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B. L. Roberts and R. G. Rogers
31. Flynn MK, Weidner AC, Amundsen CL. Sensory nerve injury after uterosacral ligament suspension. Am J Obstet Gynecol. 2006;195(6):1869–72.
32. Campbell R. The anatomy and histology of the sacrouterine ligaments. Am J Obstet Gynecol. 1950;59:1–12.
33. Umek WH, Morgan DM, Ashton-Miller JA, DeLancey JO.Quantitative analysis of uterosacral ligament ori­gin and insertion points by magnetic resonance imag­ing. Obstet Gynecol. 2004;103:447–51.
34. Siddique SA, Gutman RE, Schön Ybarra MA, Rojas F, Handa VL.Relationship of the uterosacral ligament to the sacral plexus and to the pudendal nerve. Int Urogynecol J Pelvic Floor Dysfunct. 2006;17:642–5.
35. Wieslander CK, Roshanravan SM, Wai CY, Schaffer JI, MM C.Uterosacral ligament suspension sutures: anatomic relationships in unembalmed female cadav­ers. Am J Obstet Gynecol. 2007;197(672):e671–6.
36. Schön Ybarra MA, Gutman RE, Rini D, VL H. Etiology of post-uterosacral suspension neu­ropathies. Int Urogynecol J Pelvic Floor Dysfunct. 2009;20:1067–71.
37. Florian-Rodriguez M, Hare A, Chin K, Phelan J, Ripperda C, Corton M. Inferior gluteal and other nerves associated with sacrospinous ligament: a cadaver study. Am J Obstet Gynecol. 2016;215(5):646. e641–6.
38. Hefni M, El-Toukhy T. Sacrospinous colpopexy at vaginal hysterectomy: method, results and follow up in 75 patients. J Obstet Gynaecol. 2000;20(1):59–62.
39. Chung Christopher P, Kuehl TJ, Larsen WI, Yandell PM, Shull BL. Recognition and Management of Nerve Entrapment Pain after Uterosacral Ligament Suspension. Obstet Gynecol. 2012;120:292–5.
40. Vodegel EV, vDK, Nuboer CHC, Kowalik CR, Roovers JWR. Surgical management of pudendal nerve entrapment after sacrospinous ligament xa­tion. BJOG. 2022;129(11):1908–15.
41. Maher C, Feiner B, Baessler K, Christmann-Schmid C, Haya N, Brown J.Surgery for women with api­cal vaginal prolapse. Cochrane Database Syst Rev. 2016;10(10):CD012376.
42. No Authors Listed. Management of mesh and graft complications in gynecologic surgery. Female Pelvic Med Reconstr Surg. 2017;23(3):171–6.
43. Stork AM, Giugale LE, Bradley MS, Zyczynski HM. Incidence of sacral osteomyelitis and discitis after minimally invasive Sacrocolpopexy. Female Pelvic Med Reconstr Surg. 2021;27(11):672–5.
44. Mueller MG, Jacobs KM, Mueller ER, Abernethy MG, Kenton KS.Outcomes in 450 women after mini­mally invasive abdominal Sacrocolpopexy for pelvic organ prolapse. Female Pelvic Med Reconstr Surg. 2016;22(4):267–71.
45. Glass Clark SM, Shannon MB, Gill E, Clark MD, Lamb E, Carroll A.Complications after Reperitonealization of mesh at time of Sacrocolpopexy: a retrospective cohort study. Female Pelvic Med Reconstr Surg. 2020;26(2):116–9.
46. Olsen AL.Epidemiology of surgically managed pel­vic organ prolapse and urinary incontinence. Obstet Gynecol. 1997;89(4):501–6.
47. Diwadkar GB, Barber MD, Feiner B, Maher C, Jelovsek JE.Complication and reoperation rates after apical vaginal prolapse surgical repair: a systematic review. Obstet Gynecol. 2009;113(2 Part 1):367–73.
48. Nygaard I, Brubaker L, Zyczynski HM, et al. Long-term outcomes following abdominal sacro­colpopexy for pelvic organ prolapse. JAMA. 2013;309(19):2016–24.
49. Silva W, Pauls R, Segal J, Rooney C, Kleeman S, Karram M. Uterosacral ligament vault sus­pension: ve-year outcomes. Obstet Gynecol. 2006;108:255–63.
50. Karram M, Goldwasser S, Kleeman S, Steele A, Vassallo B, Walsh P.High uterosacral vaginal vault suspension with fascial reconstruction for vaginal repair of enterocele and vaginal vault prolapse. Am J Obstet Gynecol. 2001;185:1339–42.
51. Løwenstein E, Møller LA, Laigaard J, et al. Reoperation for pelvic organ prolapse: a Danish cohort study with 15–20 years’ follow-up. Int Urogynecol J. 2018;29:119–24.
Operations forStress Urinary Incontinence
LaurenM.Conroy andO.LenaineWestney
8

Introduction

Stress urinary incontinence (SUI) is a common condition affecting up to 50% of women at some point in their lives [1]. It is characterized by the involuntary loss of urine with increased abdomi­nal pressure or physical exertion and is caused by urethral hypermobility and/or intrinsic sphincter deciency (ISD) [2].
While the initial treatments for SUI are con­servative, such as pelvic oor exercises, many women seek surgical intervention for persistently bothersome symptoms. Surgeries aim to support the urethra and bladder neck, improving urethral coaptation. They include urethral injections, slings (synthetic or autologous), and retropubic suspensions. The optimal procedure selection depends on several patient factors, such as the characterization and severity of their inconti­nence and their ability to tolerate invasive procedures.
In addition, each procedure is associated with complications, with the most prevalent being transient urinary retention and new-onset irrita-
L. M. Conroy Department of Urology, University of Texas Health Science Center at Houston, Houston, TX, USA e-mail: lauren.m.conroy@uth.tmc.edu
O. L. Westney (*) Department of Urology, University of Texas—MD Anderson Cancer Center, Houston, TX, USA e-mail: owestney@mdanderson.org
tive voiding symptoms, such as urgency and fre­quency. Complications vary between techniques, and clinicians must weigh these risks when coun­seling patients on optimal surgical management.

Injectable Therapy

An Overview

Urethral injection therapy represents a minimally invasive option to treat SUI, ideal for patients who may not tolerate or desire surgical interventions or who have SUI primarily driven by suboptimal sphincter activity [3]. A urethral bulking agent (UBA) is injected into the submucosa of the prox­imal urethra using endoscopy (Fig. 8.1). The agent is injected with a needle, either transure­thrally through a scope or periurethrally. These techniques are reported to be similarly effective. However, the periurethral route is associated with higher rates of early complications [4].
There are two prevailing types of UBAs. The rst are gels with suspended macroparticles (e.g., Macroplastique), and the second group is homo­geneous gels that provide a bulking effect through volume alone (e.g., Bulkamid) [5]. There are lim­ited data to support any one agent over another [6]. The agents are believed to increase the cen­tral lling volume of the urethra, thus increasing the power of the urethral sphincter with contrac­tion and decreasing urinary leakage [7].
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2025 M. Hoffman et al. (eds.), Major Complications of Female Pelvic Surgery,
https://doi.org/10.1007/978-3-031-66772-5_8
83
84
Fig. 8.1 Picture of transurethral injection
L. M. Conroy and O. L. Westney
UBAs, occurring in 10% of patients postopera­tively and presenting with similar urinary symp­toms [11].

Mid-Urethral Slings (MUS)

An Overview

Mid-urethral slings (MUS) are the current gold standard surgical treatment for SUI in women [6]. In an MUS procedure, a sling is placed under the urethra at the level of the mid-urethra. The sling works by compressing and securing the posterior wall of the urethra with increased intra­abdominal pressure, thus preventing urinary leakage [1, 12]. The slings are made of a polypro­pylene monolament, macroporous mesh [12].

Complications

Retention
One of the most common postoperative compli­cations associated with UBAs is urinary reten­tion. A review of 117 articles, including case reports, found that amongst 6462 patients, 542 incidents of retention were reported [8]. The retention duration needed to be claried in this
with extended follow-up periods have shown this retention to be primarily transient [9, 10]. Hoe etal. reported that of ve incidents of acute uri­nary retention requiring catheterization, four spontaneously resolved the following day [10]. Postoperative transient urinary retention rates are higher when injecting via the periurethral route [4].
De Novo Irritative Voiding Symptoms
UBAs are also associated with new-onset urgency, frequency, and urge incontinence. de Vries etal. found that amongst 6462 patients, 452 reported urinary issues such as these [8]. While symptom duration was not reported in this review, another study noted that 3years postinjection of Macroplastique, the rate of de novo irritative voiding symptoms was 1.2% [9]. Notably, uri­nary tract infections (UTIs) are common with
Tension-Free Vaginal Tape (TVT)
One of the initial MUS procedures developed was a tension-free vaginal tape (TVT), also known as a retropubic mid-urethral sling. In this procedure, a tape is inserted through the retropu­bic space. Two techniques are utilized: a bottom­ up approach and a top-down approach. In the bottom-up technique, a trocar with an attached sling is inserted through the vagina on one side of the urethra, elevated through the retropubic space, and out the suprapubic skin. This is per­formed contralaterally, leaving the tape sus­pended beneath the urethra. In the top-down technique, trocars are inserted into the suprapu­bic skin and exit in the vagina [12, 13]. The bot­tom- up approach is more effective and associated with fewer adverse effects [1].
Transobturator Tape (TOT)
The transobturator tape (TOT) procedure was developed to minimize the morbidity associated with TVT and the risk of injury to local struc­tures. In this procedure, a tape is inserted hori­zontally between the bilateral obturator foramens, avoiding the retropubic space [12] (Fig.8.2). Two techniques are utilized: outside-to-inside and inside-to-outside. Using the outside-to-inside method, a trocar is placed through the adductor longus tendon and rotated inward through the
8 Operations forStress Urinary Incontinence
Fig. 8.2 Pelvic diagram with TOT in place
vagina bilaterally. A tape is then attached to the trocars and withdrawn with them through the thigh incisions, remaining suspended beneath the urethra. In the inside-to-outside technique, tro­cars are inserted into the vagina and exit through the adductor longus tendon [1214]. These tech­niques have similar effectiveness; however, the outside-to-inside approach is associated with a higher risk of vaginal perforation and erosion [15].
Single-Incision Slings (SIS)
The most recently developed mid-urethral slings are single-incision slings (SIS) or mini-slings. These were designed to reduce further morbidity associated with slings and provide a less invasive, potentially outpatient option to treat SUI [16]. In this procedure, the sling consists of a piece of mesh positioned between two anchoring ends. A single incision is made in the vaginal epithelium, and the device is pushed under the mid-urethra [12]. Different SIS are associated with other anchoring mechanisms [17].

Complications

Mesh Erosion
In 2011, the Food and Drug Administration (FDA) released a safety communication report­ing severe complications associated with trans­vaginal placement of mesh for pelvic organ prolapse (POP) repair. While MUS were not included in this communication, media attention
85
and increased litigation raised concerns sur­rounding the use of synthetic mesh in the treat­ment of incontinence [18]. Since then, several studies have investigated the risk of mesh eroding into the urethra and vagina in patients who have undergone an MUS procedure. Overall, mesh erosion is uncommon and not more common in one type of MUS over another, as seen in two recent meta-analyses. A Cochrane review found that mesh erosion occurred in 2.0% of TVT pro­cedures vs. 2.2% of TOT procedures (Table8.1) [1]. These results were supported by Brazzelli et al., who found similar erosion rates [19]. Notably, most of the studies reviewed in these meta-analyses had short follow-up periods. One study, which followed patients for more than 10 years, found that the rates of sling erosion with TOT increased after 10years; however, the rate of erosion at this time was 2.4% [20]. The limited studies comparing MUS and SIS indicate that the erosion rates are similar [19].
Risk factors associated with mesh erosion include age, current smoking status, diabetes mellitus, vaginal incision >2cm, and a history of prior surgery for incontinence or POP. Studies have shown that older age is associated with ero­sion, likely secondary to increased urogenital atrophy and resulting thinner tissue. However, other studies have shown that younger age and increased sexual activity may also be associated with an increased erosion risk. Increased incision size and a history of a prior surgery with scar tis­sue are related to vascular damage and dimin­ished tissue perfusion [9].
Bladder Injury
Blind passage of trocars through the retropubic space with TVT puts patients at risk of bladder perforation and vascular, nerve, and bowel inju­ries [21]. As a result, bladder perforation is sig­nicantly more common with TVT than with TOT. A Cochrane review found that the risk of bladder or urethral injury was 4.9% with TVT vs.
0.6% with TOT [1].
Pain
Groin pain is a common complication associated with TOT, as the exit point of the trocars is the
86
L. M. Conroy and O. L. Westney
Comments
1
Quality of the evidence (GRADE)
No of participants
(studies)
⊕⊕⊕⊝ MODERATE
CI)
(95% CI) Relative effect (95%
*
2,3
⊕⊕⊝⊝ LOW
4
⊕⊕⊕⊝MODERATE
5
⊕⊕⊕⊝ MODERATE
6
⊕⊕⊕⊝ MODERATE
7
⊕⊕⊕⊝ MODERATE
Illustrative comparative risks
Assumed risk Corresponding risk
Table 8.1 TOT compared to TVT for SUI in women
(810–844)
Retropubic (RPR)
route Transobturator (TOR)
Study population RR 0.98 (0.96–1.00) 5514 (36 RCTs)
844 per 1000 827 per 1000
Mean control group risk across studies
Outcomes
Subjective cure (Short term
<1 year)
(800–833)
833 per 1000 816 per 1000
Study population RR 0.97 (0.92–1.03) 683 (5 RCTs)
881 per 1000 854 per 1000
Subjective cure (medium
term, 1–5years)
(810–907)
(799–895)
Mean control group risk across studies
869 per 1000 843 per 1000
(615–735)
Study population RR 0.95 (0.87–1.04) 714 (4 RCTS)
707 per 1000 671 per 1000
Mean control group risk across studies
843 per 1000 801 per 1000
Subjective cure (long term,
>5 years)
(733–877)
Study population RR 0.13 (0.08–0.20) 6372 (40 RCTs)
Bladder or urethral
49 per 1000 6 per 1000 (4–10)
Mean control group risk across studies
25 per 1000 3 per 1000 (2–5)
Study population RR 0.53 (0.43–0.65) 6217 (37 RCTs)
72 per 1000 38 per 1000 (31–47)
Mean control group risk across studies
55 per 1000 29 per 1000 (24–36)
Study population RR 0.98 (0.82–1.17) 4923 (31 RCTs)
82 per 1000 80 per 1000 (67–96)
Mean control group risk across studies
perforation
Voiding dysfunction (short
and medium term, up to 5
years)
De novo urgency or urgency
incontinence (short term, up
to 12 months)
83 per 1000 81 per 1000 (68–97)
8 Operations forStress Urinary Incontinence
87
8
⊕⊕⊕⊝ MODERATE
9
⊕⊕⊕⊝ MODERATE
10
⊕⊕⊕⊝ MODERATE
11
⊕⊕⊕⊝ MODERATE
12,13
⊕⊕⊝⊝LOW
695 (4 RCTs)
(3.36–23.00)
(139–311)
14 per 1000 66 per 1000 (44–99)
Mean control group risk across studies
45 per 1000 208 per 1000
Groin pain Study population RR 4.62 (3.09–6.92) 3226 (18 RCTs)
29 per 1000 8 per 1000 (3–23)
Mean control group risk across studies
18 per 1000 6 per 1000 (2–14)
Suprapubic pain Study population RR 0.29 (0.11–0.78) 1105 (4 RCTs)
Study population RR 1.13 (0.78–1.65) 4743 (31 RCTs)
20 per 1000 22 per 1000 (15–32)
Mean control group risk across studies
21 per 1000 24 per 1000 (16–34)
Study population RR 1.64 (0.85–3.16) 1402 (9 RCTs)
19 per 1000 31 per 1000 (16–60)
mean control group across studies
24 per 1000 39 per 1000 (20–76)
Study population RR 8.79
Vaginal tape erosion (short
and medium term, up to 5
years)
Repeat incontinence surgery
(short term, within 12
months)
Repeat incontinence surgery
(38–262)
11 per 1000 100 per 1000
(225–1000)
Mean control group across studies
67 per 1000 589 per 1000
(long term, > 5 years)
Modied from a Cochrane review
88
L. M. Conroy and O. L. Westney
medial thigh. The pain is often transient and resolves in the post-op period [22]; however, in rare cases, it can persist and become chronic [22]. This chronic pain is associated with damage to the obturator nerve as the trocar traverses the obturator foramen [12]. Not surprisingly, groin pain is signicantly more common with TOT than with TVT. A recent meta-analysis has reported the rate of groin pain to be 6.3% with TOT versus 1.3% with TVT [19]. These ndings are primarily based on studies conducted within 1-year post-op. One study, which evaluated out­comes after 13years, found 1 of 168 patients to have persistent groin pain, not requiring analge­sics [20].
SIS was developed in part to reduce the risk of developing postoperative pain. A meta-analysis of 14 studies found the immediate post-operative pain rate to be 6.8% with SIS versus 19.2% with TVT [19]. There is limited data to show the long­term comparison of pain with SIS and standard MUS.
Voiding Dysfunction
While an MUS functions to compress the urethra, patients risk obstruction and resulting voiding dysfunction if the tape is placed with too much tension around the urethra or too close to the bladder neck [12]. This is more commonly found with TVT, where the tape is placed at a more ver­tical angle, resulting in increased obstruction [23]. Within the rst 5years postoperatively, the risk of voiding dysfunction is 7.2% with TVT vs.
3.8% with TOT [1]. This is often transient, how­ever, as long-term dysfunction necessitating sur­gery or permanent catheterization is rare. One randomized controlled trial (RCT) found that the risk of requiring these measures was 2.7% with TVT vs. 0% with TOT [23].
De Novo Irritative Voiding Symptoms
One of the most common complications after an MUS surgery is new-onset irritative bladder symptoms, such as increased urinary urgency or detrusor overactivity (DO). Meta-analyses revealed no signicant difference in these symp­toms between TVT and TOT (8.2% vs. 8%) [1] or TVT and SIS (9.2% vs. 9.5%) (Brazzelli 2019) in the rst 12months post-operation [1].
Recurrent Incontinence
It is not uncommon for patients to require multi­ple procedures to manage their SUI adequately. At 12 months post-operation, 3.6% of patients with TOT vs. 2.2% with TVT will require repeat continence surgery. After 1–5 years, 18.3% of patients with TOT will require repeat surgery (vs.
0.5% with TVT) [1]. Limited data demonstrate the long-term need for repeat surgery following an SIS surgery. However, current data indicate that in the short term, the need is greater than for standard MUS [1, 17].
Recurrent or persistent SUI following an MUS surgery may also be due to various factors, including the wrong choice of the initial proce­dure, patient characteristics, and the natural his­tory of incontinence. When deciding between TVT and TOT, many factors must be considered. Some evidence indicates that TOT is less effective in patients with SUI, primarily caused by intrin­sic sphincter deciency or more severe initial SUI [23, 24]. Other factors, such as patient weight and age, may also impact surgery success [12]. Finally, with time, the pelvic oor weakens, and the intrinsic sphincter function declines, worsening SUI naturally [3].

Pubovaginal Slings (PVS)

An Overview

Before the widespread use of synthetic slings, the traditional slings used to treat SUI were pubo­vaginal slings (PVS) composed of autologous fascia. Today, this type of sling is still widely used for patients when synthetic materials are not desired or contraindicated, such as with patients at risk of poor wound healing, immunocompro­mise, or regularly require clean intermittent cath­eterization (CIC) [6, 25, 26]. Furthermore, there is a belief that these slings are more compressive and, thus, are more appropriate for patients with worse incontinence [26].
PVS are placed at the bladder neck, com­pressing the proximal urethra and bladder neck with increased abdominal stress, providing blad­der outlet resistance and thus preventing urinary leakage [26] (Fig.8.3). Fascial slings are most
8 Operations forStress Urinary Incontinence
Fig. 8.3 Diagram with an implanted pubovaginal sling
89
Fig. 8.4 Diagram demonstrating passage of sling sutures using a Sarot clamp
commonly composed of rectus abdominis fascia from the abdominal wall or fascia lata from the lateral thigh [27]. In a PVS procedure, following the harvesting of fascia, the vaginal epithelium is dissected under the mid-urethra and bladder neck. The endopelvic fascia is perforated using this dissection, and the retropubic space is devel­oped on either side of the urethra. Clamps or needles are then passed from the abdomen, through the previously developed plane, into the vaginal incision, where they grasp a suture tied to the harvested fascial sling (Fig.8.4). The ends of the graft suture are then brought out of the abdominal incision bilaterally, leaving the fascia suspended beneath the bladder neck. Finally, the suture is tied down over the rectus fascia to secure the sling and provide adequate tensioning [12, 26].

Complications

Bladder Perforation
The PVS procedure requires blind passage of instruments through the retropubic space, putting patients at risk of bladder perforation. The American Urological Association (AUA) guide­line meta-analysis reported a perforation rate of
4% [28]. Patients with previous pelvic surgeries are at an increased risk of perforation [26].
Urinary Retention
The placement of a PVS at the bladder neck, as well as the tensioning of the sling, puts patients at risk of bladder outlet obstruction, resulting in uri­nary retention [27]. Studies have shown a voiding dysfunction rate of up to 14% [26]. Several stud­ies investigated the duration of urinary retention. Mock et al. found that 4.4% of patients who received a PVS developed voiding dysfunction,
1.1% required long-term CIC, and 3.3% resolved spontaneously within 1 month of surgery [25]. Athanasopoulos et al. found that 10.6% of patients developed voiding dysfunction, with most of these cases resolving within 2 months and 1.9% eventually requiring surgical resolution [29].
De Novo Irritative Voiding Symptoms
One of the most common complications of PVS is postoperative irritative voiding symp­toms, possibly related to a degree of bladder outlet obstruction created by the sling [29]. Studies have shown a rate of de novo urgency of up to 18.5% [25, 26, 29]. Kim etal. found an increase in irritative voiding symptoms with
90
increased time from sling placement, likely secondary to worsening detrusor function with age rather than a long-term consequence of the sling [30].
Recurrent Incontinence
The need for repeat continence surgery following primary or secondary PVS placement is minimal. However, only some studies have investigated the long-term efcacy of PVS.Khan etal. found that of 61 patients who received PVS, after 10years, none required reoperation, and Kim etal. found that of 83 patients, after 14.5 years, 2 required reoperation [30, 31]. Other studies have indicated up to an 84% absence of SUI symptoms 10years following a PVS surgery [32]; however, after this extended period, it is unclear whether repeat symptoms are due to operation failure or age­related changes [30, 32].
L. M. Conroy and O. L. Westney

Retropubic Suspensions

An Overview

Retropubic suspensions involve lifting the tissue surrounding the bladder neck and proximal ure­thra into the pelvis behind the anterior pubic bones [33]. These procedures have largely been replaced by less invasive procedures, such as slings. They are now mostly reserved for patients for whom synthetic materials are contraindicated or who are undergoing concomitant pelvic sur­gery [6]. They are used to treat patients with SUI primarily caused by urethral hypermobility [33].
There are several variations of retropubic sus­pensions, with Burch colposuspension being the most common. In a Burch procedure, the anterior vaginal wall at the bladder neck level is elevated and sutured to the iliopectineal ligament [34] (Fig.8.5). This is believed to aid in continence by stabilizing the bladder, neck, and urethra and restoring them to their original retropubic posi­tion [33]. This procedure can be performed either open or laparoscopically, with similar efcacy [35].
Another common variation is the Marshall– Marchetti–Krantz (MMK) procedure, where the
Fig. 8.5 Diagram demonstrating the location of Burch suspension sutures
bladder neck is suspended onto the periosteum of the pubic symphysis. Minimal data favor Burch to MMK in effectively treating SUI [36].

Complications

Voiding Dysfunction
Voiding dysfunction or urinary retention is rare following retropubic suspension, especially com­pared to slings, the gold standard SUI treatment. Data show almost no risk of developing voiding dysfunction following retropubic suspension [3638].
Recurrent Incontinence
Compared to slings, the trade-off associated with reduced morbidity of retropubic suspensions is at a lesser degree of treatment “success.” Brubaker etal. found that 5years following Burch, 12% of patients required surgical retreatment, and Albo etal. found that 2 years following Burch, 11% needed surgical retreatment [37, 38].
8 Operations forStress Urinary Incontinence
91

Conclusions

Several procedures are available to treat SUI, each with varying risk proles. Clinicians should consider these risks and counsel patients based on their unique needs when making recommen­dations regarding the optimal procedure.

References

1. Ford AA, Rogerson L, Cody JD, Aluko P, Ogah JA. Mid-urethral sling operations for stress uri­nary incontinence in women. Cochrane Database Syst Rev. 2017;7(7):CD006375. https://doi.
org/10.1002/14651858.CD006375.pub4.
2. Ford AA, Ogah JA. Retropubic or transobturator mid-urethral slings for intrinsic sphincter deciency­related stress urinary incontinence in women: a sys­tematic review and meta-analysis. Int Urogynecol J. 2016;27(1):19–28. https://doi.org/10.1007/
s00192- 015- 2797- 3.
3. Elmelund M, Sokol ER, Karram MM, Dmochowski R, Klarskov N.Patient characteristics that may inuence the effect of urethral injection therapy for female stress urinary incontinence. J Urol. 2019;202(1):125–31.
https://doi.org/10.1097/JU.0000000000000176.
4. Kirchin V, Page T, Keegan PE, Atiemo KO, Cody JD, McClinton S, et al. Urethral injection ther­apy for urinary incontinence in women. Cochrane Database Syst Rev. 2017;7(7):CD003881. https://doi.
org/10.1002/14651858.CD003881.pub4.
5. Itkonen Freitas AM, Mentula M, Rahkola-Soisalo P, Tulokas S, Mikkola TS.Tension-free vaginal tape surgery versus polyacrylamide hydrogel injection for primary stress urinary incontinence: a randomized clinical trial. J Urol. 2020;203(2):372–8. https://doi.
org/10.1097/JU.0000000000000517.
6. Kobashi KC, Albo ME, Dmochowski RR, Ginsberg DA, Goldman HB, Gomelsky A, etal. Surgical treat­ment of female stress urinary incontinence: AUA/ SUFU guideline. J Urol. 2017;198(4):875–83. https://
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