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c
d
. Fig. 22.1 a Coronal varus tibial slope of 6.2° in a Chinese male
22
aged 57. b Accelerated medial knee OA in the same patient after
8years. c X-ray of TKA for left knee in the same patient. d Intraop­erative photograph of the same patient, demonstrating varus coronal slope compared to line marking tibial crest
ab
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. Fig. 22.2 a Thin patella in an 80-year-old Chinese female, mea-
suring 14mm thickness. b X-ray of the same patient 9years after TKA.Patella resurfacing was not possible in this patient with con-
ences in culture, gender, activity level, or ethnicity (Kim etal. 2016).
But despite the generally successful results of con­temporary TKAs, many patients’ still remain unsatised with the performance of their replaced knees. This may be especially the case among Asian patients, since their lifestyle factors such as oor-based practices call for fre­quent high-exion movement, causing them to demand greater postoperative exion for higher satisfaction (Kim et al. 2008; Kim 2013). Furthermore, if Asian patients undergoing TKA have unique demographic and anatomic features known to inuence the surgical outcome, these should also be taken into consideration at the level of patient selection, prosthesis design, and surgical technique (Kim 2013). Many studies (Chung etal. 2015; Ha and Na 2012; Ishimaru etal. 2014) have compared the structure of the Asian knee (Japanese, Chinese, Indian, and Korean) to existing Western­designed TKA prostheses systems and these anthropo­metric studies have suggested that Western-designed knee prostheses may not be suitable for Asian knees.
ventional implants, despite her patellofemoral symptoms. Care was taken to position the patella on the femoral component by adjusting component rotation to ensure the best t for the patellar prole
for Asian patients (Kim
2013). Furthermore, if Asian
patients have certain demographic and anatomical char­acteristics known to affect clinical outcomes, special strategies to accommodate the unique nature of Asian patients may be required for preoperative patient coun­seling, prosthesis design, surgical technique, and post­operative rehabilitation (Kim etal. 2016).
For instance, high-exion (HF) knee prostheses were designed to accommodate exion of up to 155° through modication of posterior condylar geometry and cam design. Unlike in the Western world, limited exion less than 130°reportedly impairs patient satisfaction in Asian populations (Kim etal. 2009b) because it limits common activities of daily living such as squatting or kneeling. Lee etal. (2013) reported the performance of these HF prostheses in Korean patients and showed that they improve function of TKA (52% could achieve >135° maximum exion) in Asian patients without decreasing early survivorship (0.9%). Furthermore, such HF prostheses might also be associated with less poly­ethylene wear and subsequent osteolysis.
Based on the observation of a two times higher fail-
> Therefore, some researchers have suggested that
Asian patients should have specially designed TKA prostheses systems (Kim etal. 2016) to better accom­modate differences in knee morphology between Asians and Caucasians.
Considering the rapidly increasing number of TKAs performed in Asia, scientic data on Asian patients undergoing TKA will prove more important in the com­ing years. Current studies of Asian populations report­ing the presence of unique anatomic characteristics of their patient population can be accommodated in designing prostheses and optimizing surgical techniques
ure rate for fracture of the gliding surfaces of a multidi­rectional oating platform knee design (FP) in Asian countries compared to European countries, Maas etal. (2014) suggested that it is likely due to a combination of anatomy-driven internally rotated tibia components and a higher range of active knee exion, producing a load­ing scenario which generates tensile stress levels above the yield strength of the ultrahigh-molecular-weight polyethylene (UHMWPE) material.
The authors also suggested that an improved poste­rior stabilized rotating platform design (RPS) would be more suitable for Asian patients. They found that at neu­tral tibia position the occurring maximum stress value at
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the FP system is 36% lower than the value determined for the RPS design. But at a tibia rotation of 10° off the neutral position, the maximum stress value determined at the FP system is 44% higher than the value computed for the RPS system (FP=26MPa vs. RPS=18MPa) and rst exceeds the material yield strength of 25MPa with a deformation of the lateral compartment, suggest­ing that such modications to current TKA prostheses systems might have some value and signicance to the Asian population.
Further research into the customization and devel­opment of prostheses to accommodate the morphologi­cal differences and intricacies of the Asian Knee is needed to improve outcomes and satisfaction of TKAs in this subpopulation of patients with unique anatomy, degree, and patterns of deformities, as well as cultural aspects, such as a traditional oor-based lifestyle and frequent high-exion activities in daily living, which necessitate a substantially higher ROM as compared to Caucasian patients (Maas etal. 2014).
22.3.2 UKA Utility inAsia
UKA has gained popularity recently because of several studies (Amin etal. 2006; Lyons etal. 2012; Noticewala etal. 2012) which have shown that it is less invasive and has a reduced operative time, larger postoperative ROM, improved pain relief, earlier return to daily activities and sports, and cost reduction, in comparison to TKA. Furthermore, recent advancements in surgical instruments have contributed to decreasing the learning curve of the once technically challenging procedure (Kim etal. 2017). National and annual registries show similar trends, with increasing usage of UKA over the past 10years, currently ranging from 5% to 11% glob­ally in 2014 (Kleeblad etal. 2017).
Kim et al. (2017) retrospectively reviewed the mid­term results of minimally invasive Oxford medial UKA and followed 82 knees in 78 relatively young Asian patients. The authors found that Oxford medial UKA was reliable and effective in young active Asian patients providing good clinical results and survival rates in the mid-term follow-up, with a low complication rate and the 10-year cumulative survival rate using the Kaplan– Meier survival method being 94.7% (95% CI: 88.7%– 100%). These mid-term results of UKA in <60-year-old Asian patients, with a different lifestyle from Western patients, have not been reported before and support the existing views that the <60-year-old contraindication for UKA should be modied,(Bruni etal. 2013; Thompson etal. 2013) especially so in the Asian context.
UKA has also been shown to give excellent results in Asian patients. Wong etal. (2014) found that the overall
clinical outcomes of the knee showed the functional outcome of the knee to be normal in 51%, nearly nor­mal in 37%, abnormal in 8%, and severely abnormal in only 4% in a study of 48 patients with 51 UKA knees in Taiwan. Based on their results, the authors concluded that UKA provides excellent pain relief and restoration of knee function including kneeling, squatting, and sit­to- stand activities that perfectly t the oriental lifestyle and high patient satisfaction in Asian patients at medium-term follow-up.
> As such, UKA is a promising option in the Asian
population as well, given its high utility in the restora­tion of the functional status even among Asians with high exion demands. However, bearing dislocation is the most common cause of failure.
Bearing dislocation requires reoperation after UKA and the risk of bearing dislocation is three times higher in Asian patients than in their Western counterparts, with an incidence of 3/82 (3.6%), in a South Korean cohort studied by Kim etal. (2017). As such, mobile- bearing UKA may not be the best solution for knee OA in most Asian patients living in cultures where high exion of the knee is essential (Bruni etal. 2013). At the very least, bearing dislocation should be considered as a potential complication for Asian patients undergoing mobile­bearing UKA (Kim et al. 2017) considering their life­style that necessitates high exion postures such as kneeling and squatting.
22.4 Cementless TKA
22.4.1 Background ofCementless TKA
For the most part, cemented tibial xations have been applied and excellent long-term results have been reported and while cemented xation remains the gold standard for TKA, aseptic loosening continues to be a common failure mechanism, particularly in young patients (Pap etal. 2018). TKA with cementless xation was thus developed to decrease cement-related compli­cations, to potentially preserve the native bone stock, and to prolong implant survivorship. Even though the original designs were associated with early failures, innovations in technology have led to newer implants and biomaterials that accelerate implant osseointegra­tion, which could eventually lead to improved long-term survivorship of cementless implants (Mont etal. 2017).
Pap etal. (2018) used the combination of titanium plasma spray and the hydroxyapatite porous-coating technique in cementless prostheses and the results showed that the novel SanatSwing cementless total knee
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prosthesis could be a good alternative to cemented TKA.The authors found normal osseointegration with the formation of a biological interface between the bone and the prosthetic components and a signicantly shorter operation time (likely due to sparing of the cementing time) with low complication rates that were almost similar in both groups without any signicant difference, suggesting the promising applications and utility of cementless TKA.
22.4.2 Cementless Versus Cemented TKA
Cementless TKA has been shown to have implant survi­vorshipof 10 and 20 years, which is comparable to cemented TKA (odds ratio [OR], 1.1; 95% condence interval [CI], 0.62–2.00) (Mont etal. 2017). In a recent review of 37 studies by Mont et al. (2017) of the out­comes of cementless TKA in patients <50 years, the cohort of patients had aseptic survivorship of 100%, with no periprosthetic complications noted clinically or radiographically. In contrast, the cemented xation has been shown to present a greater risk of future aseptic loosening Nakama etal. 2012).
Furthermore, using cementless TKA is undoubtedly time-saving, it reduces the pneumatic ischemia time (there is no need for complete exposure of the trabecular bone ready to receive the cement), and allows an easier bone-sparing revision in the event of failure (Wong etal.
2014).
In vitro studies have also demonstrated that the use of rotating platforms in cementless TKA is associated with better tribological performance and survival of the implant, related to the reduction of stresses at the bone– metal interface (Aprato etal. 2016).
However, cementless tibial baseplates may migrate early (in the rst 3 months postoperatively), while cemented tibial components do not migrate in the imme­diate postoperative period, although they may show micromotion over 60months.
> No differences have been demonstrated in the migra-
tion pattern of cemented with respect to cementless
femoral components (Aprato etal. 2016).
Nakama et al. (2012) in their systematic review con­cluded that there was a smaller displacement of the cemented tibial component as compared to cementless xation in studies with OA and RA participants who underwent primary TKA with a follow-up of 2 years. Likewise, similar results in terms of migration, clinical outcomes, and survival rates in young patients (<60years) undergoing knee replacement were found in a study by Gao etal. (2009).
> Carlsson etal. (Chockalingam and Scott 2000) com-
pared three types of xation (cemented, uncemented porous, and uncemented porous hydroxyapatite xa­tion) and reported that cementing of the tibial com­ponent offers more stable bone-implant contact for 5years postoperatively compared to uncemented xa­tion.
When cemented and cementless cases were amalgam­ated to form two groups, there was a signicant improve­ment in survival (P < 0.05, log rank test) in favor of cemented xation at year 6.
The majority of cementless TKA systems have endured limited success predominantly due to failed metal-backed patellar components with subsequent metallosis (Thompson etal. 2013). Osteolysis secondary to tibial and patellar failures (due to wear debris such as polyethylene, metal or both) have typically required removal and revision of all three components in the knee replacement in cementless TKA (Berry etal. 1993). In fact, the United Kingdom, Australia, Sweden, and New Zealand registry data have shown lower failure rates and greater usage of cemented than cementless xation, with level I and II evidence strongly supporting cemented xation (Aprato etal. 2016).
Beaupre etal. (2007) performed a prospective, ran­domized clinical trial where the subjects were random­ized to be treated with either cementless tibial xation with hydroxyapatite or cemented tibial xation. At 5-year follow-up, there was no difference between cementless tibial xation with hydroxyapatite and cemented tibial xation in terms of self-reported pain, function, HRQoL, postoperative complications, or radiographic scores. In a prospective, randomized con­trolled study of cemented versus uncemented TKA, Fricka etal. (2015) reported the following ndings:
> At 2years, KSS functional scores, Oxford scores, and
self-reported questions for satisfaction, less pain, and
better function were similar; the cemented group had
higher KSS clinical scores (96.4 vs. 92.3, P =0.03)
and more radiolucencies were seen in knees with
cementless xation (P<0.001).
To date, there is a lack of research into a comparison of cemented and cementless TKA specically in Asian populations.
However, of note, anatomical variations in the lower
limb are frequently seen in patients with arthritic knees,
more frequently in Asian populations, including exces-
sive bowing of the femoral shaft and metaphyseal bow-
ing of the proximal tibia.
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Mullaji et al. (2009, 2013) have also suggested the need for cemented stems in Asia where distorted anat­omy in the form of sagittal and coronal bowing of the femur, a larger valgus correction angle (2–12°), and tib­ial bowing are often seen, while cementless stems can only provide 5–7°of valgus. Such excessive bowing may put the patient at increased risk for end-of-stem pain and periprosthetic fractures with a long, thick, press-t uncemented stem, due to malalignment of the compo­nents, throwing the femoral component forward and resulting in a large exion gap. In these situations, a shorter cemented stem (with a cement restrictor) has been suggested to be a better option (Beaupre et al.
2007) which is worth considering, especially in Asian
patients.
Notably, cementation of the patellar component is crucial as it is now clear that cementless patellas are associated with a high risk of failure due to early loosen­ing of the component (Aprato etal. 2016).
> Compared to cemented xation, uncemented xation
has been shown to involve more PF complications,
including increased susceptibility to wear due to a
thinner polyethylene bearing on the cementless metal-
backed component.
Concluding Remarks on Cementless TKA
z
In conclusion, prosthesis systems for cementless TKA should be customized to the Asian knee (such as the use of shorter cemented stems) and assessed using further research into differential outcomes in Asians between cemented and various cementless TKA prosthesis sys­tems. Such data should be used, instead of extrapolating outcomes and results identied in Western populations, which may not be entirely applicable to Asians, given the differences in knee morphology.
22.5 Patellofemoral Arthroplasty
andBackground andUtility ofPatellar Resurfacing
As described in the earlier sections, patellar dimensions are also different between Asians and Caucasians, with the Asian patella being smaller and thinner than that of Caucasians (Kim etal. 2016). So although specic con­siderations in RP techniques for Asians are necessary, a specically designed thinner patella prosthesis has also been suggested to be essential to accommodate the thin­ner patella in the Asian knee (Hosseinzadeh etal. 2013). The challenge of restoring preoperative patellar thick­ness is also greater in Asian patients, in whom it is com­mon to nd a patella of less than 20 mm in thickness
(Hosseinzadeh et al.
2013; Kim et al. 2016; Dy et al.
2012). Jhurani etal. (2018b) recently also found that the
6.2mm thin patellar button is useful to restore the native thickness in such patients with a patellar thickness of less than 20mm, without risk of button fracture, loosen­ing, or overstufng, which is especially applicable in Asians undergoing RP.
> Yet, while some implant manufacturers have recently
taken Asian anthropometric data into consideration when designing implants for this population which has smaller and narrower bone sizes, the patellar but­ton thickness has not been revised.
Sulaiman and Nordin (2005) also reported that in a cross-sectional study on patella thickness using plain radiographs of 56 patients in Malaysia, the average thickness of the bony part of the patella was 20.05mm (range 17–23mm) and the actual thickness of cartilage varied from 2.0 to 5.5mm (mean 3.2mm). The authors concluded that since the majority of the patients in their cohort (73%) had patellar thickness of 24 mm or less, the majority of their patients in Malaysia are not suit­able for RP as a patella of 25mm or less in thickness is not suitable for resurfacing using the currently available total knee systems. This further suggests the limited util­ity of current RP systems in Asian patients and supports the need for further development and adapting of knee replacement systems to suit the thinner and smaller Asian patella.
Summary and Conclusion
z
Total knee arthroplasty is one of the most successful clinical interventions for severe, end-stage OA and sub­stantially improves the patients’ quality of life after sur­gery, especially in terms of pain reduction, suggesting the high utility and benet of TKA as the treatment of choice for severe knee OA.Given both population aging and the rapid economic growth Asia, it is likely that knee OA will become a more prevalent problem and that the utilization of TKA will increase in many Asian countries as well, with many Asian countries already showing a rapid rise in TKA rates, including South Korea, Taiwan, Vietnam, and China.
However, of note, TKA in Asian populations involves a few unique challenges, especially that of higher demands of postoperative exion among Asians. Special considerations in TKA for Asians are also required. Recent anthropometric studies have suggested that the current design of TKA does not cater to racial anthropometric differences and most of the commer­cially available TKA prostheses are designed according to the anthropometric data of Caucasian knees, causing component mismatch when used in Asian patients.
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Almost all prosthetic implants have been designed and manufactured to accommodate the knee anatomy of Caucasians, resulting in TKA component mismatch. This has led some researchers to suggest that Asians should have special designs of the TKA prostheses sys­tem based on accurate morphologic data of the Asian knee. With the higher prevalence of knee OA and the increasing use of TKA in Asia, it has become essential to understand the differences between knee morphology and anatomy of the Asian and Caucasian population to improve TKA prostheses and the outcomes of TKA in Asian populations.
Furthermore, if Asian patients have certain demo­graphic and anatomical characteristics known to affect clinical outcomes, special strategies to cater to these, in terms of modied prosthesis design, surgical technique, and postoperative rehabilitation, would be greatly ben­ecial. For instance, high-exion (HF) knee prostheses in Korean patients improve function of TKA in Asian patients without decreasing early survivorship (0.9%). Modications to current TKA prostheses systems such as an improved posterior stabilized rotating platform design (RPS) might also have some value and signi­cance to the Asian population who have lifestyle factors that demand higher exion.
Based on the mid-term results of minimally invasive Oxford medial UKA in <60-year-old Asian patients with a different lifestyle from Western patients (which have not been reported thus far), the view that the <60-year-old contraindication for UKA should be mod­ied, especially so in the Asian context, is one that is worth considering and that requires further research and data in this area. But at the same time, bearing dis­location is three times higher in Asian patients than in their Western counterparts and should be considered as a potential complication for Asian patients undergoing mobile-bearing UKA.
Moreover, with the growing number of younger, more active patients requiring TKA in Asia, cementless xation may be the best modality that is most suitable for those who have an active lifestyle; thereby, decreas­ing the risk for revision surgery. As such, more prospec­tive, randomized trials are needed to clearly delineate any differences between cemented and cementless xa­tion options and their utility in Asian populations.
PFA has also been shown to be a viable option for the treatment of isolated PFOA and modern PFA designs which onlay style, strict patient selection, and improvement in surgical techniques have produced satis­factory results in the past decades.
However, current treatment paradigms for PFOA are inadequate and published guidelines are based exclu­sively on research utilizing tibiofemoral OA, instead of evidence for PFOA.As such, future studies assessing the long-term results of new designs and technologies of
PFA as well as comparison studies to TKA are neces­sary to evaluate patient outcomes and implant perfor­mance.
Clearly, the Asian knee must be given special consid­eration in the context of TKA regarding the various dif­ferences that exist between the anatomy and functional factors of Asian versus Western knees. As such, future research into TKA should consider stratication by eth­nicity to better delineate how the Asian knee differs from Western knees, and therefore, how current TKA systems can be modied to accommodate these differ­ences to further improve knee replacement surgeries in this patient population. This will allow for further improvements in postoperative function, satisfaction, and reduction in complication rates in this subgroup of patients undergoing TKA.
Take-Home Messages
5 There is an increasing evidence delineating clini-
cally signicant anatomical differences between the Caucasian and Asian knee. These factors should play a role in implant design for purposes of TKA.
5 Cementless TKA, which is increasingly used espe-
cially for young active patients, has the benet of a lower risk of aseptic loosening. However, improve­ments to the design to account for angular and length disparities between implants of the Asian lower limb should be accounted for.
5 Implant design should also cater to lifestyle fac-
tors of the Asian population, such as the need for a high-exion prosthesis.
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Clinical Care Pathways
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Contents
Chapter 23 Preoperative Optimization in Total Joint
Arthroplasty – 263
Vignesh K. Alamanda and Bryan D. Springer
Chapter 24 Outpatient Total Knee Arthroplasty – 269
Joshua A. Greenspoon, Charles P. Hannon, and Craig Della Valle
Chapter 25 Perioperative Pain Management in Total Knee
Arthroplasty – 275
Matthew A. Harb, John P. Taliaferro, and James A. Browne
261
V
263
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Preoperative Optimization inTotal Joint Arthroplasty
VigneshK.Alamanda andBryanD.Springer
Contents
23.1 Introduction – 264
23.1.1 Scope oftheProblem—Periprosthetic Joint Infections – 264
23.1.2
Modiable Versus Non-modiable Risk Factors – 264 Currently Available Guidelines onSurgical Site Infections – 264
23.1.3
23.2 Patient-Modiable Risk Factors andCurrent Evidence – 264
23.2.1 Diabetes – 264
23.2.2 Obesity – 265
23.2.3 Malnutrition – 265
23.2.4 Smoking – 265
23.2.5 Vitamin D – 265
23.2.6 Staphylococcus Aureus Screening – 266
23.2.7 Inammatory Arthropathies – 266
23.2.8
Urinary Tract Infections – 266
23.2.9 Poor Oral Health – 266
23.2.10 Antibiotic Prophylaxis – 266
23
23.3 Conclusion – 267
References – 267
© The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2022 E. Hansen, K.-D. Kühn (eds.), Essentials of Cemented Knee Arthroplasty,
https://doi.org/10.1007/978-3-662-63113-3_23
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