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W. Wang et al.
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d
. Fig. 22.1 a Coronal varus tibial slope of 6.2° in a Chinese male
22
aged 57. b Accelerated medial knee OA in the same patient after
8years. c X-ray of TKA for left knee in the same patient. d Intraoperative photograph of the same patient, demonstrating varus coronal
slope compared to line marking tibial crest

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. Fig. 22.2 a Thin patella in an 80-year-old Chinese female, mea-
suring 14mm thickness. b X-ray of the same patient 9years after
TKA.Patella resurfacing was not possible in this patient with con-
ences in culture, gender, activity level, or ethnicity (Kim
etal. 2016).
But despite the generally successful results of contemporary TKAs, many patients’ still remain unsatised
with the performance of their replaced knees. This may
be especially the case among Asian patients, since their
lifestyle factors such as oor-based practices call for frequent high-exion movement, causing them to demand
greater postoperative exion for higher satisfaction
(Kim et al. 2008; Kim 2013). Furthermore, if Asian
patients undergoing TKA have unique demographic
and anatomic features known to inuence the surgical
outcome, these should also be taken into consideration
at the level of patient selection, prosthesis design, and
surgical technique (Kim 2013). Many studies (Chung
etal. 2015; Ha and Na 2012; Ishimaru etal. 2014) have
compared the structure of the Asian knee (Japanese,
Chinese, Indian, and Korean) to existing Westerndesigned TKA prostheses systems and these anthropometric studies have suggested that Western-designed
knee prostheses may not be suitable for Asian knees.
ventional implants, despite her patellofemoral symptoms. Care was
taken to position the patella on the femoral component by adjusting
component rotation to ensure the best t for the patellar prole
for Asian patients (Kim
2013). Furthermore, if Asian
patients have certain demographic and anatomical characteristics known to affect clinical outcomes, special
strategies to accommodate the unique nature of Asian
patients may be required for preoperative patient counseling, prosthesis design, surgical technique, and postoperative rehabilitation (Kim etal. 2016).
For instance, high-exion (HF) knee prostheses were
designed to accommodate exion of up to 155° through
modication of posterior condylar geometry and cam
design. Unlike in the Western world, limited exion less
than 130°reportedly impairs patient satisfaction in
Asian populations (Kim etal. 2009b) because it limits
common activities of daily living such as squatting or
kneeling. Lee etal. (2013) reported the performance of
these HF prostheses in Korean patients and showed that
they improve function of TKA (52% could achieve
>135° maximum exion) in Asian patients without
decreasing early survivorship (0.9%). Furthermore, such
HF prostheses might also be associated with less polyethylene wear and subsequent osteolysis.
Based on the observation of a two times higher fail-
> Therefore, some researchers have suggested that
Asian patients should have specially designed TKA
prostheses systems (Kim etal. 2016) to better accommodate differences in knee morphology between
Asians and Caucasians.
Considering the rapidly increasing number of TKAs
performed in Asia, scientic data on Asian patients
undergoing TKA will prove more important in the coming years. Current studies of Asian populations reporting the presence of unique anatomic characteristics of
their patient population can be accommodated in
designing prostheses and optimizing surgical techniques
ure rate for fracture of the gliding surfaces of a multidirectional oating platform knee design (FP) in Asian
countries compared to European countries, Maas etal.
(2014) suggested that it is likely due to a combination of
anatomy-driven internally rotated tibia components and
a higher range of active knee exion, producing a loading scenario which generates tensile stress levels above
the yield strength of the ultrahigh-molecular-weight
polyethylene (UHMWPE) material.
The authors also suggested that an improved posterior stabilized rotating platform design (RPS) would be
more suitable for Asian patients. They found that at neutral tibia position the occurring maximum stress value at

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the FP system is 36% lower than the value determined
for the RPS design. But at a tibia rotation of 10° off the
neutral position, the maximum stress value determined
at the FP system is 44% higher than the value computed
for the RPS system (FP=26MPa vs. RPS=18MPa)
and rst exceeds the material yield strength of 25MPa
with a deformation of the lateral compartment, suggesting that such modications to current TKA prostheses
systems might have some value and signicance to the
Asian population.
Further research into the customization and development of prostheses to accommodate the morphological differences and intricacies of the Asian Knee is
needed to improve outcomes and satisfaction of TKAs
in this subpopulation of patients with unique anatomy,
degree, and patterns of deformities, as well as cultural
aspects, such as a traditional oor-based lifestyle and
frequent high-exion activities in daily living, which
necessitate a substantially higher ROM as compared to
Caucasian patients (Maas etal. 2014).
22.3.2 UKA Utility inAsia
UKA has gained popularity recently because of several
studies (Amin etal. 2006; Lyons etal. 2012; Noticewala
etal. 2012) which have shown that it is less invasive and
has a reduced operative time, larger postoperative ROM,
improved pain relief, earlier return to daily activities and
sports, and cost reduction, in comparison to
TKA. Furthermore, recent advancements in surgical
instruments have contributed to decreasing the learning
curve of the once technically challenging procedure
(Kim etal. 2017). National and annual registries show
similar trends, with increasing usage of UKA over the
past 10years, currently ranging from 5% to 11% globally in 2014 (Kleeblad etal. 2017).
Kim et al. (2017) retrospectively reviewed the midterm results of minimally invasive Oxford medial UKA
and followed 82 knees in 78 relatively young Asian
patients. The authors found that Oxford medial UKA
was reliable and effective in young active Asian patients
providing good clinical results and survival rates in the
mid-term follow-up, with a low complication rate and
the 10-year cumulative survival rate using the Kaplan–
Meier survival method being 94.7% (95% CI: 88.7%–
100%). These mid-term results of UKA in <60-year-old
Asian patients, with a different lifestyle from Western
patients, have not been reported before and support the
existing views that the <60-year-old contraindication for
UKA should be modied,(Bruni etal. 2013; Thompson
etal. 2013) especially so in the Asian context.
UKA has also been shown to give excellent results in
Asian patients. Wong etal. (2014) found that the overall
clinical outcomes of the knee showed the functional
outcome of the knee to be normal in 51%, nearly normal in 37%, abnormal in 8%, and severely abnormal in
only 4% in a study of 48 patients with 51 UKA knees in
Taiwan. Based on their results, the authors concluded
that UKA provides excellent pain relief and restoration
of knee function including kneeling, squatting, and sitto- stand activities that perfectly t the oriental lifestyle
and high patient satisfaction in Asian patients at
medium-term follow-up.
> As such, UKA is a promising option in the Asian
population as well, given its high utility in the restoration of the functional status even among Asians with
high exion demands. However, bearing dislocation is
the most common cause of failure.
Bearing dislocation requires reoperation after UKA and
the risk of bearing dislocation is three times higher in
Asian patients than in their Western counterparts, with
an incidence of 3/82 (3.6%), in a South Korean cohort
studied by Kim etal. (2017). As such, mobile- bearing
UKA may not be the best solution for knee OA in most
Asian patients living in cultures where high exion of
the knee is essential (Bruni etal. 2013). At the very least,
bearing dislocation should be considered as a potential
complication for Asian patients undergoing mobilebearing UKA (Kim et al. 2017) considering their lifestyle that necessitates high exion postures such as
kneeling and squatting.
22.4 Cementless TKA
22.4.1 Background ofCementless TKA
For the most part, cemented tibial xations have been
applied and excellent long-term results have been
reported and while cemented xation remains the gold
standard for TKA, aseptic loosening continues to be a
common failure mechanism, particularly in young
patients (Pap etal. 2018). TKA with cementless xation
was thus developed to decrease cement-related complications, to potentially preserve the native bone stock,
and to prolong implant survivorship. Even though the
original designs were associated with early failures,
innovations in technology have led to newer implants
and biomaterials that accelerate implant osseointegration, which could eventually lead to improved long-term
survivorship of cementless implants (Mont etal. 2017).
Pap etal. (2018) used the combination of titanium
plasma spray and the hydroxyapatite porous-coating
technique in cementless prostheses and the results
showed that the novel SanatSwing cementless total knee

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prosthesis could be a good alternative to cemented
TKA.The authors found normal osseointegration with
the formation of a biological interface between the bone
and the prosthetic components and a signicantly
shorter operation time (likely due to sparing of the
cementing time) with low complication rates that were
almost similar in both groups without any signicant
difference, suggesting the promising applications and
utility of cementless TKA.
22.4.2 Cementless Versus Cemented TKA
Cementless TKA has been shown to have implant survivorshipof 10 and 20 years, which is comparable to
cemented TKA (odds ratio [OR], 1.1; 95% condence
interval [CI], 0.62–2.00) (Mont etal. 2017). In a recent
review of 37 studies by Mont et al. (2017) of the outcomes of cementless TKA in patients <50 years, the
cohort of patients had aseptic survivorship of 100%,
with no periprosthetic complications noted clinically or
radiographically. In contrast, the cemented xation has
been shown to present a greater risk of future aseptic
loosening Nakama etal. 2012).
Furthermore, using cementless TKA is undoubtedly
time-saving, it reduces the pneumatic ischemia time
(there is no need for complete exposure of the trabecular
bone ready to receive the cement), and allows an easier
bone-sparing revision in the event of failure (Wong etal.
2014).
In vitro studies have also demonstrated that the use
of rotating platforms in cementless TKA is associated
with better tribological performance and survival of the
implant, related to the reduction of stresses at the bone–
metal interface (Aprato etal. 2016).
However, cementless tibial baseplates may migrate
early (in the rst 3 months postoperatively), while
cemented tibial components do not migrate in the immediate postoperative period, although they may show
micromotion over 60months.
> No differences have been demonstrated in the migra-
tion pattern of cemented with respect to cementless
femoral components (Aprato etal. 2016).
Nakama et al. (2012) in their systematic review concluded that there was a smaller displacement of the
cemented tibial component as compared to cementless
xation in studies with OA and RA participants who
underwent primary TKA with a follow-up of 2 years.
Likewise, similar results in terms of migration, clinical
outcomes, and survival rates in young patients
(<60years) undergoing knee replacement were found in
a study by Gao etal. (2009).
> Carlsson etal. (Chockalingam and Scott 2000) com-
pared three types of xation (cemented, uncemented
porous, and uncemented porous hydroxyapatite xation) and reported that cementing of the tibial component offers more stable bone-implant contact for
5years postoperatively compared to uncemented xation.
When cemented and cementless cases were amalgamated to form two groups, there was a signicant improvement in survival (P < 0.05, log rank test) in favor of
cemented xation at year 6.
The majority of cementless TKA systems have
endured limited success predominantly due to failed
metal-backed patellar components with subsequent
metallosis (Thompson etal. 2013). Osteolysis secondary
to tibial and patellar failures (due to wear debris such as
polyethylene, metal or both) have typically required
removal and revision of all three components in the
knee replacement in cementless TKA (Berry etal. 1993).
In fact, the United Kingdom, Australia, Sweden, and
New Zealand registry data have shown lower failure
rates and greater usage of cemented than cementless
xation, with level I and II evidence strongly supporting
cemented xation (Aprato etal. 2016).
Beaupre etal. (2007) performed a prospective, randomized clinical trial where the subjects were randomized to be treated with either cementless tibial xation
with hydroxyapatite or cemented tibial xation. At
5-year follow-up, there was no difference between
cementless tibial xation with hydroxyapatite and
cemented tibial xation in terms of self-reported pain,
function, HRQoL, postoperative complications, or
radiographic scores. In a prospective, randomized controlled study of cemented versus uncemented TKA,
Fricka etal. (2015) reported the following ndings:
> At 2years, KSS functional scores, Oxford scores, and
self-reported questions for satisfaction, less pain, and
better function were similar; the cemented group had
higher KSS clinical scores (96.4 vs. 92.3, P =0.03)
and more radiolucencies were seen in knees with
cementless xation (P<0.001).
To date, there is a lack of research into a comparison of
cemented and cementless TKA specically in Asian
populations.
However, of note, anatomical variations in the lower
limb are frequently seen in patients with arthritic knees,
more frequently in Asian populations, including exces-
sive bowing of the femoral shaft and metaphyseal bow-
ing of the proximal tibia.

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Mullaji et al. (2009, 2013) have also suggested the
need for cemented stems in Asia where distorted anatomy in the form of sagittal and coronal bowing of the
femur, a larger valgus correction angle (2–12°), and tibial bowing are often seen, while cementless stems can
only provide 5–7°of valgus. Such excessive bowing may
put the patient at increased risk for end-of-stem pain
and periprosthetic fractures with a long, thick, press-t
uncemented stem, due to malalignment of the components, throwing the femoral component forward and
resulting in a large exion gap. In these situations, a
shorter cemented stem (with a cement restrictor) has
been suggested to be a better option (Beaupre et al.
2007) which is worth considering, especially in Asian
patients.
Notably, cementation of the patellar component is
crucial as it is now clear that cementless patellas are
associated with a high risk of failure due to early loosening of the component (Aprato etal. 2016).
> Compared to cemented xation, uncemented xation
has been shown to involve more PF complications,
including increased susceptibility to wear due to a
thinner polyethylene bearing on the cementless metal-
backed component.
Concluding Remarks on Cementless TKA
z
In conclusion, prosthesis systems for cementless TKA
should be customized to the Asian knee (such as the use
of shorter cemented stems) and assessed using further
research into differential outcomes in Asians between
cemented and various cementless TKA prosthesis systems. Such data should be used, instead of extrapolating
outcomes and results identied in Western populations,
which may not be entirely applicable to Asians, given the
differences in knee morphology.
22.5 Patellofemoral Arthroplasty
andBackground andUtility ofPatellar
Resurfacing
As described in the earlier sections, patellar dimensions
are also different between Asians and Caucasians, with
the Asian patella being smaller and thinner than that of
Caucasians (Kim etal. 2016). So although specic considerations in RP techniques for Asians are necessary, a
specically designed thinner patella prosthesis has also
been suggested to be essential to accommodate the thinner patella in the Asian knee (Hosseinzadeh etal. 2013).
The challenge of restoring preoperative patellar thickness is also greater in Asian patients, in whom it is common to nd a patella of less than 20 mm in thickness
(Hosseinzadeh et al.
2013; Kim et al. 2016; Dy et al.
2012). Jhurani etal. (2018b) recently also found that the
6.2mm thin patellar button is useful to restore the native
thickness in such patients with a patellar thickness of
less than 20mm, without risk of button fracture, loosening, or overstufng, which is especially applicable in
Asians undergoing RP.
> Yet, while some implant manufacturers have recently
taken Asian anthropometric data into consideration
when designing implants for this population which
has smaller and narrower bone sizes, the patellar button thickness has not been revised.
Sulaiman and Nordin (2005) also reported that in a
cross-sectional study on patella thickness using plain
radiographs of 56 patients in Malaysia, the average
thickness of the bony part of the patella was 20.05mm
(range 17–23mm) and the actual thickness of cartilage
varied from 2.0 to 5.5mm (mean 3.2mm). The authors
concluded that since the majority of the patients in their
cohort (73%) had patellar thickness of 24 mm or less,
the majority of their patients in Malaysia are not suitable for RP as a patella of 25mm or less in thickness is
not suitable for resurfacing using the currently available
total knee systems. This further suggests the limited utility of current RP systems in Asian patients and supports
the need for further development and adapting of knee
replacement systems to suit the thinner and smaller
Asian patella.
Summary and Conclusion
z
Total knee arthroplasty is one of the most successful
clinical interventions for severe, end-stage OA and substantially improves the patients’ quality of life after surgery, especially in terms of pain reduction, suggesting
the high utility and benet of TKA as the treatment of
choice for severe knee OA.Given both population aging
and the rapid economic growth Asia, it is likely that
knee OA will become a more prevalent problem and that
the utilization of TKA will increase in many Asian
countries as well, with many Asian countries already
showing a rapid rise in TKA rates, including South
Korea, Taiwan, Vietnam, and China.
However, of note, TKA in Asian populations
involves a few unique challenges, especially that of
higher demands of postoperative exion among Asians.
Special considerations in TKA for Asians are also
required. Recent anthropometric studies have suggested
that the current design of TKA does not cater to racial
anthropometric differences and most of the commercially available TKA prostheses are designed according
to the anthropometric data of Caucasian knees, causing
component mismatch when used in Asian patients.

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Almost all prosthetic implants have been designed
and manufactured to accommodate the knee anatomy
of Caucasians, resulting in TKA component mismatch.
This has led some researchers to suggest that Asians
should have special designs of the TKA prostheses system based on accurate morphologic data of the Asian
knee. With the higher prevalence of knee OA and the
increasing use of TKA in Asia, it has become essential
to understand the differences between knee morphology
and anatomy of the Asian and Caucasian population to
improve TKA prostheses and the outcomes of TKA in
Asian populations.
Furthermore, if Asian patients have certain demographic and anatomical characteristics known to affect
clinical outcomes, special strategies to cater to these, in
terms of modied prosthesis design, surgical technique,
and postoperative rehabilitation, would be greatly benecial. For instance, high-exion (HF) knee prostheses
in Korean patients improve function of TKA in Asian
patients without decreasing early survivorship (0.9%).
Modications to current TKA prostheses systems such
as an improved posterior stabilized rotating platform
design (RPS) might also have some value and signicance to the Asian population who have lifestyle factors
that demand higher exion.
Based on the mid-term results of minimally invasive
Oxford medial UKA in <60-year-old Asian patients
with a different lifestyle from Western patients (which
have not been reported thus far), the view that the
<60-year-old contraindication for UKA should be modied, especially so in the Asian context, is one that is
worth considering and that requires further research
and data in this area. But at the same time, bearing dislocation is three times higher in Asian patients than in
their Western counterparts and should be considered as
a potential complication for Asian patients undergoing
mobile-bearing UKA.
Moreover, with the growing number of younger,
more active patients requiring TKA in Asia, cementless
xation may be the best modality that is most suitable
for those who have an active lifestyle; thereby, decreasing the risk for revision surgery. As such, more prospective, randomized trials are needed to clearly delineate
any differences between cemented and cementless xation options and their utility in Asian populations.
PFA has also been shown to be a viable option for
the treatment of isolated PFOA and modern PFA
designs which onlay style, strict patient selection, and
improvement in surgical techniques have produced satisfactory results in the past decades.
However, current treatment paradigms for PFOA are
inadequate and published guidelines are based exclusively on research utilizing tibiofemoral OA, instead of
evidence for PFOA.As such, future studies assessing the
long-term results of new designs and technologies of
PFA as well as comparison studies to TKA are necessary to evaluate patient outcomes and implant performance.
Clearly, the Asian knee must be given special consideration in the context of TKA regarding the various differences that exist between the anatomy and functional
factors of Asian versus Western knees. As such, future
research into TKA should consider stratication by ethnicity to better delineate how the Asian knee differs
from Western knees, and therefore, how current TKA
systems can be modied to accommodate these differences to further improve knee replacement surgeries in
this patient population. This will allow for further
improvements in postoperative function, satisfaction,
and reduction in complication rates in this subgroup of
patients undergoing TKA.
Take-Home Messages
5 There is an increasing evidence delineating clini-
cally signicant anatomical differences between
the Caucasian and Asian knee. These factors
should play a role in implant design for purposes
of TKA.
5 Cementless TKA, which is increasingly used espe-
cially for young active patients, has the benet of a
lower risk of aseptic loosening. However, improvements to the design to account for angular and
length disparities between implants of the Asian
lower limb should be accounted for.
5 Implant design should also cater to lifestyle fac-
tors of the Asian population, such as the need for
a high-exion prosthesis.
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Clinical Care Pathways
https://t.me/medicina_free
Contents
Chapter 23 Preoperative Optimization in Total Joint
Arthroplasty – 263
Vignesh K. Alamanda and Bryan D. Springer
Chapter 24 Outpatient Total Knee Arthroplasty – 269
Joshua A. Greenspoon, Charles P. Hannon,
and Craig Della Valle
Chapter 25 Perioperative Pain Management in Total Knee
Arthroplasty – 275
Matthew A. Harb, John P. Taliaferro,
and James A. Browne
261
V

263
https://t.me/medicina_free
Preoperative Optimization
inTotal Joint Arthroplasty
VigneshK.Alamanda andBryanD.Springer
Contents
23.1 Introduction – 264
23.1.1 Scope oftheProblem—Periprosthetic Joint Infections – 264
23.1.2
Modiable Versus Non-modiable Risk Factors – 264
Currently Available Guidelines onSurgical Site Infections – 264
23.1.3
23.2 Patient-Modiable Risk Factors andCurrent Evidence – 264
23.2.1 Diabetes – 264
23.2.2 Obesity – 265
23.2.3 Malnutrition – 265
23.2.4 Smoking – 265
23.2.5 Vitamin D – 265
23.2.6 Staphylococcus Aureus Screening – 266
23.2.7 Inammatory Arthropathies – 266
23.2.8
Urinary Tract Infections – 266
23.2.9 Poor Oral Health – 266
23.2.10 Antibiotic Prophylaxis – 266
23
23.3 Conclusion – 267
References – 267
© The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2022
E. Hansen, K.-D. Kühn (eds.), Essentials of Cemented Knee Arthroplasty,
https://doi.org/10.1007/978-3-662-63113-3_23
Соседние файлы в папке Библиотека им академика М.И. Перельмана
