Добавил:
Sekretar
kiopkiopkiop18@yandex.ru
t.me/Prokururor I Вовсе не секретарь, но почту проверяю
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5789_Библиотеки_им_академика_М_И_Перельмана.pdf
X
- •Series Foreword
- •Book Foreword
- •Preface
- •Acknowledgments
- •Contents
- •Opening Round
- •CASE 2
- •CASE 5
- •CASE 6
- •CASE 7
- •CASE 3
- •CASE 4
- •CASE 8
- •CASE 9
- •CASE 10
- •CASE 11
- •CASE 12
- •CASE 13
- •CASE 14
- •CASE 15
- •CASE 16
- •CASE 17
- •CASE 18
- •CASE 19
- •CASE 20
- •CASE 21
- •CASE 22
- •CASE 23
- •CASE 24
- •CASE 25
- •CASE 26
- •CASE 27
- •CASE 28
- •CASE 29
- •CASE 31
- •CASE 32
- •CASE 33
- •CASE 34
- •CASE 35
- •CASE 36
- •CASE 37
- •CASE 38
- •CASE 39
- •CASE 40
- •CASE 41
- •CASE 42
- •CASE 43
- •CASE 44
- •CASE 45
- •CASE 46
- •CASE 47
- •CASE 48
- •CASE 49
- •CASE 50
- •CASE 51
- •Fair Play
- •CASE 53
- •CASE 54
- •CASE 55
- •CASE 56
- •CASE 57
- •CASE 58
- •CASE 59
- •CASE 60
- •CASE 61
- •CASE 62
- •CASE 63
- •CASE 64
- •CASE 65
- •CASE 66
- •CASE 67
- •CASE 68
- •CASE 69
- •CASE 70
- •CASE 71
- •CASE 72
- •CASE 73
- •CASE 74
- •CASE 75
- •CASE 76
- •CASE 77
- •CASE 78
- •CASE 79
- •CASE 80
- •CASE 81
- •CASE 82
- •CASE 83
- •CASE 84
- •CASE 85
- •CASE 86
- •CASE 87
- •CASE 88
- •CASE 89
- •CASE 90
- •CASE 91
- •Challenge
- •CASE 93
- •CASE 94
- •CASE 95
- •CASE 96
- •CASE 97
- •CASE 98
- •CASE 99
- •CASE 100
- •CASE 101
- •CASE 102
- •CASE 103
- •CASE 104
- •CASE 105
- •CASE 106
- •CASE 107
- •CASE 108
- •CASE 109
- •CASE 110
- •CASE 111
- •CASE 112
- •CASE 113
- •CASE 114
- •CASE 115
- •CASE 116
- •CASE 117
- •CASE 118
- •CASE 119
- •Index Of Cases
- •Index of Terms

ANSWERS
CASE 110
Sex Cord-Stromal (Thecoma-Fibroma) Tumor
1. B and C
2. A
3. B
4. B
References
Green EG, Schwartz PE, McCarthy SM: Sclerosing stromal tumor of the
ovary. J Women Imaging 2005; 7:50-53.
Jung SE, Rha SE, Lee JM, et al: CT and MRI ndings of sex cord-stromal
tumor of the ovary. AJR Am J Roentgenol 2005; 185(1):207-218.
http://www.ncbi.nlm.nih.gov/pubmed/15972425 (Accessed on June 22, 2012.)
Lee MS, Cho HC, Lee YH, et al: Ovarian sclerosing stromal tumors.
J Ultrasound Med 2001; 20(4):413-417.
http://www.ncbi.nlm.nih.gov/pubmed/11316320 (Accessed on June 22, 2012.)
Cross-Reference
Ultrasound: The REQUISITES, 2nd ed, pp 579-580.
Comment
Incidence and Clinical Presentation
Sex cord-stromal tumors (Figures A to D) constitute an
uncommon subset of ovarian neoplasms, representing about
8% of all ovarian neoplasms. They are benign. These stromal tumors usually occur in patients in the second or third
decade of life. The most common symptoms are menstrual
irregularities and pelvic pain. Sex cord-stromal tumors of the
ovary include most of the hormonally active ovarian tumors.
Subtypes include granulosa-stromal cell, thecoma-broma,
and Sertoli-Leydig cell tumors. The rst two types can secrete
estrogens, whereas the latter may secrete androgenic hormones
and cause virilization.
Sex Cord-Stromal Tumors and Endometrial
Abnormalities
Granulosa-stromal cell tumors and thecomas (Figures A to C)
for the presented case of a thecoma-broma and a second case
of thecoma produce estrogen and can result in endometrial
hyperplasia or endometrial cancer. Thecomas are more commonly estrogenic and have a higher incidence of associated
endometrial abnormality than granulosa-stromal cell tumors.
However, granulosa-stromal cell tumors are prone to rupture
and are more likely to be malignant.
Call-Exner Bodies, Theca Cell Tumors,
and Granulosa Cell Tumors
Call-Exner bodies may be seen on histologic examination;
these are macrofollicles or microfollicles. Gross pathologic
studies have shown that these tumors are often large, with a
mean size of 10 cm. Theca cell tumors are more commonly
solid. Granulosa cell tumors are usually large multiloculated
cystic masses with solid portions. Both of these types of sex
cord-stromal tumors can cause ovarian torsion. In many cases,
hemorrhage is detected within the mass. The masses usually
have cystic and solid components and are vascular, especially
in the periphery and around cysts. Ultrasound and MRI may
reveal any associated uterine enlargement and endometrial
thickening that result from the hormonal secretion.
Prognosis of Sex Cord-Stromal Tumors
The detection of a multicystic or solid ovarian mass associated
with endometrial thickening (Figure D) should prompt consideration of one of the sex cord-stromal tumors. Most of these
tumors have a good prognosis.
226

CASE 111
A
B
History: A 28-year-old woman in her second trimester of
pregnancy undergoes imaging after a recent motor vehicle
accident.
1. What should be included in the differential diagnosis based
on the imaging ndings in Figure A? (Choose all that apply.)
A. Aqueductal stenosis
B. Arnold-Chiari malformation
C. Unilateral ventriculomegaly
D. Extraaxial mass or blood, or both
E. Intracranial neoplasm
2. What is the most common location for in utero intracranial
hemorrhage?
A. Posterior fossa
B. Extraaxial/subdural
C. Germinal matrix/intraventricular
D. Cerebral cortex
C
Used with permission from McGahan JP, et al: Fetal head and brain. In
McGahan JP, Goldberg BB [eds]: Diagnostic Ultrasound, 2nd ed. New
York: Informa Healthcare USA, 2008; 1148.
3. Ultrasound ndings of germinal matrix hemorrhage can
result in all of the following except:
A. Hydrocephalus
B. Ventriculitis
C. Porencephaly
D. Subdural hematoma
4. Which of the following statements concerning germinal
matrix or intraventricular hemorrhage is false?
A. Thrombocytopenic purpura is a common etiology of in
utero intracranial hemorrhage.
B. Concomitant fetal anomalies may be associated with in
utero intracranial hemorrhage.
C. In utero grade 4 intracranial hemorrhage has a high
mortality rate.
D. There is an increased rate of recurrence of intracranial
hemorrhage in subsequent pregnancies.
227

ANSWERS
CASE 111
Subdural Hematoma
1. D
2. C
3. D
4. B
References
Ghi T, Simonazzi G, Perolo A, et al: Outcome of antenatally diagnosed
intracranial hemorrhage: case series and review of the literature. Ultrasound
Obstet Gynecol 2003; 22(2):121-130.
http://www.ncbi.nlm.nih.gov/pubmed/12905503 (Accessed on June 22, 2012.)
Hiller L 4th, McGahan JP, Bijan B, et al: Sonographic detection of in utero
isolated cerebellar hemorrhage. J Ultrasound Med 2003; 22(6):649-652.
http://www.ncbi.nlm.nih.gov/pubmed/12795563 (Accessed on June 22, 2012.)
Strigini FA, Cioni G, Canapicchi R, et al: Fetal intracranial hemorrhage: is
minor maternal trauma a possible pathogenetic factor? Ultrasound Obstet
Gynecol 2001; 18(4):335-342.
http://www.ncbi.nlm.nih.gov/pubmed/11778992 (Accessed on June 22, 2012.)
Cross-Reference
Ultrasound: The REQUISITES, 2nd ed, p 383.
Comment
Differential Diagnosis
There is a pitfall in this case, which was misinterpretation of
the medial wall of the lateral ventricle and the lateral portion
of the cerebral cortex as the lateral ventricle. A clue to this
misdiagnosis was the fact that the choroid plexus, which is seen
in Figure A, is not dangling within the presumed downside of
the lateral ventricle. Once this pitfall was identied, extraaxial
mass and collection of blood were included in the differential
diagnosis. Given the history of trauma, a subdural hematoma
would be most likely. Most in utero intracranial hemorrhages
occur in the late second or early third trimester. Hemorrhages
most often occur spontaneously, or they may occur in association with various maternal or fetal conditions. Predisposing
maternal conditions include platelet or coagulation disorders,
use of medications such as warfarin, and drug abuse (e.g.,
cocaine). Intracranial hemorrhage originates from the germinal matrix with evolution into the lateral ventricles.
Ultrasound Findings
Subdural hematoma may be spontaneous or may be due to
numerous potential etiologies, including maternal trauma.
Trauma can result in extraaxial uid or blood collection as
shown in Figure B. In these cases MRI may better dene the
extent of the subdural hematoma and any potential evolving
complications (Figure C). Hemorrhage elsewhere within the
brain, including the posterior fossa, has been reported.
Prognosis and Management
The prognosis depends on the severity of in utero intracranial
hemorrhage. The outcome is poorer if the intracranial hemorrhage involves a large portion of the brain substance or there is
massive ventriculomegaly. On one hand, subdural hematomas
can have no adverse outcome; on the other hand, they have
been associated with fetal death.
228

CASE 112
A
B
History: A 50-year-old postmenopausal woman presents
with vaginal bleeding.
1. What should be included in the differential diagnosis?
(Choose all that apply.)
A. Large broid
B. Adenomyosis
C. Endometrial cancer
D. Multiple small broids
2. What nding is not shown in transabdominal sagittal and
transvaginal transverse ultrasound images of the uterus in a
50-year-old postmenopausal woman with vaginal bleeding?
A. Focal myometrial solid mass
B. Thick posterior myometrium
C. Indistinct junctional zone
D. Globular uterus
3. Which of the following is not a sign or symptom of
adenomyosis?
A. Uterine enlargement
B. Menorrhagia
C. Dysmenorrhea
D. Fever
4. How does the sagittal MRI T2-weighted image help narrow
the diagnosis?
A. Thick junctional zone
B. Large cysts along the inner myometrium
C. Thick endometrium stripe
D. Globular uterus
C
229

ANSWERS
CASE 112
Adenomyosis
1. B and D
2. A
3. D
4. A
References
Kido A, Togashi K, Koyama T, et al: Diffusely enlarged uterus: evaluation
with MR imaging. Radiographics 2003; 23(6):1423-1439.
http://www.ncbi.nlm.nih.gov/pubmed/14615554 (Accessed on June 22, 2012.)
Sakhel K, Abuhamad A: Sonography of adenomyosis. J Ultrasound Med
31:805-808. 2012.
http://www.ncbi.nlm.nih.gov/pubmed/22535729 (Accessed on June 28, 2012.)
Tamai K, Togashi K, Tsuyoshi I, et al: MR imaging ndings of adeno-
myosis: correlation with histopathologic features and diagnostic pitfalls.
Radiographics 2005; 25(1):21-40.
http://www.ncbi.nlm.nih.gov/pubmed/15653584 (Accessed on June 22, 2012.)
Cross-Reference
Ultrasound: The REQUISITES, 2nd ed, pp 534, 541, 549, 553, 571.
Comment
Etiology and Clinical Presentation
Adenomyosis is dened as a nonneoplastic condition of
migration of ectopic endometrial glands and stroma in the
myometrium, with associated hyperplastic smooth muscle.
In contrast to endometriosis, only 13% of these glandular
implants respond to endogenous estrogen and progesterone
stimulation. Women present with menorrhagia or dysmenorrhagia and enlargement of the uterus.
Ultrasound Imaging
This case of adenomyosis shows loss of the discrete junctional
zone, which appears heterogeneous with a thick posterior
myometrium (Figures A and B). In most cases, the uterus is
enlarged and globular. Detection of irregular, cystic spaces in
the myometrium is the most specic nding for adenomyosis
on ultrasound. However, several studies have shown ndings
that can be much more subtle on ultrasound, including loss of
the junctional zone, a slight decrease in the echogenicity of
the uterus, posterior uterine wall thickening, and displacement
of the endometrial lining. A focal region of adenomyosis,
called an adenomyoma, can be seen in some cases. An adenomyoma may have a more irregular shape than the characteristic
rounded appearance of a leiomyoma. Adenomyomas are often
more subtle than leiomyomas compared with the background
normal uterine tissue. Because of limited spatial resolution,
ultrasound is not as accurate a modality as MRI to diagnose
adenomyosis.
MRI
MRI (Figure C) is highly accurate for making the diagnosis of
adenomyosis. On MRI, many of the ndings reect smooth
muscle proliferation in reaction to the heterotopic endometrial
tissue. The junctional zone is thickened (Figure C), and a cutoff measurement of 12 mm is used to suggest the diagnosis.
Small foci with high signal intensity are seen within the myometrium on T2-weighted sequences (Figure C) and sometimes
on T1-weighted sequences. It is important to distinguish focal
adenomyosis from a leiomyoma because the treatment differs
for each entity. MRI is helpful in this role, particularly when
subtle ultrasound ndings are present and additionally because
the appearance of an adenomyoma as a calcied uterine mass,
mimicking a myoma on ultrasound, has been reported in the
literature. On MRI, the borders of an adenomyoma are irregular, and the presence of the high signal foci in the myometrium on T2-weighted sequences should aid in the distinction
of these two entities. Adenomyosis can now be diagnosed and
differentiated with a high degree of accuracy by both ultrasound and MRI.
230

CASE 113
A
History: A patient with a 20-week pregnancy presents with
a suspected broid on physical examination.
1. What should be included in the differential diagnosis of a
palpated pelvic mass distinct from the uterus? (Choose all
that apply.)
A. Pedunculated broid
B. Abdominal ectopic pregnancy
C. Uterine anomaly with a rudimentary horn
D. Theca lutein cyst
2. Which of the following is not a presentation of an abdominal ectopic pregnancy?
A. Vaginal bleeding
B. Fetal heart sounds in maternal epigastrium
C. Fever
D. Lack of cervical changes
B
3. Which of the following is not a recommended treatment of
abdominal ectopic pregnancy?
A. Methotrexate
B. Laparotomy
C. Laparoscopy
D. Observation with follow-up by physical examination
4. What is the most common cause of an abdominal ectopic
pregnancy?
A. Secondary implantation of a tubal ectopic pregnancy
B. Primary implantation in an extrauterine location distant
from the fallopian tube
C. Trauma during pregnancy
D. Genetic
231

ANSWERS
CASE 113
Abdominal Ectopic Pregnancy
1. A, B, C, and D
2. C
3. D
4. A
References
Oki T, Baba Y, Yoshinaga M, et al: Super-selective arterial embolization for
uncontrolled bleeding in abdominal pregnancy. Obstet Gynecol 2008;
112(2 Pt 2):427-429.
http://www.ncbi.nlm.nih.gov/pubmed/18669751 (Accessed on June 22, 2012.)
Show SW, Hsu JJ, Chueh HY, et al: Management of primary abdominal preg-
nancy: twelve years of experience in a medical center. Acta Obstet Gynecol
Scand 2007; 86(9):1058-1062.
http://www.ncbi.nlm.nih.gov/pubmed/17712645 (Accessed on June 22, 2012.)
Siow A, Chern B, Soong Y: Successful laparoscopic treatment of an abdominal
pregnancy in the broad ligament. Singapore Med J 2004; 45(2):88-89.
http://www.ncbi.nlm.nih.gov/pubmed/14985849 (Accessed on June 22, 2012.)
Cross-Reference
Ultrasound: The REQUISITES, 2nd ed, pp 357-373.
Comment
General Description of Abdominal Ectopic
Pregnancy
Abdominal ectopic pregnancies are rare medical emergencies
associated with high maternal and fetal morbidity and mortality rates. The most common cause is a secondary implantation
of a tubal ectopic pregnancy. In the United States, 1% of ectopic pregnancies are abdominal ectopic pregnancies. There is 1
abdominal ectopic pregnancy per 10,000 births. Early diagnosis is essential. A high index of suspicion is necessary.
Presentation
The physical presentation of an abdominal ectopic pregnancy
includes abdominal pain, abdominal tenderness, vaginal bleeding, fetal movements in the upper abdomen, abnormal fetal
lie, fetal heart sounds in the maternal epigastrium, palpation
of a pelvic mass distinct from the uterus, and lack of cervical
changes. Maternal cocaine use is a risk factor.
Ultrasound Imaging
One study concluded that abdominal ultrasound and CT studies must be performed before operative treatment if an ectopic pregnancy is suspected and no intrauterine gestational sac
can be shown on transvaginal ultrasound. An ultrasound study
would show the placenta and gestational sac separate from the
uterus (Figures A and B). Abdominal ectopic pregnancies have
been seen on images of the spleen and omentum.
Treatment
Treatments include laparoscopy, laparotomy, and intravenous
methotrexate. Surgical dissection is difcult. Hemorrhage is
common. If attempted removal of the placenta aggravates
bleeding, the fetus alone can be removed. Superselective arterial embolization with a microcatheter is a useful treatment
for abdominal bleeding, often from a retained placenta in an
abdominal pregnancy. One study showed that patients treated
with laparoscopy did better than patients who underwent a
laparotomy because of less blood loss. Intravenous methotrexate has been used to treat abdominal ectopic pregnancies successfully after a laparoscopic diagnosis. Ultrasound has been
used to follow the involution of placentas over periods of up
to 5 years. MRI added no additional information.
232

CASE 114
A
B
History: A 32-year-old woman presents in the second tri-
mester with a small-for-dates gestation.
1. What should be included in the differential diagnosis?
(Choose all that apply.)
A. Posterior ureteral valves
B. Ureteral atresia
C. Megacystis microcolon syndrome
D. Prune-belly syndrome
E. Bilateral urethral vesicular junction obstruction
2. Which of the following would be a potentially favorable
prognostic factor in posterior urethral valves?
A. Severe oligohydramnios
B. Echogenic kidneys
C. Marked bladder distention
D. Presence of urine ascites
3. Which of the following syndromes is not associated with
posterior urethral valves?
A. Potter syndrome
B. VATER syndrome
C
D
Used with permission from McGahan JP, et al: Fetal abdomen and pelvis. In McGahan JP, Goldberg BB [eds]: Diagnostic Ultrasound, 2nd ed.
New York: Informa Healthcare USA, 2008; 1324.
C. Amniotic band syndrome
D. Eagle-Barrett syndrome
4. All of the following statements concerning the management
of posterior urethral valves or urethral atresia are true except:
A. Development of a vesicocutaneous stula has a poor
prognosis.
B. The presence of oligohydramnios may prevent detec-
tion of other anomalies.
C. There may be associated chromosomal abnormalities.
D. Placement of a vesicoamniotic shunt may be a treat-
ment option.
233

ANSWERS
CASE 114
Fetal Bladder Outlet Obstruction
1. A, B, C, and D
2. D
3. C
4. A
References
Bernardes LS, Salomon R, Aksnes G, et al: Ultrasound evaluation of
prognosis in fetuses with posterior urethral valves. J Pediatr Surg 2011;
46(7):1412-1418.
http://www.ncbi.nlm.nih.gov/pubmed/21763844 (Accessed on June 22, 2012.)
Chen L, Cai A, Wang X, et al: Two- and three-dimensional prenatal
sonographic diagnosis of prune-belly syndrome. J Clin Ultrasound 2010;
38(5):279-282.
http://www.ncbi.nlm.nih.gov/pubmed/20014136 (Accessed on June 22, 2012.)
Ruano R, Yoshisaki CT, Salustiano EM, et al: Early fetal cystoscopy for rst-
trimester severe megacystis. Ultrasound Obstet Gynecol 2011; 37(6):696-701.
http://www.ncbi.nlm.nih.gov/pubmed/21337440 (Accessed on June 22, 2012.)
Cross-Reference
Ultrasound: The REQUISITES, 2nd ed, pp 458-465.
Comment
Differential Diagnosis
The differential diagnosis in this case includes any bladder outlet obstruction; this could include the most severe form of urethral atresia. When the bladder outlet is completely obstructed,
posterior urethral valves in which a membrane with a very
small opening is situated within the posterior urethra would
be considered. Prune-belly syndrome is a variation of bladder
outlet obstruction but with associated abnormal abdominal
wall muscle and cryptorchidism. Other entities may be considered within the differential diagnosis, including megacystis
microcolon syndrome, which could produce bladder dilation
and bilateral hydronephrosis but usually with polyhydramnios.
Ultrasound Findings
Ultrasound ndings of posterior urethral valves include dilated
bladder with “keyhole” bladder outlet and bilateral hydronephrosis (Figures A and B). In a “keyhole” bladder, the proximal urethra is dilated (Figure C). The renal pelvis or calyx may
be ruptured, producing perinephric hematoma or urinoma.
Urine ascites is probably due to rupture and decompression of
the bladder into the abdomen (Figure D).
Prognosis and Management
Severe oligohydramnios, massive bladder distention, bilateral
hydronephrosis, and echogenic kidneys are associated with a
poor prognosis. When amniotic uid is preserved, less hydronephrosis and leakage of urine from the bladder into the fetal
abdomen are better prognostic features. Vesicoamniotic shunts
have been placed in selected cases for decompression of the
urinary bladder, but shunts may be associated with various
complications, including chorioamnionitis, shunt misplacement, preterm labor, and fetal demise.
234

CASE 115
A
B
B = body; H = head.
D
Used with permission from Anderson Publishing Ltd. from Victoria T,
et al: Fetal MRI of common non-CNS abnormalities: a review. Appl
Radiol 2011;40[6]:8-17. © Anderson Publishing Ltd.
History: A woman with Graves disease and in the third tri-
mester of pregnancy undergoes screening ultrasound.
1. What should be included in the differential diagnosis of the
neck mass? (Choose all that apply.)
A. Teratoma
B. Lymphostasis
C. Cystic hygroma
D. Fetal goiter
2. What is the linear static anechoic area in the center of the
neck mass?
A. Trachea
B. Esophagus
C. Aorta
D. Inferior vena cava
3. What is the usual etiology of this disorder?
A. Genetics
B. X-ray exposure of the mother
C. Treatment of maternal Graves disease with propylthio-
uracil (PTU)
D. Treatment of maternal Graves disease with iodine-131
4. Which of the following is not a potential consequence of
this untreated disorder?
A. Obstruction of the airway
C
B. Obstruction of the esophagus
C. Lower intelligence scores
D. Follicular thyroid carcinoma
235
Соседние файлы в папке Библиотека им академика М.И. Перельмана
