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Chapter 4 Organization of the Body and Integumentary System 71
Chapter Terms
Adipose Albinism Anabolism Anatomy Catabolism Cerumen Cyanosis
Dermatosis Epidermis Erythema Extracellular uid Homeostasis Impetigo Intracellular uid
Jaundice Keratin Melanin Melanoma Metabolism Negative feedback Physiology
Abbreviations
BSA HPV SLE
All medical sciences rely on the study of the anatomy and physiology of the human body. Anatomy refers to the structure of the body and physiology the function of those body parts. When you understand the structure and function of the body, it is easier to study and analyze the disease process.
C O G
ORGANIZATIONAL
STRUCTURE OF THE HUMAN BODY
The best way to study the anatomy of the body is to begin with the organization of the body from the sim­ple level, or smallest components, to the more complex level, the body systems. The cells of the body are the smallest components and are the basic units of life. The body’s cells are specialized meaning that they all have a specic function. A nerve cell functions differently than a muscle cell. These specialized groups of cells form the tissues of the body, for example, muscle tissue or nerve tissue. The tissues work together as an organ. Organs work together to make up a body system. Now we have a whole organism, the human body.
Body Systems
The human body is composed of eleven (11) different systems, all responsible for a different function within the body.
The systems and major function include:
Integumentary system
r
Skeletal system
r
Muscular system
r
Nervous system
r
Endocrine system
r
Cardiovascular system
r
r r r r r
Integumentary System
The word integument means skin. The integumentary system is composed of the skin and accessory structures including the hair, nails, sweat glands, and oil glands. The main function of the skin is to protect the body. Later in the chapter, we will cover the integumentary system.
Skeletal System
The skeletal system provides the basic framework for the body. There are 206 bones with joints between the bones allowing for movement. Ligaments are the struc­tures that hold the bones together. The skeleton also protects internal organs from injury.
Muscular System
Muscles are attached to the bones allowing movement of body parts. Muscles help the body to maintain pos­ture and provide protection to internal organs. Muscles produce heat in the body. In addition to skeletal muscle, which is voluntary, there are smooth muscles found in blood vessels and internal organs and cardiac muscle only found in the heart.
Nervous System
The brain, spinal cord, and nerves are the major parts of the nervous system. The body relies on the nervous system for control and coordination. The special sense organs require the nervous system to act as a relay sys­tem sending electrical signals to and from the brain.
Psoriasis Sebum Urticaria Vitiligo
Lymphatic system Respiratory system Digestive system Urinary system Reproductive system
72 Section II Anatomy and Physiology
Inthe chapter discussing the nervous system, the special senses are included.
Endocrine System
Endocrine glands are organs that produce hormones, which regulate the body activities. The hormones affect growth and reproduction as well as metabolism and nutrient utilization.
Cardiovascular System
The heart and blood vessels, arteries and veins, make up the cardiovascular system of the body. The heart pumps blood through the arteries to carry oxygen and nutrients to the body tissues. The veins carry blood back to heart from the body. The blood in the veins contains carbon dioxide and waste products from the tissues.
Lymphatic System
The lymphatic system assists the circulatory system. Lymph vessels return uids from the tissues to the blood. The tonsils, thymus, and spleen are organs of the lym­phatic system and support the immune system of the body. Lymphatic uid (lymph) lls the lymphatic vessels.
Respiratory System
C O G
Homeostasis means that there is a state of internal
balance in the normal body. Literally, the term means “staying the same.” Environmental conditions may change the balance; however, the body is equipped with the ability to maintain the balance or homeostasis. In order to stay healthy, conditions need to be maintained including body temperature, volume and composition of body uids, blood gas concentrations, and blood pressure.
HOMEOSTASIS
ANDMETABOLISM
Body Fluids
The body uids must remain in constant balance, vol­ume, and composition, in order for homeostasis to be maintained. Fluids include extracellular uid found outside the body’s cells and intracellular uid on the inside of cells. includes blood plasma, the liquid portion of blood, and lymphatic uid. Blood plasma carries nutrients to and from the cells. The intracellular uid, inside the cells, maintains the homeostatic internal environment of the cell.
Extracellular uid, outside the cell,
The lungs are the primary organs of the respiratory sys­tem. The respiratory system is responsible for conduct­ing air to the lungs where the exchange of oxygen and carbon dioxide takes place. The blood transports oxy­gen to the body, and carbon dioxide, a waste product, is transported back to the lungs and expelled from the body by breathing out.
Digestive System
This system is responsible for changing our foods into nutrients that the body can use for cell metabolism. Organs of the digestive system include the mouth, esoph­agus, stomach, and small and large intestines. Accessory organs are the liver, gallbladder, and pancreas.
Urinary System
The primary organs of the urinary system are the kid­neys. They lter the body’s blood removing waste prod­ucts and excess water. Other structures associated with the urinary system include the ureters, bladder, and urethra.
Reproductive System
This system includes external and internal structures concerned with reproduction of offspring. Male and female sex organs are different, but both systems pro­vide the necessary components to reproduce.
Negative Feedback
Homeostasis is primarily maintained through the pro­cess of negative feedback, a method that reverses any shift from normal range by upward or downward changes. Negative feedback responds to stimuli. This feedback loop requires three components:
A sensor gathering information about a body
r
condition A control center receiving input and sending correc-
r
tive action if necessary An effector responding to the signal or action
r
A common example of this is a household thermo­stat, the sensor, set at a preferred temperature called the “set point.” The thermometer responds to changes in the room temperature. When the temperature in the room drops below the set point, the control center noties the furnace, the effector, to turn on and produce heat to warm the room. When the temperature reaches a set point, the furnace shuts off. Figure 4-1 demonstrates how a furnace responds to the thermostat either activat­ing it or shutting it off.
Our body works in the same way regulating internal body temperature. A region of the brain is the control center sending signals to effectors such as sweat glands when the body temperature is too hot and to the muscles, to shiver, when the body is too cool. The nervous system acts to relay electrical
Chapter 4 Organization of the Body and Integumentary System 73
Room cools
down
Thermostat
shuts off furnace
Room temperature
rises to 70˚F (21˚C)
Heat
output
Room temperature falls to 66˚F (19˚C)
Thermostat
activates furnace
Anterior (ventral)
Medial
Lateral
Superior
Proximal
Distal
Posteri (dorsal)
or
Figure 4-1
(Reprinted from Cohen BJ. Memmler’s The Human Body in Health and Disease. 13th ed. Philadelphia, PA: Wolters
Kluwer; 2014.)
Thermostat regulation (negative feedback).
impulses, signals, between the components of the feedback loop.
Metabolism
Metabolism is the sum of all chemical and physical
changes that occur in the body’s tissues. There are two types of metabolism:
Catabolism—the breakdown of complex substances
r
into simpler compounds
Anabolism—the building up of tissues through
r
growth and repair
C O G
Before the exploration of body directions, it is nec­essary to understand the anatomical position of the body. When a person is in anatomical position, they are standing upright facing forward, arms to the side of the body with the palms forward, and feet parallel
BODY DIRECTIONS
Inferior
Figure 4-2 Directional terms. (Reprinted from Cohen
BJ. Memmler’s The Human Body in Health and Disease. 13thed. Philadelphia, PA: Wolters Kluwer; 2014.)
to the ground. Figure 4-2 shows each of the direc­tional terms.
Directional Terms
The main terms used to describe the body directions are:
Superior—above or in a higher position
r
Inferior—below or lower
r
Anterior or ventral—toward the belly surface or front
r
of the body Posterior or dorsal—nearer the back or backside of
r
the body Medial—midline of the body dividing it into left and
r
right sides Lateral—away from the midline, toward the side
r
Proximal—nearer to the origin or attachment point
r
of a structure Distal—farther from the point of attachment
r
Body Planes
A plane describes a two-dimensional at surface. Body planes are used to describe the body as it is divided
74 Section II Anatomy and Physiology
Frontal
(coronal)
plane
Figure 4-3
Disease. 13th ed. Philadelphia, PA: Wolters Kluwer; 2014.)
Body planes. (Reprinted from Cohen BJ. Memmler’s The Human Body in Health and
Sagittal
plane
Transverse
(horizontal)
plane
into different directions. Figure 4-3 shows each of the body planes.
Frontal plane—an imaginary line down the middle of
r
the body dividing it into anterior and posterior sec­tions; also called the coronal plane. Sagittal plane—an imaginary line down the body
r
separating it into right and left portions. If the line is exactly down the midline of the body, dividing it into equal right and left halves, it is a midsagittal plane.
Cranial cavity
Spinal cavity (canal)
Thoracic cavity
Diaphragm
Ventral cavity
Abdomino­pelvic cavity
Abdominal cavity
Pelvic cavity
Transverse plane—an imaginary horizontal line made
r
across the body separating it into superior (upper) and inferior (lower) parts. Also called a horizontal plane.
Body Cavities
The internal body is divided into cavities or spaces that contain the body’s organs. The two main cavities are the dorsal cavity and ventral cavity. See Figure 4-4, which demonstrates the cavities of the body.
Dorsal cavity
Figure 4-4 Body cavities. (Reprinted from
Cohen BJ. Memmler’s The Human Body in Health and Disease. 13th ed. Philadelphia, PA:
Wolters Kluwer; 2014.)
Chapter 4 Organization of the Body and Integumentary System 75
Dorsal Cavity
The dorsal cavity lies on the posterior side of the body and is divided into the cranial cavity and the spinal cavity. The brain is contained within the cranial cavity and the spinal cord is found in the spinal cavity.
Ventral Cavity
The ventral cavity lies on the anterior side of the body and is divided into the thoracic cavity and the abdomi­nopelvic cavity. These two cavities are separated by the diaphragm, the major muscle of breathing. The heart, lungs, and large blood vessels that join the heart are located in the thoracic cavity. The heart and vessels are located in the middle space of the thoracic cavity called the mediastinum.
The abdominopelvic cavity is the subdivision of the ventral cavity that lies below the diaphragm. It is further divided into two sections, the abdominal cav­ity and the pelvic cavity. The abdominal cavity con­tains the stomach, liver, gallbladder, pancreas, spleen, and most of the intestine. The pelvic cavity is below the abdominal cavity separated by an imaginary line across the top of the hip bones. This cavity contains the urinary bladder, rectum, and internal reproductive organs.
Abdominal Regions
The abdomen is divided into nine regions that assist in describing areas of examination. The regions as shown in Figure 4-5 are:
Epigastric region—centrally located just inferior to
r
the breastbone Umbilical region—centrally located around the umbi-
r
licus (navel) Hypogastric regions—centrally located just inferior
r
to the umbilical region Hypochondriac regions, right and left—located just
r
inferior to the ribs Lumbar regions, right and left—level with the lumbar
r
region of the spine Iliac or inguinal regions, right and left—iliac is named
r
for the upper rounded edge of the hip bone and ingui­nal for the groin region
Body Quadrants
There are four quadrants of the body, which are more gen­eral than the regions. They include the right and left upper and the right and left lower quadrants. These quadrants represent an equal division of the abdominal region into four parts. Figure 4-6 shows the four abdominal quadrants.
Figure 4-5 Regions of the body. (Reprinted from Cohen
BJ. Memmler’s The Human Body in Health and Disease. 13th ed. Philadelphia, PA: Wolters Kluwer; 2014.)
Figure 4-6 Body quadrants. (Reprinted from Cohen
BJ. Memmler’s The Human Body in Health and Disease. 13thed. Philadelphia, PA: Wolters Kluwer; 2014.)
76 Section II Anatomy and Physiology
C O G
MEDICAL TERMINOLOGY
Throughout the chapters of this textbook, you encounter medical terms used to describe anatomy, physiology, pathology, procedures, and treatments. Medical terminology can seem complicated and hard to understand unless you look at each term and liter­ally break it apart into word parts, prex, root, and sufx. The root is the main part of the word. Some terms have more than one root. The prex starts the word and modies the root, giving it more meaning. The sufx is at the end, following the root, and modi­es the root. When the prex, root, and sufx com­bine, a complete term is formed. Putting these parts together may require the addition of a vowel to the root in order for it to blend together. When a prex is written alone, it requires a dash after the prex, and when the sufx is written by itself, a dash is placed in front of the sufx. Table 4-1 provides an example of how the word parts are put together to make a fullterm.
Study Skill
As you begin to study the anatomy and physiology of the body, you will understand that although there are many systems, organs, and functions, the body is very organized. The trick to studying this informa­tion is to organize your thoughts. Mind mapping is a technique or method of building a diagram on paper to visually organize the information. The mind map resembles a spider web when nished. You start at the center of the diagram with a circle, and there are extensions coming out of various points on the circle. For example, if you want to mind map the body sys­tems and organs in each, start the middle of the dia­gram with the word body systems, and draw a line away from the circle for each body system. Next, draw a line away from each body system to repre­sent each organ in that system. You can go further and add the function of the organ. When nished, you will have a visual diagram of the body systems with each one represented as a separate extension of the circle.
Case Study
Evelyn Miller is a 56-year-old patient who fre­quently sees the dermatologist to evaluate new lesions she discovers on her skin. She had four skin cancer lesions removed from her face and now has found a new lesion on her forearm that she wants checked out. As the medical assis­tant, Natalie, escorts her to an exam room, Ms. Miller says that she doesn’t understand why she is always getting these lesions. She said that she
Table 4-1
Medical Term Word Parts Example
Homeostasis homeo—same
Pathology path/o—disease
Intracellular intra—within
Anatomy ana—apart
Terminology Word Parts
stat or stasis—stoppage, consistency
ology—study of ology—study of
-ar—pertaining to
tomy—to cut, incision dissect
does not recall any of skin cancer in her family. She has always been a healthy woman who loves working in her garden and swimming in the com­munity pool. She still continues to do these things and loves to wear a tank top and shorts when she does her gardening and of course she wears a swimsuit to the pool. She says that even though she is aging, she still wants to keep her beautiful bronze skin.
Homeostasis is the steady state (sameness) within an organism.
Pathology is the study of diseases or the disease process.
Intracellular means pertaining to inside of or within a cell.
Anatomy means to cut apart to discover the structure of an organism.
Chapter 4 Organization of the Body and Integumentary System 77
Case Question
A F F
If the physician asks Natalie to provide patient education to this person, what
should she tell her? If the patient asks about skin cancer and if it is fatal, what should the medical assistant explain to the patient?
C O G
THE INTEGUMENTARY
SYSTEM
The integumentary system is the natural place to start introducing each of the body systems. The skin provides the rst line of defense against infections and harmful agents that would damage the body. The term integu­mentary means “covering” and can reect a person’s health and emotional state. The accessory structures that are associated with the integumentary system are the
sweat and oil glands, hair, and nails. Figure 4-7 shows a cross section of the skin with the structures contained within each layer.
Structure of the Skin
There are three layers associated with the skin:
Epidermis
r
Dermis
r
Subcutaneous
r
Epidermis
The epidermis is the top layer of the skin and contains no blood vessels. It is entirely made of epithelial cells. The epidermal cells are constantly sloughed off, and replaced by new cells. The new cells are produced in the stratum basale, the deepest layer of the epidermis. These new cells are pushed toward the top layer of the epi­dermis. They also undergo changes replacing the cell’s cytoplasm with protein called keratin. Keratin thickens
Nerve ending
Epidermis
Dermis (corium)
Subcutaneous layer
Hair
Pore (opening of sweat gland)
Stratum corneum
Touch receptor (Meissner cor
Stratum basale (growing layer)
Dermal
Sebaceous (oil) gland
Pressure receptor (Pacinian corpuscle)
Sudoriferous (sweat) gland
puscle)
Artery
Nerve
Vein
Adipose (fat) cells
Figure 4-7 Skin structure. (Reprinted from Cohen BJ. Memmler’s The Human Body in Health and Disease. 13th ed.
Philadelphia, PA: Wolters Kluwer; 2014.)
Hair follicle
Arrector pili muscle
78 Section II Anatomy and Physiology
and protects the skin. This thickened, uppermost layer of the epidermis is the stratum corneum. This layer is more prominent in thick skin, found on the palms of hands, than in thin skin, as found on the eyelids. dark pigment that colors the skin and protects it from the harmful rays of the sun. The cells that produce mela­nin are call melanocytes.
Melanin is a
Dermis
The dermis is referred to as “true skin.” It is where the skin’s vital functions take place. Blood vessels and nerves supply this layer of skin. Dense irregular connective tis­sue allows the dermis to be elastic and able to stretch. This layer of true skin also contains the sweat and oil glands and the hair follicles.
The dermal papillae are supercial projections of the dermis that forms a pattern of ridges that help prevent slipping. The pattern of the ridges is inherited and is unique to each person. Fingerprints and footprints are an example of the pattern of ridges. They are used for a personal identication since there are no two persons with the same pattern.
Subcutaneous Layer
The subcutaneous layer is a connective tissue membrane also referred to as the hypodermis since it lies beneath the dermal layer. This layer connects the skin to the deep fascia covering the muscles. The subcutaneous layer is primarily made of areolar connective tissue and vary­ing amounts of acts as insulation and provides a reserve energy supply. The blood vessels, supplying this layer of skin, help to regulate the body temperature.
adipose (fatty tissue). The adipose tissue
Accessory Structures of the Skin
Structures that are included with the integumentary sys­tem are:
Sebaceous glands (oil)
r
Sudoriferous glands (sweat)
r
Hair
r
Nails
r
Sebaceous Glands
The sebaceous glands are structures that secrete sebum (oil), which lubricates the skin and hair preventing dry­ness. The ducts of the glands open into the hair follicles.
Sudoriferous Glands
The sudoriferous glands are sweat glands. They are coiled, tube-like structures located in the dermis and subcutaneous tissue. Their function is to cool the body. As they release sweat (perspiration), heat is drawn from the skin as the moisture evaporates at the sur­face of the skin. The eccrine-type sweat glands secrete
perspiration and excrete water and waste through this process. Another type of sudoriferous gland is the apo­crine sweat gland located in the armpits and groin area. Secretions from these glands increase with emotional stress and sexual stimulation. Body odor is caused through the action of bacteria breaking down organic cellular materials, which are excreted from the apocrine glands.
Another type of gland is the ceruminous glands in the
ear canal that produce ear wax,
Hair
The body is covered with hair even though some hair is barely visible, very soft, and ne. Hairless areas of the body are the palms of the hands, soles of the feet, lips, nipples, and parts of the external genitalia. Hair devel­ops from stem cells located in the bulb at the base of the hair follicle. Melanocytes add pigment to developing hair. The visible part of the hair seen above the skin is the shaft and the portion below the skin is the root.
Most hair follicles have an attached thin band of involuntary muscle, the arrector pili. This muscle con­tracts when a person is cold or frightened, raising the hair causing “goose bumps.”
Nails
The ngers and toes are protected by the nails. Nails also help us grasp items too small to pick up with the hands. They are comprised of hardened keratin ( protein). Parts of the nail are:
Nail root—growth region located under the proximal
r
end of the nail Nail plate—main portion of the visible nail
r
Lunula—visible “little moon” at the proximal end of
r
the nail Cuticle—an extension of the skin that seals the space
r
between the nail plate and the skin above the root
Figure 4-8 shows a photo of a nail from the top and a cross section of a nail.
The nails can tell us a little something about a per­son’s general health. Changes in the nail’s appearance might indicate the presence of chronic diseases such as heart disease, peripheral vascular disease, malnutrition, and anemia. With these types of diseases, the nail may have an abnormal color, thickness, shape, or texture such as grooves or splitting.
cerumen.
Functions of the Integumentary System
The main functions of the integumentary system include:
Protecting against infection
r
Protecting against dehydration or drying
r
Regulating the body temperature
r
Collecting sensory information
r
Chapter 4 Organization of the Body and Integumentary System 79
LunulaNail plate CuticleFree edge
A
Nail bed
Nail plate
B
Figure 4-8 Nail structure. A. Healthy nail. B. Internal
nail and nger structures. (Reprinted from Cohen BJ. Memmler’s The Human Body in Health and Disease. 13thed. Philadelphia, PA: Wolters Kluwer; 2014.)
Distal bone of finger
Lunula
Cuticle
Nail root
Growth region (nail matrix)
Protecting Against Infection
Pathogens are all around us just waiting to invade the body. One common route of entry is through broken skin. However, intact skin forms a primary barrier against invasion of pathogenic organisms. The skin’s surface cells are constantly shed, removing the patho­gens with those dead cells. There are harmful chemicals in our environment that do not enter the body due to the protective layer of the skin.
Protecting Against Dehydration
The skin is a waterproof surface protecting the body from drying out. Keratin and oil keep it moist and soft. Even though some water is lost through perspiration and evaporation, these substances prevent excessive water loss. When the skin is signicantly damaged, excessive uid is lost through the skin. An example is a person who has experienced serious burns.
the body part becomes cooler. In a cold environment, body heat is maintained in the core of the body. This is why our feet and hands are colder. In warm climates, blood ow is increased bringing blood closer to the sur­face of the skin. Heat dissipates through this process. When we are warm, the skin actually becomes red. In cold temperatures, the skin can become pale or bluish in color.
Collecting of Sensory Information
The skin is one of the chief sensory organs containing many nerve endings and special receptors. The receptors detect pain, temperature changes, touch, and pressure. These skin receptors initiate reexes that cause our body to respond to the stimulus. For example, if you touch something very hot, the immediate reaction is to pull away from the heat.
Observing the Skin
During physical examination of a patient, the physician inspects the skin for characteristics that indicate the gen­eral health of the individual. The physician will observe the color and texture of the skin as well as any damaged areas or abnormalities. Terms associated with the skin color are:
Discoloration—distinct change in skin color.
r
Melanin—skin’s main pigment produced by melano-
r
cytes, darker people have a larger quantity of melanin because their melanocytes are more active.
Albinism—impairs melanin production resulting
r
in lack of pigment in the skin, hair, and eyes. See Figure4-9, a photo of an infant with albinism.
Vitiligo—blanching of the skin to near whiteness, due
r
to the defective action of the melanocytes. Pallor—paleness of the skin usually caused by reduced
r
blood ow or reduced hemoglobin (anemia). Flushing—redness caused by increased blood ow to
r
the skin, usually around the face and neck.
Cyanosis—bluish discoloration when there is not
r
enough oxygen in the blood, may indicate heart or respiratory condition.
Jaundice—yellowish skin discoloration, which may
r
be caused by excessive amounts of bile pigments (bilirubin) or may be due to hepatitis or bile ow obstruction.
Erythema—redness of the skin.
r
Disorders of the Integumentary System
Regulating Body Temperature
The skin is essential in the homeostatic management of heat and cold. Heat increases when blood ow increases to a part of the body, and when blood ow decreases,
Physical and chemical trauma or disease can cause vari­ous skin conditions. They can be very simple or quite intense. The general term used for any skin disease is
dermatosis. Lesions are wounds or damage to the skin.
Figure 4-10 shows various lesions of the skin.
80 Section II Anatomy and Physiology
on the skin is called an eruption. Other types of surface skin lesions are:
Papulea rm, raised area (pimple)
r
Macule—a spot on the skin, not raised or depressed
r
(freckles) Nodule—a large rm papule
r
Vesicle—a blister or uid lled sac (shingles)
r
Pustule—vesicle lled with pus
r
Many lesions develop from trauma, sounds, or injury to the skin. These result in deeper lesions and include:
Excoriation—a scratch into the skin
r
Laceration—a rough, jagged wound caused by tear-
r
ing the skin Ulcer—death of the tissue resulting in a deep sore
r
Fissure—a crack in the skin
r
Burns
Burns can be minor or very serious. They can be caused from contact with hot objects and chemicals, exposure to sunlight, and electrical injuries. Burns are classied by the depth of damage and the amount of surface area affected.
Figure 4-9 Albinism. (Reprinted from Kronenberger J,
Ledbetter J. Lippincott Williams & Wilkins’ Comprehensive Medical Assisting. 5th ed. Philadelphia, PA: Wolters
Kluwer; 2016.)
Lesions are classied by their type and location, above or below the surface of the skin. A rash is a type of surface skin lesion. A diaper rash is an example of a localized rash and a disease like the measles can cause a generalized rash over the entire body. A raised rash is
Macule Papule Nodule Vesicle
First-degree burn—supercial involving only the epi-
r
dermis; skin is red, dry with minimal pain; an exam­ple is a mild sunburn. Second-degree burn—partial-thickness burn involves
r
the epidermis and dermis forming blisters; an exam­ple is scalding with water or severe sunburn. Third-degree burn—full-thickness burn involving
r
destruction of the entire skin, extend into subcutane­ous fat, muscle, or bone; skin is broken, dry and pale, or charred; may require skin grafting or may result in loss of digits or limbs; an example is exposure to open ames.
Pustule
Figure 4-10 Skin lesions. (Reprinted from Kronenberger J, Ledbetter J. Lippincott Williams &
Wilkins’ Comprehensive Medical Assisting. 5th ed. Philadelphia, PA: Wolters Kluwer; 2016.)
Fissure Ulcer