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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_753_Библиотеки_им_академика_М_И_Перельмана.pdf
X
- •Foreword
- •Preface
- •Contents
- •1: History and Evolution of Hernia Surgery
- •References
- •2.1 Introduction
- •3.2.2 Matrix Metalloproteinases (MMPs)
- •3.2.3 Growth Factors
- •References
- •3.1 Introduction
- •3.2.1 Collagen Fibers
- •3.2.4 Elastic Fibers
- •3.3 Discussion
- •References
- •References
- •5.1 Introduction
- •5.3.2 Ultrasound
- •5.3.3 CT Scan
- •5.3.4 MRI
- •5.3.5 Herniography
- •5.3.6 Diagnostic Laparoscopy
- •References
- •6.1 Prosthetic Mesh Materials
- •6.1.1 Introduction
- •6.1.3.1 Wound Healing Process
- •6.1.3.2 The Foreign Body Reaction
- •6.1.4 The Ideal Prosthetic Mesh
- •6.2 Mesh Properties
- •6.2.1 Materials
- •6.2.1.1 Plastic (Synthetic) Meshes: Non-Absorbable
- •Polypropylene Mesh (PPM)
- •Polyester Mesh
- •ePTFE
- •cPTFE
- •PVDF
- •Polyglycolic Acid
- •Polyglactin 910
- •6.2.1.4 Composite/Hybrid Meshes
- •6.2.1.5 Biological Meshes
- •6.2.1.6 Cross-Linked Vs. Non-Cross-Linked
- •6.2.2 Mesh Construction
- •6.2.6.1 Low-Cost Mesh
- •6.3.1 Introduction
- •6.3.2 Fixation Methods
- •6.3.2.1 Suture Fixation
- •Suture Material
- •Suture Technique
- •6.3.2.2 Glue Fixation
- •6.3.2.3 Fibrin Sealant Fixation
- •6.3.2.4 Staple Fixation
- •6.3.2.6 No Fixation
- •6.3.2.7 Self-Fixing Mesh
- •References
- •7.1 Introduction
- •7.2.3 Other Tools
- •7.2.5.2 Group Members
- •7.2.6 The GRADE Approach
- •References
- •8.1 Introduction
- •8.4 Registry-Based Research
- •References
- •9.1 Introduction
- •References
- •10.1 Background
- •10.2 Trends
- •10.3 The Mesh Implant
- •10.5.1 Day Surgery
- •10.5.2 Laparoscopic Ventral Hernia Surgery
- •10.6 Actual Situation
- •10.6.1 Innovative Surgical Techniques
- •10.6.2 Sub-Specialisation
- •References
- •11.1 Hernia Epidemiology
- •11.1.1 Groin Hernia
- •11.1.2 Ventral Incisional Hernia
- •11.2 Pre-Habilitation
- •11.3 Operative Techniques
- •11.5 Robot-Assisted Hernia Repair
- •References
- •12.1 Introduction
- •References
- •13.4.1 Inguinal Hernia Repair
- •13.4.3 Incisional Hernia Repair
- •13.5 Laparoscopic Training
- •13.6 TAPP Versus TEP
- •13.7 Open Inguinal Hernia Repair
- •13.8 Mesh Controversy
- •References
- •14.1 Summary
- •15: Humanitarian Hernia Surgery: Lessons Learned
- •15.1 Introduction
- •15.2 Service Missions
- •15.2.1 Surgeon Selection
- •15.4.4 Surgeon Trainee Selection
- •References
- •15.3.5 Incisional Hernias
- •15.3.6 Anesthesia Care
- •15.3.7 Patient Follow-Up
- •15.4 Training Missions
- •15.4.1 Capacity Building
- •15.4.2 Training Method
- •References
- •17: Anatomy of the Inguinal Region
- •17.2 The Inguinal Canal (Fig. 17.7)
- •17.3 Entrance to the Channel: the Deep Inguinal Ring
- •17.5 Floor of the Channel: the Inguinal Ligament
- •17.8 Spermatic Cord and Vascular Issues
- •References
- •18: Ambulatory Hernia Surgery
- •18.2 History
- •18.4 International Comparison
- •References
- •Suggested Readings
- •20.1 Etiology
- •20.2 Clinical Manifestation
- •20.5 Treatment
- •20.5.5 Preoperative Preparation
- •20.5.7 Surgical Procedures
- •20.5.9 Surgical Procedures
- •References
- •21.2 Statistical Relevance
- •21.3 Pure Tissue Repairs
- •21.8.1 Foreign Object
- •21.9 Material-Related Changes
- •References
- •22.1 Introduction
- •22.2 Personal Experience
- •22.3 Indications
- •22.4 Surgical Technique
- •References
- •23: Bassini Repair
- •23.1 Introduction
- •23.3 Skin Incision
- •23.12 The Filzetta Stitch
- •23.13 The First Stitch
- •23.14 The Second Stitch
- •23.15 The Third Stitch
- •23.16 The Last Stitch
- •24: The Shouldice Repair
- •24.1 Introduction
- •24.2 Local Anaesthesia
- •24.3.1 Dissection
- •24.3.2 Reconstruction
- •24.4.1 Dissection
- •24.4.2 Reconstruction
- •References
- •25.1 Introduction
- •25.2 Surgical Indications
- •25.3 Surgical Technique
- •25.5 Outcomes
- •References
- •26.1 Indications
- •26.2 Patient Preparation
- •26.3 Original Technique
- •26.3.1 Anesthesia
- •26.3.2 Local Anesthesia
- •26.3.2.1 Mixture
- •26.3.3 Technique
- •26.4 Surgical Dissection
- •26.4.1 Hernia Sac Treatment
- •26.4.1.1 Medial Hernia Sac
- •26.4.1.2 Lateral Hernia Sac
- •26.4.2 The Mesh: Material
- •26.4.3 Mesh Fixation
- •References
- •27: Mesh Plug Repair
- •27.1 Introduction
- •27.2 Surgical Technique
- •27.3 Comments
- •References
- •28.1 Introduction
- •28.3 Surgical Procedure
- •28.3.1 Anesthesia
- •28.4.1 Antibiotic Prophylaxis
- •28.4.2 Preoperative Landmarks
- •28.4.3 Anesthesia
- •28.4.4 Nerve Management
- •28.4.5 Hernial Sac Management
- •28.4.6 Mesh Application
- •28.4.7 In Females
- •28.5 Discussion and Conclusions
- •References
- •29: Gilbert Technique: PHS Bilayer Repair
- •29.3 Suture Repairs
- •29.4 Anterior Mesh Repairs
- •29.9.4.1 Medial (Direct) Hernias
- •29.9.4.2 Lateral (Indirect) Hernias
- •29.9.7 Post-op Care
- •29.10 Results
- •29.13 Discussion
- •References
- •30.1 Introduction
- •30.2 The ONSTEP Technique
- •30.3 Clinical Data
- •30.5 Health Economics
- •30.6 Perspectives
- •References
- •31.1 Introduction
- •31.2 Anesthesia
- •31.3 Operative Technique: Lateral Hernia
- •31.3.1 First Step: Skin Incision
- •31.3.2 Second Step: Nerve Preservation
- •31.4 Operative Technique: Medial Hernia
- •31.6 Results
- •References
- •32: Minimal Open Preperitoneal (MOPP) Technique
- •32.1 Introduction
- •32.3 Surgical Technique
- •32.4 Indications
- •32.5 Special Cases
- •32.5.1 Female Hernias
- •32.5.2 Femoral Hernia
- •32.5.3 Scrotal Hernia
- •32.5.4 Strangulated Hernia
- •32.6 Contraindications
- •32.7 Personal Data
- •References
- •33.1 Introduction
- •33.2 Indications
- •33.3 Contraindications
- •33.4 Relative Contraindications
- •33.5 Preoperative Preparation
- •33.6 Operating Theatre Setup
- •33.6.1 Instruments
- •33.7 Surgical Technique
- •33.7.5 Hernia Reduction
- •33.7.5.1 Medial or Direct Hernia
- •33.7.5.2 Femoral Hernia
- •33.7.5.3 Obturator Hernia
- •33.7.5.4 Indirect Hernia
- •33.7.5.5 Mesh Repair
- •33.8 Postoperative Care
- •33.9 Complications
- •References
- •34: Primary Inguinal Hernia: TAPP
- •34.1 Introduction
- •34.3 The Standardized TAPP Technique
- •34.3.1 Pneumoperitoneum
- •34.3.2 Trocar Placement
- •34.3.3 Dissection
- •34.3.4 Mesh Placement
- •34.3.5 Fixation
- •34.3.6 Peritoneal Closure
- •34.3.8 Antibiotic and Thromboembolic Prophylaxes
- •References
- •35.1 Introduction
- •35.2 Biological Prosthesis
- •35.2.1 Features
- •35.4 Complications
- •35.5 Clean Fields
- •35.6 Contaminated Fields
- •35.7 Inguinal Sports Hernias
- •References
- •36: Inguinal Hernia Recurrence
- •36.1 Introduction
- •References
- •37.1 Introduction
- •37.2 Clinical Presentation
- •37.3 Literature Review
- •37.4 Surgical Technique
- •References
- •38: Pubic Inguinal Pain Syndrome (PIPS)
- •38.1 Introduction
- •38.2 Clinical Aspect
- •38.3 Diagnosis
- •38.4 Management
- •38.4.1 Conservative Treatment
- •38.4.2 Surgical Treatment
- •References
- •39.1.1 Incarcerated Hernia
- •39.1.2 Intestinal Occlusion
- •39.1.3 Strangulation
- •39.2 Diagnosis
- •39.2.1 Physical Examination
- •39.2.2 Ultrasound
- •39.2.3 Abdominal Radiographs
- •39.2.4 Computed Tomography
- •39.2.6 Laparoscopy
- •39.2.7 Deep Inguinal Ring Laparoscopy
- •39.3 Surgical Options
- •Bibliography
- •40.1 Watchful Waiting
- •40.2.1 Open Inguinal Hernia Repair
- •40.2.1.1 Mesh-Based Repair
- •40.2.1.2 Mesh Types
- •40.2.1.3 Lichtenstein Repair
- •40.2.1.6 Bilayered Mesh System
- •40.2.1.7 Self-Gripping Mesh
- •40.2.1.8 Glue Fixation
- •40.2.1.9 Preperitoneal Approaches
- •40.2.1.10 Suture-Based Open Repairs
- •40.2.2 Laparoscopic Inguinal Hernia Repair
- •40.2.3 Complications
- •40.2.3.1 Recurrence
- •40.2.3.2 Chronic Pain
- •40.2.3.4 Infections
- •40.2.3.5 Urinary Retention
- •40.2.3.6 Sexual Dysfunction
- •40.2.3.8 Seroma
- •References
- •41.2 Epidemiology
- •41.3.1 Neuropathic Pain Syndromes
- •41.3.1.1 Inguinal Nerve Involvement
- •41.3.1.2 Lower Intercostal Nerve
- •41.3.1.3 Neuroma Formation
- •41.3.2.1 Mesh-Related Pain
- •Meshoma Formation
- •41.3.2.2 Adductor Tendinopathy
- •41.3.2.3 Periostitis Pubis
- •41.3.2.4 Iliopectineal Bursitis
- •41.3.3 Combined Groin Pain Syndromes
- •41.3.3.1 Dysejaculation
- •41.4 Assessment
- •41.4.1 Patient’s History
- •41.4.1.3 Diagnostic Questionnaires
- •41.4.2 Physical Examination
- •41.4.2.4 Spine Examination
- •41.4.3 Pitfalls
- •41.4.4 Imaging
- •41.4.4.1 Ultrasonography
- •41.4.4.2 Computed Tomography
- •41.4.4.3 Magnetic Resonance Imaging
- •41.4.5 Other Diagnostics
- •41.4.5.1 Diagnostic Injections
- •Local Anaesthetic Agents
- •Corticosteroids
- •41.4.5.2 Quantitative Sensory Testing
- •41.4.5.3 Other Imaging Techniques
- •References
- •42.1 Clinical Assessment
- •42.2 Treatment
- •References
- •43.1 Surgical Techniques
- •43.1.1 Endoscopic Groin Exploration
- •43.1.2 Meshoma
- •43.1.3 Fixation
- •43.1.5 Orchialgia
- •43.1.6.1 Operative Technique
- •43.2 Results
- •References
- •References
- •45: Primary Femoral Hernia: Open Anterior Treatment
- •45.1 Introduction
- •45.4 Anaesthesia
- •45.5 Surgical Techniques
- •45.5.1 UHS: Ultrapro Hernia System
- •45.5.2 PHS: Prolene Hernia System
- •45.5.3 UPP: Ultrapro Plug
- •45.9.2 Anaesthesia
- •45.9.3 Local Complications n. 41 (16.8%)
- •45.9.4 Abdominal Complications
- •References
- •46.1 Introduction
- •46.1.2 Anesthesia
- •46.1.3 Surgical Techniques
- •46.1.3.1 The Kugel Approach
- •46.1.3.2 The Transinguinal Preperitoneal Technique (TIPP)
- •46.1.3.3 The Transrectus Sheath Preperitoneal Mesh Technique (TREPP)
- •46.1.3.4 Postoperative Recommendations
- •References
- •47: Laparoscopic Femoral Hernia Repair
- •47.5 Operative Technique
- •47.5.1 Total Extraperitoneal Repair (TEP)
- •References
- •48.1 Risk Factors
- •48.3 Surgical Technique Repair
- •48.4 Surgical Site Infection
- •48.5 Persisting Chronic Pain
- •References
- •49.1.1 Rectus Muscle
- •References
- •50: Umbilical Hernia Repair
- •50.1 Introduction
- •50.2 Open Repair
- •50.2.1 Tissue Repair
- •50.2.2 Mesh Repair
- •50.3 Minimally Invasive Repair
- •50.3.1 Laparoscopic Repair
- •50.3.2 Robotic Repair
- •References
- •51.1 Introduction
- •51.2 The MILOS Technique

6 Materials, Devices andGadgets forHernia Surgery
51
PPM 7, 30days
®
®
16weeks
) 1, 3, 9,
®
– 28days
) PPM (Marlex
®
®
) Open ePTFE (DualMesh
®
)
®
)
®
®
21days
)
®
®
Sepramesh
PPM (Parietene
®
)
®
E/X
®
Composix
ePTFE (DualMesh
Parietene Composite
Open Parietex Composite™
®
)
®
E/X
®
®
)
®
– 4weeks
Open PPM
)
®
– 4weeks
®
)
®
®
)+AlloDerm
®
(Prolene
Sepramesh
Open ePTFE (DualMesh
®
)
®
)+AlloDerm
®
16weeks
– 14days
) – 1, 3, 9,
®
®
®
Mesh)+Interceed
Open ePTFE (DualMesh
)
®
®
E/X
®
Open PPM (Bard
Mesh)
®
®
E/X
®
Lap Parietex Composite™ – 28days
)
®
®
)
®
®
(continued)
– 30, 90days
) (30days)
®
(90days)
®
Surgisis
Open PPM (Marlex
)
®
®
Parietex™
PPM+Icodextrin Parietex™ PPM+Icodextrin
Sepramesh
Rats 91 PPM Open Sepramesh
[134]
2003 Van‘t Riet etal.
Sepramesh
ePTFE (DualMesh
PPM (Marlex
Rabbits 20 ePTFE (DualMesh
Pigs 21 PPM Lap Sepramesh
[135]
2003 Matthews etal.
2004 Borrazzo etal.
Rats 80 PPM (Parietene
[136]
2004 González etal.
Composix
ePTFE (DualMesh
Parietex Composite™
Sepramesh
Parietene Composite
[137]
PPM
ePTFE (DualMesh
(Prolene
Sepramesh
19 PPM (Prolene
Guinea
pigs
Rats 60 PPM (Surgipro™)
[138]
2004 Butler and Prieto
[139]
2005 Kayaoglu etal.
Vypro II®Parietex Composite™
Sepramesh
Composix
Rabbits 30 ePTFE (DualMesh
[140]
2005 Matthews etal.
2005 Demir etal. [141] Rats 30 PPM (Bard
PPM (Bard
Composix
Mesh)+Interceed
Pigs 8 PPM (Prolene
2005 McGinty etal.
ePTFE (DualMesh
Surgisis
Parietex Composite™
Rats 48 PPM (Marlex
[142]
etal. [143]
2005 Konstantinovic

52
D. L. Sanders et al.
30days
) 2months
®
PPM (Prolene
®
Open Sepramesh
®
)
®
)+Hyalobarrier
®
®
®
)+Tissucol
®
) 28days
®
PPM (Prolene
®
Open PPM+Interceed
®
)
)
®
®
– 7, 30days
®
®
Sepramesh
Open Sepramesh
®
)
®
®
Parietex Composite™
)
®
®
®
) 16weeks
®
) PPM (Marlex
®
ePTFE (DualMesh
Sequential
lap
)
®
E/X
®
®
)
®
®
)
®
®
®
PPM (Prolene
PPM+Vicryl
Mersilene
®
®
Proceed
Open ePTFE Bard
)
®
®
®
®
®
Lap Parietex Composite™ PPM 28days
) 1, 3months
®
PPM (Marlex
Composix™
Open cPTFE (MotifMESH™)
)
®
)
®
®
Year Author Animal N Meshes Open/Lap Fewer adhesions More adhesions Timescale
2006 Sikkink etal. [144] Rats 60 PPM (Prolene
Table 6.2 (continued)
PPM
(Prolene
ePTFE (DualMesh
gel
Sepramesh
PPM (Prolene
Parietene Composite
Sepramesh
PPM +Interceed
2006 Dilege etal. [145] Rats 30 PPM (Prolene
2006 Burger etal. [146] Rats 200 PPM (Prolene
ePTFE (DualMesh
Timesh®Sepramesh
Parietex Composite™
Ultrapro
Proceed®Tutomesh
Composix
2006 Harrell etal. [147] Rabbits 60 ePTFE (DualMesh
PPM (Marlex
Proceed
PPM+Vicryl®ePTFE Bard
Mersilene
2007 Kiudelis etal. [148] Rabbits 42 PPM (Prolene
Proceed
Parietex Composite™
2007 Jacob etal. [149] Pigs 10 Proceed
PPM
ePTFE (DualMesh
Proceed
Composix™
PPM (Marlex
Rats – cPTFE (MotifMESH™)
[93]
2007 Voskerician etal.

6 Materials, Devices andGadgets forHernia Surgery
53
3, 7,
14days
) 1year
®
®
Sepramesh
) PPM (Marlex
®
Parietex Composite™
PPM-PU 99
Sequential
®
Proceed
lap
®
Sepramesh
Open ePTFE (DualMesh
)
®
)
®
E/X
®
ePTFE (DualMesh
Composix
PPM (Surgipro™) 28days
E/X PPM 3months
®
®
Open Composix
Lap Sepramesh
E/X
®
Composix
PPM-PU 99
5weeks
PPM
Open PPM+brin glue
E/X
®
®
Sepramesh
Composix
)
®
ePTFE (DualMesh
Plus
)+brin glue
®
ePTFE (DualMesh
Plus
PPM 30days
®
Open Parietene Composite
)
)
®
ePTFE (DualMesh Plus
®
®
)
®
)+brin glue
®
ePTFE (DualMesh
PPM+brin glue
ePTFE (DualMesh
Parietene Composite
Plus
90days
Lap No difference No difference 7, 21,
®
PPM (Prolene)
PPM
Lap No difference No difference 3months
®
Light)
®
®
PPM
Open PPM+brin glue PPM –
)+SurgiWrap
(TiMesh
30days
)
®
PPM
ePTFE (DualMesh
PPM+Col
Lap PVDF+PPM
)
®
PPM
PPM+Col
ePTFE (DualMesh
) 7, 30days
®
PPM (Prolene
(7days)
®
PPM+NVP/BMA
(30days)
Open Proceed
)
®
®
PPM+NVP/BMA
Proceed
PPM
(continued)
Rabbits 24 PPM (Surgipro™)
2007 Novitsky etal. [46] Rabbits 20 PPM (Marlex
2007 Bellón etal. [150] Rabbits 24 Parietex Composite™
2007 Miwa etal. [53] Rats 20 PPM
2008 Marcondes etal.
Pigs 10 PPM
[151]
[152]
2008 Matin-Cartes etal.
Pigs 6 PPM (TiMesh
[153]
2008 Junge etal. [97] Rats 40 PVDF+PPM (DynaMesh
2008 Conze etal. [98] Rabbits – Co-PVDF
2008 Schug-Pass etal.
Rats 40 PPM+brin glue
etal. [154]
2008 Prieto-Diaz-Chavez
2009 Junge etal. [97] Rats 40 PVDF+PPM
2009 Emans etal. [155] Rats – PPM (Prolene

54
D. L. Sanders et al.
120days
®
®
Composix
Open C-Qur™ Proceed
3, 6 ,12,
–
– 7, 30days
®
(7days)
C-Qur™ (7days)
No difference (30days)
Lap Parietex Composite
)
®
\0
®
®
®
®
)
®
®
®
PPM+PAF
Open SIS PPM
180days
PPM+ePTFE 21, 90,
PPM+SIS
Open PP—PU 99
30days
– 90days
Polyester—collagen
composite
Open HPM
Open cPTFE+HPM cPTFE
cPTFE+HFL
18months
)
®
PVDF+PPM
(DynaMesh
®
Lap Parietex Composite
)
®
®
Year Author Animal N Meshes Open/Lap Fewer adhesions More adhesions Timescale
2009 Pierce etal. [156] Rabbits 41 C-Qur™
Table 6.2 (continued)
PPM (Prolite Ultra™)
Composix
Parietex™
Proceed®Sepramesh
ePTFE (DualMesh
Rats – PPM (Prolene
2009 Schreinemacheret
PPM (Ultrapro
TiMesh
Parietex Composite
Proceed
al. [157]
c-Qur™
2009 Costa etal. [158] Rats 55 PPM
PPM+PAF
SIS
Rats 60 PPM
2009 Ansaloni etal.
PPM-PU 99
PPM+SIS
PPM+ePTFE
No mesh (control)
[159]
cPTFE+HPM
Polyester—collagen
composite
HPM
2009 Jin etal. [160] Pigs 9 cPTFE
cPTFE+HPM
cPTFE+HFL
Rats 20 cPTFE
[161]
2010 Voskerician etal.
2010 Zinther etal. [162] Sheep 16 Parietex Composite
PVDF+PPM (DynaMesh

6 Materials, Devices andGadgets forHernia Surgery
55
– 7days
®
Sepramesh
Open Parietex Composite™
)
®
)
®
E/X
®
ePTFE (STP
PPM (Surgipro™)
Composix
)
®
®
®
Mesh
®
ePTFE (DualMesh
MycroMesh
Parietex Composite™
Vypro II
Vicryl
®
®
Sepramesh
AlloDerm
Permacol™
30days
®
SurgiWrap
®
Lap SurgiWrap
®
®
®
Peri-Guard
Veritas
3, 7,
®
®
®
Prevadh
Open Parietex Composite™ Sepramesh
®
®
Prevadh®Sepralm
14days
Proceed
Open PPM+PLLA – 4weeks
®
®
Sepramesh
Proceed
30, 60,
90days
PPM+HA+PLC
Open PPM+Collagen+PLC PPM+PLC
PPM+Sepralm
PPM+HA+PLC
PPM+Collagen+PLC
– Poloxamer—triblock copolymers consisting of central hydrophobic block of polyethylene glycol anked
)
®
)—monolament PPM mesh (Bard
®
by two
– PPM (Marlex
– Polyester composite—polyurethane-covered Dacron mesh (Braun)
(continued)
)—monolament PPM mesh (Ethicon)
®
– PPM (Prolene
Rats 32 SurgiWrap
2010 Gaertneret al. [163] Rats – PPM (Marlex
2010 Gruber–Blum etal.
Rabbits 18 Parietex Composite™
[164]
2011 Rodriguez etal.
[165]
2011 Fujino etal. [166] Rabbits – PPM+PLLA
2011 Yao etal. [167] Rats 93 PPM+PLC
)
®
) – Hydrophilic blocks of polyethylene glycol
®
)—nonwoven macroporous
®
—nonwoven ePTFE (Bard
®
polymer (Solvay)
– Composix
E/X—PPM mesh sewn with polypropylene
®
stitching to a thin sheet of ePTFE (Bard
– Composix
– cPTFE (MotifMESH
—auto manufactured mesh woven with PVDF
—decellularized human dermis (LifeCell™) – PGA—polyglycolic acid
®
®
– Co-PVDF
– AlloDerm
coating (atrium)
condensed PTFE (Proxy Biomedical)
– C-Qur™—PPM with an omega-3 fatty acid bioabsorbable

56
D. L. Sanders et al.
)
®
(Bard
®
)—two-component (PPM+PVDF) monolament mesh (DynaMesh)
®
– PPM (ProLite Ultra™)—PPM (atrium)
)
®
)—auto manufactured mesh woven out of
®
ePTFE suture thread CV-4 (Gore
Year Author Animal N Meshes Open/Lap Fewer adhesions More adhesions Timescale
– ePTFE (CV-4
Table 6.2 (continued)
– PPM+PLC—PPM with a polylactide-co-caprolactone coating
– PPM+PAF—PPM with a coating of polylactic acid lm
)
®
)—two-layered ePTFE mesh with one
®
)—Gore-Tex Soft Tissue Patch, ePTFE with
®
smooth surface and one corduroy surface (Gore
– ePTFE (DualMesh
– ePTFE (STP
– PPM+HA+PLC—PPM with a hyaluronic acid and polylactide-co-caprolactone coatings
) – PPM+PLLA—PPM with poly--lactic acid lm
®
)
®
—uoropassivated polyester (SulzerVacutek
®
—absorbable gelatin lm (Pharmacia and
®
two laminar microporous surfaces (Gore
– Fluorosoft
– Gellm
—PPM mesh coated on one side with a Sepralm
®
—bioabsorbable translucent membrane composed of carboxymethylcellulose and hyaluronic
®
—biological anti-adhesive barrier (Sofradim)
—PPM, polydioxanone composite with oxidized cellulose coating (Ethicon)
®
®
polyurethane lm
– PPM+Collagen+PLC—PPM/collagen composite with a polylactide-co-caprolactone coating
Gel—sterile transparent and highly viscous
®
Upjohn)
gel obtained by condensation of hyaluronic acid (Fidia
Advanced Biopolymers SRL)
– Hyalobarrier
– HFL—human fascia lata – PPM+NVP/BMA—PPM with N-vinyl pyrrolidone and n-butyl methacrylate coating
– PPM (Surgipro™)—monolament PPM mesh (Covidien™)
) – Proceed
®
—lyophilized Dura mater (Braun
®
polymer solution (Baxter)
– HPM—human peritoneal membrane – PPM-PU 99—auto designed prosthesis composed of reticular PPM mesh and a non-absorbable
– Icodextrin—iso-osmolar biodegradable, 1,4-linked glucose
– Interceed—oxidized regenerated cellulose (Ethicon) – Prevadh
– Lyodura
acid (Genzyme)
– Silastic—polydimethylsiloxone prosthesis (Dow Corning)
– Sepramesh
) – Sepralm
®
—PPM mesh bonded on one side to
®
—ePTFE (Gore
®
polyester mesh (Covidien™)
a collagen-oxidized lm (Sofradim)
– Parietex Composite™—collagen-oxidized lm treated
– Mersilene—polyester mesh (Ethicon) – PVDF+PPM (DynaMesh
– Parietene Composite
– MycroMesh
—bioresorbable adhesion barrier lm (Mast)
®
—derived from porcine small intestine submucosa (Cook)
—PPM with titanium coating (PFM Medical)
®
®
– SIS—porcine small intestine submucosa mesh
– SurgiWrap
—patch made from bovine pericardium
®
(Covidien™)
– Permacol™—porcine dermal collagen implant
– Peri-Guard
– TiMesh
)
®
(Synovis
hydrophobic block of polyethylene glycol anked by two
hydrophilic blocks of polyethylene glycol
– Poloxamer—triblock copolymers consisting of central
– PGA—polyglycolic acid – Surgisis

6 Materials, Devices andGadgets forHernia Surgery
57
—acellular collagen matrix from bovine pericardium (RTI Biologics)
®
—brin glue (Baxter)
®
– Tissucol
– Polyester composite—polyurethane-covered Dacron mesh
—partially absorbable composite PPM/poliglecaprone-25 monolament mesh (Ethicon)
®
—acellular bovine pericardium (collagen not cross-linked) (Synovis)
®
– Veritas
) – Tutomesh
®
)—monolament PPM mesh (Bard
®
(Braun)
– PPM (Marlex
– PGA—polyglycolic acid – Ultrapro
– Poloxamer—triblock copolymers consisting of central
®
(Mesh)—Polyglactin 910 (Ethicon)
®
– Vicryl
hydrophobic block of polyethylene glycol anked by two
hydrophilic blocks of polyethylene glycol
—PPM/polyglactin 910 composite mesh (Ethicon)
– Vypro II

58
Fig. 6.8 TiMesh
®
whilst coughing or jumping [135]. Therefore,
meshes used in hernia repair need to tolerate pressure up to at least 180 mmHg before bursting (tensile strength up to 32 N). Moreover, it is important
that the strength of meshes is tested in a biaxial fashion. Virtually all meshes tested invitro are able to
withstand this pressure, even the lightweight meshes
(e.g. Vypro burst pressure = 360 mmHg [136]).
Exceptions are ‘ultra-lightweight’ meshes, such a
TiMesh® extralight (16g/m2) (Fig.6.8), which has a
tensile strength of only 12N [137]; however, in a
clinical trial assessing its performance in groin hernia repair, it performed favourably [137].
The natural elasticity of the abdominal wall at
32 N is about 38%. More compliant lightweight
meshes have been shown to have an elasticity of
about 20–35% at 16 N [136]. Less compliant
heavyweight meshes have only half this elasticity
(4–16% at 16N) and therefore may restrict abdominal movement and distension in some patients.
6.2.5 Classication ofMeshes
Classication systems are vital in improving the
possibility of comparing different studies and
their associated results and would enable us to
structure evidence-based therapeutic guidelines
regarding the use of certain meshes in different
clinical scenarios.
The best-documented mesh classication system was created by Amid in 1997 [138] based on
mesh porosity (Table6.3).
In 2012, a German research group, in conjunction with mesh manufacturers, devised an alternative classication system taking into account
developments in the prosthetics industry [139].
D. L. Sanders et al.
Table 6.3 Amid mesh classication system [178]
Type Description
Type I Macroporous
Type II Microporous
Type III Macroporous or microporous components
Type IV Biomaterials with submicronic pores/sheets
Table 6.4 The German group mesh classication system
[179]
Class Description
Class ILarge pore meshes (textile
porosity of >60% or an
effective porosity of >0%)
Class IISmall pore meshes (textile
porosity of <60% and
without any effective
porosity)
Class
Meshes with special features To prevent
III
Class IVMeshes with lms Meshes without
Class V3D meshes
Class VIBiological Non-cross-linked
Subgroups/
features
Monolament
Multilament
Mixed structure
or polymer
Monolament
Multilament
Mixed structure
or polymer
infection
porosity
Submicronic
pore size
Secondarily
excised pores
Cross-linked
Special features
This classication system differentiates ‘major’
differences (objectied through randomized controlled trials) and ‘minor’ differences (not signicantly different in randomized controlled trials)
between available meshes (Table6.4).
The classication is intended to be used for
analysis of the data from the registry of hernia
repairs, as well as implant failures to detect
major mesh material-related problems. These
classication systems provide useful comparative groups for research purposes; however, none
of the current classication systems give a concise hernia-specic overview of which mesh/
group of meshes is best for a particular
scenario.
Coda and his working colleagues have proposed a classication system based on dening
the weight [140]:

6 Materials, Devices andGadgets forHernia Surgery
59
1. Ultralight ≤35 g/m
2. Light C 35–70 g/m
3. Standard C 70–140 g/m
4. Heavy C ≥140 g/m
2
2
2
2
This classication involves grouping of simple, composite or combined meshes, which is
based on biomaterial composition: simple (prosthetics made of one pure biomaterial), composite
(prosthetics made of two or more different layers), combined (prosthetics made of two materials knitted or woven together) and biologic.
6.2.6 Commercially Available
Meshes
Some of the commercially available meshes are
shown in Tables 6.5, 6.6 and 6.7. Whilst this is a
comprehensive list, it is by no means exhaustive
and since writing this more meshes will likely be
available on the market. For clarity, they are
divided into (a) synthetic non-composite meshes,
(b) composite meshes and (c) biological meshes.
The list is not exhaustive but rather includes the
most commonly used meshes in each category. In
addition to the meshes listed, many manufacturers produce plugs/hernia systems made of the
same material as the at meshes for hernia-specic repairs.
6.2.6.1 Low-Cost Mesh
Although the use of alloplastic mesh is a commonplace in more economically developed countries, in developing countries the cost of mesh
often prohibits its use. In situations, where commercial material is not available or not affordable, large-pore high-density polyethylene
mosquito net has been used as an alternative
[141–148]. It has been found to have a similar
microscopic structure to the commercially available large-pore meshes (Fig.6.9) and has comparable bursting forces [149]. In two clinical trials
assessing the use of mosquito net compared to a
commercial hernia mesh, there was no signicant
difference in the clinical short-term outcome or
in the surgeons’ comfort in handling the two different materials [141, 143]. The price of the
locally bought polyethylene mesh was US$0.0043
as compared to US$108 for the commercial mesh
[143]. Some surgeons initially raised concern
over the use of nylon mosquito net and the risk of
infection and recurrence [53, 150]; however,
recent data shows no difference in complication
rate or recurrence rate when compared with commercial mesh [151, 152].
6.3 Techniques ofMesh Fixation
6.3.1 Introduction
The assessment of success rate of surgical repair
depends on multiple factors that can be broadly
classied into two categories: patient-based outcome measures and surgical outcome measures.
The patient-based outcome measures include
wound complications, recurrence, length of
hospital stay, chronic pain and quality of life.
Surgical outcome measures include ease of material handling and its implantation, in addition to
the operative time. These two categories are further inuenced by a number of factors including
patient’s demographics and comorbidities, the
hernia itself (type, size and complexity), surgical
technique, the mesh and the method of xation
used in the repair.
The purpose of mesh xation is to prevent
migration that can potentially lead to hernia recurrence. Different xation methods have been
described including sutures, tacking, stapling
devices, brin sealant, glues and self-xing meshes;
however, this xation process can be time consuming and costly. Furthermore, signicant complications have been attributed to the method of xation,
presumably due to insufcient xation or nerve
and tissue damage [153]. Complications reported
include mesh migration and recurrence [154–158],
meshoma [159], tack hernias [160], chronic pain
[153, 161–165] and infection [166, 167].
The desirable characteristics of a xation
device (or non-xation technique) are the same
as those factors considered previously in relation
to meshes, namely, biocompatibility, prevention
of recurrence, handling, socioeconomics, infection risk and longevity.

60
D. L. Sanders et al.
(continued)
(Bard)
®
(Bard)
®
P1 (Cousin)
®
(Ethicon)
®
Prolene
Biomesh
Bard Mesh
Preshaped Atrium™ Mesh (Atrium)
pore
(Bard)
®
Mesh (Meadox)
®
Surgipro™ Monolament (Covidien™)
Trelex
3DMax
Preshaped Bard Soft Mesh
Lightweight/large
(Braun)
®
, Optilene Elastic
®
Mesh (Braun)
®
P8 (Cousin)
/Optilene LP
®
®
Optilene
Biomesh
ProLite™ Mesh/ProLite Ultra™ Mesh (Atrium)
Premilene
pore
Titanium coating
Light/
®
(SulzerVacutek)
(Ethicon)
®
ExtraLight/TiMesh
Strong (PFM Medical)
®
®
Surgipro™ Open Weave (Covidien™)
3DMax™ Light Mesh (Bard)
TiMesh
TiMesh
®
Mersilene
Fluorosoft
Coated C-Qur™ Mesh (Atrium) Omega-3 fatty acid coating
Parietex™ (2D, 3D, lightweight monolament) (Covidien™)
Preshaped Parietex™ (various preshaped and folding meshes) (Covidien™)
Sutureless ParietexProGrip™ (Covidien™)
microporous surface and one macroporous
surface
surface and one corduroy surface
) Two-layered ePTFE mesh with one smooth
®
(Gore
®
Dulex™ Mesh Two-layered ePTFE mesh with one
®
DualMesh
regularly spaced macropores
) Two laminar microporous surfaces
®
)
(Gore
®
®
®
Gore Soft Tissue Patch
®
) Silver carbonate and chlorhexidine diacetate
®
) Microporous node and bril structure with
(Gore
MycroMesh
Plus (Gore
®
Plus (Gore
®
MycroMesh
Antimicrobial coating DualMesh
PPM Monolament Heavyweight/small
Non-
absorbable
Non-composite meshes Special characteristics Mesh and manufacturer
Table 6.5 Commonly used commercially available meshes (synthetic non-composite)
Multilament Surgipro™ (Covidien™)
Polyester
mesh
ePTFE mesh Bard
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