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16 Ocular Surface Examination
199
out anesthesia and with open eyes), Schirmer II (after nasal stimulation), and Schirmer III (reex­stimulated secretion by looking into the sun) [11]. To avoid confusion, dening the Schirmer test with or without anesthesia is better than using I or II [21]. Schirmer test values <10mm indicate dry eye disease; however, values <5mm are path­ological, and between 5 and 10 mm should be interpreted carefully [22].
For measuring TMH, slit-lamp-based menis­cometry and non-invasive optical coherence tomography (OCT) can be used [20]. Due to its non-invasive nature and less chances of reex tearing, OCT-based TMH is more repeatable and reproducible than the Schirmer test. Time- and spectral-domain OCT can be used for calculating TMH, but they are not interchangeable. The reported normal mean TMH values are 0.29mm (SD = 0.13 mm, slit lamp), 0.27–0.29 mm (SD = 0.05–0.12 mm, keratograph), and 0.19–
0.34mm (SD=0.02–0.15mm, SD-OCT) [23].
16.5 Conclusion
The ocular surface examination should be com­prehensive and inclusive of all components of the surface, i.e., cornea, conjunctiva, eyelids, and eyelashes. Fluorescein stain for ocular surface evaluation is crucial and should be performed for every case. Diagnostic devices like ASOCT, ocu­lar surface analyzer, and keratograph for non­invasive tear lm assessment are adjunctive tools that help in diagnosis and follow-up evaluations.
Funding Hyderabad Eye Research Foundation, Hyderabad, India.
Disclosure None.
References
1. Kenyon KR.Anatomy and pathology of the ocular surface. Int Ophthalmol Clin. 1979;19(2):3–35.
2. Cher I. Ocular surface concepts: development and citation. Ocul Surf. 2014;12:10–3.
3. Srinivas SP, Rao SK. Ocular surface staining: cur­rent concepts and techniques. Indian J Ophthalmol. 2023;71(4):1080–9.
4. Han SB, Liu YC, Noriega KM, Mehta JS.Applications of anterior segment optical coherence tomography in cornea and ocular surface diseases. J Ophthalmol. 2016;2016:4971572.
5. Kate A, Basu S.A review of the diagnosis and treat­ment of limbal stem cell deciency. Front Med (Lausanne). 2022;9:836009.
6. Vazirani J, Donthineni PR, Goel S, etal. Chronic cica­trizing conjunctivitis: a review of the differential diag­nosis and an algorithmic approach to management. Indian J Ophthalmol. 2020;68(11):2349–55.
7. Knop E, Knop N, Zhivov A, etal. The lid wiper and muco-cutaneous junction anatomy of the human eyelid margins: an invivo confocal and histological study. J Anat. 2011;218(4):449–61.
8. Shanbhag SS, Singh S, Koshy PG, etal. A beginner’s guide to mucous membrane grafting for lid margin keratinization: review of indications, surgical tech­nique and clinical outcomes. Indian J Ophthalmol. 2021;69(4):794–805.
9. Singh S. Distichiasis: an update on etiology, treatment and outcomes. Indian J Ophthalmol. 2022;70(4):1100–6.
10. Adewara B, Singh S.Ocular adnexa and antiglaucoma medications. Int Oph Clin. 2023;63:47.
11. Singh S, Srivastav S, Donthineni PR, etal. Lacrimal and meibomian gland evaluation in dry eye disease: a mini-review. Indian J Ophthalmol. 2023;71:1090.
12. Singh S, Shanbhag SS, Basu S. Palpebral lobe of human lacrimal gland: morphometric analy­sis in normal versus dry eyes. Br J Ophthalmol.
2021. [Epub].;105:1352. https://doi.org/10.1136/
bjophthalmol- 2020- 316929.
13. Singh S, Shanbhag SS, Basu S. Tear secretion from the lacrimal gland: variations in normal ver­sus dry eyes. Br J Ophthalmol. 2022;106(6): 772–6.
14. Singh S, Vemuganti GK, Basu S. Morphological variants of meibomian glands: correlation of mei­bography features with histopathology ndings. Br J Ophthalmol. 2021. [Epub].;107:195. https://doi.
org/10.1136/bjophthalmol- 2021- 318876.
15. Swiderska K, Read ML, Blackie CA, et al. Latest developments in meibography: a review. Ocul Surf. 2022;25:119–28.
16. Finis D, Pischel N, Schrader S, Geerling G.Evaluation of lipid layer thickness measurement of the tear lm as a diagnostic tool for Meibomian gland dysfunction. Cornea. 2013;32:1549–53.
17. Singh S, Srivastav S, Modiwala Z, etal. Repeatability, reproducibility and agreement between three different diagnostic imaging platforms for tear lm evaluation of normal and dry eye disease. Eye. 2023;37:2042–7.
18. Cox SM, Nichols KK, Nichols JJ.Agreement between automated and traditional measures of tear lm break­ up. Optom Vis Sci. 2015;92(9):257–e263.
19. Singh S, Srivastav S, Mohamed A, Basu S. Non­invasive tear lm assessment in normal population: effect of age, sex, and interparametric relationship. Front Med (Lausanne). 2022;9:894184.
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20. Niedernolte B, Trunk L, Wolffsohn JS, et al. Evaluation of tear meniscus height using different clinical methods. Clin Exp Optom. 2021;104(5): 583–8.
21. Serin D, Karsloğlu S, Kyan A, Alagöz G.A simple approach to the repeatability of the Schirmer test without anesthesia: eyes open or closed? Cornea. 2007;26(8):903–6.
22. Singh S, Basu S.Effect of topical anesthesia on the secretory activity of the main lacrimal gland. Cornea. 2020;39(10):e24–5.
23. Donthineni PR, Doctor M, Kate A, et al. Aqueous­decient dry eye disease: preferred practice pattern guidelines on clinical approach, diagnosis, and man­agement. Indian J Ophthalmol. 2023;71:1332. https://
doi.org/10.4103/IJO.IJO_2808_22.
Intraocular Pressure
RamyashriS , AparnaRao , andSardarM.Khan
17
17.1 Introduction
Intraocular pressure (IOP) measurement is essential for diagnosing and managing glau­coma. The Goldmann applanation tonometer (GAT) is the current gold standard for measur­ing IOP, although several newer technologies are currently available for IOP measurement [14]. Some new IOP measurement technolo­gies and devices include dynamic contour tonometry (DCT), ocular response analyzer (ORA), Pascal dynamic contour tonometer (DCT-Pascal), rebound tonometry, Tono-Pen Avia, and the Bioresonator applanation reso­nance tonometer (ART). This chapter will describe the GAT and the newer devices used for IOP measurement.
R. S Kallam Anji Reddy Campus, L V Prasad Eye Institute, Hyderabad, India
Drishti Eye Centre, Hyderabad, India
A. Rao (*) Kallam Anji Reddy Campus, L V Prasad Eye Institute, Hyderabad, India
L V Prasad Eye Institute, Bhubaneshwar, India e-mail: aparna@lvpei.org
S. M. Khan Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye Care, L V Prasad Eye Institute, Siddipet, India
17.2 Goldmann Applanation
Tonometry (GAT)
The technique is named after its inventor, Hans Goldmann, who discovered it in 1948 [5].
Technology—By applying a known force to the cornea and measuring the area of applanation (the attened area), the Goldmann applanation tonometer (GAT) calculates the IOP based on Imbert Fick’s law. The device uses a truncated cone with a surface area of 7.35mm2 and a diam­eter of 3.06mm mounted on a slit lamp. It is lit with a blue lter, and the doubling prism embed­ded in the cone divides the circular tear meniscus into two equal semicircular halves, which are aligned at their inner edges (Fig.17.1) to obtain precise applanation of the cornea. The force required to atten the corresponding surface of the cornea is directly proportional to the IOP in mmHg from the scale of the measuring drum [6].
Technique—The patient is made to sit with his/her forehead rmly placed against the head­band and the chin comfortably placed on the chinrest of the device. After adequate anesthesia, the uorescein dye is added to each eye. The patient’s lateral canthus should align at the mark on the headrest column, and the patient is instructed to look straight ahead with eyes wide open. The clean tip of the tonometer biprism with the cobalt blue lter is moved toward the eye to be examined; the lter helps visualize the bright yellow- green uorescence of the dye. The tip of the biprism is illuminated at a wide angle, and the
© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024 T. Das, P. Satgunam (eds.), Ophthalmic Diagnostics, https://doi.org/10.1007/978-981-97-0138-4_17
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a
c
b
Fig. 17.1 (a) Slit-lamp mounted Goldmann applanation tonometer; (b) the measuring dial; (c) the biprism illuminated with a blue lter; (d) the mires of the biprism; and (e) the Perkins tonometer
instrument is set at low magnication and highest illumination. The examiner should look monocu­larly through the oculus to identify the spot of uorescein on the cornea that has just been appla­nated (converted into two semicircular halves). The height of the slit lamp is adjusted such that the two halves of the applanated cornea are equal. The force adjustment knob or measuring dial is moved in the appropriate direction such that the inner edges of the two semicircles touch each other but do not overlap. The number on the mea­suring dial multiplied by 10 gives the IOP in mmHg (Fig.17.1).
Clinical Application—Goldmann applana­tion tonometry provides accurate and reproduc­ible IOP measurements; nevertheless, this depends on the physician’s (user’s) experience. Interobserver variability of ±2 mmHg may be observed [7]. The measurement of IOP using
malities such as scarring or other irregularities can result in inaccurate IOP measurements. The technique may also underestimate IOP in thin corneas and overestimate IOP in thick corneas [7, 8]. Other drawbacks of using GAT include interference in IOP measurement due to tear lms with too little or too much uorescein dye, quenching of the dye, and other calibration errors [9].
Recent advancements in technology and design have improved the accuracy and reproduc­ibility of GAT.Newer models use a digital dis­play to provide more precise IOP measurements, and some integrate with electronic medical records for easier tracking and analysis of col­lected data. A portable version of GAT is the Perkins tonometer, which works on the same principle as the Goldmann applanation tonometer but is useful for people lying supine.
GAT, however, is not without limitations. Since the technique requires the device to contact the cornea, it is a potential source of corneal abra-
17.3 Dynamic Contour Tonometry
sion and infection. The device is slit-lamp mounted and requires that the patient is in an upright position. Additionally, the IOP value obtained by GAT can be affected by corneal parameters like corneal thickness, curvature, and
Dynamic contour tonometry (DCT) is a low­contact method of measuring IOP.The technique uses a small probe gently placed near the eye to measure the eye pressure.
other biomechanical properties [8]. Any abnor-
17 Intraocular Pressure
203
Technology—DCT uses a small, sensor­equipped probe that lightly touches the surface of the eye and records the changes in the pressure as the eye is deformed. The sensor of the probe has a exible and curved surface that conforms to the shape of the cornea, allowing it to measure the pressure accurately [10, 11].
Clinical Application—DCT is more accurate than applanation tonometry, especially in patients with corneal abnormalities, such as scarring or irregular curvature. In addition, DCT is easy to use and requires no special skills or training. However, DCT is affected by eye movements and can result in inaccurate readings, and the devices used are asso­ciated with high costs. The comparison of DCT and GAT, and other tonometers is shown in Table17.1.
New developments and versions of DCT tech­nology [12] include:
• Corvis ST: This is a new generation DCT
device developed by Oculus (Switzerland).
The Corvis ST measures corneal deformation
responses and IOP using a high-speed
Scheimpug camera that captures images of
the cornea when a puff of air deforms it. It also
provides biomechanical information on the
cornea, such as corneal hysteresis.
• DCT Pro: This is an upgraded version of the Pascal DCT tonometer developed by Zeimer (Switzerland). The DCT Pro uses a smaller and more ergonomic probe, which improves patient comfort and ease of use for the opera­tor. It also features enhanced measurement stability, thus improving the accuracy and reproducibility of IOP measurements.
• Bidirectional DCT: This is a new DCT tech­nology developed by Nidek (Japan). The bidi­rectional DCT uses a two-way air jet to measure IOP, improving accuracy and reduc­ing corneal biomechanics' effect on IOP measurements.
• DCT with Ocular Pulse Amplitude (OPA): This is a new feature added to some DCT devices, such as the Reichert ORA.The OPA measures the pulsatile component of IOP, which reects changes in blood ow and ocu­lar perfusion [13, 14]. Adding OPA to DCT measurements provides additional informa­tion about ocular health and can help diagnose and manage glaucoma and hypertension.
Despite the advantages of other IOP measure-
ment systems, GAT is more widely used and remains the standard of care.
Table 17.1 Comparisons of different tonometers
Schiotz tonometer Working principle Indentation
Goldmann Applanation tonometer
Perkins tonometer
Relation with cornea Contact Corneal biomechanics Not considered, but affects the measurements Clinical application Useful in low-resource countries
IOP in post-Kpro eyes with scleral indentation
Availability/cost Available easily
Inexpensive Working principle Applanation Relation with cornea Contact Corneal biomechanics Affected by corneal biomechanics and corneal thickness Clinical application In all cases, but not accurate when corneal scarring is present Availability/cost Easily available and routinely used by all
Current gold standard Working principle Indentation Relation with cornea Contact Corneal biomechanics Same as GAT Clinical application Can be used in supine position Availability/cost Can be used as a replacement for GAT
(continued)
204
Table 17.1 (continued)
Tono-pen Working principle Indentation/applanation
Relation with cornea Contact Corneal biomechanics Same as GAT Clinical application Underestimates IOP value
Availability/cost Moderately available
DCT Working principle Contour matching
Relation with cornea Contact Corneal biomechanics Independent of corneal properties Clinical application Precise but difcult to use
Availability/cost Not available easily
ORA Working principle Applanation
Relation with cornea Non-contact Corneal biomechanics Provides information on corneal biomechanics and IOP
Clinical application Useful in post-refractive surgery; self-calibration possible
Corvis ST Availability/cost Expensive
Working principle Indentation/applanation Relation with cornea Non-contact Corneal biomechanics Provides information on corneal biomechanics and IOP
Clinical application Useful in post-refractive surgery cases and glaucoma cases
Availability/cost Expensive
iCare Rebound tonometer
Bioresonator ART Working principle Applanation, based on the acoustic impedance
Sensimed Triggersh
Working principle Rebound principle using a ballistic probe Relation with cornea Contact Corneal biomechanics Inuenced by corneal properties Clinical application Can be used for screening purposes and in GA cases Availability/cost Expensive but feasible to use
Relation with cornea Contact Corneal biomechanics Affected by corneal properties Clinical application No need for uorescein, self-calibrated, provides a quality
Availability/cost Expensive Working principle Scleral stretch monitoring Relation with cornea Contact Corneal biomechanics Affected by corneal biomechanics Clinical application Used for continuous 24-h IOP monitoring
Availability/cost Expensive
Highly variable and poor repeatability
Expensive
Needs high patient cooperation
Expensive
corrected for corneal biomechanical property
Provides a quality index, but there is limited evidence for
application
corrected for corneal biomechanical property
Tends to underestimate the GAT values
index
Has a learning curve to measuring IOP
Does not provide direct IOP (only an estimate)
R. S et al.
17 Intraocular Pressure
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17.4 Ocular Response Analyzer (ORA)
Technology—ORA measures the biomechanical properties of the cornea. It rapidly delivers a puff of air to the cornea that deforms/indents the cor­neal surface [1518]. The ORA measures two key parameters of the cornea’s response to this puff: (a) corneal hysteresis (CH) and (b) corneal resistance factor (CRF).
The CH measures the cornea's ability to absorb and dissipate energy during deformation. It reects the cornea's elasticity or “bounce­back,” and a low CH may indicate a stiffer cornea associated with a higher risk of developing glau­coma [16]. The CRF is a measure of the overall resistance of the cornea to deformation. A higher CRF value suggests the cornea’s ability to resist deformation, which may be protective against glaucoma.
Clinical Application—ORA measurements help identify individuals at increased risk of developing glaucoma, even if their IOP is within the normal range; this can aid in early and more individualized interventions.
Over the years, the design and technology of ORAs have evolved. The most recent version, the ORA G3 (2016), features a waveform analysis that provides more detailed information on the corneal response to the puff of air. The ORA G3 also includes a more user-friendly interface and a redesigned, easy-to-use probe that is less prone to operator error. Other improvements in the ORA G3 include individualized measurement proto­cols and the ability to integrate with optical coherence tomography (OCT). The proposed developments in ORA technology that may improve its accuracy and reliability and expand its diagnostic capabilities include corneal biome­chanical imaging [16, 18], articial intelligence integration [1922], and improved waveform analysis.
The ORA and Goldmann applanation tonom­eter differ in their approaches to measuring IOP and the information they provide. In certain con­ditions, ORA may be more accurate and reliable, but GAT remains the gold standard for measuring IOP in most patients.
17.5 Telemetric 24-h IOP Monitoring
Technology—Telemetric 24-h screening of IOP is a non-invasive method for measuring IOP over an extended period, typically 24h [2327]. This method uses a tiny wireless sensor implanted inside the eye to transmit data to an external receiver/recorder. The data is then analyzed to obtain a comprehensive prole of the uctuations in the patient's IOP over 24h.
Currently, there are several modes/types of telemetric 24-h screening of IOP for monitoring glaucoma. These include (a) continuous record­ing mode: the sensor records the IOP continu­ously over 24h, (b) pulsatile mode: the sensor records the IOP at intervals during the cardiac cycle, allowing for the detection of IOP uctua­tions related to changes in blood pressure, (c) triggered mode: the sensor is triggered by a spe­cic event or activity, such as physical activity or changes in posture, to record the IOP during that specic period, (d) hybrid mode: a combination of two or more of the above modes to provide a more comprehensive prole of the patient’s IOP uctuations over the 24h. The choice of a specic telemetric mode depends on the specic research question or clinical need.
Telemetric 24-h screening of IOP in glaucoma is a growing area of research and clinical prac­tice, with potential applications in the early detection and management of glaucoma and other eye diseases. Several investigators are cur­rently working on the development and commer­cialization of such devices. Here are some examples:
1. Eyemate-SC (Implantable Ophthalmic
Products, Germany): The system consists of a tiny pressure sensor implanted inside the eye and a wireless handheld device reading the sensor's data. The pressure sensor is implanted in a minimally invasive surgical procedure under local anesthesia. The device is powered by a small battery that can last up to 5years, after which the device can be eas­ily replaced. It is used with the EyeMate Reader, a handheld device that wirelessly
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reads the data from the pressure sensor. The data from the Eyemate- SC system is trans­mitted to a secure cloud- based platform where physicians and other healthcare pro­fessionals can analyze it. The Eyemate-SC system has received regulatory approval in Europe and is currently undergoing clinical trials in the USA [28].
2. Triggersh (Sensimed AG, Switzerland) [26]: This device uses “continuous monitor­ing of ocular dimensional changes” (CMOD) technology, which measures changes in the diameter of the eye over 24h. Changes in the diameter of the eye are directly related to changes in IOP. During the monitoring period, the patient wears a contact lens with the sensor, and the data is recorded by a por­table recorder that can be worn on a belt or carried in a pocket. The data is then trans­ferred to a computer for analysis. The Triggersh device has been approved by the US Food and Drug Administration (FDA) and is available in the USA and several other countries.
3. EyeSeal (Bausch + Lomb, USA): The EyeSEAL is a small, disposable patch worn on the skin around the eye. The patch contains a tiny wireless sensor capable of measuring changes in the shape of the eye due to changes in IOP. The sensor wirelessly transmits the data to a small portable device worn by the patient and can store up to 24h of data. The device is currently undergoing clinical trials and is not yet commercially available.
4. IOP Watcher (NovaSight, Israel): The sys­tem consists of a small wireless sensor placed on the skin near the eye and a mobile app that wirelessly reads the data from the sensor. It provides a comprehensive view of a patient's IOP over 24h. It can also help identify the peak and trough times in IOP values, which can be used to determine the most effective time for administering glau­coma medications. The IOP Watcher system has been approved for use in Europe and is currently undergoing clinical trials in the USA.
17.5.1 Clinical Application ofTelemetric IOP Monitoring
While 24-h monitoring of IOP can provide valu­able information for diagnosing and managing glaucoma, this technology has safety concerns and pitfalls. These include an increased risk of infection, damage to the cornea, false positive or negative results [22], high cost, and the possibil­ity of poor patient compliance. Currently, there is also limited evidence of the utility of this form of monitoring. The clinical application of 24-h monitoring in glaucoma practice may take time to evolve and will need radical ways of dealing with the enormous amount of data from such measurements. Novel AI-based algorithms may help incorporate the data into clinical treatment decisions in glaucoma practice in the future.
17.6 Rebound Tonometer
Technology—A rebound tonometer is a portable handheld tonometer that uses a disposable probe propelled from the tonometer toward the cornea by an electrical-pulse generator to create a mag­netic eld via a solenoid. The speed with which the probe returns to the device changes the magnetic eld, and the tonometer uses this value to calculate the IOP [29, 30]. In patients with higher IOPs, the probe touches the cornea for a shorter time and therefore rebounds into the tonometer faster.
Clinical Application—This tonometer does not require topical anesthesia, making it useful for IOP measurements in less cooperative patients and children [31]. It is also used for IOP monitor­ing at home for patients who cannot follow-up regularly but require frequent IOP assessment [2]. The other advantages of this tonometer are lightweight and portable, easy to use, there is no need for staining with uorescein, and there is a lower risk of eye infections since it uses a dispos­able probe [31]. In addition, this tonometer can also measure IOP in people with corneal abnor­malities [32]. However, the disadvantages of this device are its high cost and that the IOP measure-
17 Intraocular Pressure
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ments made with the device may vary with varia­tions in eyelid position.
17.7 Corvis ST
Technology—The Corvis ST combines tonome­try with corneal imaging to provide a more com­prehensive assessment of the eye. It uses a high-speed Scheimpug camera to capture images of the cornea as it responds to a puff of air. The camera captures over 4300 images per second, allowing for a detailed analysis of the corneal responses. In this device, an all-blue UV-free light (of wavelength 455nm) covers an
8.5mm horizontal slit that evaluates the dynamic corneal deformation resulting in 140 images cap­tured during the 30 ms after a puff of air is directed at the cornea. The bidirectional corneal deformation by the air puff is recorded during the entire process [33]. When a puff of air is directed at the cornea, it causes the cornea to applanate (A1 or rst applanation) and then deform (to the point of highest concavity or HC) and then recover with second applanation (A2 or second applanation) before it returns to the primary posi­tion. With the help of algorithms, this device identies the anterior and posterior limits of the deformation, and the IOP is measured at A1.
Clinical Application—The Corvis ST provides parameters related to the shape of the cornea, IOP, and depth, like deformation amplitude (DA), tim­ing, and velocity [34, 35]. The advantages of this device are its ease of use (specially trained person­nel not required), it is non-contact (reduces the risk of eye infection and contamination), has diverse applicability (can be used for ectatic corneas like those in patients with keratoconus or glaucoma), and is accurate (not affected by the central corneal thickness (CCT)). The disadvantages of the device include its high cost and currently limited evidence of precise IOP measurement.
17.8 Tono-Pen
Technology—The Tono-pen is a handheld device that works on the principles of applanation and indentation. The Tono-pen XL and the more
recent Tono-pen Avia (Reichert Ophthalmic Instruments, Depew, NY, USA) are portable battery- operated devices. The measured IOP is displayed on the digital screen with a standard deviation of an average of 10 consecutive readings.
Clinical application—The Tono-pen is com­monly used in clinical practice because it is a portable and easy-to-use device that can quickly and accurately measure IOP.However, the vari­ability in intra-session measurements is quite high (±4.3mmHg) [36]. It is particularly useful when traditional GAT is difcult or impossible to use, such as in patients with corneal abnor­malities or those who cannot sit upright. However, CCT is known to impact the IOP mea­surements by the Tono-pen [37]. The advantages of the Tono-pen include its portability, ease of use, quick and accurate measurements, and reduced risk of corneal infection since the device uses a disposable latex cap. The disad­vantages of the device include its high cost, the need for calibration before every use, and regu­lar maintenance requirements. Studies have also shown that the Tono-pen consistently underesti­mates IOP in high ranges (at IOP values >30mmHg) [38]. Recent advances in Tono-pen technology have focused on improving its accu­racy, reliability, and ease of use. For example, newer models may include automatic calibra­tion, data storage, and improved algorithms for calculating IOP. Additionally, some devices may incorporate additional diagnostic tools, such as pachymetry and/or imaging.
17.9 Schiotz Tonometry in Today’s
Practice
Introduced by the Norwegian ophthalmologist Professor Magne Schiotz in 1905 [39], Schoitz tonometry has since been widely used in ophthal­mic practice. Technology—The footplate of the tonometer is placed on the anaesthetized cornea with known standard weights via a plunger that indents the cornea. The indentation distorts the globe with aqueous displacement inside the ante­rior chamber. The movement of the plunger from its “0” position is correlated to the deformation of
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Scale
Needle
Weights
Lever arm
Plunger
Holder
Barrel
Foot plate
Fig. 17.2 Schiotz tonometer. Left panel: the device; mid­dle panel: the nomogram to translate the scale reading to intraocular pressure in mmHg; right panel: the tonometer in use. (Source for left and middle panels: Understanding
the cornea and can be translated via a calibrated scale read with the help of the lever that indicates it. Friedewald’s formula relates to it and needs a constant “K,” which is the ocular rigidity coef­cient [39]. The IOP can be obtained from the table, which calculates this value using the weight and the scale reading (Fig.17.2).
Technique—After the cornea is adequately anesthetized, the mid-temporal sclera (3 mm from the temporal corneoscleral limbus) is tested by asking the patient to look at the medial side for good exposure; in other cases, the extreme temporal gaze is used with a point mid­way between the medial canthus and medial corneoscleral limbus. The readings are taken with 5.5g weights. If the reading is less than 4, the weight is increased to 7.5g, and the IOP is measured again. The measured reading is con­verted to IOP using the nomogram. Figure17.2 (right panel) shows Schiotz tonometry per­formed on the Kpro eye at an extreme temporal gaze while the nasal sclera is widely exposed for tonometry.
Clinical applications—Senthil etal. (2019) showed that the IOP values recorded using
and caring for a Schiotz tonometer. Comm Eye Health, 2014; 27(87): 57. Ismael Cordero. Copyright 2014, used under the Creative Common Attribution 2.0 license)
scleral Schiotz tonometry had better agreement with GAT [40]. The main advantages of this method are that it is simple to use, affordable, can be used in people in supine position, and does not require other equipment like a slit lamp. The disadvantages of this method are that it is operator dependent, needs frequent calibra­tion, and may cause corneal abrasion and infec­tion. Due to these limitations, Schiotz tonometry has been replaced by the current gold standard, GAT, and the other newer tonometers due to their greater accuracy and reproducibility. However, there are certain situations where GAT/newer tonometers are unreliable or cannot be used, such as post- keratoprosthesis, post­keratoplasty, or in scarred irregular corneas where the central cornea cannot be used for the measurement of the IOP.
Modications and advances in Schiotz tonom­etry include (a) a digital scale to measure the force required to indent the cornea, thus eliminat­ing the need for the operator to read the scale manually, and (b) the use of a disposable plunger, which reduces the risk of transmitting infections between patients.