuray Bayar Muluk, and Suela Sallavaci
59 Retropharyngeal Abscess . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 737
Mesut Yesilova, Nuray Bayar Muluk, and Nitin R. Ankle
60 Submandibular Space Infections (Ludwig’s Angina) . . . . . . . . . . . . . . 747
Taha Yasin Yildiz, Nuray Bayar Muluk, and Jeffrey C. Bedrosian
ix
Part VI Surgical Interventions for Upper Airway Management
61 Choanal Atresia Management . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 757
Rezzan Budak, Cemal Cingi, and Mario Milkov
62 Pediatric Functional Endoscopic Sinus Surgery . . . . . . . . . . . . . . . . . . 767
Ali Budak, Cemal Cingi, and Hesham Negm
63 Septoplasty to Provide Nasal Breathing in Children . . . . . . . . . . . . . . . 779
Soner Taşar, Cemal Cingi, and Jeffrey C. Bedrosian
64 Tracheostomy to Eliminate Upper Airway Obstruction
in Children . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 785
Murat Gumussoy and İbrahim Çukurova
65 Adenoidectomy and Tonsillectomy to Eliminate
Airway Obstruction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 805
Omer Çağatay Ertugay and Sema Zer Toros
66 Management of Laryngeal Webs in Children . . . . . . . . . . . . . . . . . . . . 811
Perçin Serhat Yergin and Sema Zer Toros