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26 Complications ofResection ofRetroperitoneal Tumors intheFemale Pelvis
277
will describe some injuries and complications in each category and the mechanisms by which they may occur. Understanding these mechanisms will inherently provide insight into some strategies to avoid such complications. Complications and reconstruction of vascular and some genitouri­nary tract injury (ureter and bladder) are covered extensively in other Chaps.12, 13, 14, 15, 16, and
17 and will be just briey mentioned herein with
reference to those chapters.

Genitourinary Complications

Background

The genitourinary organs of the female pelvis include the vagina, cervix, uterus, fallopian tubes, ovaries, bladder, urethra, and ureters. Injury to the cervix, uterus, fallopian tubes, and ovaries is most easily dispatched with the removal of the injured organ.
Laceration of the vaginal wall can occur either through sharp or inadvertent intrusion of bipolar thermal energy while separating the tumor from it. Injury to the anterior vagina most commonly occurs during the separation of tumors arising in the space of Retzius and injury to the posterior vagina from anterior rectal tumors that invade it.

Prevention

margin is possible with partial removal of the uterus and preservation of at least one tube and ovary, myomectomy/myoplasty can be pursued with the aid of the gynecologic surgeon.
Prevention of injury to the female GU organs is rooted in two principles: an awareness of ana­tomic relationships between the tumor and the surrounding organs and a low threshold to remove the organs en-bloc with the tumor mass or pre­emptively to avoid injury. The younger patient wishing to preserve fertility creates a higher level of complexity with regard to the prevention of injury. Absence of invasion must be established with high-resolution imaging prior to resection of any pelvic pathology and, when no invasion is noted, mobilization of the reproductive organs and retraction outside of the direct operative eld is the most effective means of preventing injury.

Recognition

Injury to reproductive organs is usually quite obvious, and most of these organs are resilient and quite hardy. Injury to the vagina is easily diagnosed but difcult to manage. Simple digital or speculum exam following tumor extirpation will conrm the integrity of the vagina. In doing so, establishing the length of the vagina and the precise location of the injury is critical in guiding management.
By the time most tumors (other than rectal cancer) within the true pelvis are diagnosed, total abdomi­nal hysterectomy and salpingo- oophorectomy have either already happened or are unavoidable for oncologic or preventative indications. In such cases, the best strategy to mitigate injury to these organs is either en bloc or isolated resection. Individual and up-front resection offers the advan­tage of creating space and clarity for primary tumor mobilization. Rarely, preservation of the uterus may be useful when tissue to occupy space created by the resected tumor is required to prevent pelvic herniation. A note of caution is that a uterus utilized for such a purpose will be difcult to remove sub­sequently should this become necessary. In cases where fertility preservation is a goal and a negative

Management

The repair of these defects can range from simple closure to complex vaginoplasty. In cases that involve either obligate (for margin) or inadvertent resection of the vaginal wall, early engagement of the gynecologic oncologist and/or plastic and reconstructive surgery team provides the greatest chance for a good functional outcome. Upper vagi­nal injuries can often be resolved with hysterec­tomy and incorporation of the injury in the resection specimen. Injuries occurring in the lower third of the vagina are most problematic owing to their implications for vaginal stenosis at or near the introitus and its impact on sexual intercourse. Figure26.2 depicts a breakdown of a primary vagi-
278
ab c
E. Zervos and N. A. Vohra
Fig. 26.2 Perineal dehiscence following abdominal peri­neal resection for anal cancer invading the vagina. (a) Dehiscent wound—note foley and attenuated labia and introitus; (b) Close up of dehiscence of prior vaginoplasty
nal repair following abdominal perineal resection for rectal cancer that resulted from negative pres­sure wound therapy in a dehiscent perineal inci­sion. Ultimate reconstruction with skin graft and gluteal advancement ap is shown in the panels. Mid-vaginal injuries are a gray area and must be assessed on an individual basis taking into consid­eration the precise location and extent of the injury, the length of the vaginal remnant and the patient’s desire to engage in sexual intercourse. More com­plicated vaginal reconstruction using a skin graft or vascularized transposition aps can be fashioned from the epidermal components of planned trans­position aps mobilized to ll the pelvic void cre­ated by radical extirpation. This subject is covered in greater detail in Chap. 41. Figure26.3 demon­strates vaginal reconstruction using the preserved skin from a vertical rectus myocutaneous ap employed to ll the pelvis in a thin patient with a bulky lower rectal tumor that invaded the vagina.
Perineal Hernia
A perineal hernia is a rare and particularly difcult complication to address. It usually occurs in thin, malnourished patients who undergo partial or total exenteration as part of the resection of their underlying tumor. The presentation in the acute postoperative
(arrow); (c) Gluteal advancement ap created 38 days after wound dehiscense lled the defect with excellent cosmetic result
period is dramatic as it manifests as intesti-
nal herniation through a dehiscent perineal
wound. This is a surgical emergency and
must be addressed in the operating room
immediately due to the high risk of bowel
ischemia, incarceration and strangulation.
Successful management in the acute setting
always involves lling the pelvis with via-
ble, space-occupying tissue. Rectus, glu-
teal, tensor fascia lata (TFL), or gracilis
transposition aps are the most common
with the latissimus dorsi pedicle ap anas-
tomosed to the common iliac vessels as a
salvage strategy in patients in whom trans-
position aps are otherwise not possible.
Perineal hernia in the late postoperative
period most commonly manifests as a
“bulge” or fullness in the perineum. It may
present as a small bowel obstruction-
forcing operative intervention sooner rather
than later. Again, repair must include oblit-
eration of the pelvic space with vascular-
ized tissue. In the circumstance of delayed
presentation, preservation of the healed
perineal wound by using a transabdominal
approach adds strength to the repair and
decreases the potential for evisceration due
to skin dehiscence.
26 Complications ofResection ofRetroperitoneal Tumors intheFemale Pelvis
279
Fig. 26.3 Complete vaginal reconstruction using composite vertical rectus myocutaneous ap
280
E. Zervos and N. A. Vohra

Urinary Tract

Background

Injury to the female urethra is exceedingly rare given its short length and sheltered anatomic loca­tion. Cases in which the urethra/base of the bladder is at risk for injury are usually consented for resec­tion with possible anterior or total pelvic exentera­tion. By far, the most common urinary injury during any pelvic surgery for non- gynecologic pathology is to the ureters given their vertical pres­ence along almost the entire length and both sides of the pelvis. There are a number of mechanisms by which this can occur including laceration or transection with sharp instruments (most com­mon), traction, and thermal injury resulting from the use of cautery or other energy device.

Prevention

For benign or low-grade tumors like schwannoma or paraganglioma, leaving some tumor intact along the cystic or ureteral margin is a preferred strategy over pursuing margin-negative resection that may require complex bladder or ureteral reconstruction especially, when such expertise is not readily available. In cases of sarcoma, margin negative resection is the primary objective of extirpation and should be pursued up to and including total pelvic exenteration when neces­sary. Unless arising from those organs, most pel­vic sarcomas can be separated from surrounding viscera due to the “pushing” (not inltrating) nature of these tumors. If the tumor extends to the pelvic sidewall or periosteum of the sacrum these structures should be excised with the primary tumor and intraoperative radiotherapy or ducials placed to facilitate adjunctive radiotherapy.
The adage that an ounce of prevention equates to a pound of cure is particularly relevant in cases of ureteral injury. Due to the narrow connes of the pelvis, ureteral injury should be at the fore­front of the pelvic surgeon’s consciousness before, during and after he or she endeavors to operate in that space. Identication of both ure­ters prior to any “blind” or blunt dissection below the sacral promontory is absolutely essential to
avoid injury. The ureters are most easily identi­ed as they course over the common iliac vessels (water over the bridge). When one ureter is iden­tied, its unique anatomic relationships to xed anatomic landmarks such as the common iliac artery and bony pelvis are usually mirrored on the other side informing identication of the con­tralateral ureter. As such, if the ureter on one side cannot be identied, then attention should be directed to the contralateral ureter for this pur­pose. Occasionally, the underlying pelvic pathol­ogy, prior surgical history or anatomy precludes identication of the ureter at this level and it must then be identied more proximally; evenup to the level of the renal hilum if necessary. Once the ureters are identied, they can be dissected along their length up to their insertion into the bladder and kept out of harm’s way. Again, the insepara­bility of the ureter from the tumor mandates resection and reconstruction in cases of sarcoma and other malignant pathology when margin­negative resection is the goal.

Recognition

Complete transection of the ureter is usually apparent by exposure of preoperatively placed stents, leakage of urine from the proximal cut end of the ureteror unexplained hematuria. Ureteral injury may be subtle, especially in the absence of complete transection. Subtle injury usually results from diathermy and delayed scarring which later presents as ureter obstruction/hydro­nephrosis. Cystoscopy with retrograde ureterog­raphy is the rst step in diagnosis in these cases. If the stricture cannot be traversed with a wire, then attempts to pass the stricture through ante­grade ureterography should be made before pur­suing surgical exploration. Figure26.4a, b and c shows ureteral blockage at the uretero-cystic junction in a patient who underwent LAR for rec­tal cancer. If one is concerned about ureteral injury but cannot identify any—a vial of methy­lene blue or “brilliant blue” can be given by the anesthesia team through the i.v. and the pelvis can be surveyed for extravasation of the dye. Once recognized, then appropriate steps can be taken to repair or mitigate the injury.
a b c
26 Complications ofResection ofRetroperitoneal Tumors intheFemale Pelvis
281
Fig. 26.4 Delayed ureteral stenosis due to thermal injury. Retrograde attempt to pass a wire in a patient who
sustained thermal injury to the left ureter showing abrubt

Management

blockage in the distal ureter (a). Antegrade ureterogram establishes a complete obstruction near that level (b) and, fol­lowing operative repair with Broari ap, a stent in place (c)
nizes they are in the wrong anatomic plane. Such
inadvertent injury can be a “double edged sword” Primary repair by ureteroneocystostomy or end­to- end over a stent is usually possible with tran­section or short-segment resection. With the mobilization of the bladder and ipsilateral kid­ney, gaps up to 7 or 8 cm can be bridged.
in the sense that once the lumen is violated, digital
palpation from inside the bladder can prevent fur-
ther injury as the tumor is separated from it and
this strategy may even be employed intentionally
to minimize bladder injury. Maintenance of one intact ureter allows such reconstructive options as well as others like uretero- ureterostomy or wet colostomy, which

Prevention

are discussed in greater detail in other chapters in this textbook, particularly Chap. 17.
Preventing bladder injury is similar to other com-
plications described in this chapter. A keen appre-
ciation and recognition of where the bladder is at

Bladder Injury

all times is the key to avoiding injury. The bladder
can even be instilled with saline through the foley

Background

and then clamped to dene its borders more
clearly. This is rarely necessary but is a useful tool As in real estate, injury to the bladder and its man-
in the reoperative or otherwise hostile pelvis. agement is heavily dependent on three factors: location, location and location. The higher up and closer to the dome, the better for both the patient

Recognition

and the surgeon. Bladder injury most commonly results from loss of “normal” orientation of the bladder due to primary pelvic pathology. Owing to the relatively thin wall of the bladder, full-thick­ness injury frequently occurs before one recog-
Bladder injury during pelvic dissection is easy to
recognize. The rst indication is recognition of
the shiny, moist and “normal” appearing mucosal
lining in the background of signicant inamma-
282
E. Zervos and N. A. Vohra
tion and tumor reactive tissue. All one needs to do is insert a nger into the space and palpate the foley balloon to conrm that it is the bladder and not the vagina or rectum that has been violated. In cases where injury is suspected, but can’t be proven, lling the bladder with 150ml of saline (can be doubled if necessary to effect maximal distension) via the foley catheter will expose occult injury through leakage into the pelvis.

Management

This subject is covered more in depth in Chap.
12. Injury at the level of the trigone may require
separating the ureter from the bladder at that level and reimplantation over a stent. Resection of the dome of the bladder to mitigate injury or achieve margin is possible as long as there is no signi­cant reduction in bladder volume. As injury extends more distal in the bladder or more length needs to be bridged with a bladder ap, the risk of microbladder increases.. The bladder is forgiv­ing and will tolerate tension and ischemia more readily than the gut. Simple cystotomy can be oversewn in two layers with an absorbable suture to approximate the mucosa and interrupted sero­muscular sutures to reinforce the repair. A drain should be left in place in the rare event that a leak does occur in the postoperative period and should be assayed for creatinine prior to removal. A foley catheter should remain in place for at least 7 days following repair and, as a precaution, the drain should be removed only after the patient demonstrates the ability to void normally.
Finally, when utilizing a lower mid-line inci­sion, one must always be cognizant of the risk of bladder injury as the incision extends towards the pubic symphysis. Extra care must be taken in the obese and reoperative patient as the planes of the anterior abdominal wall and bladder may be fused and difcult to separate. Bladder injury of this nature at the very outset of an anticipated complex and difcult planned procedure is particularly dis­satisfying and, needless to say, should be avoided. Consideration of the possibility of such injury and close supervision of trainees as the pelvis is exposed is usually sufcient to prevent it.

Vascular Injury

Background

Vascular injury is covered extensively in other chapters in this textbook but warrants some com­ment here with respect to bulky or locally inva­sive pelvic tumors.

Prevention

Vascular injury during resection of pelvic tumors usually occurs at the sharp end of a metal instrument such as a ne scissor or scalpel, which are frequently utilized to dissect a solid tumor away from surrounding named blood ves­sels. Blunt and/or blind dissection deep in the female pelvis can also lead to signicant venous hemorrhage as side branches arising from the hypogastric vein are easily avulsed. We use the small- jawed Maryland Ligasure dissector (MedTronic, Inc. St. Paul, MN) deep in the pel­vis, following the pelvic sidewall closely to minimize risk of avulsion. This bipolar surgical instrument is better suited to insinuate between tumors and the pelvic sidewall than its larger counterpart and is capable of sealing named and unnamed venous tributaries as large as 7mm. A word of caution is in order at this time: use of the larger “Impact” Ligasure device reduces precise visualization of the entire length of the active jaws, especially in tight spaces. As such, there is risk of unintended and or unrecognized “side biting” of the named deep pelvic vessels (Fig.26.5). This area of sealing may be initially hemostatic but can result in catastrophic blow­out at any point, especially when venous return increases with resuscitation, normal positioning and normalization of the blood pressure in the postoperative period. Inammation and abscess formation in the early postoperative period can also weaken an already compromised lengthy vascular seal and lead to dehiscence. Extreme caution should be exercised bearing this specic complication in mind when using this partially blind technique in mobilizing deep attachments of pelvic tumors. Figure26.6 shows a bulky pel-
Tumor
26 Complications ofResection ofRetroperitoneal Tumors intheFemale Pelvis
283
Fig. 26.5 Mechanism of venous injury that can occur with “blind” application of bipolar thermal energy deep in the pelvis
vic liposarcoma where this technique is utilized using the larger instrument.
In cases where the EEA stapler is used to anastamose the rectum to the colon, it is also pos­sible to cause vascular injury as the “spike” from the handle of the stapler is advanced through the stapled distal rectum into an engorged sacral plexus. This usually occurs at the very end of a long and difcult resection and fatigue or inatten­tion can lead to what would seem to be an exqui­sitely avoidable complication. Awareness that this can and does occur should be sufcient to
reminds the surgeon of its presence with each beat of the patient’s heart and the relief felt in the heart of both the patient and surgeon is unmistak­able. Compromise of arterial inow to the lower extremity in the setting of arterial injury and repair should be ruled out using Doppler ultra­sound anywhere distal to the repair in the arterial tree. Venous injury as described abovethat isrec­ognized in the recovery room or beyond is likelycatastrophic and must be approached as a traumatic injury for there to be any hope of
salvage. avoid it in almost every circumstance given the vast space and enhanced visualization that mani­fests after resection of bulky pelvic pathology.

Management

Figure26.7 illustrates how this injury can occur.
First and foremost, hypogastric (internal iliac)
arteries and veins can be unilaterally sacriced

Recognition

with impunity. This is the ultimate exit strategy
when other, less radical interventions fail. Vascular injury is the easiest of any injury for the surgeon to recognize. It declares itself and
Bilateral ligation of the hypogastric arteries car-
ries some risk of ischemic proctitis and pelvic
284
E. Zervos and N. A. Vohra
Fig. 26.6 Resection of giant liposarcoma from pelvis using bipolar thermal energy
VP
26 Complications ofResection ofRetroperitoneal Tumors intheFemale Pelvis
An exit strategy for uncontrollable hemor­rhage from the sacral venous plexus is packing, temporary closure and re-exploration. In cases where a perineal wound has been created, a large
IVVS
size (8½) surgical glove can be inserted into the perineal defect and packed with lubricated laparotomy packsor Kerlix gauze to exert pres-
BVV
sure on the sacrum and pelvic sidewalls. The abdomen can then be closed denitively and the
PS
packs can be removed at the bedside or in the OR once the coagulopathy is corrected. The perineal defect can then be closed without having to re­enter the peritoneal cavity.
Fig. 26.7 Mechanism of venous laceration with sharp end of EEA anvil

Neurologic Injury

pain syndromes but is a viable strategy in the set­ting of otherwise unreconcileable life threaten­ing hemorrhage. Bleeding from the sacral plexus is unavoidable to some degree when dealing with any large tumor arising from the rectum or behind it. In most cases, such bleeding is easily managed with simple maneuvers like pressure, excellent visualization and cautery. Inability to safely and expeditiously manage troublesome bleeding from the sacral plexus can usually be attributed to one of these factors. Just as the abil­ity to bag mask ventilate a patient provides time to formulate a plan to manage a difcult airway, control of pelvic hemorrhage from the sacral plexus with pressure alone allows time to: reverse hemodynamic instability; correct coagu­lopath; gather necessary supplies and equip­ment; and call for help. In cases of problematic bleeding from the sacral plexus, the best help is that which isn’t needed—asking for it early rather than later can avoid those factors that turn otherwise manageable hemorrhage into a life­threatening emergency as characterized by the “triad of death”: hypothermia, coagulopathy and acidosis. Waiting for help to arrive while pres­sure is being held gives all members of the surgi­cal team the opportunity to take a breath, avoid premature assessment of the area of hemorrhage by removing pressure too soon and instills a sense of control or calmness in thetense operat­ing environment.

Background

Finally, and least commonly, neurologic injury can occur with resection of pelvic tumors. Risk factors for injury include bulky tumors compro­mising visualization in a conned space, dis­torted anatomy from direct extension or invasion of tumor, loss of normal tissue planes from prior radiation therapy or pelvic surgery, body habitus, aberrant anatomy, improper placement of retrac­tors and suboptimal patient positioning. Nerve injury can result from traction, compression, entrapment or transection; most commonly trac­tion and compression injuries result from malpo­sitioning the patient or the retractors while entrapment and transection occur from failure to recognize the nerve during the conduct of the operation.

Prevention

The sympathetic, parasympathetic, and somatic (sensory/ motor) nerves in the pelvis control criti­cal functions of micturition, defecation, sexual activity and ambulation. Unless one understands the anatomy of these nerves including their rela­tionship to surrounding structures, during a com­plex operation their preservation is left to chance or luck. A thorough knowledge of the resulting de-
285
286
E. Zervos and N. A. Vohra
cits from division of the nerve allows one to make an informed and balanced intraoperative decision regarding radical extirpation versus preservation while achieving the best oncologic outcome.
Prevention of these injuries starts with a care­ful evaluation of the patient to assess for any neu­rological decits (pain, paresthesia, weakness, incontinence, sexual dysfunction) prior to sur­gery. A careful review of a pelvic MRI paying particular attention to the nerves as they descend into the pelvis and their relationship to the tumor can alert one to difculties they may encounter in the operating room. Such preparation helps improve situational awareness during the conduct of the case, thus decreasing the potential for inad­vertent partial or complete transection.
Traction or compression injury is the most common nerve injury that occurs with open pel­vic surgery and results from lateral retraction of the femoral nerve as it courses along the pelvic sidewall towards the femoral canal. This usually happens with use of a self-retaining retractor such as a Bookwalter retractor, particularly in patients who are thin and when a transverse abdominal incision is used. Owing to the increas­ing use of minimally invasive approaches to pel­vic pathology, the rate of femoral nerve injury is decreasing. Having said that, minimally invasive pelvic surgery can cause ilioinguinal and iliohy­pogastric nerve injury with placement of trocars below the anterior superior iliac spine. Clinical manifestation of femoral injury can range from pain, paresthesia, sensory loss to weakness and can be transient or permanent. Femoral nerve injury is a frequent source of litigation, especially when symptoms persist. Avoidance of such injury includes avoidance of such retractors altogether and, when not possible, padding blades with lap­arotomy pads and avoidance of excessive lateral traction when possible. Whenever possible, I avoid using the longer body wall retractors and use the shorter ones to open the surgical incision through retraction of the skin, muscle and subcu­taneous fat only and then utilizing hand held retractors when needed only temporarily.
Most sympathetic and parasympathetic nerve injuries occur during dissection along the pelvic fascia which envelops the autonomic nerves that regulate sexual, bladder and bowel function. The retrorectal space described as the “holy plane” by Heald corresponds to the nerve sparing dissec­tion plane that he described in 1996. Adherence to this plane and preservation of the parietal pel­vic fascia effectively preserves the superior hypo­gastric plexus, the hypogastric nerves and the inferior hypogastric plexus.

Recognition

Somatic nerve injury is by far the most conspicu­ous as it manifests in the recovery room. Injury to sympathetic and parasympathetic nerves is more insidious and may take months or even years to recognize, diagnose and treat when possible. Table26.1 describes the named somatic nerves of the female pelvis, their component parts and ana­tomic function.

Management

Complete or partial transection of the nerves of the lumbosacral plexus as they emerge from the spine and course through the pelvis can occur when dissecting large tumors in the pelvis and can result in substantial morbidity postopera­tively. Intraoperative recognition of such injury should prompt consideration for reapproximation of the epineurium with ne suture and placement of a neurogenic wrap.
Decits resulting from traction and compres­sion of the nerves during surgery can result in various degrees of pain, paresthesia, and/or weakness, depending on the severity of injury. In most cases their recognition is delayed and usu­ally managed with physical therapy, with resolu­tion of symptoms over time. Entrapment v can be a major source of pain and may require decom­pression of the involved nerve.