During the preoperative work-up of patients with right colon pathology, a funda­mental requirement is a complete colonoscopy with conrmation of the location of the tumor. When the tumor is not within the cecum, it is commonly tattooed to allow for visualization at the time of MIS.It is important to clarify with the endoscopist if the tattoo is at the site of the neoplasia, distal, proximal, or both distal and proximal to the lesion, in order to precisely map the tumor’s location and plan the extent of the resection. This is particularly important when creating an ICA as there will not be the ability to palpate the bowel until after extraction. When right colectomy is being performed for malignancy, staging CT scans of the chest, abdomen, and pel­vis are completed in order to rule out metastatic disease and invasion into adjacent organs that may require en bloc oncologic resection. Patients are prepared for sur­gery using enhanced recovery protocols including full mechanical bowel prepara­tion, oral antibiotics, cleansing of the skin, and oral carbohydrate loading, among other strategies [10]. The use of mechanical bowel preparation for right colectomy has not been shown to reduce major postoperative complications [11]. That being said, the prepped bowel may be easier to handle utilizing minimally invasive tech­niques with less risk of spillage during creation of the anastomosis, especially when ICA is performed. For more details on enhanced recovery programs, please refer to Chap. 7 on debunking enhanced recovery protocols in colorectal surgery.