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Section 1: General Topics
Figure 1
ter an open transtibial amputation. A negative­pressure dressing covers the wound.
Photograph of a re sidual limb af-
the incision, but they do not provide a substantial degree of wound protec-
1,2
tion.
Soft dressings are ubiquitous in their use and inexpensive. Wrapping gauze rolls over the end of the residual limb frequently requires some exper­tise to ensure even distribution. Major disadvantages of soft dressings are that they tend to loosen and require reap­plication as frequently as every 3 to 4 hours. These dressings may provide padding when a compressive sleeve or rigid dressing is required.
Petroleum-impregnated gauze is fre­quently applied to the incision site at the conclusion of the surgical proce­dure, and it is then covered with reg­ular gauze. Some form of wrap (often a gauze roll or elastic wrap) is then ap­plied. Many surgeons use these dress­ings instead of rigid dressings because they prefer to view the incision site on a daily basis, although it has been shown that this is often unnecessary.
3
In 1980, Kane and Pollak4 reported no statistical difference in narcotic use among patients with amputations
Figure 2
after an open transfemoral amputation. A negative- pressure wound dressing was applied at the end of the rst-stage surgery.
Photograph of a residual limb
resulting from vascular causes who were treated with soft dressings or those who were fitted with an immediate postop­erative prosthesis (IPOP). However, the analgesic protocols at that time were different from those in current use. Nonetheless, wound necrosis developed in 21% of the patients treated with the IPOP, and infection occurred in another 21% of those patients. In the patients treated with soft dressings, wound ne­crosis developed in 17% and infection occurred in 33%, which was not statis­tically different from those treated with rigid dressings. The authors noted that 56% of the patients managed with the IPOP became prosthesis users compared with 22% of the patients managed with soft dressings. There were no reported important beneficial or harmful effects of the IPOP on early healing outcomes after amputation.
Negative-Pressure Wound Dressings
Negative-pressure wound dressings (also known as vacuum-assisted closure dressings) are becoming more widely used and are commonly applied in
orthopaedic surgery for open wounds associated with fractures, after wound débridements, and before skin closure, as well as for contaminated and infect­ed wounds when closure is contraindi­cated (Figures 1 and 2). These devices use open-pore foam to fill the wound cavity, an occlusive wound dressing, suction tubing, and a suction device. A wound-healing mechanism of action of negative-pressure wound dressings is the bringing together of the wound edges by the suction distributed through the foam sponge.
5,6
Another healing mechanism of action, which has been determined by finite element computer analysis, is the 5% to 20% strain that negative-pressure wound dressings pro­duce across the healing tissues. This strain promotes cell division and pro­liferation, growth factor production, and angiogenesis.6 Other reported benefits of negative-pressure wound dressings are removal of edematous fluid and ex­udate from the extracellular space and removal of inflammatory mediators and cytokines, whose prolonged effect can hinder the ability of the microcirculation to support damaged tissue. Another pos­itive factor in wound healing is reduc­tion of wound desiccation and enhanced formation of granulation tissue. There is convincing evidence to support the hypothesis that the reduction of lateral tension and hematoma, coupled with an acceleration of the elimination of tissue edema, are the main beneficial mech­anisms of action of negative-pressure wound therapy over the incision site.
7
Over the past several years, there has been an increased frequency in managing residual limb wounds with negative-pressure dressings applied over the incision site at the conclusion of sur­gery (Figures 3 and 4). Applying these dressings to closed incisions reduces the relative risk of infection.8 A ran­domized controlled trial demonstrated a decrease in postoperative seromas after the application of incisional negative­pressure wound dressings after total hip
Atlas of Amputations and Limb Deciencies, Fourth Edition © 2016 American Academy of Orthopaedic Surgeons
32
Chapter 3: General Principles of Postoperative Residual Limb Management
arthroplasty.
9
A study by Hansen et al10 confirmed that negative-pressure dress­ings reduced or eliminated incisional drainage after hip arthroplasty, and no adverse effects were reported. Negative pressure set between 50 and 125 mm Hg helps to reduce edema and decrease incisional drainage.6 Negative-pressure incisional dressings are kept in place for 3 days and may be reapplied or dis­carded. If no additional fluid collects in the canister over a 12-hour period, it is recommended that the dressing be discontinued. However, it is likely that, because of the decreased wound edge tension created by the negative-pressure dressing, there is often no measurable fluid accumulation in the collection reservoir. Recent studies have noted that the benefits of negative-pressure dressings may be associated with ede­ma reduction, increased blood flow, and increased granulation tissue in the wound.
6,7
After 3 to 5 days of postoper­ative negative-pressure wound therapy, healing time may be reduced, and there is evidence of a reduced incidence of wound healing complications and a re­duced frequency of infections.7 Karlakki et al7 reported the existence of good ev­idence for incisional negative-pressure wound therapy in orthopaedic surgery because of the frequency of patient co­morbidities and the substantial inci­dence of infection. Brem et al11 reported that incisional negative-pressure wound therapy may reduce the risk of delayed wound healing and infection after severe trauma and orthopaedic interventions. In some instances, a rigid dressing may be placed over the negative-pressure wound dressing on the residual limb for added protection.
12
Negative-pressure wound dressings also can be used over open wounds be­fore definitive skin closure in situations such as traumatic amputations and in the presence of infection when a two- or three-stage amputation is planned.13 For open wounds, a new negative-pressure dressing is applied at the second-stage
Figure 3
after a transtibial amputation. An incisional negative-pressure dressing was applied imme­diately postoperatively.
Photograph of a residual limb
surgery. Two studies reported good re­sults with the application of a custom, topical negative-pressure dressing for open amputations.
14,15
Hydrofiber Dressings
Hydrofiber wound dressings consist of soft nonwoven sodium carboxymeth­ylcellulose fibers integrated with ionic silver. This is a moisture-retention dress­ing, which forms a gel on contact with wound fluid and has the antimicrobial properties of ionic silver.
1,16
After the use of a negative-pressure dressing, a hydrofiber with silver dress­ing may be applied over the incision (Figure 5). This dressing can remain in place for up to 7 days and may cover sutures. Because the dressing is imper­vious to water, patients may shower with the dressing in place. There has been renewed interest and research in using ionic silver (the oxidized active state of silver) as a prophylactic antimicrobial agent in wound dressings because of its broad-spectrum antibacterial range.16 The gel promotes a moist wound­healing environment but absorbs any wound exudate and contains it away from the wound. Because of the anti­microbial effect of silver, this dressing has the potential to reduce postoperative infections.1 Cutting et al17 reported that
Figure 4
after a transfemoral amputation. An incisional negative-pressure wound dressing was appli ed at wound closure.
Photograph of a residual limb
the silver in the hydrofiber dressing pro­vides a certain amount of resistance to infection. In a randomized study of acute surgical wounds in 100 patients, the performance of hydrofiber and alginate dressings was compared.18 Ninety-two percent of patients randomized to the hydrofiber dressing were found to ex­perience less pain (mild or none) com­pared with 80% of those who received alginate dressings. Similarly, 84% of patients who had hydrofiber dressings were pain free at 1 week postoperative­ly compared with 58% of those treated with alginate dressings. Although sta­tistical significance was not shown, the authors concluded that hydrofiber dressings consistently performed better than the alginate dressings.
Compressive Dressings
Compressive dressings consist of elastic and conforming dressings. The origi­nal compressive dressing was an elastic bandage or sleeve. Newer materials have been developed to apply more uniform pressure over the residual limb. These dressings apply a measure of com­pression to the limb and help control postoperative edema. sic compression dressing is the elastic wrap, which should be applied in a fig­ure-of-8 configuration, with the most pressure applied distally to proximally
19,20
The most ba-
© 2016 American Academy of Orthopaedic Surgeons Atlas of Amputations and Limb Deciencies, Fourth Edition
33
Section 1: General Topics
Figure 5
(A) and the incision site 10 days after surgery (B).
Photographs of a hydrober dressing in place over a transtibial amputation incision
(Figure 6). Applying uniform pressure is difficult with this method, so the wraps have to be reapplied every 4 to 6 hours. Volume reduction takes more time in the first 2 weeks after surgery with elastic compression dressings compared with rigid dressings and is not as effective.
21,22
Another form of elastic dressing is an elastic shrinker or sock, which has built-in elasticity and is rolled onto the limb23 (Figure
7). The socks are available in various sizes and materials, are provided by a prosthetist, and may be kept in place throughout the day and night for as long as required. They are helpful at night to reduce edema when a prosthesis has been fitted and is doffed after daily use. In shorter residual limbs, a suspension belt may be required to hold the shrink­er sock in place.
Compression devices to help reduce edema include polymer gel socks and thermoplastic and silicone liners
24,25
(Figures 8 and 9). These devices are rolled onto the limb and stay in place because of their compressive force and associated evenly distributed shear fric­tion. They are more effective in edema reduction than elastic bandages. The
liners also are used within the prosthetic socket and may provide suspension as­sistance in addition to padding.
A technique that is now rarely used after amputations is the Unna paste dressing, a mixture of zinc oxide, cal­amine, gelatin, and glycerin that is ap­plied over successive layers of residual limb bandages that have been applied in a figure-of-8 configuration.
26,27
After 24 hours, a semirigid, inextensible dress­ing is formed that prevents edema. The dressing may be used for any level of amputation. This type of dressing was previously used primarily by physical therapists and physical medicine and re­habilitation physicians, but it has fallen out of favor because of newer materials and techniques.
Protective Dressings
Protective dressings include rigid and semirigid dressings and pneumatic postamputation mobility (PPAM) aids. These dressings are designed to protect the residual limb in the immediate post­operative period and are used only for a limited time until edema of the resid­ual limb has decreased and provisional wound healing has occurred.
Figure 6
wrapped with a gure-of-8 elastic compressive bandage after a transtibial amputation.
Figure 7
elastic sock rolled over a residual limb after a transtibial amputation.
Photograph of a residual limb
Photograph showing a tubular
Rigid Dressings
Rigid dressings are recommended for transtibial and more distal amputations in the lower limb and for transradial and more distal amputations in the upper limb. Rigid dressings are kept in place for 5 to 7 days by a suspension strap28 (Figure 10). A rigid dressing is applied in the operating room by the surgeon or prosthetist, with appropriate padding
Atlas of Amputations and Limb Deciencies, Fourth Edition © 2016 American Academy of Orthopaedic Surgeons
34
Chapter 3: General Principles of Postoperative Residual Limb Management
Figure 8
and a tubular liner for a transtibial amputation (B).
Photographs of a thermoplastic liner in place over a transfemoral amputation (A)
over the bony prominences. The rigid dressing is removed after 5 to 7 days, and may be replaced if required. At the time of removal, the wound can be evaluated. In a review of the published literature, Smith et al2 reported that several studies demonstrated that pa­tients treated with plaster cast dressings had substantially quicker rehabilitation times and less edema compared with those treated with soft gauze dressings. The authors also noted that patients treated with prefabricated prostheses had substantially fewer postoperative complications and required fewer revi­sions to a higher level compared with those treated with soft gauze dressings. A retrospective study by Sumpio et al28 noted that transtibial amputations man­aged with a rigid dressing as opposed to a soft dressing had significantly quicker healing times (P = 0.02) as measured by the time needed before prosthesis casting. Of 151 patients analyzed, 60 were treated with soft dressings and 91 with rigid dressings. Patients with a soft dressing had a statistically increased prevalence of diabetes mellitus, hyper­tension, and chronic renal failure com­pared with the rigid dressing group. The two groups did not show any significant
differences with regard to complications caused by infection or cellulitis. Patients with rigid dressings healed in a median time of 76 days compared with 127 days for the group treated with soft-dressings. Fifty percent of patients treated with a rigid dressing had an initial casting for a prosthesis within 43 days compared with 75 days for those receiving a soft dressing.
A 2005 study reported an improve­ment in the time to delivery of the pros­thesis when a rigid dressing was used.19 In comparison to the elastic bandaging method, the use of a rigid dressing re­sulted in a statistically significant shorter period from amputation to the delivery of the first regular prosthesis (110 days versus 50 days, respectively) and a de­creased risk of knee flexion contracture. Other studies have confirmed that rigid dressings are preferable to soft dressings for managing patients with transtibial amputation and result in substantially shorter times from amputation to cast­ing or fitting of a prosthesis.
20,2 9,30
Vigier et al31 noted that rigid dress­ings helped promote healing in open wounds of residual limbs associated with transtibial amputations for vascu­lar disease, as well as leading to shorter
Figure 9
silicone liner with rings for vacuum suspension.
Figure 10
with an outer covering of berglass on a re­sidual limb after a transtibial amputation. The device for the suspension strap is seen at the anterior brim.
Photograph of a transfemoral
Photograph of a rigid dressing
hospital stays. In 2010, Johannesson et al25 evaluated outcomes using rigid dressings and silicone compression lin­ers in a standardized surgical and reha­bilitation program for 217 individuals
© 2016 American Academy of Orthopaedic Surgeons Atlas of Amputations and Limb Deciencies, Fourth Edition
35
Section 1: General Topics
who had undergone transtibial ampu­tation for peripheral vascular disease. The authors reported a reduction in morbidity in patients treated by a ded­icated team using a protocol requiring a rigid dressing for 5 to 7 days postop­eratively and subsequent incremental applications of a silicone liner to apply residual limb compression. Prosthetic fitting was achieved in 119 of the pa­tients (55%), and 76 of those patients (64%) achieved good function. Of the 217 patients in the study, 51% had diabetes, more than 75% could walk before amputation, and approximate­ly 50% were living in an elderly care nursing home. The reamputation rate (amputation to a higher level) during the first year was 8.2%.
The use of rigid dressings may be limited by application difficulties and gaining access to the incision. In a 2008 study, Johannesson et al32 compared the use of a removable vacuum-formed rigid dressing and a conventional rigid plaster of Paris dressing in 27 patients treated with transtibial amputation. The authors found that a vacuum-formed removable rigid dressing appears to achieve results similar to those of a conventional rigid dressing regarding time to prosthetic fitting and a patient’s function with a prosthesis.
Removable Rigid Dressings
Removable rigid dressings are most frequently used after transtibial ampu­tations and are easy to apply and use (Fig ure 11). A removable rigid dressing is a transtibial cast that is suspended using an outer layer of stockinette and held by a supracondylar femoral cuff. This technique is an effective method for postoperative, preprosthetic, and prosthetic care of transtibial amputees.33 Removal rigid dressings allow additional shrinker socks to be applied as edema in the residual limb decreases.34 The re­moval rigid dressing is used for 2 to 3 weeks in preparation for fitting with a preparatory prosthesis.
Figure 11
applying a supracondylar femoral suspension strap over an outer stockinette.
Photographs of an individual
A 2005 randomized controlled study of 50 dysvascular transtibial amputees reported that primary wound healing of the residual limb occurred approx­imately 2 weeks earlier in patients treated with a removable rigid dress­ing compared with those treated with a standard soft dressing.35 Both dressing types were applied immediately post­operatively and were only removed for wound dressing changes. There were no significant differences in the two groups in time to prosthetic fitting, length of hospital stay, incidence of residual limb breakdown, and time needed for volume stabilization of the residual limb. The authors proposed that removable rigid dressings protect the new residual limb from trauma while permitting regular wound access, care, and assessment.
Although upper limb amputations are less frequent than those for the lower limb, removable rigid dressings have a place in the management of these patients. The principles of wound care are the same, and timely healing is a major goal.
IPOP Fitting
IPOP use has been recommended for mobilizing patients immediately after amputation surgery. A rigid dressing is applied after an incisional dress­ing has been placed. Adequate pad­ding over bony prominences (such as the fibular head, tibial crest, and
Figure 12
postoperative prosthesis made using a plaster cast and prosthetic foot.
Photograph of an immediate
patella) is essential, and a pylon and foot are incorporated below the cast30 (Fig- ure 12). A prosthetist should ensure correct alignment of the IPOP, and pa­tient mobilization should be supervised by a therapist. Initially, partial weight bearing is permitted for a few minutes at a time, with a gradual increase as the patient is able to cooperate and regain strength. Cast changes are necessary when edema has decreased and there is a volume discrepancy between the residual limb and the cast. For patients to be considered for an IPOP fitting, certain requirements should be met, including preoperative ambulatory sta­tus, no evidence of active infection, good motivation, willingness to comply with the required postoperative protocol, and good healing potential.30 Incision break­down with the IPOP fitting technique has been noted, and its use has become less popular. One study reported that skin breakdown was higher in the IPOP group of patients than in the non-IPOP group, but the need for revision surgery was lower.30 The current practice is to
Atlas of Amputations and Limb Deciencies, Fourth Edition © 2016 American Academy of Orthopaedic Surgeons
36
Chapter 3: General Principles of Postoperative Residual Limb Management
ensure wound healing in a 2- to 4-week timeframe and then begin prosthetic fit­ting and supervised therapy.
Postoperative Pneumatic Systems
The initial popularity and enthusi­asm of pneumatic systems seen in the 1980s has substantially declined, and there have been no scientific articles published in the past 10 years regard­ing their routine use. Pneumatic sleeves are not used in the United States but still see sporadic use in the United Kingdom, Europe, and Australia.
In the early 2000s, a pneumatic IPOP system was advocated for the mobili­zation of lower limb amputees. This prefabricated pneumatic system was applied in the operating room at the time of wound closure.35 The average time to custom prosthetic limb fitting was 8.1 weeks (range, 4 to 16 weeks). Another study reported on a removable, adjustable, prefabricated IPOP with pneumatic air bladders inflated to 20 to 30 mm Hg.36 In a study by Schon et al,37 19 patients managed with an IPOP were compared with a retrospective matched control group of 23 patients managed with soft dressings. Eleven patients in the soft dressing group required revi­sion procedures, whereas no patients in the IPOP group required surgical revi­sion. The pneumatic systems were used until the wound was healed; a custom prosthesis was then applied at an av­erage of approximately 3 months after the amputation surgery. For a variety of reasons, 11 patients were able to use the temporary device for only 14 days or less; however, this was not considered a failure of the technique.
Although the PPAM aid is not used in the United States, the device is used in select Scottish, Scandinavian, and Aus­tralian settings.38 The PPAM aid helps to reduce residual limb edema; allows reeducation of postural reactions, bal­ance, and gait; and prepares the residual limb for a standard prosthetic socket. It can be placed over a soft dressing, an
elastic wrapping, or a plaster cast. It is initially used for a very limited amount of time on a daily basis and under the supervision of a therapist. The PPAM aid is designed for partial weight bearing. With progress, use of the PPAM aid is increased over time to achieve longer weight bearing periods in the early postoperative period. The PPAM aid is suitable for individuals with knee dis­articulations and transtibial and long transfemoral amputations. A disadvan­tage of the PPAM aid is that it does not allow a transtibial amputee to flex or extend the knee during walking.38 An alternative device was developed that allows for knee flexion; however, no functional differences between the two devices was noted.
38
Pneumatic devices were purported to be superior to rigid cast IPOP because they are lighter in weight, allow for bet­ter compression control, and permit easy removal for incision inspection.2 Despite these early claims, they are infrequently used and have been superseded by mod­ern postoperative amputation dressings.
Summary
Because soft dressings for amputation wounds do not provide adequate protec­tion, the use of dressings that are more compressive and protective is general­ly recommended. With the advent of improved materials and techniques, rigid and removable rigid dressings are considered superior for the immedi­ate postoperative care of patients with transtibial and transradial amputations. Negative-pressure wound therapy is valuable for the first few days after sur­gery and is followed by an appropriate alternative dressing. Modern dressings reduce edema, enhance wound healing, and facilitate early mobilization. This al­lows for accelerated, definitive prosthetic fitting and initiation of gait training. In individuals with an upper limb ampu­tation, postoperative residual limb man­agement is vital to early prosthetic fitting and subsequent daily use of a prosthesis.
In the United States, current postoper­ative residual limb management after amputation involves the use of modern treatment techniques, removable rigid devices, systems for edema control and wound protection, and no or protected weight bearing until incision and wound healing are achieved.
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Atlas of Amputations and Limb Deciencies, Fourth Edition © 2016 American Academy of Orthopaedic Surgeons
38
Chapter 3: General Principles of Postoperative Residual Limb Management
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© 2016 American Academy of Orthopaedic Surgeons Atlas of Amputations and Limb Deciencies, Fourth Edition
39
Chapter 4
General Principles of Limb Salvage Versus Amputation in Adults
Christopher Bibbo, DO, FACS David J. Polga, MD Samir Mehta, MD Stephen J. Kovach III, MD
Abstract
e decision to attempt limb salvage of an injured or diseased limb requires good clini­cal judgment, knowledge of the pathologic process that put the limb in jeopardy, and an understanding of the social and psychological prole of the patient. Each patient must be treated as an individual based on his or her current medical and physiologic status. A few of the factors that require consideration are the patient’s premorbid conditions, psychosocial factors, desires and expectation, social support network, and accessibility to reconstruction services. Knowledge of the general principles of limb salvage versus amputation will aid in providing optimal treatment for these patients.
Keywords: amputation; diabetes; extremity; flaps; infection; limb salvage; trauma; tumor; vascular disease
Introduction
A limb (primarily a lower limb) that is at risk for amputation and being con­sidered for salvage may be simplistically categorized to primarily possess a vas­cular, infectious, tumorous, or trauma­related etiology. In reality, however, these categories often overlap, increas­ing the degree of difficulty to achieve limb salvage; unfortunately, difficulties in healing and recovery after an ampu­tation can escalate concurrently.
The general principles of limb salvage versus amputation in adults mandate that the first consideration is always life over limb. Dire circumstances are most commonly encountered in patients with
Dr. Polga or an immediate family member is a member of a speakers’ bureau or has made paid presentations on behalf of Synthes. Dr. Mehta or an immediate family member has received research or institutional support from Amgen, Medtronic, and Smith & Nephew; is a member of a speakers’ bureau or has made paid presentations on behalf of Smith & Nephew, Zimmer, and AO North America; serves as a paid consultant to or is an employee of Smith & Nephew and Synthes; and serves as a board member, owner, ocer, or committee member of the Pennsylvania Orthopaedic Society. Dr. Kovach or an immediate family member has received research or in stitutional support from KCI and is a member of a speakers’ bureau or has made paid presentations on behalf of Davol. Neither Dr. Bibbo nor any immediate family member has received anything of value from or has stock or stock options held in a commercial company or institution related directly or indirectly to the subject of this chapter.
serious infections or multiple traumatic injuries. If limb salvage is contemplated, the surgical team must weigh wheth­er the treatment required for salvage is worse than the condition or the disease state. For example, if salvage of a limb with extensive tibial osteomyelitis is be­ing considered in a patient who is frail, elderly, and diabetic, the possibility of organ failure, irreversible functional decline, and a stiff nonfunctional limb, may indicate amputation as the prudent option. The adage of “burn no bridges” is especially important for the at-risk limb. Any procedure must be executed with deference to subsequent surgical interventions: how step one will affect
steps two, three, and so forth. An essen­tial component to the overall treatment strategy is that backup management plans must be in place in the event of a change in the patient’s condition.
The principles of limb salvage versus amputation in adults—whether in acute, chronic, or staged settings—mandate the assessment of several key issues that immediately and secondarily surround the patient’s symptoms, including the patient’s physiologic reserve and medical comorbidities; arterial, venous, and lym­phatic patency (vascular status); neu­rologic and psychological/psychiatric statuses; functional potential and qual­ity of life; surgical site considerations and surgical procedures available from the surgical team(s); and the availabil­ity of multidisciplinary resource teams during the immediate perioperative and rehabilitative phases of treatment. The key assessments in all patients are phys­iologic reserve, medical comorbidities, and vascular status.
Physiologic Reserve and Medical Comorbidities
A patient must have adequate phys­iologic reserve to withstand limb sal­vage. Moreover, all correctable organ system pathologies (for example, renal, endocrine, cardiac, and hepatic) must be addressed to maximize healing of both limb salvage and amputation pro­cedures. The most commonly encoun­tered conditions are acute metabolic and cardiac issues resulting from the cir­cumstances of acute settings, as well as age-related conditions. A patient’s nutri­tional health and immune competence
© 2016 American Academy of Orthopaedic Surgeons Atlas of Amputations and Limb Deciencies, Fourth Edition
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