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5 Masters Program Colorectal Pathway: Laparoscopic Left Colon Resection…
Standard venous thromboembolism prophylaxis and preoperative intravenous antibiotics should be administered in accordance with SCIP (Surgical Care Improvement Project) guidelines [12]. This has been shown to minimize the risk of surgical site infection. Enhanced recovery programs also call for antinausea prophy­laxis to be administered [12]. Currently, alvimopan is not indicated for laparoscopic surgery, as it has not been clearly shown to improve postoperative outcomes; how­ever, we will give a single dose to patients at high risk of conversion, and this will continue postoperatively if the patient is converted to open surgery. For more details on enhanced recovery recommendations, please refer to the chapter on enhanced recovery protocols in colorectal surgery (Chaps. 7 and 8).
65

Operative Setup

Patients are placed in a modied lithotomy position, ensuring that the legs and arms are positioned appropriately to avoid nerve injury. The patient’s arms should both be tucked by their sides, with the use of sleds if needed for larger patients. In order to overcome the steep Trendelenburg positioning, a bean bag may be placed under­neath the patient, the chest may be taped to the table, or anti-sliding padding can be used. The lithotomy position is important so access to the anus is maintained.

Operative Technique: Surgical Steps

The basics steps of laparoscopic colectomy for CD follow similar principles to those described in the chapters on laparoscopic left and sigmoid colectomy for benign (Chap. 3) and malignant disease (Chap. 17). In cases of abscess and stula with inammatory bowel disease, and similar to some complex diverticular disease, there are several operative steps that are helpful.
Laparoscopic Access
Many of these cases are re-operative in nature. Even so, we start with a sub- umbilical cutdown to insert a Hasson balloon port. This commonly is quite straightforward. If there are adhesions or concerns of adherent intestine, a lateral 5mm visual port is inserted, away from the area of the pathology. This guides placement of a second port which allows adhesiolysis and insertion of additional ports as required.
Definition ofAnatomy andPathology andAbscess Management
The procedure starts with a review of the area of pathology. Multiple small bowel loops may be involved and there may be extensive adhesions. The operation then starts with lysis of adhesions, separating each loop individually off the phlegmon.
66
A. R. Bhama and C. P. Delaney
In these cases, the entire small bowel will be examined extracorporeally, but if there are areas of particular concern, they are marked with a laparoscopic 3-0 polygly­colic acid suture. Loops of small bowel that contain stulas are controlled by an endoloop suture, to minimize intraabdominal leakage and contamination. Generally, each adherent loop of bowel is separated so that they can be removed through a small incision for resection or examination.
Once the small bowel loops have been separated, the colon can be evaluated. The decision of whether the mesentery or bowel is mobilized rst really depends on what step will facilitate dissection of the diseased segment most safely and effec­tively. Oftentimes, the best strategy is to start by mobilizing the bowel proximal to the pathology in order to dene the correct anatomical planes. This will help iden­tify anatomic landmarks and guide the dissection safely toward the diseased seg­ments and associated phlegmons, abscess cavities, and/or stulas. This dissection will lead next to taking down colovesical, colovaginal stulas, or even left lower quadrant cutaneous stulas. These are transected with a combination of sharp dis­section with scissors and blunt dissection using a Maryland or bowel grasper. For those who like energy devices for dissection, these are particularly unsuitable in stula and abscess cases, as the tissues are often so thickened that the energy devices cannot be closed effectively. When a pericolonic abscess cavity is unroofed, a suc­tion device is immediately positioned into the cavity to aspirate out all pus before it contaminates the abdomen. The goal at this stage is simply to control and minimize spillage of purulence. The use of monopolar cautery should be minimized in order to avoid inadvertent burn injury to the bowel. Sponges can be very helpful to achieve hemostasis as well as to provide effective bowel retraction. Frequently ovaries, fal­lopian tubes, or the appendix may be adherent to the inammatory phlegmon or abscess and must be carefully separated. If the appendix is involved, it is removed as per routine. Once the pathology and anatomy have been fully dened, the entire small bowel should be examined for disease, as described above.
Another important consideration is identication of the ureter. Frequently the ureter may be more medial than expected due to distorted anatomy from the inam­matory process. Consider ureteral stents, although these are generally not required except for cases with a psoas abscess, prior pelvic surgery, or some colovaginal stulae with a phlegmon involving the pelvic sidewall.
Mobilization andDivision ofMesentery
For the left colon, a low ligation of the inferior mesenteric vessels is adequate unless there is dysplasia or a concern for cancer. Our preferred approach in cancer is a medial to lateral approach to the mesentery. This frequently also works well in cases with inammatory disease. Usually the easiest rst step is to grasp the rectosigmoid mesentery and elevate it from the retroperitoneum and incise with scissors or cau­tery parallel to the inferior mesenteric vessels over the sacral promontory. This allows CO routine. If there is too much tethering on the mesentery because of a vesical stula,
to distend the presacral space, and the mesentery is mobilized as per
2
5 Masters Program Colorectal Pathway: Laparoscopic Left Colon Resection…
67
this is taken down rst. The left colic vessels may need to be divided to achieve adequate length for tension-free colorectal anastomosis.
In cases where the abscess is medial, however, a medial approach is fraught with difculty, and there is frequently too much inammation to visualize any plane. Rather than transecting the mesentery blindly, we will switch to a lateral to medial approach. The planes there are often more manageable, even allowing mobilization as far medial as the ureter and presacral space. If that is not the case, move proxi­mally on the descending colon, and a plane can usually be found. The last option is a high medial approach, coming between the duodenojejunal exure and the infe­rior mesenteric vein, which generally allows entry to a clean anatomical plane.
If there is any doubt about an anatomical plane, stay inside the mesenteric fascia. While this causes a little more bleeding, it is much safer. It is important not to dis­sect blindly, particularly with an energy device, as these can so effectively stop bleeding that one may stray outside the correct plane and cause injury to surround­ing urinary, vascular, or nerve structures.
Many of these abscesses and stulas involve the left pelvic sidewall. In these cases, one must carefully combine blunt and sharp dissection techniques, and fre­quently switch from medial to lateral views, to progress gradually to completely dissect the mesentery off the abscess wall or pelvic sidewall. The goal is to have adequately mobilized the left colon, so that the diseased segment can be removed, with an adequate margin of normal tissue and adequate length for a tension-free anastomosis. Splenic exure mobilization is almost routinely required in these cases but division of the inferior mesenteric vein again at the tail of the pancreas is rarely required. Please refer to specic laparoscopic techniques in Chap. 4 on laparoscopic splenic exure release.
Colon Transection
Proximal colonic division is generally extracorporeal. The distal transection margin is critical and may be complex. The most frequent consideration is whether one is distal to the inammation. Our goal is always to mobilize enough rectum and meso­rectum so that we reach visibly and palpably normal tissue. Sometimes a loop of sigmoid is stuck in the pelvis, and this must be completely mobilized. Sometimes the upper rectal wall is thickened because of an adjacent abscess, and we generally mobilize more distally, sometimes below the peritoneal reection until normal bowel can be identied. If the rectum does not look healthy enough for an anasto­mosis, it is transected as a Hartmann’s stump and an end colostomy is brought out, which may subsequently be closed depending on a variety of factors such as pathol­ogy, patient status, etc. Indeed, the quality of the distal rectum is usually a predomi­nant determinant of whether an anastomosis will be performed, or a Hartmann’s stump left for safety. Additional considerations for anastomosis include the extent and severity of any residual proctitis in the rectal stump. For details on steps to take during Hartman’s procedures, please refer to the chapter on Key steps to facilitate minimally invasive Hartmann’s reversal (Chap. 20).
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A. R. Bhama and C. P. Delaney
Specimen Extraction
In simple cases requiring a sigmoid or left colon resection, a left lower quadrant muscle splitting incision is made. This is technically straightforward with a low complication rate. If a diverting stoma is required, the specimen is removed through that opening, if necessary making a “key-hole” incision to enlarge the opening.
For patients with an enterocolic stula that required dissection of tethered small bowel loops from an abscess or phlegmon, or with concurrent ileocolic and left colon disease, a short periumbilical midline incision is used. A wound protector is critical to prevent contamination by the abscess or stula. This permits sequential exteriorization of the entire length of the small bowel, which can be examined, resected, or repaired as appropriate.
Anastomosis
Small bowel anastomoses are performed most frequently using a stapled side-side functional end-end approach. Left-sided anastomoses are stapled transanally. We use a 28mm circular stapler to minimize anal stretching and to facilitate reaching the apex of the rectal stump. Sizers are not usually required for these cases, although they are sometimes used to gently stretch the rectum. In rare cases, a hand-sewn colorectal anastomosis may be performed, and this can be performed through a short Pfannenstiel incision.
Fistula Repair
The enteric and colon sides of stulas are generally both resected as segmental resections (Fig.5.3). In the setting of Crohn’s disease, it is necessary to rst evaluate both for active inammation. If the tissues are actively inamed, then a stula repair is not advisable, and formal resection should be carried out (Figs.5.4 and 5.5a, b). If there is no surrounding inammation, a tiny stula in small bowel may be man­aged with a wedge resection and hand-sewn closure of the enterotomy. While some surgeons advocate selective use of stapling across stulas when only one of the bowel segments is involved with Crohn’s disease, we do not routinely staple across stula tracts, as we feel this is by denition abnormal tissue and at higher risk for recurrence. We tend to reserve this for patients with multiple prior Crohn’s resec­tions and less residual small bowel (Fig.5.6a–c). For more discussions on laparo­scopic management of complex Crohn’s ileocolic disease, please refer to the chapter on advanced laparoscopic right colectomy techniques (Chap. 16).
Small colovesical stulas are tested by distending the bladder with very dilute methylene blue. If there is no leak, they are not sutured. Larger stulas are repaired with laparoscopic suturing. An omental pedicle graft should be placed next to the bladder, and a drain should be placed and monitored in case of a urine leak. A con­trast study is done at 48hours for small stulas. Larger (sutured) stulas are imaged
5 Masters Program Colorectal Pathway: Laparoscopic Left Colon Resection…
69
at 2weeks by cystography before removing the Foley catheter. Vaginal stulas are left open unless they are large in which case they are sutured with absorbable sutures. An omental pedicle graft is placed over the defect when possible.
Other Steps
A segment of omentum is brought down as an omental pedicle graft between any remaining wall of a stula or abscess cavity if reach permits. Drains are placed into residual contained abscess cavities, although not if the abscess cavity has not been mostly excised. Surgical wounds are closed in a standard fashion, and a wound protector is used in all cases. Vacuum-assisted (VAC) dressings are not used. In rare cases of extreme purulence or wound contamination, the wound is partially closed and a betadine wick is inserted and removed on POD3 for delayed primary closure. If there is a colocutaneous stula that requires excision of the abdominal wall and skin (Fig.5.1a, b), these defects are typically managed with wet to dry dressing changes, which can be switched to negative pressure dressing changes once healthy granulation tissue is visible. The utilization of laparoscopy helps reduce the rates of surgical site infection when compared to open operations. Standard enhanced recov­ery protocols and intraoperative surgical site infection measures are implemented.
Pitfalls andTroubleshooting
The level of difculty can range from straightforward to highly complex depending on the degree of severity of the inammation. The learning curve in general for laparoscopic left colectomy is upward of 50 cases and may not necessarily include the challenges specic to safely managing penetrating CD [13]. Common chal­lenges include the ability to separate the colon from adjacent structures, identifying and protecting the left ureter, managing the difcult Crohn’s mesentery, and closure of the stula on the organ remaining in situ (typically bladder or vagina). When separating the colon from adjacent structures, if standard techniques are not suc­cessful, some surgeons favor conversion to hand-assist to optimize blunt dissection while minimizing the size of the incision to maintain the benets of a laparoscopic approach.
Identifying the ureter can be difcult in the setting of severe inammation. Keep in mind that the ureter may be more medial than normal. Ureteral stents may be placed preoperatively or intraoperatively if necessary [14]. We tend to favor selec­tive intraoperative placement since a previous study we performed showed that this made surgery faster and was just as manageable for urology [14]. Typically, ureteral stents may help identify but not prevent ureteral injuries, and their presence should not supplant safe dissection and knowledge of the anatomy.
The mesentery in CD can be challenging as it is frequently thickened, friable, woody, and tends to bleed easily. Even when taking segments of mesentery with small vascular branches, blood loss can be quite signicant. When using an energy
70
A. R. Bhama and C. P. Delaney
device, it may be necessary to take the mesentery in layers and cauterize/seal the vessel in multiple locations prior to ligation. Endoloop® (Ethicon, Somerville, NJ, USA) and endoscopic clip appliers may be helpful when taking named vessels and should be available.
The predominant overarching theme in completing these cases laparoscopically should be safety. Safe and quality surgical technique should not be compromised for the sole purpose of completing the case in a minimally invasive fashion. Specically, in cases where there is difculty in managing a bleeding mesentery or a question of integrity of bowel, bladder, or vaginal repair; conversion is indicated. Conversion is also indicated for several technical reasons such as inability to establish or maintain pneumoperitoneum, inability to maintain adequate visualization, or inability to clear gross fecal contamination.

Outcomes

While no specic studies evaluate left-sided colectomy specically, several studies have shown that segmental colectomy for CD can be performed safely [6, 7, 11, 15]. The review article by Lightner and colleagues examined the results of six studies looking at colectomy in Crohn’s disease with a follow-up ranging from 5 to 14years [11]. However, they conclude that 50–65% of patients will have recurrent disease involving the colon requiring additional immunosuppression. Furthermore, up to 57% will require additional operation, and 5–35% will have a permanent stoma due to medically refractory disease (Table5.1).
A meta-analysis by Tekkis and colleagues included six studies comparing seg­mental resection vs subtotal/total colectomy with ileorectal anastomosis. A total of 488 patients with CD were included (223 ileorectal anastomosis patients and 265 segmental colectomy patients). The time to recurrence was longer in patients who had total colectomy with ileorectal anastomosis by 4.4 years (95% CI 3.1–5.8, P<0.001), but there was no difference in the incidence of postoperative complica­tions (OR=1.4, 95% CI 0.16–12.74) or the need for a permanent stoma between the
Table 5.1 Recurrence rates after segment resection for Crohn’s colitis
Year Author Longo [8] 1988 21 62 5 Prabhakar Makowiec [9] Andersson [5] Martel Fichera [10] 2005 55 61 5.1
Modied with permission of Oxford University Press from Lightner [11]
a
Prabhakar etal. [24]
b
Martel etal. [25]
published
a
1997 49 49 14
1998 141 63 10
2002 31 39 13
b
2002 4 65 8.7
Number of patients
Percent recurrence
Average length of follow-up (years)
5 Masters Program Colorectal Pathway: Laparoscopic Left Colon Resection…
71
two groups (OR=2.75, 95% CI 0.78–9.71) demonstrating that both segmental col­ectomy and total abdominal colectomy with ileorectal anastomosis were safe and effective treatment options for colonic CD, even though patients who underwent segmental colectomy exhibited earlier recurrence than those in the ileorectal anas­tomosis group. Their recommendation was that for patients with medically refrac­tory CD, a segmental resection may be preferred in the setting of segmental colitis and absence of perianal disease since the disease recurs regardless of the operative approach. Total proctocolectomy with an end ileostomy remains the preferred approach in the setting of colonic dysplasia.
Regarding the use of minimally invasive surgery in CD, the benets of laparos­copy for ileocolonic resections have been well-established even in the setting of abscess, stula, and recurrent disease [2, 1618]. The feasibility of laparoscopy for complex stulizing disease has been described with similar outcomes to that of nonstulizing disease [1921]. In the prospective study by Goyer and colleagues, postoperative outcomes between patients with CD undergoing laparoscopic ileoco­lic resection for uncomplicated disease were compared with those undergoing lapa­roscopic ileocolic resection for complicated or recurrent disease [21]. A total of 124 consecutive patients were analyzed over a 9-year period. The indications for laparo­scopic ileocolic resection within the cohort of complex CD included stula (43%), abscess (30%), and recurrent disease after prior ileocolic resection (27%). Although complex disease was signicantly associated with increased average operative time (214±13 vs 191±53minutes, P<0.05), increased conversion rate to open proce­dure (37% vs 14%, P<0.01), and increased use of a temporary stoma (39% vs 9%, P <0.001), the overall postoperative morbidity was similar between both groups (17% vs 17%, P=not signicant(NS)), including major surgical postoperative com­plications (7% vs 6%, P=NS). The average hospital stay was also not statistically different between both groups (8 vs 7days, P=NS) [21]. This prospective study of consecutive patients suggests that laparoscopy in complex CD is safe and feasible.
With regards to minimally invasive approach to colectomy in patients with CD, despite a paucity of contemporary studies on this topic, older studies have demon­strated laparoscopy to be safe and feasible when performed at centers of expertise. A single institutional experience was described by Holubar and colleagues identify­ing a total of 92 patients with CD undergoing minimal invasive colectomy from 1997 to 2008 [22]. Procedures included 43 total colectomies, 17 subtotal colecto­mies, and 32 segmental colectomies. Overall, straight laparoscopy was used in 57% of cases and 43% were hand-assisted with no signicant difference in operative times between lap- and hand-assisted groups. The rate of conversion to open lapa­rotomy was 16%, and only small bowel disease predicted conversion (OR 7 (1.6–
35)). Conversion was not associated with increased length of hospital stay or postoperative complications. Overall postoperative length of stay was 5 (4–7) days with a 34% rate of early postoperative complications. Only perianal disease pre­dicted complications after multivariate analysis (OR 2.6 (1.0–6.6)).
A case-matched study by da Luz Moreira and colleagues analyzing Crohn’s patients undergoing laparoscopic vs open colectomy showed that although median operative times were signicantly longer in the laparoscopic cohort (240 vs 150min,
72
A. R. Bhama and C. P. Delaney
P<0.01), postoperative complications were similar and the laparoscopic group had shorter median length of stay (5 vs 6days, P=0.07) and median time to rst bowel movement (3 vs 4days, P=0.4) [23].

Conclusions

Laparoscopy is feasible and safe in patients with abscess or stula due to inamma­tory bowel disease. It is important to thoroughly evaluate the patient and optimize preoperative parameters through management of medications, nutrition, and utiliza­tion of enhanced recovery pathways. It is important to recognize patient-specic contraindications and surgeon-specic limitations in attempting to approach these operations laparoscopically. Several unique considerations need to be observed in order to perform a safe operation, and conversion should be considered whenever safety or quality is in question.

References

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Current surgical therapy. 12th ed. Philadelphia: Elsevier; 2017.
2. Duepree H, Senagore A, Delaney C, Brady K, Fazio V.Advantages of laparoscopic resection
for ileocecal Crohn’s disease. Dis Colon Rectum. 2002;45(5):605–10.
3. Delaney C, Lawrence J, Keller D, Champagne B, Senagore A.Operative techniques in laparo-
scopic colorectal surgery. Philadelphia: Lippincott, Wiliiams, & Wilkins; 2014.
4. Bosio R, Delaney C. Surgical treatment of diverticulitis and its complications. In: Fazio V,
Church J, Delaney C, Kiran P, editors. Current therapy in colon and rectal surgery. Philadelphia: Elsevier; 2017.
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Crohn’s colitis? Dis Colon Rectum. 2002;45(1):47–53.
6. Angriman I, Pirozzolo G, R B CF, Castoro C, Scarpa M.A systematic review of segmental
vs subtotal colectomy and subtotal colectomy vs total proctocolectomy for colonic Crohn’s disease. Color Dis. 2017;19(8):279–87.
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tion? Am J Surg. 1984;147(1):38–42.
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vs sequential prophylactic ureteric catheter insertion in re-operative and complicated colorec­tal surgery. Int J Color Dis. 2007;22(6):683–7.
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segmental vs subtotal/total colectomy for colonic Crohn’s disease: a meta-analysis. Color Dis. 2006;8(2):82–90.
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for Crohn’s disease. In: Nguyen N, Scott-Conner C, editors. The SAGES manual. 2nd ed. NewYork: Springer International Publishing; 2012.
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tion for Crohn’s disease: an experience with 335 cases. Surg Endosc. 2009;23(10):2380–4.
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23. da Luz Moreira A, Stocchi L, Remzi F, Geisler D, Hammel J, Fazio V.Laparoscopic surgery for
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abdominal colectomy in Crohn’s colitis. Dis Colon Rectum. 1997;40(1):71–8.
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Part II
Preoperative Considerations