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ANSWERS
CASE 110
Sex Cord-Stromal (Thecoma-Fibroma) Tumor
1. B and C
2. A
3. B
4. B
References
Green EG, Schwartz PE, McCarthy SM: Sclerosing stromal tumor of the
ovary. J Women Imaging 2005; 7:50-53.
Jung SE, Rha SE, Lee JM, et al: CT and MRI ndings of sex cord-stromal
tumor of the ovary. AJR Am J Roentgenol 2005; 185(1):207-218.
http://www.ncbi.nlm.nih.gov/pubmed/15972425 (Accessed on June 22, 2012.)
Lee MS, Cho HC, Lee YH, et al: Ovarian sclerosing stromal tumors.
J Ultrasound Med 2001; 20(4):413-417.
http://www.ncbi.nlm.nih.gov/pubmed/11316320 (Accessed on June 22, 2012.)
Cross-Reference
Ultrasound: The REQUISITES, 2nd ed, pp 579-580.
Comment
Incidence and Clinical Presentation
Sex cord-stromal tumors (Figures A to D) constitute an uncommon subset of ovarian neoplasms, representing about 8% of all ovarian neoplasms. They are benign. These stro­mal tumors usually occur in patients in the second or third decade of life. The most common symptoms are menstrual irregularities and pelvic pain. Sex cord-stromal tumors of the ovary include most of the hormonally active ovarian tumors. Subtypes include granulosa-stromal cell, thecoma-broma, and Sertoli-Leydig cell tumors. The rst two types can secrete estrogens, whereas the latter may secrete androgenic hormones and cause virilization.
Sex Cord-Stromal Tumors and Endometrial Abnormalities
Granulosa-stromal cell tumors and thecomas (Figures A to C) for the presented case of a thecoma-broma and a second case of thecoma produce estrogen and can result in endometrial hyperplasia or endometrial cancer. Thecomas are more com­monly estrogenic and have a higher incidence of associated endometrial abnormality than granulosa-stromal cell tumors. However, granulosa-stromal cell tumors are prone to rupture and are more likely to be malignant.
Call-Exner Bodies, Theca Cell Tumors, and Granulosa Cell Tumors
Call-Exner bodies may be seen on histologic examination; these are macrofollicles or microfollicles. Gross pathologic studies have shown that these tumors are often large, with a mean size of 10 cm. Theca cell tumors are more commonly solid. Granulosa cell tumors are usually large multiloculated cystic masses with solid portions. Both of these types of sex cord-stromal tumors can cause ovarian torsion. In many cases, hemorrhage is detected within the mass. The masses usually have cystic and solid components and are vascular, especially in the periphery and around cysts. Ultrasound and MRI may reveal any associated uterine enlargement and endometrial thickening that result from the hormonal secretion.
Prognosis of Sex Cord-Stromal Tumors
The detection of a multicystic or solid ovarian mass associated with endometrial thickening (Figure D) should prompt consid­eration of one of the sex cord-stromal tumors. Most of these tumors have a good prognosis.
226

CASE 111

A
B
History: A 28-year-old woman in her second trimester of
pregnancy undergoes imaging after a recent motor vehicle accident.
1. What should be included in the differential diagnosis based on the imaging ndings in Figure A? (Choose all that apply.)
A. Aqueductal stenosis B. Arnold-Chiari malformation C. Unilateral ventriculomegaly D. Extraaxial mass or blood, or both E. Intracranial neoplasm
2. What is the most common location for in utero intracranial hemorrhage?
A. Posterior fossa B. Extraaxial/subdural C. Germinal matrix/intraventricular D. Cerebral cortex
C
Used with permission from McGahan JP, et al: Fetal head and brain. In McGahan JP, Goldberg BB [eds]: Diagnostic Ultrasound, 2nd ed. New York: Informa Healthcare USA, 2008; 1148.
3. Ultrasound ndings of germinal matrix hemorrhage can result in all of the following except:
A. Hydrocephalus B. Ventriculitis C. Porencephaly D. Subdural hematoma
4. Which of the following statements concerning germinal matrix or intraventricular hemorrhage is false?
A. Thrombocytopenic purpura is a common etiology of in
utero intracranial hemorrhage.
B. Concomitant fetal anomalies may be associated with in
utero intracranial hemorrhage.
C. In utero grade 4 intracranial hemorrhage has a high
mortality rate.
D. There is an increased rate of recurrence of intracranial
hemorrhage in subsequent pregnancies.
227
ANSWERS
CASE 111
Subdural Hematoma
1. D
2. C
3. D
4. B
References
Ghi T, Simonazzi G, Perolo A, et al: Outcome of antenatally diagnosed
intracranial hemorrhage: case series and review of the literature. Ultrasound
Obstet Gynecol 2003; 22(2):121-130.
http://www.ncbi.nlm.nih.gov/pubmed/12905503 (Accessed on June 22, 2012.)
Hiller L 4th, McGahan JP, Bijan B, et al: Sonographic detection of in utero
isolated cerebellar hemorrhage. J Ultrasound Med 2003; 22(6):649-652.
http://www.ncbi.nlm.nih.gov/pubmed/12795563 (Accessed on June 22, 2012.)
Strigini FA, Cioni G, Canapicchi R, et al: Fetal intracranial hemorrhage: is
minor maternal trauma a possible pathogenetic factor? Ultrasound Obstet
Gynecol 2001; 18(4):335-342.
http://www.ncbi.nlm.nih.gov/pubmed/11778992 (Accessed on June 22, 2012.)
Cross-Reference
Ultrasound: The REQUISITES, 2nd ed, p 383.
Comment
Differential Diagnosis
There is a pitfall in this case, which was misinterpretation of the medial wall of the lateral ventricle and the lateral portion of the cerebral cortex as the lateral ventricle. A clue to this misdiagnosis was the fact that the choroid plexus, which is seen
in Figure A, is not dangling within the presumed downside of the lateral ventricle. Once this pitfall was identied, extraaxial mass and collection of blood were included in the differential diagnosis. Given the history of trauma, a subdural hematoma would be most likely. Most in utero intracranial hemorrhages occur in the late second or early third trimester. Hemorrhages most often occur spontaneously, or they may occur in asso­ciation with various maternal or fetal conditions. Predisposing maternal conditions include platelet or coagulation disorders, use of medications such as warfarin, and drug abuse (e.g., cocaine). Intracranial hemorrhage originates from the germi­nal matrix with evolution into the lateral ventricles.
Ultrasound Findings
Subdural hematoma may be spontaneous or may be due to numerous potential etiologies, including maternal trauma. Trauma can result in extraaxial uid or blood collection as shown in Figure B. In these cases MRI may better dene the extent of the subdural hematoma and any potential evolving complications (Figure C). Hemorrhage elsewhere within the brain, including the posterior fossa, has been reported.
Prognosis and Management
The prognosis depends on the severity of in utero intracranial hemorrhage. The outcome is poorer if the intracranial hemor­rhage involves a large portion of the brain substance or there is massive ventriculomegaly. On one hand, subdural hematomas can have no adverse outcome; on the other hand, they have been associated with fetal death.
228

CASE 112

A
B
History: A 50-year-old postmenopausal woman presents
with vaginal bleeding.
1. What should be included in the differential diagnosis? (Choose all that apply.)
A. Large broid B. Adenomyosis C. Endometrial cancer D. Multiple small broids
2. What nding is not shown in transabdominal sagittal and transvaginal transverse ultrasound images of the uterus in a 50-year-old postmenopausal woman with vaginal bleeding?
A. Focal myometrial solid mass B. Thick posterior myometrium C. Indistinct junctional zone D. Globular uterus
3. Which of the following is not a sign or symptom of adenomyosis?
A. Uterine enlargement B. Menorrhagia C. Dysmenorrhea D. Fever
4. How does the sagittal MRI T2-weighted image help narrow the diagnosis?
A. Thick junctional zone B. Large cysts along the inner myometrium C. Thick endometrium stripe D. Globular uterus
C
229
ANSWERS
CASE 112
Adenomyosis
1. B and D
2. A
3. D
4. A
References
Kido A, Togashi K, Koyama T, et al: Diffusely enlarged uterus: evaluation
with MR imaging. Radiographics 2003; 23(6):1423-1439.
http://www.ncbi.nlm.nih.gov/pubmed/14615554 (Accessed on June 22, 2012.)
Sakhel K, Abuhamad A: Sonography of adenomyosis. J Ultrasound Med
31:805-808. 2012.
http://www.ncbi.nlm.nih.gov/pubmed/22535729 (Accessed on June 28, 2012.)
Tamai K, Togashi K, Tsuyoshi I, et al: MR imaging ndings of adeno-
myosis: correlation with histopathologic features and diagnostic pitfalls.
Radiographics 2005; 25(1):21-40.
http://www.ncbi.nlm.nih.gov/pubmed/15653584 (Accessed on June 22, 2012.)
Cross-Reference
Ultrasound: The REQUISITES, 2nd ed, pp 534, 541, 549, 553, 571.
Comment
Etiology and Clinical Presentation
Adenomyosis is dened as a nonneoplastic condition of migration of ectopic endometrial glands and stroma in the myometrium, with associated hyperplastic smooth muscle. In contrast to endometriosis, only 13% of these glandular implants respond to endogenous estrogen and progesterone stimulation. Women present with menorrhagia or dysmenor­rhagia and enlargement of the uterus.
Ultrasound Imaging
This case of adenomyosis shows loss of the discrete junctional zone, which appears heterogeneous with a thick posterior myometrium (Figures A and B). In most cases, the uterus is
enlarged and globular. Detection of irregular, cystic spaces in the myometrium is the most specic nding for adenomyosis on ultrasound. However, several studies have shown ndings that can be much more subtle on ultrasound, including loss of the junctional zone, a slight decrease in the echogenicity of the uterus, posterior uterine wall thickening, and displacement of the endometrial lining. A focal region of adenomyosis, called an adenomyoma, can be seen in some cases. An adeno­myoma may have a more irregular shape than the characteristic rounded appearance of a leiomyoma. Adenomyomas are often more subtle than leiomyomas compared with the background normal uterine tissue. Because of limited spatial resolution, ultrasound is not as accurate a modality as MRI to diagnose adenomyosis.
MRI
MRI (Figure C) is highly accurate for making the diagnosis of adenomyosis. On MRI, many of the ndings reect smooth muscle proliferation in reaction to the heterotopic endometrial tissue. The junctional zone is thickened (Figure C), and a cut­off measurement of 12 mm is used to suggest the diagnosis. Small foci with high signal intensity are seen within the myo­metrium on T2-weighted sequences (Figure C) and sometimes on T1-weighted sequences. It is important to distinguish focal adenomyosis from a leiomyoma because the treatment differs for each entity. MRI is helpful in this role, particularly when subtle ultrasound ndings are present and additionally because the appearance of an adenomyoma as a calcied uterine mass, mimicking a myoma on ultrasound, has been reported in the literature. On MRI, the borders of an adenomyoma are irregu­lar, and the presence of the high signal foci in the myome­trium on T2-weighted sequences should aid in the distinction of these two entities. Adenomyosis can now be diagnosed and differentiated with a high degree of accuracy by both ultra­sound and MRI.
230

CASE 113

A
History: A patient with a 20-week pregnancy presents with
a suspected broid on physical examination.
1. What should be included in the differential diagnosis of a palpated pelvic mass distinct from the uterus? (Choose all that apply.)
A. Pedunculated broid B. Abdominal ectopic pregnancy C. Uterine anomaly with a rudimentary horn D. Theca lutein cyst
2. Which of the following is not a presentation of an abdomi­nal ectopic pregnancy?
A. Vaginal bleeding B. Fetal heart sounds in maternal epigastrium C. Fever D. Lack of cervical changes
B
3. Which of the following is not a recommended treatment of abdominal ectopic pregnancy?
A. Methotrexate B. Laparotomy C. Laparoscopy D. Observation with follow-up by physical examination
4. What is the most common cause of an abdominal ectopic pregnancy?
A. Secondary implantation of a tubal ectopic pregnancy B. Primary implantation in an extrauterine location distant
from the fallopian tube C. Trauma during pregnancy D. Genetic
231
ANSWERS
CASE 113
Abdominal Ectopic Pregnancy
1. A, B, C, and D
2. C
3. D
4. A
References
Oki T, Baba Y, Yoshinaga M, et al: Super-selective arterial embolization for
uncontrolled bleeding in abdominal pregnancy. Obstet Gynecol 2008;
112(2 Pt 2):427-429.
http://www.ncbi.nlm.nih.gov/pubmed/18669751 (Accessed on June 22, 2012.)
Show SW, Hsu JJ, Chueh HY, et al: Management of primary abdominal preg-
nancy: twelve years of experience in a medical center. Acta Obstet Gynecol
Scand 2007; 86(9):1058-1062.
http://www.ncbi.nlm.nih.gov/pubmed/17712645 (Accessed on June 22, 2012.)
Siow A, Chern B, Soong Y: Successful laparoscopic treatment of an abdominal
pregnancy in the broad ligament. Singapore Med J 2004; 45(2):88-89.
http://www.ncbi.nlm.nih.gov/pubmed/14985849 (Accessed on June 22, 2012.)
Cross-Reference
Ultrasound: The REQUISITES, 2nd ed, pp 357-373.
Comment
General Description of Abdominal Ectopic Pregnancy
Abdominal ectopic pregnancies are rare medical emergencies associated with high maternal and fetal morbidity and mortal­ity rates. The most common cause is a secondary implantation of a tubal ectopic pregnancy. In the United States, 1% of ecto­pic pregnancies are abdominal ectopic pregnancies. There is 1 abdominal ectopic pregnancy per 10,000 births. Early diagno­sis is essential. A high index of suspicion is necessary.
Presentation
The physical presentation of an abdominal ectopic pregnancy includes abdominal pain, abdominal tenderness, vaginal bleed­ing, fetal movements in the upper abdomen, abnormal fetal lie, fetal heart sounds in the maternal epigastrium, palpation of a pelvic mass distinct from the uterus, and lack of cervical changes. Maternal cocaine use is a risk factor.
Ultrasound Imaging
One study concluded that abdominal ultrasound and CT stud­ies must be performed before operative treatment if an ecto­pic pregnancy is suspected and no intrauterine gestational sac can be shown on transvaginal ultrasound. An ultrasound study would show the placenta and gestational sac separate from the uterus (Figures A and B). Abdominal ectopic pregnancies have been seen on images of the spleen and omentum.
Treatment
Treatments include laparoscopy, laparotomy, and intravenous methotrexate. Surgical dissection is difcult. Hemorrhage is common. If attempted removal of the placenta aggravates bleeding, the fetus alone can be removed. Superselective arte­rial embolization with a microcatheter is a useful treatment for abdominal bleeding, often from a retained placenta in an abdominal pregnancy. One study showed that patients treated with laparoscopy did better than patients who underwent a laparotomy because of less blood loss. Intravenous methotrex­ate has been used to treat abdominal ectopic pregnancies suc­cessfully after a laparoscopic diagnosis. Ultrasound has been used to follow the involution of placentas over periods of up to 5 years. MRI added no additional information.
232

CASE 114

A
B
History: A 32-year-old woman presents in the second tri-
mester with a small-for-dates gestation.
1. What should be included in the differential diagnosis? (Choose all that apply.)
A. Posterior ureteral valves B. Ureteral atresia C. Megacystis microcolon syndrome D. Prune-belly syndrome E. Bilateral urethral vesicular junction obstruction
2. Which of the following would be a potentially favorable prognostic factor in posterior urethral valves?
A. Severe oligohydramnios B. Echogenic kidneys C. Marked bladder distention D. Presence of urine ascites
3. Which of the following syndromes is not associated with posterior urethral valves?
A. Potter syndrome B. VATER syndrome
C
D
Used with permission from McGahan JP, et al: Fetal abdomen and pel­vis. In McGahan JP, Goldberg BB [eds]: Diagnostic Ultrasound, 2nd ed.
New York: Informa Healthcare USA, 2008; 1324.
C. Amniotic band syndrome D. Eagle-Barrett syndrome
4. All of the following statements concerning the management of posterior urethral valves or urethral atresia are true except:
A. Development of a vesicocutaneous stula has a poor
prognosis.
B. The presence of oligohydramnios may prevent detec-
tion of other anomalies. C. There may be associated chromosomal abnormalities. D. Placement of a vesicoamniotic shunt may be a treat-
ment option.
233
ANSWERS
CASE 114
Fetal Bladder Outlet Obstruction
1. A, B, C, and D
2. D
3. C
4. A
References
Bernardes LS, Salomon R, Aksnes G, et al: Ultrasound evaluation of
prognosis in fetuses with posterior urethral valves. J Pediatr Surg 2011;
46(7):1412-1418.
http://www.ncbi.nlm.nih.gov/pubmed/21763844 (Accessed on June 22, 2012.)
Chen L, Cai A, Wang X, et al: Two- and three-dimensional prenatal
sonographic diagnosis of prune-belly syndrome. J Clin Ultrasound 2010;
38(5):279-282.
http://www.ncbi.nlm.nih.gov/pubmed/20014136 (Accessed on June 22, 2012.)
Ruano R, Yoshisaki CT, Salustiano EM, et al: Early fetal cystoscopy for rst-
trimester severe megacystis. Ultrasound Obstet Gynecol 2011; 37(6):696-701.
http://www.ncbi.nlm.nih.gov/pubmed/21337440 (Accessed on June 22, 2012.)
Cross-Reference
Ultrasound: The REQUISITES, 2nd ed, pp 458-465.
Comment
Differential Diagnosis
The differential diagnosis in this case includes any bladder out­let obstruction; this could include the most severe form of ure­thral atresia. When the bladder outlet is completely obstructed,
posterior urethral valves in which a membrane with a very small opening is situated within the posterior urethra would be considered. Prune-belly syndrome is a variation of bladder outlet obstruction but with associated abnormal abdominal wall muscle and cryptorchidism. Other entities may be con­sidered within the differential diagnosis, including megacystis microcolon syndrome, which could produce bladder dilation and bilateral hydronephrosis but usually with polyhydramnios.
Ultrasound Findings
Ultrasound ndings of posterior urethral valves include dilated bladder with “keyhole” bladder outlet and bilateral hydrone­phrosis (Figures A and B). In a “keyhole” bladder, the proxi­mal urethra is dilated (Figure C). The renal pelvis or calyx may be ruptured, producing perinephric hematoma or urinoma. Urine ascites is probably due to rupture and decompression of the bladder into the abdomen (Figure D).
Prognosis and Management
Severe oligohydramnios, massive bladder distention, bilateral hydronephrosis, and echogenic kidneys are associated with a poor prognosis. When amniotic uid is preserved, less hydro­nephrosis and leakage of urine from the bladder into the fetal abdomen are better prognostic features. Vesicoamniotic shunts have been placed in selected cases for decompression of the urinary bladder, but shunts may be associated with various complications, including chorioamnionitis, shunt misplace­ment, preterm labor, and fetal demise.
234

CASE 115

A
B
B = body; H = head.
D
Used with permission from Anderson Publishing Ltd. from Victoria T, et al: Fetal MRI of common non-CNS abnormalities: a review. Appl Radiol 2011;40[6]:8-17. © Anderson Publishing Ltd.
History: A woman with Graves disease and in the third tri-
mester of pregnancy undergoes screening ultrasound.
1. What should be included in the differential diagnosis of the neck mass? (Choose all that apply.)
A. Teratoma B. Lymphostasis C. Cystic hygroma D. Fetal goiter
2. What is the linear static anechoic area in the center of the neck mass?
A. Trachea B. Esophagus C. Aorta D. Inferior vena cava
3. What is the usual etiology of this disorder?
A. Genetics B. X-ray exposure of the mother C. Treatment of maternal Graves disease with propylthio-
uracil (PTU)
D. Treatment of maternal Graves disease with iodine-131
4. Which of the following is not a potential consequence of this untreated disorder?
A. Obstruction of the airway
C
B. Obstruction of the esophagus C. Lower intelligence scores D. Follicular thyroid carcinoma
235