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V. K. Alamanda and B. D. Springer
https://t.me/medicina_free
23
23.1 Introduction
23.1.1 Scope oftheProblem—
Periprosthetic Joint Infections
Total joint arthroplasties represent some of the most commonly performed surgeries in the United States. However, periprosthetic joint infection (PJI) is a signi­cant problem associated with increased morbidity and healthcare costs. The incidence of PJI after primary total hip and knee replacements has been reported in the literature to range from 0.5% to up to 2% (Bozic and Ries 2005; Sculco 1993).
PJI has a signicant impact on the patient, the sur-
geon, and the healthcare system (Bozic and Ries 2005).
> The economic burden of PJI is expected to be in
excess of 1.62 billion $ by the year 2020 (Kurtz etal.
2012).
This is crucial to address as current estimates project large increases in demand for total hip (growth of 174% by 2030) and knee arthroplasties (growth of 673% by
2030) (Kurtz etal. 2007). Similar trends are also antici­pated with revision arthroplasty surgery.
23.1.2 Modiable Versus Non-modiable
Risk Factors
It is imperative to appropriately recognize risk factor variables as modiable versus non-modiable. While the scope of this chapter is limited to identifying and acting on modiable risk factors to improve rates of PJI, non- modiable risk factors have also been recog­nized to affect rates of PJI.Specically, revision surgery and non-same day surgery, i.e., surgery performed >24h after admission, have been identied as negatively affecting rates of PJI by Maoz etal. (2015). While it is important to recognize, these risk factors are unfortu­nately beyond the control of the surgeon and their patients.
23.1.3 Currently Available Guidelines
onSurgical Site Infections
The Centers for Disease Control and Prevention (CDC) provided new guidelines that have important updates and recommendations for the prevention of surgical site infections(SSI). These include guidelines from the use of antiseptic soap the night before surgery to maintaining appropriate oxygenation and glycemic control in the perioperative period (Berrios-Torres et al. 2017).
However, as noted by Parvizi etal., the lack of evidence in many of the areas prevents it from being a compre­hensive guide (Parvizi etal. 2017).
Thus, it is essential that we attempt to further under­stand and minimize the risk factors that can affect rates of PJI.In this review, the effects of both patient as well as perioperative modiable risk factors that can affect PJI are analyzed.
23.2 Patient-Modiable Risk Factors
andCurrent Evidence
23.2.1 Diabetes
Diabetes and poor glycemic control have not only been associated with increased risk of surgical site infection in a variety of procedures but are also negatively impli­cated in PJI in multiple studies. Analysis of these studies has shown diabetes to increase the odds ratio by 2.28 times in one of the largest series (Marchant Jr. et al.
2009).
Hemoglobin A1c (Hgb A1c) has been regularly used as a prognostic indicator of long-term glycemic control in patients and may take 3months to reect signicant changes. Patients with good glycemic control should ideally have Hgb A1C levels <7.0. Hgb A1c, a simple test, has frequently been used as a routine screening test which allows the provider to gain insight into the patient’s glycemic control over the past 3 months (Stryker etal. 2013).
> However, perioperative glucose levels may serve as a
better adjunct in predicting PJI as opposed to Hgb
A1c alone (Iorio et al. 2012). Additionally, other
markers such as serum fructosamine have also been
proposed to serve as an adjunct to measuring glyce-
mic control (Shohat etal. 2017).
The stress due to surgery results in an increased produc­tion of hormones antagonizing insulin and predisposes patients to hyperglycemia. Thus, it is important that perioperative glycemic control be strictly enforced. Sur­gical stress-related postoperative hyperglycemia, even in patients without a diagnosis of diabetes, can increase the risk of developing surgical site infection in a dose-related manner.
> Thus, the authors recommend that blood glucose lev-
els be maintained between 110 and 180mg/dL (opti-
mal cutoff of around137 mg/dL) (Kheir etal. 2018) in
the perioperative period through frequent blood
sugar checks and initiation of diabetic management
protocols postoperatively (Gallagher etal. 2017).
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23.2.2 Obesity
Obesity has been correlated with higher rates of osteoar­thritis and eventual increased use of arthroplasty (Workgroup of the American Association of H, Knee Surgeons Evidence Based C 2013). Studies have shown that patient satisfaction and functional improvement in the obese patient population is similar to the nonobese group; however, obese patients are at higher risk of postoperative complications, specically PJI (Mason etal. 2014).
Obesity predisposes patients to increased surgical dis­sections needed for exposure which results in higher sur­gical times. The poor vascularity of adipose tissue further compounds this problem. The consensus opinion from the workgroup of the American Association of Hip and Knee Surgeons (AAHKS) evidence-based committee emphasized delaying total joint arthroplasty in a patient with a BMI >40, especially when associated with other comorbid conditions such as poorly controlled diabetes or malnutrition (Workgroup of the American Association of H, Knee Surgeons Evidence Based C 2013).
Furthermore, a small minority of obese patients may develop metabolic syndrome. This is composed of a cluster of conditions arising from insulin resistance that impairs normal leukocyte function. It is dened as hav-
2
ing a BMI >30kg/m
with central obesity, as well as two of the following conditions: hyperlipidemia, hyperglyc­eridemia, hypertension, or diabetes (Gage etal. 2014). Zmistowski etal. have shown an increased risk of PJI (14.3% vs. 0.8%) in patients with uncontrolled metabolic syndrome compared to patients with controlled disease/ the healthy cohort (Zmistowski etal. 2013).
> Patients with obesity should be screened for other
characteristics that may dene metabolic syndrome.
ferrin level of <200 mg/dL. Of these, preoperative albumin has been found to be highly specic with a high positive predictive value for PJI (Blevins etal.
2018).
Patients with preoperative malnutrition should be encouraged to work with a dietician to help improve their nutritional intake and help prepare them for the catabolic demands required in the postsurgical period.
23.2.4 Smoking
Smoking, and its principal ingredient, nicotine, has been associated with decreased oxygen delivery to tissues sec­ondary to microvascular constriction. Duchman et al. reported an increased risk of wound complications with both current and former smokers in a large national database study. Specically, they found current smokers to have higher rates of wound complications than for­mer smokers as it pertains to PJI (Duchman etal. 2015). The deleterious effects, in particular PJI, seen with smoking have also been conrmed by multiple other studies (Teng etal. 2015).
> Studies have shown that smoking cessation programs
may help decrease complications associated with the use of nicotine, even if introduced as late as just 4weeks before surgery (Lindstrom etal. 2008).
Thus, the authors recommend that patients undergoing total joint arthroplasty have a minimum period of 4 weeks of smoking cessation prior to their surgery. Smoking cessation can be conrmed via easily available laboratory tests such as the serum cotinine assay (nor­mal value of 10μg/L).
23.2.3 Malnutrition
A frequently unrecognized aspect of obesity involves malnutrition and is associated with high caloric but nutritionally poor diets.
> Malnutrition was found to be present in 42.9% of
obese patients in a prospective study evaluating the role of malnutrition in total joint arthroplasty patients (Huang etal. 2013).
Laboratory tests are easily available and can help to identify patients at risk for malnutrition.
> These include a total lymphocyte count of <1500
cells/mm
3
, a serum albumin of <3.5g/dL, or a trans-
23.2.5 Vitamin D
Vitamin D has long been identied as playing a crucial role in bone health. Vitamin D deciency, as dened by a serum 25-hydroxyvitamin D concentration20ng/mL, is unfortunately prevalent in the population of the United States with an overall reported rate of 41.6% (Forrest and Stuhldreher 2011). Studies have shown patients with PJI to have low levels of Vitamin D.Animal models have also demonstrated that reversal of Vitamin D deciency can help improve rates of PJI (Hegde etal. 2017).
> Thus, the authors recommend that Vitamin D levels
be obtained preoperatively and if decient, i.e.,< 20ng/mL, supplementation be instituted.
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23.2.6 Staphylococcus Aureus Screening
Nasal swab rapid polymerase chain reaction has allowed physicians to identify patients who are colonized with methicillin-resistant Staphylococcus aureus (MRSA). This helps eliminate the bacteria from the patient’s nasal ora prior to surgery. Implementation of an institution­wide prescreening program allows for the identication of the carrier status of S. aureus among patients; this can then lead to a signicant reduction in postoperative rates of surgical site infections (Kim etal. 2010).
It is the authors‘recommendation that patients undergoing elective total joint arthroplasty undergo screening for S. aureus through nasal swabs.
> The authors recommend that patients undergo appli-
cation of mupirocin nasal ointment twice daily to
both nares and a daily bath with chlorhexidine for
5days immediately prior to the scheduled surgery if
the nasal swab testing is positive.
> Additionally, patients screened positive for MRSA
should also receive a single dose of vancomycin along
with standard perioperative antibiotics during their
surgery.
disease-modifying antirheumatic medications (DMARDS) do not need to be withheld prior to sur­gery.
> However, immunomodulating agents such as TNFα
inhibitors place patients at an increased risk for the development of PJI and should be withheld one dos­ing cycle prior to surgery.
23.2.8 Urinary Tract Infections
A common type of nosocomial infection, urinary tract infections (UTI), creates a reservoir of pathogens and potentially increases patient morbidity during surgical intervention. The role of UTI in the development of PJI, however, remains controversial. Some authors have noted the development of PJI in patients with UTI (David and Vrahas 2000) while others have shown no association between UTI and PJI (Koulouvaris et al.
2009).
> It is the authors’ recommendation that if the patient
has symptoms of UTI such as dysuria, urgency, and frequency and has >1 × 10 (CFU)/mL of urine, surgery should be postponed.
5
colony forming units
23
23.2.7 Inammatory Arthropathies
Patients aficted with inammatory arthropathies such as rheumatoid arthritis and lupus are at increased risk of postoperative infection. Multiple systematic reviews have validated the correlation between inammatory arthropathies and periprosthetic infection. Pooled stud­ies such as that by Kong etal. have shown that rheuma­toid arthritis can increase the odds of PJI by 1.57 (Kong etal. 2017).
Many of these patients are on multiple-drug regi­mens that may include immunomodulators. These medi­cations often have signicant effects on wound healing and infections. For example, tumor necrosis factor alpha (TNFα) inhibitors are frequently used as a powerful agent in the management of these diseases. However, by modulating the immune system, they place patients at signicant risk for developing infections. Momohara et al. reported that patients on TNFα inhibitors were found to be at higher risk for surgical site infections (Momohara etal. 2011).
Guidelines jointly published by the American College of Rheumatology (ACR) and the American Association of Hip and Knee Surgeons (AAHKS) used available evidence to make recommendations on which medications should be continued and which medica­tions should be stopped in elective total joint arthro­plasty (Goodman et al. 2017). In general, traditional
> However, if the patient is asymptomatic but has
5
1×10
or more CFU/mL of urine, the authors rec­ommend not withholding surgery and treating his UTI with a routine course of postoperative oral anti­biotics.
23.2.9 Poor Oral Health
Total joint replacement patients tend to have good den­tal hygiene in general (Wood etal. 2016). However, there is not a lot of literature on the role of preoperative screening as well as the association between poor dental hygiene and PJI. Recent studies have questioned the need to obtain routine preoperative dental screening for hip and knee arthroplasty patients (Lampley etal. 2014).
> In general, the authors recommend a common-sense
approach—patients should have a dental exam and clearance if they have evidence of decayed teeth, abscess, gingivitis, or periodontitis and should have routine cleanings done prior to surgical intervention.
23.2.10 Antibiotic Prophylaxis
Preoperative antibiotic prophylaxis is effective in reduc­ing rates of surgical site infections and has been incor-
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porated in many surgical checklists (Fernandez et al.
2001). Routine prophylactic antibiotics should be dosed
in accordance with the patient’s weight and should include a rst-generation cephalosporin such as cefazo­lin. Patients allergic to β-lactam antibiotics should receive vancomycin or clindamycin in a timely fashion. Prophylactic antibiotics should ideally be administered as close to the time of the incision as possible.
> First-generation cephalosporin and clindamycin
should be administered within 1 h and vancomycin within 2h of incision.
> The authors recommend that a single dose of vanco-
mycin be considered in addition to standard preoper­ative antibiotics for those who have been shown to be colonized with MRSA or those who had a prior infec­tion with MRSA.
23.3 Conclusion
The well-known saying, a stitch in time saves nine, is cer­tainly applicable to PJI.Targeting modiable risk fac­tors in the preoperative setting can help alter the risk prole for PJI postoperatively. While enacting on these variables may not completely eliminate the risk of PJI, it can certainly help improve the odds.
Take-Home Messages
5 Periprosthetic joint infections pose high morbid-
ity; however, modiable risk factors can be opti­mized preoperatively to decrease risks.
5 Diabetic patients should have their glycemic con-
trol optimized preoperatively, and frequent blood sugar checks and diabetic management protocols should be implemented postoperatively.
5 Consideration should be given to delaying total
joint arthroplasty in patients with a BMI >40, especially when associated with other comorbid conditions such as poorly controlled diabetes or malnutrition.
5 Patients undergoing total joint arthroplasty should
have a minimum period of 4 weeks of smoking cessation prior to their surgery.
5 Strict antibiotic prophylaxis should be adhered to
including the use of rst- generation cephalospo­rins such as cefazolin. Patients with true allergies to cefazolin should receive vancomycin or clindamycin in a timely fashion.
Disclosure The authors have no funding sources and no
conicts of interest to report for this study.
References
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Kelz RR etal (2017) Centers for disease control and prevention guideline for the prevention of surgical site infection, 2017. JAMA Surg 152(8):784–791
Blevins K, Aalirezaie A, Shohat N, Parvizi J (2018) Malnutrition and
the development of periprosthetic joint infection in patients undergoing primary elective total joint arthroplasty. J Arthroplast
Bozic KJ, Ries MD (2005) The impact of infection after total hip
arthroplasty on hospital and surgeon resource utilization. J Bone Joint Surg Am 87(8):1746–1751
David TS, Vrahas MS (2000) Perioperative lower urinary tract infec-
tions and deep sepsis in patients undergoing total joint arthro­plasty. J Am Acad Orthop Surg 8(1):66–74
Duchman KR, Gao Y, Pugely AJ, Martin CT, Noiseux NO,
Callaghan JJ (2015) The effect of smoking on short-term com­plications following total hip and knee arthroplasty. J Bone Joint Surg Am 97(13):1049–1058
Fernandez AH, Monge V, Garcinuno MA (2001) Surgical antibiotic
prophylaxis: effect in postoperative infections. Eur J Epidemiol 17(4):369–374
Forrest KY, Stuhldreher WL (2011) Prevalence and correlates of
vitamin D deciency in US adults. Nutr Res 31(1):48–54
Gage MJ, Schwarzkopf R, Abrouk M, Slover JD (2014) Impact of
metabolic syndrome on perioperative complication rates after total joint arthroplasty surgery. J Arthroplast 29(9):1842–1845
Gallagher JM, Erich RA, Gattermeyer R, Beam KK (2017)
Postoperative hyperglycemia can be safely and effectively con­trolled in both diabetic and nondiabetic patients with use of a subcutaneous insulin protocol. JB JS Open Access 2(1):e0008
Goodman SM, Springer B, Guyatt G, Abdel MP, Dasa V, George
M et al (2017) 2017 American College of Rheumatology/ American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty. J Arthroplast 32(9):2628–2638
Hegde V, Dworsky EM, Stavrakis AI, Loftin AH, Zoller SD, Park
HY etal (2017) Single-dose, preoperative vitamin-D supplemen­tation decreases infection in a mouse model of periprosthetic joint infection. J Bone Joint Surg Am 99(20):1737–1744
Huang R, Greenky M, Kerr GJ, Austin MS, Parvizi J (2013) The
effect of malnutrition on patients undergoing elective joint arthroplasty. J Arthroplast 28(8 Suppl):21–24
Iorio R, Williams KM, Marcantonio AJ, Specht LM, Tilzey JF,
Healy WL (2012) Diabetes mellitus, hemoglobin A1C, and the incidence of total joint arthroplasty infection. J Arthroplast 27(5):726–729. e1
Kheir MM, Tan TL, Kheir M, Maltenfort MG, Chen AF (2018)
Postoperative blood glucose levels predict infection after total joint arthroplasty. J Bone Joint Surg Am 100(16):1423–1431
Kim DH, Spencer M, Davidson SM, Li L, Shaw JD, Gulczynski D
etal (2010) Institutional prescreening for detection and eradica­tion of methicillin-resistant Staphylococcus aureus in patients undergoing elective orthopaedic surgery. J Bone Joint Surg Am 92(9):1820–1826
Kong L, Cao J, Zhang Y, Ding W, Shen Y (2017) Risk factors for
periprosthetic joint infection following primary total hip or knee arthroplasty: a meta-analysis. Int Wound J 14(3):529–536
Koulouvaris P, Sculco P, Finerty E, Sculco T, Sharrock NE (2009)
Relationship between perioperative urinary tract infection and deep infection after joint arthroplasty. Clin Orthop Relat Res 467(7):1859–1867
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primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am 89(4):780–785
Kurtz SM, Lau E, Watson H, Schmier JK, Parvizi J (2012) Economic
burden of periprosthetic joint infection in the United States. J Arthroplast 27(8 Suppl):61–5 e1
Lampley A, Huang RC, Arnold WV, Parvizi J (2014) Total joint
arthroplasty: should patients have preoperative dental clear­ance? J Arthroplast 29(6):1087–1090
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H etal (2008) Effects of a perioperative smoking cessation inter­vention on postoperative complications: a randomized trial. Ann Surg 248(5):739–745
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The Otto Aufranc Award: modiable versus nonmodiable risk factors for infection after hip arthroplasty. Clin Orthop Relat Res 473(2):453–459
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The impact of glycemic control and diabetes mellitus on periop­erative outcomes after total joint arthroplasty. J Bone Joint Surg Am 91(7):1621–1629
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(2014) Obesity in total joint arthroplasty: an issue with gravity. J Arthroplast 29(10):1879
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Hiroshima R etal (2011) Prosthetic joint infection after total hip or knee arthroplasty in rheumatoid arthritis patients treated with nonbiologic and biologic disease-modifying antirheumatic drugs. Mod Rheumatol 21(5):469–475
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joint infection: new guidelines. Bone Joint J 99-B(4 Supple B):3– 10
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plasty. Instr Course Lect 42:349–351
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Serum fructosamine: a simple and inexpensive test for assessing preoperative glycemic control. J Bone Joint Surg Am 99(22):1900–1907
Stryker LS, Abdel MP, Morrey ME, Morrow MM, Kor DJ, Morrey
BF (2013) Elevated postoperative blood glucose and preopera­tive hemoglobin A1C are associated with increased wound com­plications following total joint arthroplasty. J Bone Joint Surg Am 95(9):808–814, S1–2
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prosthesis-related complications after total hip arthroplasty: a meta-analysis of cohort studies. PLoS One 10(4):e0125294
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Beer J (2016) Dental hygiene in maintaining a healthy joint replacement: a survey of Canadian total joint replacement patients. Curr Orthop Pract 27(5):515–519
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Evidence Based C (2013) Obesity and total joint arthroplasty: a literature based review. J Arthroplast 28(5):714–721
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23
Outpatient Total Knee
https://t.me/medicina_free
Arthroplasty
JoshuaA.Greenspoon, CharlesP.Hannon, andCraigDellaValle
Contents
24.1 Introduction – 270
24.2 Outpatient Total Knee Arthroplasty – 270
24.3 Clinical Outcomes – 272
24.4 Conclusion – 272
References – 273
269
24
© The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2022 E. Hansen, K.-D. Kühn (eds.), Essentials of Cemented Knee Arthroplasty,
https://doi.org/10.1007/978-3-662-63113-3_24
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24.1 Introduction
There has been an increased interest in performing total joint arthroplasty (TJA) in the outpatient setting over the past decade (Berger et al. 2009; Kelly et al. 2018; Kolisek etal. 2009; Meneghini and Ziemba-Davis 2017; Springer et al. 2017). Advances in surgical technique and pain management protocols have allowed for many surgical cases to be safely and successfully performed in the outpatient setting. Surgeons have been motivated to perform procedures in an outpatient setting by several factors including the ability to control more aspects of patient care and the surgical environment, increased patient satisfaction, and potential economic savings for the patient and the healthcare system (Meneghini etal.
2018). As outpatient procedures have become more
prevalent, there is also a growing patient demand for outpatient TJA.In order to achieve optimal patient out­comes and safety, a multidisciplinary approach led by the surgeon must be utilized to create an outpatient TJA program.
24.2 Outpatient Total Knee Arthroplasty
The American Association of Hip and Knee Surgeons (AAHKS) released a consensus statement identifying the following elements as key to successfully performing outpatient TJA:
5 Patient selection 5 Patient education 5 Social support system 5 Clinical and surgical expertise 5 Evidence-based protocols for perioperative manage-
ment (Meneghini etal. 2018)
> Patient selection from both a medical and a social
perspective is key to safely and effectively perform joint replacement surgery in the outpatient setting.
The patient as a whole is considered with regard to the
following:
5 Past medical history 5 Age 5 Body mass index (BMI) 5 Physical tness 5 Mental capacity 5 Social support system 5 Environmental factors
Scoring systems such as the outpatient arthroplasty risk assessment (OARA) score or American Society of Anes­thesiologists (ASA) can be utilized (Ziemba-Davis etal.
2019). The complexity of the surgical case is also evalu-
ated and outpatient surgery is typically reserved for straightforward procedures that do not require extended operative times or complex equipment. Ultimately, the decision to perform surgery as an inpatient or an outpa­tient is a shared decision between patient and surgeon.
In general, patients selected for outpatient total joint
replacements tend to be healthier, younger, and more physically t. The authors do not employ an absolute cut-off for age or BMI.
> Particular attention is paid to cardiac history, history
of anticoagulation, sleep apnea, prior prostate sur­gery or history of urinary retention, and preoperative narcotic use.
History of prostate surgery or urinary retention can pose a challenge with discharge after surgery due to the inability to void and preoperative narcotic use raises concerns about the ability to effectively control pain after surgery (Meneghini etal. 2018). All patients are required to see an internist for preoperative medical evaluation and clearance prior to surgery. If there are any modiable risk factors, these are optimized prior to surgical intervention. There is a low threshold to indi­cate a patient for inpatient total joint replacement if concerns exist.
> As part of patient selection, the patient’s social situa-
tion is carefully evaluated. This includes type of resi­dence, presence of stairs in the house, location of bedrooms, and presence of a family member/care­giver that can assist in the postoperative setting.
Patients who must be able to go up several ights of stairs to get into their home or to their bedroom within the home may need additional physical therapy and thus may be better suited for an inpatient procedure. Detailed preoperative teaching is performed with both the patient and caregiver in either a group or individual setting. The teaching includes setting expectations for the day of sur­gery and postoperatively, outpatient-specic issues including transportation after surgery, and periopera­tive pain management.
A strong working relationship with anesthesia col-
leagues is needed to design and implement an appropri­ate multimodal analgesic regimen. Our current pain protocol is outlined in .
Table 24.1. In multimodal
anesthesia and analgesia, multiple analgesic medica­tions are delivered in different routes and timing that synergistically and additively target different aspects of the pain pathway. Multimodal analgesia has been asso­ciated with better pain control, rapid recovery, and shorter hospitalizations after surgery (Golladay et al.
2017; Kehlet and Dahl 1993).
24
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24
. Table 24.1 Multimodal analgesia protocol at our
institution
Preoperative 1. Acetaminophen (Tylenol) 1000mg PO
2. Celecoxib (Celebrex) 400mg PO
3. Pregabalin (Lyrica) 100mg PO
Intraoperative 1.
Postoperative 1.
> Multimodal analgesia starts before surgery with pre-
emptive analgesia to blunt the sensitization of the peripheral and central nervous system from tissue injury induced during surgery (Kissin 2000).
Periarticular injection (PAI) consisting of ropivicaine 300mg, epinephrine
0.2mg, ketorolac 30mg, clonidine 100 mcg
2. Acetaminophen (Ormev) 1g IV
3. Ketorolac (Toradol) 15mg IV
4. Dexamethasone (Decadron) 10mg IV
Acetaminophen (Tylenol) 1g PO every 8hours scheduled
2. Celecoxib (Celebrex) 200mg PO every 12hours scheduled
3. Gabapentin (Neurontin) 200mg PO every 8hours
4.
Tramadol (Ultram) 100mg PO every 6hours scheduled
5. Oxycodone (OxyIR) 5mg PO every 4hours as needed
We conducted a prospective randomized controlled trial evaluating the quantity of opioid pills prescribed after surgery and found that patients who received 30 oxycodone pills as opposed to 90 oxycodone pills had signicantly fewer leftover pills (15 versus 73) (Hannon
2019). In addition, patients who received 30 oxy-
etal. codone pills were associated with taking fewer oxyco­done pills.
> Today, all patients including inpatient and outpatient
patients receive 30 oxycodone immediate release pills
upon discharge.
Clinical and surgical expertise including preoperative planning is required to be successful in an outpatient setting. Ambulatory surgery centers have inherent limi­tations with respect to inventory and sterile processing capabilities relative to the hospital. Therefore, it is cru­cial to plan cases and communicate effectively with your vendor and surgery center to ensure the necessary equip­ment is ready and available on the day of surgery. Strict discharge criteria must be met prior to discharge includ­ing the following:
5 Hemodynamic stability 5 Ability to tolerate oral uids 5 Adequate pain control with oral pain medications 5 Voiding without difculty, and 5 Safe ambulation and clearance from physical
therapy
We utilize a spinal anesthetic and adductor canal block, which have been shown to lead to improved ambulation and pain control compared to an epidural alone (Kayu­pov etal. 2018).
> For many of our outpatient TKAs, we use a general
anesthetic to avoid any lower extremity weakness and reduce the risk of urinary retention (Kayupov etal.
2018).
Intraoperatively, we administer a periarticular injection, which provides pain relief and reduces opioid consump­tion after TJA (Ma et al. 2019). We also administer intravenous acetaminophen, ketorolac, and dexametha­sone intraoperatively (Murata-Ooiwa etal. 2017; Tam­machote and Kanitnate 2020). Postoperatively, we use a multimodal analgesic program to minimize the use of opioids. Acetaminophen, celecoxib, and gabapentin are given as scheduled medications and tramadol is the rst breakthrough pain medication. Oxycodone immediate release is the last resort breakthrough pain medication. After discharge, we historically prescribed 90–120 opi­oid pills, however, reevaluated this quantity, given the need to reduce overprescribing.
> If a patient fails to meet these criteria, pathways must
be in place to escalate care appropriately to an
overnight-
care suite or facility.
In our practice, a team meeting is held every week to review cases and radiographs for the following week to ensure that all members of the clinical team are on the same page and aware of all the details pertaining to the patients and surgeries for the upcoming week.
In a traditional hospital setting, there is a large network of individuals participating in perioperative patient care and education including social workers, physicians, nurses, nursing aides, physical and occu­pational therapists, dieticians, and other medical providers.
> When performing TJA in the outpatient setting the
responsibility of perioperative care is placed onto the
family and surgeon (Shah etal. 2019).
When comparing the time and encounters between patients that underwent outpatient to inpatient surger­ies, Shah etal. found that each patient undergoing out-
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J. A. Greenspoon et al.
patient surgery required an additional 48.4minutes of staff time to prepare for surgery and care for in the rst 7days postoperatively (Shah etal. 2019).
> Surgeons starting to perform outpatient total joints
should anticipate the additional resources required to care for patients and ensure that the team is ade­quately staffed to do so.
In our practice, a phone call is made from the attending surgeon to the patient in the evening after surgery as well as the following morning to check in with the patient and address additional questions, concerns, or problems. Physician extenders are utilized and readily available to answer and address concerns that arise in the postopera­tive period. An extensive effort is made to encourage patients to contact our ofce initially with any questions or issues that arise in the immediate postoperative period, as opposed to presenting to the emergency department or seeking the advice of their primary care provider. We have a very low threshold to bring patients into the clinic in the postoperative period for further evaluation.
24.3 Clinical Outcomes
department visits, readmission rates, or unplanned clinic visits.
> The authors concluded that in the appropriate patient
population, outpatient TJA had no difference in out-
comes with regard to complications compared to the
traditional inpatient hospital setting (Darrith et al.
2019).
Patient satisfaction has been a focus in evaluating healthcare delivery with the Centers for Medicare and Medicaid services starting to tie nancial reimburse­ment to high-quality care. Kelly et al. investigated patient satisfaction in the inpatient and outpatient TJA population using specic questions from the Hospital Consumer Assessment of Healthcare Providers and Sys­tems (HCAHPS) survey and a satisfaction scale of 0–10 (Kelly etal. 2018). Overall satisfaction scores were simi­larly high in the outpatient (9.7/10) and inpatient group (9.5/10) (Kelly et al. 2018). However, outpatient TJA patients were more satised with courtesy and respect from nurses, assistance getting to bathroom or bedpan, assistance with pain management, staff explanation of medications received, and information concerning symptoms or health problems upon discharge (Kelly etal. 2018).
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Several studies have been published recently pertaining to cost, safety, and clinical outcomes, with a general consensus that outpatient arthroplasty can be performed safely and in a cost-effective manner in the appropriately selected patient (Courtney et al. 2018; Darrith et al.
2019; Huang etal. 2017; Kelly etal. 2018; Lovald etal.
2014)
> Potential decreases in cost on a per-case basis result
from decreased stafng needs, decreased resource uti­lization, and increased efciency in the outpatient set­ting as compared to the traditional hospital setting (Huang etal. 2017).
Savings have been reported up to $8500 or 30% per case for a primary total knee arthroplasty (Huang etal. 2017; Lovald etal. 2014).
A matched single-surgeon cohort analysis consisting of 486 primary arthroplasties performed in either an inpatient or outpatient setting was investigated looking at complications between the two groups in the rst 90days postoperatively (Darrith etal. 2019); 243 con­secutive patients who underwent outpatient total joint replacements were matched to similar patients in the inpatient setting with respect to gender, age, ASA score, and BMI.Results demonstrated that there were no sta­tistically signicant differences in rates of major compli­cations, minor complications, reoperations, emergency
24.4 Conclusion
Outpatient TJA can successfully be performed if careful attention is paid to patient selection and establishing a care pathway focusing on pain management, patient education, and evidence-based protocols for periopera­tive management. Performing surgery in the outpatient setting has the potential to increase patient satisfaction without compromising the quality of patient care and patient safety.
Take-Home Messages
5 Outpatient total joint arthroplasty can be
safely performed in the properly selected patient in both a freestanding ambulatory surgery center or in a hospital setting.
5 Special attention must be given to patient
selection and education for outpatient pro­cedures.
5 A multidisciplinary effort between surgeon,
clinical staff, patient, caregiver, physical therapy, and anesthesia is required to achieve optimal outcomes.
5 Outpatient arthroplasty has the potential to
increase patient and surgeon satisfaction.
Outpatient Total Knee Arthroplasty
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